Auditory Outcomes in Patients Who Received Proton Radiotherapy for Craniopharyngioma

Purpose

Compared to photon-based radiotherapy, protons deliver less radiation to healthy tissue resulting in the potential reduction of late complications such as sensorineural hearing loss (SNHL). We report early auditory outcomes in children treated with proton radiotherapy (PRT) for craniopharyngioma.

Method

Conventional frequency (CF = 0.25–8.0 kHz) audiometry, extended high-frequency (EHF = 9.0–16.0 kHz) audiometry, distortion product otoacoustic emission (DPOAE) testing, and speech-in-noise (SIN) assessments were prospectively and longitudinally conducted on 74 children with a median of 2 post-PRT evaluations (range, 1–5) per patient. The median age at PRT initiation was 10 years, and median follow-up time was 2 years. Ototoxicity was classified using the Chang Ototoxicity Grading Scale (Chang & Chinosornvatana, 2010) and the American Speech-Language-Hearing Association (ASHA) criteria (ASHA, 1994). Comparisons were made between baseline and most recent DPOAE levels, with evidence of ototoxicity based on criterion reductions of ≥ 6 dB. The critical difference values for comparing SIN scores between two conditions (i.e., pre- and post-PRT) were used to determine a significant change between test scores.

Results

At last evaluation, no patients had SNHL in the CF range, and 2 patients had SNHL (Chang Grade 1a) in the EHF range. Based on the ASHA criteria, a decrease in hearing was observed in 0 patients in the CF range alone, in 9 patients in the EHF range alone, and in 15 patients in both the CF and EHF ranges. DPOAE levels decreased at a faster rate at higher versus lower frequencies. For 41 evaluable patients, SIN perception did not decline over time (p = .6463).

Conclusion

At a median follow-up time of 2 years post-PRT, normal hearing was maintained within the CF range. However, subclinical decreases in hearing were observed, particularly in the EHF range and in the DPOAE level; thus, long-term follow-up is recommended to monitor for potential auditory late effects from PRT.

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Auditory Outcomes in Patients Who Received Proton Radiotherapy for Craniopharyngioma

Purpose

Compared to photon-based radiotherapy, protons deliver less radiation to healthy tissue resulting in the potential reduction of late complications such as sensorineural hearing loss (SNHL). We report early auditory outcomes in children treated with proton radiotherapy (PRT) for craniopharyngioma.

Method

Conventional frequency (CF = 0.25–8.0 kHz) audiometry, extended high-frequency (EHF = 9.0–16.0 kHz) audiometry, distortion product otoacoustic emission (DPOAE) testing, and speech-in-noise (SIN) assessments were prospectively and longitudinally conducted on 74 children with a median of 2 post-PRT evaluations (range, 1–5) per patient. The median age at PRT initiation was 10 years, and median follow-up time was 2 years. Ototoxicity was classified using the Chang Ototoxicity Grading Scale (Chang & Chinosornvatana, 2010) and the American Speech-Language-Hearing Association (ASHA) criteria (ASHA, 1994). Comparisons were made between baseline and most recent DPOAE levels, with evidence of ototoxicity based on criterion reductions of ≥ 6 dB. The critical difference values for comparing SIN scores between two conditions (i.e., pre- and post-PRT) were used to determine a significant change between test scores.

Results

At last evaluation, no patients had SNHL in the CF range, and 2 patients had SNHL (Chang Grade 1a) in the EHF range. Based on the ASHA criteria, a decrease in hearing was observed in 0 patients in the CF range alone, in 9 patients in the EHF range alone, and in 15 patients in both the CF and EHF ranges. DPOAE levels decreased at a faster rate at higher versus lower frequencies. For 41 evaluable patients, SIN perception did not decline over time (p = .6463).

Conclusion

At a median follow-up time of 2 years post-PRT, normal hearing was maintained within the CF range. However, subclinical decreases in hearing were observed, particularly in the EHF range and in the DPOAE level; thus, long-term follow-up is recommended to monitor for potential auditory late effects from PRT.

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Executive Function in Deaf Children: Auditory Access and Language Access

Purpose

Deaf children are frequently reported to be at risk for difficulties in executive function (EF); however, the literature is divided over whether these difficulties are the result of deafness itself or of delays/deficits in language that often co-occur with deafness. The purpose of this study is to discriminate these hypotheses by assessing EF in populations where the 2 accounts make contrasting predictions.

Method

We use a between-groups design involving 116 children, ages 5–12 years, across 3 groups: (a) participants with normal hearing (n = 45), (b) deaf native signers who had access to American Sign Language from birth (n = 45), and (c) oral cochlear implant users who did not have full access to language prior to cochlear implantation (n = 26). Measures include both parent report and performance-based assessments of EF.

Results

Parent report results suggest that early access to language has a stronger impact on EF than early access to sound. Performance-based results trended in a similar direction, but no between-group differences were significant.

Conclusions

These results indicate that healthy EF skills do not require audition and therefore that difficulties in this domain do not result primarily from a lack of auditory experience. Instead, results are consistent with the hypothesis that language proficiency, whether in sign or speech, is crucial for the development of healthy EF. Further research is needed to test whether sign language proficiency also confers benefits to deaf children from hearing families.

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Memory Span for Spoken Digits in Adults With Cochlear Implants or Typical Hearing: Effects of Age and Identification Ability

Purpose

Short-term and working memory vary across individuals and life span. Studies of how cochlear implant (CI) users remember spoken words often do not fully disentangle perceptual influences from memory assessment because stimulus identification is rarely checked; instead, correct perception is assumed by using simple or practiced stimuli. Here, we examine whether the accuracy and speed of auditory digit identification are associated with short-term and working memory in adults with CIs as a function of age. Do perceptual errors and longer processing times depress memory span scores for such listeners? An intensive digit span assessment using manual responses is compared with traditional digit span, which uses only a few speech-based trials. We also assess how vocoder-based degradation impacts identification and digit span in older versus younger listeners with normal hearing (NH).

Method

We measured forward and backward recall for spoken digits in 25 adults with CIs (M = 57 years; range = 20–82 years), 10 older adults with NH (> 55 years; M = 64 years), and 11 younger adults with NH (< 22 years). Listeners identified recorded digits one at a time by clicking numerals on a computer screen and then were cued to recall the list. In a comparison condition, listeners only identified each item. Listeners with NH also completed the tasks under four conditions of signal degradation implemented using a channel vocoder: four or eight channels crossed with 0- or 6-mm simulated tonotopic shift, administered in randomized blocks. A mixed design was used, with the effects of degradation examined within subject, across different listener groups, and as a function of age.

Results

CI users were near perfect at identifying auditory digits (> 99% correct, on average), both in isolation and while experiencing a memory load. Perceptual accuracy, thus, did not affect digit span in these listeners. Identification times, however, were significantly slower under memory load. Age was only weakly related to span in CI listeners. Instead, individual differences in span in the CI group were better predicted by simple no-load identification times. Among listeners with NH, spans for vocoded digits that were not frequency shifted did not differ from spans for unprocessed stimuli. Frequency-shifted vocoded digits, however, yielded lower scores that could mostly, but not entirely, be accounted for by crediting for perceptual errors. Frequency-shifted vocoded digits were particularly challenging for older adult listeners with NH to identify. Traditional digit span correlated more strongly with our primary span measure for listeners with CIs than for listeners with NH.

Conclusions

Digit span can be studied independently of perception in many adult CI users. For both CI listeners and listeners with NH, stimulus degradation does not appear to significantly affect memory span, unless an effect on simple identification is also present. Auditory degradation that may slow, but which does not ultimately prevent identification, appears to have negligible impact on short-term and working memory spans.

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Testing the Hyperarticulation and Prosodic Hypotheses of Child-Directed Speech: Insights From the Perceptual and Acoustic Characteristics of Child-Directed Cantonese Tones

Purpose

The function of child-directed speech has been debated for decades. This study examined the perceptual and acoustic characteristics of child- and adult-directed Cantonese tones to test the hyperarticulation and prosodic hypotheses that have been proposed to account for the acoustic modifications in child-directed speech.

Method

Sixty-two mother–child dyads participated in the study. The mothers verbally labeled 30 pictures in monosyllabic isolated words and in the final position of a carrier sentence to the experimenter and their 1- to 5-year-old children. The 8,634 adult- and child-directed productions were low-pass filtered to eliminate lexical information and presented to 5 judges for tone identification. Acoustic analysis was performed on the productions.

Results

Acoustically, child-directed tones were produced with an elevated pitch, and the pitch level decreased as the child's age increased. Acoustic contrasts between phonetically similar and more confusing tones were not enhanced in child-directed speech, and unexpectedly, child-directed tones were identified with a lower accuracy than adult-directed tones. The perceptual errors of child-directed tones mirrored the errors found in identifying tones excised from sentence-final position, which had a pitch-lowering effect on the tones. The lower perceptual accuracy, the lack of enhanced acoustic contrasts in confusing tone pairs, and the similarities in the error patterns in identifying tones in child-directed speech and tones in utterance-final position suggest that the acoustic modifications in child-directed tones are prosodic effects serving pragmatic purposes.

Conclusion

The findings reject the hyperarticulation hypothesis and support the prosodic hypothesis of child-directed speech.

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Executive Function in Deaf Children: Auditory Access and Language Access

Purpose

Deaf children are frequently reported to be at risk for difficulties in executive function (EF); however, the literature is divided over whether these difficulties are the result of deafness itself or of delays/deficits in language that often co-occur with deafness. The purpose of this study is to discriminate these hypotheses by assessing EF in populations where the 2 accounts make contrasting predictions.

Method

We use a between-groups design involving 116 children, ages 5–12 years, across 3 groups: (a) participants with normal hearing (n = 45), (b) deaf native signers who had access to American Sign Language from birth (n = 45), and (c) oral cochlear implant users who did not have full access to language prior to cochlear implantation (n = 26). Measures include both parent report and performance-based assessments of EF.

Results

Parent report results suggest that early access to language has a stronger impact on EF than early access to sound. Performance-based results trended in a similar direction, but no between-group differences were significant.

Conclusions

These results indicate that healthy EF skills do not require audition and therefore that difficulties in this domain do not result primarily from a lack of auditory experience. Instead, results are consistent with the hypothesis that language proficiency, whether in sign or speech, is crucial for the development of healthy EF. Further research is needed to test whether sign language proficiency also confers benefits to deaf children from hearing families.

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Memory Span for Spoken Digits in Adults With Cochlear Implants or Typical Hearing: Effects of Age and Identification Ability

Purpose

Short-term and working memory vary across individuals and life span. Studies of how cochlear implant (CI) users remember spoken words often do not fully disentangle perceptual influences from memory assessment because stimulus identification is rarely checked; instead, correct perception is assumed by using simple or practiced stimuli. Here, we examine whether the accuracy and speed of auditory digit identification are associated with short-term and working memory in adults with CIs as a function of age. Do perceptual errors and longer processing times depress memory span scores for such listeners? An intensive digit span assessment using manual responses is compared with traditional digit span, which uses only a few speech-based trials. We also assess how vocoder-based degradation impacts identification and digit span in older versus younger listeners with normal hearing (NH).

Method

We measured forward and backward recall for spoken digits in 25 adults with CIs (M = 57 years; range = 20–82 years), 10 older adults with NH (> 55 years; M = 64 years), and 11 younger adults with NH (< 22 years). Listeners identified recorded digits one at a time by clicking numerals on a computer screen and then were cued to recall the list. In a comparison condition, listeners only identified each item. Listeners with NH also completed the tasks under four conditions of signal degradation implemented using a channel vocoder: four or eight channels crossed with 0- or 6-mm simulated tonotopic shift, administered in randomized blocks. A mixed design was used, with the effects of degradation examined within subject, across different listener groups, and as a function of age.

Results

CI users were near perfect at identifying auditory digits (> 99% correct, on average), both in isolation and while experiencing a memory load. Perceptual accuracy, thus, did not affect digit span in these listeners. Identification times, however, were significantly slower under memory load. Age was only weakly related to span in CI listeners. Instead, individual differences in span in the CI group were better predicted by simple no-load identification times. Among listeners with NH, spans for vocoded digits that were not frequency shifted did not differ from spans for unprocessed stimuli. Frequency-shifted vocoded digits, however, yielded lower scores that could mostly, but not entirely, be accounted for by crediting for perceptual errors. Frequency-shifted vocoded digits were particularly challenging for older adult listeners with NH to identify. Traditional digit span correlated more strongly with our primary span measure for listeners with CIs than for listeners with NH.

Conclusions

Digit span can be studied independently of perception in many adult CI users. For both CI listeners and listeners with NH, stimulus degradation does not appear to significantly affect memory span, unless an effect on simple identification is also present. Auditory degradation that may slow, but which does not ultimately prevent identification, appears to have negligible impact on short-term and working memory spans.

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Testing the Hyperarticulation and Prosodic Hypotheses of Child-Directed Speech: Insights From the Perceptual and Acoustic Characteristics of Child-Directed Cantonese Tones

Purpose

The function of child-directed speech has been debated for decades. This study examined the perceptual and acoustic characteristics of child- and adult-directed Cantonese tones to test the hyperarticulation and prosodic hypotheses that have been proposed to account for the acoustic modifications in child-directed speech.

Method

Sixty-two mother–child dyads participated in the study. The mothers verbally labeled 30 pictures in monosyllabic isolated words and in the final position of a carrier sentence to the experimenter and their 1- to 5-year-old children. The 8,634 adult- and child-directed productions were low-pass filtered to eliminate lexical information and presented to 5 judges for tone identification. Acoustic analysis was performed on the productions.

Results

Acoustically, child-directed tones were produced with an elevated pitch, and the pitch level decreased as the child's age increased. Acoustic contrasts between phonetically similar and more confusing tones were not enhanced in child-directed speech, and unexpectedly, child-directed tones were identified with a lower accuracy than adult-directed tones. The perceptual errors of child-directed tones mirrored the errors found in identifying tones excised from sentence-final position, which had a pitch-lowering effect on the tones. The lower perceptual accuracy, the lack of enhanced acoustic contrasts in confusing tone pairs, and the similarities in the error patterns in identifying tones in child-directed speech and tones in utterance-final position suggest that the acoustic modifications in child-directed tones are prosodic effects serving pragmatic purposes.

Conclusion

The findings reject the hyperarticulation hypothesis and support the prosodic hypothesis of child-directed speech.

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P 045 - Is the maximum functional performance a meaningful parameter in children with cerebral palsy?

Publication date: Available online 1 August 2018

Source: Gait & Posture

Author(s): C. Schranz, A. Kruse, T. Belohlavek, G. Steinwender, M. Tilp, M. Svehlik

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P 128 – Influence of stance phase shifts in the movement analysis profile and the Gait Profile Score for cerebral palsy patients

Publication date: Available online 1 August 2018

Source: Gait & Posture

Author(s): B. Pobatschnig, B. Dumphart, A. Kranzl

Abstract

The Gait Profile Score (GPS) is used as a summary index to interpret gait abnormalities compared to a reference group, but stance phase shifts in gait cycles are not considered. The aim of this work is to point out, if stance phase shifts affects the GPS estimations and lead clinically relevant changes.

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P 045 - Is the maximum functional performance a meaningful parameter in children with cerebral palsy?

Publication date: Available online 1 August 2018

Source: Gait & Posture

Author(s): C. Schranz, A. Kruse, T. Belohlavek, G. Steinwender, M. Tilp, M. Svehlik

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P 128 – Influence of stance phase shifts in the movement analysis profile and the Gait Profile Score for cerebral palsy patients

Publication date: Available online 1 August 2018

Source: Gait & Posture

Author(s): B. Pobatschnig, B. Dumphart, A. Kranzl

Abstract

The Gait Profile Score (GPS) is used as a summary index to interpret gait abnormalities compared to a reference group, but stance phase shifts in gait cycles are not considered. The aim of this work is to point out, if stance phase shifts affects the GPS estimations and lead clinically relevant changes.

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Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder.

Related Articles

Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder.

Int J Audiol. 2018 Jul 31;:1-12

Authors: O'Hara B, Mealings K

Abstract
OBJECTIVE: The aim of this study was to develop a screening questionnaire for auditory processing disorder (APD).
DESIGN: Fifty-two questions were created to enable parent/teacher proxies to rate students listening skills in terms of auditory processing, attention and language factors.
STUDY SAMPLE: Parents rated their child's frequency of competent performance (regularly, often, sometimes or rarely) on 52 questions. Scores were calculated for three scales: auditory processing, attention and language. Data was collected from 198 normal controls, 20 students with auditory processing disorder, 40 students with attention deficit hyperactivity disorder and 10 students with a learning disability. Subjects were split into a younger group (7-10 y) and an older group (11-17 y).
RESULTS: Factor analysis revealed substantial internal validity. Analysis of external validity using a regression model revealed significant differences between normal and clinical groups for all scales (p < 0.001) and also significantly separated the three clinical groups. A group differential analysis of scale score results clearly demonstrated inter-group differences at 89% (on average) sensitivity and specificity levels.
CONCLUSION: The auditory processing domains questionnaire appears to be an effective screening questionnaire for APD with scale score patterns likely to be helpful in making appropriate clinical referrals.

PMID: 30063869 [PubMed - as supplied by publisher]

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Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder.

Related Articles

Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder.

Int J Audiol. 2018 Jul 31;:1-12

Authors: O'Hara B, Mealings K

Abstract
OBJECTIVE: The aim of this study was to develop a screening questionnaire for auditory processing disorder (APD).
DESIGN: Fifty-two questions were created to enable parent/teacher proxies to rate students listening skills in terms of auditory processing, attention and language factors.
STUDY SAMPLE: Parents rated their child's frequency of competent performance (regularly, often, sometimes or rarely) on 52 questions. Scores were calculated for three scales: auditory processing, attention and language. Data was collected from 198 normal controls, 20 students with auditory processing disorder, 40 students with attention deficit hyperactivity disorder and 10 students with a learning disability. Subjects were split into a younger group (7-10 y) and an older group (11-17 y).
RESULTS: Factor analysis revealed substantial internal validity. Analysis of external validity using a regression model revealed significant differences between normal and clinical groups for all scales (p < 0.001) and also significantly separated the three clinical groups. A group differential analysis of scale score results clearly demonstrated inter-group differences at 89% (on average) sensitivity and specificity levels.
CONCLUSION: The auditory processing domains questionnaire appears to be an effective screening questionnaire for APD with scale score patterns likely to be helpful in making appropriate clinical referrals.

PMID: 30063869 [PubMed - as supplied by publisher]

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Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder

.


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Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder

.


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via IFTTT

Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder.

Related Articles

Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder.

Int J Audiol. 2018 Jul 31;:1-12

Authors: O'Hara B, Mealings K

Abstract
OBJECTIVE: The aim of this study was to develop a screening questionnaire for auditory processing disorder (APD).
DESIGN: Fifty-two questions were created to enable parent/teacher proxies to rate students listening skills in terms of auditory processing, attention and language factors.
STUDY SAMPLE: Parents rated their child's frequency of competent performance (regularly, often, sometimes or rarely) on 52 questions. Scores were calculated for three scales: auditory processing, attention and language. Data was collected from 198 normal controls, 20 students with auditory processing disorder, 40 students with attention deficit hyperactivity disorder and 10 students with a learning disability. Subjects were split into a younger group (7-10 y) and an older group (11-17 y).
RESULTS: Factor analysis revealed substantial internal validity. Analysis of external validity using a regression model revealed significant differences between normal and clinical groups for all scales (p < 0.001) and also significantly separated the three clinical groups. A group differential analysis of scale score results clearly demonstrated inter-group differences at 89% (on average) sensitivity and specificity levels.
CONCLUSION: The auditory processing domains questionnaire appears to be an effective screening questionnaire for APD with scale score patterns likely to be helpful in making appropriate clinical referrals.

PMID: 30063869 [PubMed - as supplied by publisher]

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Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder.

Related Articles

Developing the auditory processing domains questionnaire (APDQ): a differential screening tool for auditory processing disorder.

Int J Audiol. 2018 Jul 31;:1-12

Authors: O'Hara B, Mealings K

Abstract
OBJECTIVE: The aim of this study was to develop a screening questionnaire for auditory processing disorder (APD).
DESIGN: Fifty-two questions were created to enable parent/teacher proxies to rate students listening skills in terms of auditory processing, attention and language factors.
STUDY SAMPLE: Parents rated their child's frequency of competent performance (regularly, often, sometimes or rarely) on 52 questions. Scores were calculated for three scales: auditory processing, attention and language. Data was collected from 198 normal controls, 20 students with auditory processing disorder, 40 students with attention deficit hyperactivity disorder and 10 students with a learning disability. Subjects were split into a younger group (7-10 y) and an older group (11-17 y).
RESULTS: Factor analysis revealed substantial internal validity. Analysis of external validity using a regression model revealed significant differences between normal and clinical groups for all scales (p < 0.001) and also significantly separated the three clinical groups. A group differential analysis of scale score results clearly demonstrated inter-group differences at 89% (on average) sensitivity and specificity levels.
CONCLUSION: The auditory processing domains questionnaire appears to be an effective screening questionnaire for APD with scale score patterns likely to be helpful in making appropriate clinical referrals.

PMID: 30063869 [PubMed - as supplied by publisher]

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FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.

Related Articles

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.

Proc Natl Acad Sci U S A. 2018 Jul 30;:

Authors: Honda A, Kita T, Seshadri SV, Misaki K, Ahmed Z, Ladbury JE, Richardson GP, Yonemura S, Ladher RK

Abstract
The mechanosensory hair cells of the inner ear are required for hearing and balance and have a distinctive apical structure, the hair bundle, that converts mechanical stimuli into electrical signals. This structure comprises a single cilium, the kinocilium, lying adjacent to an ensemble of actin-based projections known as stereocilia. Hair bundle polarity depends on kinociliary protocadherin-15 (Pcdh15) localization. Protocadherin-15 is found only in hair-cell kinocilia, and is not localized to the primary cilia of adjacent supporting cells. Thus, Pcdh15 must be specifically targeted and trafficked into the hair-cell kinocilium. Here we show that kinocilial Pcdh15 trafficking relies on cell type-specific coupling to the generic intraflagellar transport (IFT) transport mechanism. We uncover a role for fibroblast growth factor receptor 1 (FGFR1) in loading Pcdh15 onto kinociliary transport particles in hair cells. We find that on activation, FGFR1 binds and phosphorylates Pcdh15. Moreover, we find a previously uncharacterized role for clathrin in coupling this kinocilia-specific cargo with the anterograde IFT-B complex through the adaptor, DAB2. Our results identify a modified ciliary transport pathway used for Pcdh15 transport into the cilium of the inner ear hair cell and coordinated by FGFR1 activity.

PMID: 30061390 [PubMed - as supplied by publisher]

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FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.

Related Articles

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.

Proc Natl Acad Sci U S A. 2018 Jul 30;:

Authors: Honda A, Kita T, Seshadri SV, Misaki K, Ahmed Z, Ladbury JE, Richardson GP, Yonemura S, Ladher RK

Abstract
The mechanosensory hair cells of the inner ear are required for hearing and balance and have a distinctive apical structure, the hair bundle, that converts mechanical stimuli into electrical signals. This structure comprises a single cilium, the kinocilium, lying adjacent to an ensemble of actin-based projections known as stereocilia. Hair bundle polarity depends on kinociliary protocadherin-15 (Pcdh15) localization. Protocadherin-15 is found only in hair-cell kinocilia, and is not localized to the primary cilia of adjacent supporting cells. Thus, Pcdh15 must be specifically targeted and trafficked into the hair-cell kinocilium. Here we show that kinocilial Pcdh15 trafficking relies on cell type-specific coupling to the generic intraflagellar transport (IFT) transport mechanism. We uncover a role for fibroblast growth factor receptor 1 (FGFR1) in loading Pcdh15 onto kinociliary transport particles in hair cells. We find that on activation, FGFR1 binds and phosphorylates Pcdh15. Moreover, we find a previously uncharacterized role for clathrin in coupling this kinocilia-specific cargo with the anterograde IFT-B complex through the adaptor, DAB2. Our results identify a modified ciliary transport pathway used for Pcdh15 transport into the cilium of the inner ear hair cell and coordinated by FGFR1 activity.

PMID: 30061390 [PubMed - as supplied by publisher]

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Special Report: Part 3 Consumers Choosing ‘Cautious Optimism’ for OTC Hearing Aids

No abstract available

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Insurance Expansions to Cover Hearing Aids

No abstract available

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Affordable, State-of-the-Art Hearing Care in Dominican Republic

No abstract available

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Effects of Occupational Metal Exposure on the Auditory System

No abstract available

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Reconstruction of the Ossicular Chain with a 3D-Printed Prosthesis

No abstract available

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CI Programming in Patients with Neurologic Impairment

No abstract available

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Fitting Complications of Small and Distorted Ear Canals

No abstract available

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Addressing the Confidence Gap in Audiology

No abstract available

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Symptom: Congenital Hearing Loss

No abstract available

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Student Speaks: Finding a Confidence Boost in Mentorship

No abstract available

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Let the Numbers Speak: Promoting Evidenced-Based Hearing Wellness

No abstract available

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Pediatric CI Care and Student Learning in a University Clinic

No abstract available

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Noise and Toys: Dos and Don'ts

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Evolution and Future of Aural Rehabilitation

No abstract available

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Manufacturers News

No abstract available

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Special Report: Part 3 Consumers Choosing ‘Cautious Optimism’ for OTC Hearing Aids

No abstract available

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Insurance Expansions to Cover Hearing Aids

No abstract available

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Affordable, State-of-the-Art Hearing Care in Dominican Republic

No abstract available

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Effects of Occupational Metal Exposure on the Auditory System

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Reconstruction of the Ossicular Chain with a 3D-Printed Prosthesis

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CI Programming in Patients with Neurologic Impairment

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Fitting Complications of Small and Distorted Ear Canals

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Addressing the Confidence Gap in Audiology

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Symptom: Congenital Hearing Loss

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Student Speaks: Finding a Confidence Boost in Mentorship

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Let the Numbers Speak: Promoting Evidenced-Based Hearing Wellness

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Pediatric CI Care and Student Learning in a University Clinic

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Noise and Toys: Dos and Don'ts

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Evolution and Future of Aural Rehabilitation

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Manufacturers News

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