The Listening Project: Interview with Jane Madell, PhD

Jane Madell, PhD, is an internationally recognized expert in pediatric hearing loss and spoken language. She has been on the front lines of advancing efforts in pediatric audiology and speech-language pathology for over 45 years. A few years ago, while giving a workshop she ran across the mother of a former patient, who happened to be the award-winning filmmaker Irene Taylor Brodsky. The serendipitous encounter resulted in The Listening Project, a documentary film about 15 deaf adults who were former pediatric patients of Dr. Madell.

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Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle.

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Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle.

Front Mol Neurosci. 2018;11:137

Authors: You D, Guo L, Li W, Sun S, Chen Y, Chai R, Li H

Abstract
Dysfunctions in hearing and balance are largely connected with hair cell (HC) loss. Although regeneration of HCs in the adult cochlea does not occur, there is still limited capacity for HC regeneration in the mammalian utricle from a distinct population of supporting cells (SCs). In response to HC damage, these Lgr5+ SCs, especially those in the striolar region, can regenerate HCs. In this study, we isolated Lgr5+ SCs and Plp1+ SCs (which originate from the striolar and extrastriolar regions, respectively) from transgenic mice by flow cytometry so as to compare the properties of these two subsets of SCs. We found that the Lgr5+ progenitors had greater proliferation and HC regeneration ability than the Plp1+ SCs and that the Lgr5+ progenitors responded more strongly to Wnt and Notch signaling than Plp1+ SCs. We then compared the gene expression profiles of the two populations by RNA-Seq and identified several genes that were significantly differentially expressed between the two populations, including genes involved in the cell cycle, transcription and cell signaling pathways. Targeting these genes and pathways might be a potential way to activate HC regeneration.

PMID: 29760650 [PubMed]

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StatPearls

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StatPearls

Book. 2018 01

Authors:

Abstract
Special education is the process by which students with special needs are educated by the process of addressing their differences while integrating them as much as possible in the typical environment where their peers are educated. Success, measured as self-sufficiency, academic achievement, and future contributions to the community may not be achieved if the student is not provided this additional help. In the United States and many other countries, children who have educational needs are entitled by law to the identification of these needs, to be evaluated, and to receive services and accommodations that will help them perform to the best of their abilities and reach their academic potential. Special needs can include learning disabilities, speech and language impairments, autism spectrum disorders, cognitive impairments, emotional and behavioral disorders, physical disabilities like cerebral palsy, muscular dystrophies, sensory impairments like vision or hearing, chronic medical illnesses, and any condition that affects optimal education. Whenever possible, the needs of these students should be met in the same environment where typically developing peers learn. Only when progress is lacking in this mainstream setting, then a different classroom placement can be selected for their education. This new setting may include fewer students in the classroom, more teachers, or an increased level of support. The process of moving a child from the typical classroom or educational setting to a more restrictive one is gradual. Emphasis should be placed on finding the balance where the students' educational needs are met in the least restrictive environment.

PMID: 29763032

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Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle.

Related Articles

Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle.

Front Mol Neurosci. 2018;11:137

Authors: You D, Guo L, Li W, Sun S, Chen Y, Chai R, Li H

Abstract
Dysfunctions in hearing and balance are largely connected with hair cell (HC) loss. Although regeneration of HCs in the adult cochlea does not occur, there is still limited capacity for HC regeneration in the mammalian utricle from a distinct population of supporting cells (SCs). In response to HC damage, these Lgr5+ SCs, especially those in the striolar region, can regenerate HCs. In this study, we isolated Lgr5+ SCs and Plp1+ SCs (which originate from the striolar and extrastriolar regions, respectively) from transgenic mice by flow cytometry so as to compare the properties of these two subsets of SCs. We found that the Lgr5+ progenitors had greater proliferation and HC regeneration ability than the Plp1+ SCs and that the Lgr5+ progenitors responded more strongly to Wnt and Notch signaling than Plp1+ SCs. We then compared the gene expression profiles of the two populations by RNA-Seq and identified several genes that were significantly differentially expressed between the two populations, including genes involved in the cell cycle, transcription and cell signaling pathways. Targeting these genes and pathways might be a potential way to activate HC regeneration.

PMID: 29760650 [PubMed]

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via IFTTT

StatPearls

Related Articles

StatPearls

Book. 2018 01

Authors:

Abstract
Special education is the process by which students with special needs are educated by the process of addressing their differences while integrating them as much as possible in the typical environment where their peers are educated. Success, measured as self-sufficiency, academic achievement, and future contributions to the community may not be achieved if the student is not provided this additional help. In the United States and many other countries, children who have educational needs are entitled by law to the identification of these needs, to be evaluated, and to receive services and accommodations that will help them perform to the best of their abilities and reach their academic potential. Special needs can include learning disabilities, speech and language impairments, autism spectrum disorders, cognitive impairments, emotional and behavioral disorders, physical disabilities like cerebral palsy, muscular dystrophies, sensory impairments like vision or hearing, chronic medical illnesses, and any condition that affects optimal education. Whenever possible, the needs of these students should be met in the same environment where typically developing peers learn. Only when progress is lacking in this mainstream setting, then a different classroom placement can be selected for their education. This new setting may include fewer students in the classroom, more teachers, or an increased level of support. The process of moving a child from the typical classroom or educational setting to a more restrictive one is gradual. Emphasis should be placed on finding the balance where the students' educational needs are met in the least restrictive environment.

PMID: 29763032

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