Publication date: February 2018
Source:Gait & Posture, Volume 60
Author(s): Lindsay V. Slater, Austin S. Simpson, Silvia S. Blemker, Jay Hertel, Susan A. Saliba, Arthur L. Weltman, Joseph M. Hart
Lower extremity injuries are most common in more active and fit individuals, suggesting that adaptations from neuromuscular fatigue may differ depending on type of exercise and fitness level. The purpose of this study was to compare changes in gait in highly fit and recreationally active individuals before and after two exercise protocols. Lower extremity kinematics and kinetics were measured on the dominant leg during running before and after two exercise protocols (walking/sport) from 0 to 100% of gait in 24 healthy individuals divided into higher (n=13) and lower fitness (n=11) groups. Change scores were calculated for each point of the gait cycle with 95% confidence intervals. There were no differences between groups in knee or hip kinematics and kinetics in response to the walking exercise protocol, however the higher fit group increased trunk extension and the lower fit group increased trunk lateral flexion after walking exercise. After the sport exercise, the higher fit group increased knee extension, knee valgus, trunk extension, knee flexion moment, knee varus moment, knee abduction moment, knee internal rotation moment, and hip flexion moment compared to the lower fit group. The lower fit group increased hip extension, hip abduction, hip internal rotation, trunk lateral flexion, trunk rotation, and knee external rotation moment compared the higher fit group after sport exercise. Greater between group differences were found with sport exercise compared to walking exercise. It is important to consider type of exercise and fitness level when assessing altered movement patterns in response to fatiguing exercise.
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Πέμπτη 16 Νοεμβρίου 2017
Author response to the letter “The association of bradykinesia and balance control in patients with Alzheimer’s disease?”
Source:Gait & Posture, Volume 60
Author(s): Gro Gujord Tangen, Astrid Bergland, Knut Engedal, Anne Marit Mengshoel
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Biomechanical adaptations during running differ based on type of exercise and fitness level
Publication date: February 2018
Source:Gait & Posture, Volume 60
Author(s): Lindsay V. Slater, Austin S. Simpson, Silvia S. Blemker, Jay Hertel, Susan A. Saliba, Arthur L. Weltman, Joseph M. Hart
Lower extremity injuries are most common in more active and fit individuals, suggesting that adaptations from neuromuscular fatigue may differ depending on type of exercise and fitness level. The purpose of this study was to compare changes in gait in highly fit and recreationally active individuals before and after two exercise protocols. Lower extremity kinematics and kinetics were measured on the dominant leg during running before and after two exercise protocols (walking/sport) from 0 to 100% of gait in 24 healthy individuals divided into higher (n=13) and lower fitness (n=11) groups. Change scores were calculated for each point of the gait cycle with 95% confidence intervals. There were no differences between groups in knee or hip kinematics and kinetics in response to the walking exercise protocol, however the higher fit group increased trunk extension and the lower fit group increased trunk lateral flexion after walking exercise. After the sport exercise, the higher fit group increased knee extension, knee valgus, trunk extension, knee flexion moment, knee varus moment, knee abduction moment, knee internal rotation moment, and hip flexion moment compared to the lower fit group. The lower fit group increased hip extension, hip abduction, hip internal rotation, trunk lateral flexion, trunk rotation, and knee external rotation moment compared the higher fit group after sport exercise. Greater between group differences were found with sport exercise compared to walking exercise. It is important to consider type of exercise and fitness level when assessing altered movement patterns in response to fatiguing exercise.
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Source:Gait & Posture, Volume 60
Author(s): Lindsay V. Slater, Austin S. Simpson, Silvia S. Blemker, Jay Hertel, Susan A. Saliba, Arthur L. Weltman, Joseph M. Hart
Lower extremity injuries are most common in more active and fit individuals, suggesting that adaptations from neuromuscular fatigue may differ depending on type of exercise and fitness level. The purpose of this study was to compare changes in gait in highly fit and recreationally active individuals before and after two exercise protocols. Lower extremity kinematics and kinetics were measured on the dominant leg during running before and after two exercise protocols (walking/sport) from 0 to 100% of gait in 24 healthy individuals divided into higher (n=13) and lower fitness (n=11) groups. Change scores were calculated for each point of the gait cycle with 95% confidence intervals. There were no differences between groups in knee or hip kinematics and kinetics in response to the walking exercise protocol, however the higher fit group increased trunk extension and the lower fit group increased trunk lateral flexion after walking exercise. After the sport exercise, the higher fit group increased knee extension, knee valgus, trunk extension, knee flexion moment, knee varus moment, knee abduction moment, knee internal rotation moment, and hip flexion moment compared to the lower fit group. The lower fit group increased hip extension, hip abduction, hip internal rotation, trunk lateral flexion, trunk rotation, and knee external rotation moment compared the higher fit group after sport exercise. Greater between group differences were found with sport exercise compared to walking exercise. It is important to consider type of exercise and fitness level when assessing altered movement patterns in response to fatiguing exercise.
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Author response to the letter “The association of bradykinesia and balance control in patients with Alzheimer’s disease?”
Publication date: February 2018
Source:Gait & Posture, Volume 60
Author(s): Gro Gujord Tangen, Astrid Bergland, Knut Engedal, Anne Marit Mengshoel
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Source:Gait & Posture, Volume 60
Author(s): Gro Gujord Tangen, Astrid Bergland, Knut Engedal, Anne Marit Mengshoel
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Biomechanical adaptations during running differ based on type of exercise and fitness level
Publication date: February 2018
Source:Gait & Posture, Volume 60
Author(s): Lindsay V. Slater, Austin S. Simpson, Silvia S. Blemker, Jay Hertel, Susan A. Saliba, Arthur L. Weltman, Joseph M. Hart
Lower extremity injuries are most common in more active and fit individuals, suggesting that adaptations from neuromuscular fatigue may differ depending on type of exercise and fitness level. The purpose of this study was to compare changes in gait in highly fit and recreationally active individuals before and after two exercise protocols. Lower extremity kinematics and kinetics were measured on the dominant leg during running before and after two exercise protocols (walking/sport) from 0 to 100% of gait in 24 healthy individuals divided into higher (n=13) and lower fitness (n=11) groups. Change scores were calculated for each point of the gait cycle with 95% confidence intervals. There were no differences between groups in knee or hip kinematics and kinetics in response to the walking exercise protocol, however the higher fit group increased trunk extension and the lower fit group increased trunk lateral flexion after walking exercise. After the sport exercise, the higher fit group increased knee extension, knee valgus, trunk extension, knee flexion moment, knee varus moment, knee abduction moment, knee internal rotation moment, and hip flexion moment compared to the lower fit group. The lower fit group increased hip extension, hip abduction, hip internal rotation, trunk lateral flexion, trunk rotation, and knee external rotation moment compared the higher fit group after sport exercise. Greater between group differences were found with sport exercise compared to walking exercise. It is important to consider type of exercise and fitness level when assessing altered movement patterns in response to fatiguing exercise.
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via IFTTT
Source:Gait & Posture, Volume 60
Author(s): Lindsay V. Slater, Austin S. Simpson, Silvia S. Blemker, Jay Hertel, Susan A. Saliba, Arthur L. Weltman, Joseph M. Hart
Lower extremity injuries are most common in more active and fit individuals, suggesting that adaptations from neuromuscular fatigue may differ depending on type of exercise and fitness level. The purpose of this study was to compare changes in gait in highly fit and recreationally active individuals before and after two exercise protocols. Lower extremity kinematics and kinetics were measured on the dominant leg during running before and after two exercise protocols (walking/sport) from 0 to 100% of gait in 24 healthy individuals divided into higher (n=13) and lower fitness (n=11) groups. Change scores were calculated for each point of the gait cycle with 95% confidence intervals. There were no differences between groups in knee or hip kinematics and kinetics in response to the walking exercise protocol, however the higher fit group increased trunk extension and the lower fit group increased trunk lateral flexion after walking exercise. After the sport exercise, the higher fit group increased knee extension, knee valgus, trunk extension, knee flexion moment, knee varus moment, knee abduction moment, knee internal rotation moment, and hip flexion moment compared to the lower fit group. The lower fit group increased hip extension, hip abduction, hip internal rotation, trunk lateral flexion, trunk rotation, and knee external rotation moment compared the higher fit group after sport exercise. Greater between group differences were found with sport exercise compared to walking exercise. It is important to consider type of exercise and fitness level when assessing altered movement patterns in response to fatiguing exercise.
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Author response to the letter “The association of bradykinesia and balance control in patients with Alzheimer’s disease?”
Publication date: February 2018
Source:Gait & Posture, Volume 60
Author(s): Gro Gujord Tangen, Astrid Bergland, Knut Engedal, Anne Marit Mengshoel
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Source:Gait & Posture, Volume 60
Author(s): Gro Gujord Tangen, Astrid Bergland, Knut Engedal, Anne Marit Mengshoel
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Glutamate is down-regulated and tinnitus loudness-levels decreased following rTMS over auditory cortex of the left hemisphere: A prospective randomized single-blinded sham-controlled cross-over study
Publication date: Available online 3 November 2017
Source:Hearing Research
Author(s): Anthony T. Cacace, Jiani Hu, Stephen Romero, Yang Xuan, Robert F. Burkard, Richard S. Tyler
Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy (1H-MRS) obtained from left and right auditory cortical areas. While no subject in our sample had complete abatement of their tinnitus percept, active but not sham rTMS significantly reduced the loudness level of the tinnitus perception on the order of 4.5 dB; improved subscales in several content areas on the THQ, and down regulated (reduced) glutamate concentrations specific to the auditory cortex of the left temporal lobe that was stimulated.In addition, significant pair-wise correlations were observed among questionnaire variables, metabolite variables, questionnaire-metabolite variables, and metabolite-loudness variables. As part of this correlation analysis, we demonstrate for the first time that active rTMS produced a down regulation in the excitatory neurotransmitter glutamate that was highly correlated (r = 0.77, p < 0.05) with a reduction in tinnitus loudness levels measured psychoacoustically with a magnitude estimation procedure. Overall, this study provides unique information on neurochemical, psychoacoustic, and questionnaire-related profiles which emphasizes the emerging fields of perceptual and cognitive MRS and provides a perspective on a new frontier in auditory and tinnitus-related research.
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Source:Hearing Research
Author(s): Anthony T. Cacace, Jiani Hu, Stephen Romero, Yang Xuan, Robert F. Burkard, Richard S. Tyler
Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy (1H-MRS) obtained from left and right auditory cortical areas. While no subject in our sample had complete abatement of their tinnitus percept, active but not sham rTMS significantly reduced the loudness level of the tinnitus perception on the order of 4.5 dB; improved subscales in several content areas on the THQ, and down regulated (reduced) glutamate concentrations specific to the auditory cortex of the left temporal lobe that was stimulated.In addition, significant pair-wise correlations were observed among questionnaire variables, metabolite variables, questionnaire-metabolite variables, and metabolite-loudness variables. As part of this correlation analysis, we demonstrate for the first time that active rTMS produced a down regulation in the excitatory neurotransmitter glutamate that was highly correlated (r = 0.77, p < 0.05) with a reduction in tinnitus loudness levels measured psychoacoustically with a magnitude estimation procedure. Overall, this study provides unique information on neurochemical, psychoacoustic, and questionnaire-related profiles which emphasizes the emerging fields of perceptual and cognitive MRS and provides a perspective on a new frontier in auditory and tinnitus-related research.
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Glutamate is down-regulated and tinnitus loudness-levels decreased following rTMS over auditory cortex of the left hemisphere: A prospective randomized single-blinded sham-controlled cross-over study
Publication date: Available online 3 November 2017
Source:Hearing Research
Author(s): Anthony T. Cacace, Jiani Hu, Stephen Romero, Yang Xuan, Robert F. Burkard, Richard S. Tyler
Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy (1H-MRS) obtained from left and right auditory cortical areas. While no subject in our sample had complete abatement of their tinnitus percept, active but not sham rTMS significantly reduced the loudness level of the tinnitus perception on the order of 4.5 dB; improved subscales in several content areas on the THQ, and down regulated (reduced) glutamate concentrations specific to the auditory cortex of the left temporal lobe that was stimulated.In addition, significant pair-wise correlations were observed among questionnaire variables, metabolite variables, questionnaire-metabolite variables, and metabolite-loudness variables. As part of this correlation analysis, we demonstrate for the first time that active rTMS produced a down regulation in the excitatory neurotransmitter glutamate that was highly correlated (r = 0.77, p < 0.05) with a reduction in tinnitus loudness levels measured psychoacoustically with a magnitude estimation procedure. Overall, this study provides unique information on neurochemical, psychoacoustic, and questionnaire-related profiles which emphasizes the emerging fields of perceptual and cognitive MRS and provides a perspective on a new frontier in auditory and tinnitus-related research.
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Source:Hearing Research
Author(s): Anthony T. Cacace, Jiani Hu, Stephen Romero, Yang Xuan, Robert F. Burkard, Richard S. Tyler
Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy (1H-MRS) obtained from left and right auditory cortical areas. While no subject in our sample had complete abatement of their tinnitus percept, active but not sham rTMS significantly reduced the loudness level of the tinnitus perception on the order of 4.5 dB; improved subscales in several content areas on the THQ, and down regulated (reduced) glutamate concentrations specific to the auditory cortex of the left temporal lobe that was stimulated.In addition, significant pair-wise correlations were observed among questionnaire variables, metabolite variables, questionnaire-metabolite variables, and metabolite-loudness variables. As part of this correlation analysis, we demonstrate for the first time that active rTMS produced a down regulation in the excitatory neurotransmitter glutamate that was highly correlated (r = 0.77, p < 0.05) with a reduction in tinnitus loudness levels measured psychoacoustically with a magnitude estimation procedure. Overall, this study provides unique information on neurochemical, psychoacoustic, and questionnaire-related profiles which emphasizes the emerging fields of perceptual and cognitive MRS and provides a perspective on a new frontier in auditory and tinnitus-related research.
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Glutamate is down-regulated and tinnitus loudness-levels decreased following rTMS over auditory cortex of the left hemisphere: A prospective randomized single-blinded sham-controlled cross-over study
Source:Hearing Research
Author(s): Anthony T. Cacace, Jiani Hu, Stephen Romero, Yang Xuan, Robert F. Burkard, Richard S. Tyler
Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy (1H-MRS) obtained from left and right auditory cortical areas. While no subject in our sample had complete abatement of their tinnitus percept, active but not sham rTMS significantly reduced the loudness level of the tinnitus perception on the order of 4.5 dB; improved subscales in several content areas on the THQ, and down regulated (reduced) glutamate concentrations specific to the auditory cortex of the left temporal lobe that was stimulated.In addition, significant pair-wise correlations were observed among questionnaire variables, metabolite variables, questionnaire-metabolite variables, and metabolite-loudness variables. As part of this correlation analysis, we demonstrate for the first time that active rTMS produced a down regulation in the excitatory neurotransmitter glutamate that was highly correlated (r = 0.77, p < 0.05) with a reduction in tinnitus loudness levels measured psychoacoustically with a magnitude estimation procedure. Overall, this study provides unique information on neurochemical, psychoacoustic, and questionnaire-related profiles which emphasizes the emerging fields of perceptual and cognitive MRS and provides a perspective on a new frontier in auditory and tinnitus-related research.
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Glutamate is down-regulated and tinnitus loudness-levels decreased following rTMS over auditory cortex of the left hemisphere: A prospective randomized single-blinded sham-controlled cross-over study
Source:Hearing Research
Author(s): Anthony T. Cacace, Jiani Hu, Stephen Romero, Yang Xuan, Robert F. Burkard, Richard S. Tyler
Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy (1H-MRS) obtained from left and right auditory cortical areas. While no subject in our sample had complete abatement of their tinnitus percept, active but not sham rTMS significantly reduced the loudness level of the tinnitus perception on the order of 4.5 dB; improved subscales in several content areas on the THQ, and down regulated (reduced) glutamate concentrations specific to the auditory cortex of the left temporal lobe that was stimulated.In addition, significant pair-wise correlations were observed among questionnaire variables, metabolite variables, questionnaire-metabolite variables, and metabolite-loudness variables. As part of this correlation analysis, we demonstrate for the first time that active rTMS produced a down regulation in the excitatory neurotransmitter glutamate that was highly correlated (r = 0.77, p < 0.05) with a reduction in tinnitus loudness levels measured psychoacoustically with a magnitude estimation procedure. Overall, this study provides unique information on neurochemical, psychoacoustic, and questionnaire-related profiles which emphasizes the emerging fields of perceptual and cognitive MRS and provides a perspective on a new frontier in auditory and tinnitus-related research.
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Glutamate is down-regulated and tinnitus loudness-levels decreased following rTMS over auditory cortex of the left hemisphere: A prospective randomized single-blinded sham-controlled cross-over study
Source:Hearing Research
Author(s): Anthony T. Cacace, Jiani Hu, Stephen Romero, Yang Xuan, Robert F. Burkard, Richard S. Tyler
Using a prospective randomized single-blinded sham-controlled cross-over design, we studied the efficacy of low frequency (1-Hz) repetitive transcranial magnetic stimulation (rTMS) over auditory cortex of the left temporal lobe as an experimental treatment modality for noise-induced tinnitus. Pre/post outcome measures for sham vs. active rTMS conditions included differential changes in tinnitus loudness, self-perceived changes in the Tinnitus Handicap Questionnaire (THQ), and neurochemical changes of brain metabolite concentrations using single voxel proton magnetic resonance spectroscopy (1H-MRS) obtained from left and right auditory cortical areas. While no subject in our sample had complete abatement of their tinnitus percept, active but not sham rTMS significantly reduced the loudness level of the tinnitus perception on the order of 4.5 dB; improved subscales in several content areas on the THQ, and down regulated (reduced) glutamate concentrations specific to the auditory cortex of the left temporal lobe that was stimulated.In addition, significant pair-wise correlations were observed among questionnaire variables, metabolite variables, questionnaire-metabolite variables, and metabolite-loudness variables. As part of this correlation analysis, we demonstrate for the first time that active rTMS produced a down regulation in the excitatory neurotransmitter glutamate that was highly correlated (r = 0.77, p < 0.05) with a reduction in tinnitus loudness levels measured psychoacoustically with a magnitude estimation procedure. Overall, this study provides unique information on neurochemical, psychoacoustic, and questionnaire-related profiles which emphasizes the emerging fields of perceptual and cognitive MRS and provides a perspective on a new frontier in auditory and tinnitus-related research.
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Hearing Loss in Children With Otitis Media With Effusion: Actual and Simulated Effects on Speech Perception.
Objective: Conductive hearing loss simulations have attempted to estimate the speech-understanding difficulties of children with otitis media with effusion (OME). However, the validity of this approach has not been evaluated. The research aim of the present study was to investigate whether a simple, frequency-specific, attenuation-based simulation of OME-related hearing loss was able to reflect the actual effects of conductive hearing loss on speech perception. Design: Forty-one school-age children with OME-related hearing loss were recruited. Each child with OME was matched with a same sex and age counterpart with normal hearing to make a participant pair. Pure-tone threshold differences at octave frequencies from 125 to 8000 Hz for every participant pair were used as the simulation attenuation levels for the normal-hearing children. Another group of 41 school-age otologically normal children were recruited as a control group without actual or simulated hearing loss. The Mandarin Hearing in Noise Test was utilized, and sentence recall accuracy at four signal to noise ratios (SNR) considered representative of classroom-listening conditions were derived, as well as reception thresholds for sentences (RTS) in quiet and in noise using adaptive protocols. Results: The speech perception in quiet and in noise of children with simulated OME-related hearing loss was significantly poorer than that of otologically normal children. Analysis showed that RTS in quiet of children with OME-related hearing loss and of children with simulated OME-related hearing loss was significantly correlated and comparable. A repeated-measures analysis suggested that sentence recall accuracy obtained at 5-dB SNR, 0-dB SNR, and -5-dB SNR was similar between children with actual and simulated OME-related hearing loss. However, RTS in noise in children with OME was significantly better than that for children with simulated OME-related hearing loss. Conclusions: The present frequency-specific, attenuation-based simulation method reflected the effects of OME-related hearing loss on speech perception impairment in quiet environments. In noisy environments, the simulation method could only approximately estimate the effects of OME-related hearing loss on speech perception in typical classroom noise levels. Children with OME-related hearing loss may develop compensatory strategies to reduce the effects of hearing loss in adverse listening environments. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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Hearing Loss in Children With Otitis Media With Effusion: Actual and Simulated Effects on Speech Perception.
Objective: Conductive hearing loss simulations have attempted to estimate the speech-understanding difficulties of children with otitis media with effusion (OME). However, the validity of this approach has not been evaluated. The research aim of the present study was to investigate whether a simple, frequency-specific, attenuation-based simulation of OME-related hearing loss was able to reflect the actual effects of conductive hearing loss on speech perception. Design: Forty-one school-age children with OME-related hearing loss were recruited. Each child with OME was matched with a same sex and age counterpart with normal hearing to make a participant pair. Pure-tone threshold differences at octave frequencies from 125 to 8000 Hz for every participant pair were used as the simulation attenuation levels for the normal-hearing children. Another group of 41 school-age otologically normal children were recruited as a control group without actual or simulated hearing loss. The Mandarin Hearing in Noise Test was utilized, and sentence recall accuracy at four signal to noise ratios (SNR) considered representative of classroom-listening conditions were derived, as well as reception thresholds for sentences (RTS) in quiet and in noise using adaptive protocols. Results: The speech perception in quiet and in noise of children with simulated OME-related hearing loss was significantly poorer than that of otologically normal children. Analysis showed that RTS in quiet of children with OME-related hearing loss and of children with simulated OME-related hearing loss was significantly correlated and comparable. A repeated-measures analysis suggested that sentence recall accuracy obtained at 5-dB SNR, 0-dB SNR, and -5-dB SNR was similar between children with actual and simulated OME-related hearing loss. However, RTS in noise in children with OME was significantly better than that for children with simulated OME-related hearing loss. Conclusions: The present frequency-specific, attenuation-based simulation method reflected the effects of OME-related hearing loss on speech perception impairment in quiet environments. In noisy environments, the simulation method could only approximately estimate the effects of OME-related hearing loss on speech perception in typical classroom noise levels. Children with OME-related hearing loss may develop compensatory strategies to reduce the effects of hearing loss in adverse listening environments. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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Hearing Loss in Children With Otitis Media With Effusion: Actual and Simulated Effects on Speech Perception.
Objective: Conductive hearing loss simulations have attempted to estimate the speech-understanding difficulties of children with otitis media with effusion (OME). However, the validity of this approach has not been evaluated. The research aim of the present study was to investigate whether a simple, frequency-specific, attenuation-based simulation of OME-related hearing loss was able to reflect the actual effects of conductive hearing loss on speech perception. Design: Forty-one school-age children with OME-related hearing loss were recruited. Each child with OME was matched with a same sex and age counterpart with normal hearing to make a participant pair. Pure-tone threshold differences at octave frequencies from 125 to 8000 Hz for every participant pair were used as the simulation attenuation levels for the normal-hearing children. Another group of 41 school-age otologically normal children were recruited as a control group without actual or simulated hearing loss. The Mandarin Hearing in Noise Test was utilized, and sentence recall accuracy at four signal to noise ratios (SNR) considered representative of classroom-listening conditions were derived, as well as reception thresholds for sentences (RTS) in quiet and in noise using adaptive protocols. Results: The speech perception in quiet and in noise of children with simulated OME-related hearing loss was significantly poorer than that of otologically normal children. Analysis showed that RTS in quiet of children with OME-related hearing loss and of children with simulated OME-related hearing loss was significantly correlated and comparable. A repeated-measures analysis suggested that sentence recall accuracy obtained at 5-dB SNR, 0-dB SNR, and -5-dB SNR was similar between children with actual and simulated OME-related hearing loss. However, RTS in noise in children with OME was significantly better than that for children with simulated OME-related hearing loss. Conclusions: The present frequency-specific, attenuation-based simulation method reflected the effects of OME-related hearing loss on speech perception impairment in quiet environments. In noisy environments, the simulation method could only approximately estimate the effects of OME-related hearing loss on speech perception in typical classroom noise levels. Children with OME-related hearing loss may develop compensatory strategies to reduce the effects of hearing loss in adverse listening environments. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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The Acoustic Voice Quality Index Version 03.01 for the Japanese-speaking Population
Source:Journal of Voice
Author(s): Kiyohito Hosokawa, Ben Barsties v Latoszek, Toshihiko Iwahashi, Mio Iwahashi, Shinobu Iwaki, Chieri Kato, Misao Yoshida, Hisanori Sasai, Akira Miyauchi, Naoki Matsushiro, Hidenori Inohara, Makoto Ogawa, Youri Maryn
ObjectivesWe aimed to determine the most appropriate syllable number for analyzing the Acoustic Voice Quality Index for the Japanese-speaking population (AVQIv3-JP) and to validate AVQIv3-JP using the determined syllable number.MethodsFirst, we counted how many syllables should be included in each continuous speech (CS) sample to achieve time-balanced analysis between CS and sustained vowel samples using our previous dataset including 336 CS samples with 58 syllables. From the descriptive statistics of the counted syllable numbers, the most appropriate syllable number was identified. Subsequently, we performed validation procedures of AVQIv3-JP using our latest dataset including 455 recordings.ResultsThirty Japanese syllables were judged to be the most appropriate syllable number. The concurrent validity of the AVQIv3-JP using 30 syllables was confirmed by Spearman's rho of 0.873. Subsequently, the receiver operating characteristic analysis demonstrated the excellent discriminative capability of AVQIv3-JP, showing the area under the curve of 0.915. The AVQIv3's original threshold of 2.43 in the Dutch language corresponded to sensitivity and specificity of 64.6% and 97.3%, respectively. In the present study, a threshold of 1.41 achieved the best accuracy with balanced sensitivity and specificity of 84.4% and 85.6%, respectively. Furthermore, the 95th percentile of the control participants exhibited a threshold of 2.06, showing sensitivity and specificity of 72.1% and 93.8%, respectively, as well as reasonable positive and negative likelihood ratios of 11.7 and 0.298, respectively.ConclusionThe AVQIv3 using 30 Japanese syllables is a reliable measurement tool for estimating the severity of voice quality and detecting abnormal voices.
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Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.
Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.
Int J Dev Biol. 2017;61(8-9):557-563
Authors: Shin JO, Ankamreddy H, Jakka NM, Lee S, Kim UK, Bok J
Abstract
The mammalian inner ear is a complex organ responsible for balance and hearing. Sonic hedgehog (Shh), a member of the Hedgehog (Hh) family of secreted proteins, has been shown to play important roles in several aspects of inner ear development, including dorsoventral axial specification, cochlear elongation, tonotopic patterning, and hair cell differentiation. Hh proteins initiate a downstream signaling cascade by binding to the Patched 1 (Ptch1) receptor. Recent studies have revealed that other types of co-receptors can also mediate Hh signaling, including growth arrest-specific 1 (Gas1), cell-adhesion molecules-related/down-regulated by oncogenes (Cdon), and biregional Cdon binding protein (Boc). However, little is known about the role of these Hh co-receptors in inner ear development. In this study, we examined the expression patterns of Gas1, Cdon, and Boc, as well as that of Ptch1, in the developing mouse inner ear from otocyst (embryonic day (E) 9.5) until birth and in the developing middle ear at E15.5. Ptch1, a readout of Hh signaling, was expressed in a graded pattern in response to Shh signaling throughout development. Expression patterns of Gas1, Cdon, and Boc differed from that of Ptch1, and each Hh co-receptor was expressed in specific cells and domains in the developing inner and middle ear. These unique and differential expression patterns of Hh co-receptors suggest their roles in mediating various time- and space-specific functions of Shh during ear development.
PMID: 29139542 [PubMed - in process]
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Patient-reported benefits from patient organization magazines and Internet-based peer support in Ménière's disease.
| Related Articles |
Patient-reported benefits from patient organization magazines and Internet-based peer support in Ménière's disease.
Patient Prefer Adherence. 2017;11:1851-1857
Authors: Manchaiah V, Pyykkö I, Zou J, Levo H, Kentala E
Abstract
Objectives: To facilitate self-help, the Finnish Ménière's Federation (FMF) provides various kinds of support to persons with Ménière's disease (MD), which includes patient magazines (PM) and Internet-based peer support (iPS). The current study aimed to evaluate the benefits reported by MD patients in terms of PM and iPS.
Method: The study used a cross-sectional survey design with a mixture of structured and open-ended questions administered online. A sample of 185 patients from the FMF membership database provided complete data.
Results: Ninety-two percent of the respondents rated PM as useful, or very useful. The main benefits of PM included: information on the disease and complaints, information about elements of peer support program, patient's experience with useful positive case studies, relevant news on MD, and information of activity of the FMF. Of the 185 persons, 68 reported that they did not have a need for peer support as their disease was either in silent phase or did not cause any annoyance. The main reasons for nonuse were: mild disease, personal reasons, and problems in using. Regarding the benefits of iPS, 75% of recent and 64% of chronic MD patients said that they would benefit from such a program. The main benefits of iPS included: reliable information on the disease and its management, peer support useful for coping with the disease, information about managing MD symptoms, information about managing attitude, and information about therapy. Moreover, the study identified different groups of individuals, which included: nonusers of support from patient organizations, those who used the support but did not feel they benefited, and those who used and also benefited from such programs.
Conclusion: The current study results provide some information about the preferences of MD patients regarding different forms of support and could certainly prove helpful while developing wider support strategies.
PMID: 29138539 [PubMed]
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Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.
Temporal and spatial expression patterns of Hedgehog receptors in the developing inner and middle ear.
Int J Dev Biol. 2017;61(8-9):557-563
Authors: Shin JO, Ankamreddy H, Jakka NM, Lee S, Kim UK, Bok J
Abstract
The mammalian inner ear is a complex organ responsible for balance and hearing. Sonic hedgehog (Shh), a member of the Hedgehog (Hh) family of secreted proteins, has been shown to play important roles in several aspects of inner ear development, including dorsoventral axial specification, cochlear elongation, tonotopic patterning, and hair cell differentiation. Hh proteins initiate a downstream signaling cascade by binding to the Patched 1 (Ptch1) receptor. Recent studies have revealed that other types of co-receptors can also mediate Hh signaling, including growth arrest-specific 1 (Gas1), cell-adhesion molecules-related/down-regulated by oncogenes (Cdon), and biregional Cdon binding protein (Boc). However, little is known about the role of these Hh co-receptors in inner ear development. In this study, we examined the expression patterns of Gas1, Cdon, and Boc, as well as that of Ptch1, in the developing mouse inner ear from otocyst (embryonic day (E) 9.5) until birth and in the developing middle ear at E15.5. Ptch1, a readout of Hh signaling, was expressed in a graded pattern in response to Shh signaling throughout development. Expression patterns of Gas1, Cdon, and Boc differed from that of Ptch1, and each Hh co-receptor was expressed in specific cells and domains in the developing inner and middle ear. These unique and differential expression patterns of Hh co-receptors suggest their roles in mediating various time- and space-specific functions of Shh during ear development.
PMID: 29139542 [PubMed - in process]
from #Audiology via ola Kala on Inoreader http://ift.tt/2mvlF7X
via IFTTT
Patient-reported benefits from patient organization magazines and Internet-based peer support in Ménière's disease.
| Related Articles |
Patient-reported benefits from patient organization magazines and Internet-based peer support in Ménière's disease.
Patient Prefer Adherence. 2017;11:1851-1857
Authors: Manchaiah V, Pyykkö I, Zou J, Levo H, Kentala E
Abstract
Objectives: To facilitate self-help, the Finnish Ménière's Federation (FMF) provides various kinds of support to persons with Ménière's disease (MD), which includes patient magazines (PM) and Internet-based peer support (iPS). The current study aimed to evaluate the benefits reported by MD patients in terms of PM and iPS.
Method: The study used a cross-sectional survey design with a mixture of structured and open-ended questions administered online. A sample of 185 patients from the FMF membership database provided complete data.
Results: Ninety-two percent of the respondents rated PM as useful, or very useful. The main benefits of PM included: information on the disease and complaints, information about elements of peer support program, patient's experience with useful positive case studies, relevant news on MD, and information of activity of the FMF. Of the 185 persons, 68 reported that they did not have a need for peer support as their disease was either in silent phase or did not cause any annoyance. The main reasons for nonuse were: mild disease, personal reasons, and problems in using. Regarding the benefits of iPS, 75% of recent and 64% of chronic MD patients said that they would benefit from such a program. The main benefits of iPS included: reliable information on the disease and its management, peer support useful for coping with the disease, information about managing MD symptoms, information about managing attitude, and information about therapy. Moreover, the study identified different groups of individuals, which included: nonusers of support from patient organizations, those who used the support but did not feel they benefited, and those who used and also benefited from such programs.
Conclusion: The current study results provide some information about the preferences of MD patients regarding different forms of support and could certainly prove helpful while developing wider support strategies.
PMID: 29138539 [PubMed]
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via IFTTT
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