Genetic mutation susceptibility of hearing loss in child with severe neonatal jaundice

Genetic mutation susceptibility of hearing loss in child with severe neonatal jaundice: 2015-11-05T17-39-20Z

Source: Rawal Medical Journal

Farah Dayana Zahedi, Roslenda Abdul Rahman, Adli Ali, Asma Abdullah.


This case report demonstrates a case of 5-year-old non-syndromic Malay boy who passed the hearing screening test however he was confirmed has bilateral profound sensorineural hearing loss diagnosed at 3 months of age by brain stem evoked response (BSER). He has background history of severe neonatal jaundice and male siblings of hearing impairment.
The antenatal and birth history was uneventful apart from maternal hypothyroidism. His other two elder brothers have bilateral sensorineural hearing loss and history of severe neonatal jaundice as well. The ear examinations, computed tomography scan and magnetic resonance imaging revealed normal findings. Right sided cochlear implantation was done at the age of 3 years old and he is still under audiology follow-up.
Conclusion: Genetic studies are important to determine the cause of genetic mutation in susceptibility to hearing impairment that run in his family after severe neonatal jaundice. Those baby with risk of developing hearing loss required diagnostic hearing assessment.