| EDITORIALS | ||
From "only decompression" to "only fixation:" A century-long journey of surgical treatment for spinal spondylosis  | p. 219 | |
| Atul Goel DOI:10.4103/jcvjs.JCVJS_118_18 | ||
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| Suboccipital pain in Chiari formation: Its cause and significance | p. 221 | |
| Atul Goel DOI:10.4103/jcvjs.JCVJS_117_18 | ||
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| ORIGINAL ARTICLES |  | |
  | Preliminary results of anterior cervical arthroplasty by porous alumina ceramic cage for cervical disc herniation surgery | p. 223 |
| Keyvan Mostofi, Babak Gharaei Moghaddam, Morad Peyravi, Reza Karimi Khouzani DOI:10.4103/jcvjs.JCVJS_95_18 Objective: Anterior cervical arthroplasty (ACA) is the gold standard surgery in severe or unresponsive cases of cervical disc herniation, uncarthrosis, and foraminal stenosis. The aim of this study is to establish the impact and outcome evaluations of managing the patients operated for cervical arthroplasty by the intersomatic porous alumina ceramic cervical cages (PACC). The authors describe their experience in the area to allow the comparison of effectiveness of ceramic cages versus other interbody fusion cages. Materials and Methods:Between April 2015 and September 2018, we operated 118 for ACA by using PACC. Among them, 52 were female and 66 were male, with an average age of 46.78 years. Results: The mean symptoms duration was 14.1 months. The most frequent level of the disorder was C5–C6 followed by C6–C7 level. Mean follow-up was 3.3 years. The Neck Disability Index (NDI) and the visual analog scale (VAS) were used to evaluate the patients status. No significant differences were observed between our results and literature data regarding operative time, duration of hospitalization, and NDI; however, we observed a shorter period and higher rate of bony fusion. Conclusion: The results from the present study corroborate that implementing of PACC is a good alternative treatment for the patient operated by ACA for cervical disc herniation or foraminal cervical stenosis. | ||
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 | Timing for surgical intervention in DISHphagia | p. 227 |
| Waeel Ossama Hamouda DOI:10.4103/jcvjs.JCVJS_83_18 Introduction: Dysphagia in old patients secondary to diffuse idiopathic skeletal hyperostosis (DISH) syndrome is underdiagnosed. Surgical resection of the offending osteophytes is the definitive treatment. However, the timing of surgery in the course of the disease is still controversial. The study tries to find a correlation if any, between the timing of osteophytectomy surgery aimed to relieve DISH syndrome-induced dysphagia and the surgical outcome.Methods: During the period from 2010 to 2015, clinical and radiological data of patients who presented with dysphagia attributed to DISH syndrome were retrospectively reviewed along with their management and outcome.Results: One female and seven male patients were included in the study. Mean age was 71 years. Mean duration of dysphagia was 3 years and 10 months. Surgical resection was attempted through anterolateral cervical approach in five cases who were fit for surgery, in which four showed complete resolution of dysphagia (one experienced transient hoarseness of voice for 4 weeks postoperatively), and the fifth showed minimal improvement after limited resection due to intraoperative finding of marked esophageal adherence to osteophytes. The two unfavorable outcomes (subtotal resection and transient hoarseness of voice) occurred in relatively older patients (average: 75.5 years) with longer standing dysphagia (average: 7 years). Conclusion: DISH syndrome as a cause of dysphagia is commonly underlooked. Surgical resection of the offending osteophytes through an anterolateral approach is a safe and effective procedure. For patients who are fit for surgery, older age or longer duration of dysphagia might be associated with less favorable surgical outcome. | ||
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 | Who benefits more in osteoporotic fractures: Pedicle screw instrumentation or kyphoplasty for American Society of Anesthesiologists II/III patients? | p. 232 |
| Tjark Tassemeier, Marcel Haversath, Moritz Schutzbach, Marcus Jäger DOI:10.4103/jcvjs.JCVJS_55_18 Purpose: Osteoporotc fractures with posterior wall injury are commonly treated with a pedicle srcrew instrumentation (PSI) or a ballonkyphoplasty (BKP). A predictor for complications for these patients is the American Society of Anesthesiologists (ASA) class. Clinical results in ASA II/III patients who underwent BKP and PSI due to OF were evaluated to find the optimal treatment regimen. Materials and Methods: In a retrospective study design, ASA Class II and III patients with OF type OF 2 and OF 3 according to the German Society of Orthopedics and Trauma Surgery classification who underwent surgery between 2011 and 2016 were enrolled. Perioperative data such as time of surgery, cement leakage, adjacent level fractures, screw loosening, wound infections, and segmental kyphosis correction were measured and a statistical analysis was conducted. Results:Ninety-nine patients met the inclusion criteria, 17 were classified as ASA II and 82 patients were classified as ASA III. Twenty-eight individuals were treated by PSI, whereas 71 underwent BKP. Not only a longer average operation (120 min) and hospital stay (21 days) were documented in the PSI group but also a better kyphosis correction (7.5°). In comparison, the BKP group required an average operation time of 35.5 min with a mean kyphosis correction of 2.1°. A statistical analysis revealed the surgical procedure and not the ASA class to be a relevant factor for complication and revision surgery. Conclusions: BKP is a safe and effective therapy including also fractures with posterior wall defects while PSI showed advantages in restoring the sagittal realignment but higher complication and revision risk. | ||
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| Lumbar disk herniation: How far should efforts go to minimally invasive procedure? | p. 238 | |
| Keyvan Mostofi, Babak Gharaei Moghadam, Morad Peyravi, Reza Karimi Khouzani DOI:10.4103/jcvjs.JCVJS_70_18 Background: Minimally invasive surgery (MIS) of lumbar disk herniation allows avoiding less of a mess in crossing structures, reducing muscular and cutaneous scarring, postoperative pain, lengthy recovery times, and the rate of infection. The aim of this study is to explain our experience in MIS of disc herniation. We compare the outcome of three different surgical techniques used for the treatment of lumbar disc herniation. Materials and Methods: A total of 1147 patients have been operated from July 2008 to December 2015 for lumbar disk herniation by posterior endoscopic approach. Three hundred and seventy-nine patients underwent discectomy and herniectomy (DH), 557 patients have been operated by herniectomy (H), and 211 patients underwent only bone decompression (BD). Results: The results show 80.10%, 82.06%, and 84.02% excellent outcome, respectively, in BD, DH, and BD techniques. Conclusion: Analysis of the data demonstrates that the results obtained are equivalent and comparable in different used techniques for the treatment of disc herniation, we do not need to perform discectomy in all cases in a systematic way. | ||
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| Ability of magnetic resonance imaging to accurately determine alar ligament integrity in patients with atlanto-occipital injuries | p. 241 | |
| Adam R Dyas, Thomas E Niemeier, Gerald Mcgwin, Steven M Theiss DOI:10.4103/jcvjs.JCVJS_81_18 Objective: The objective of this study is to evaluate the the reliability of magnetic resonance imaging (MRI) in diagnosing alar ligament disruption in patients with potential atlanto-occipital dissociation (AOD). Materials and Methods: Three-blinded readers performed retrospective review on 6 patients with intra-operative confirmed atlanto-occipital dissocation in addition to a comparison cohort of patients with other cervical injuries that did not involve the atlanto-occipital articulation. Ligament integrity was graded from 1 to 3 as described by Krakenes et al. The right and left ligaments were assessed separately. Inter-observer agreement by patient, by group (AOD vs. non-AOD), and intra-observer agreement was calculated using weighted Cohen's kappa. Results: Interobserver agreement of alar ligament grade for individual patients ranged from slight to fair (κ = 0.05–0.30). Interobserver agreement of alar ligament grade for each group (AOD vs. non-AOD) ranged from fair to substantial (κ = 0.37–0.66). No statistically significant difference in categorical analysis of groups (AOD vs. non-AOD) and grade (0–1 vs. 2–3) was observed. Intraobserver agreement of individual patient's alar ligament grade ranged from moderate to substantial (κ = 0.50–0.62). Conclusion: The use of MRI to detect upper cervical ligament injuries in AOD is imperfect. Our results show inconsistent and unsatisfactory interobserver and intraobserver reliability in evaluation of alar ligament injuries. While MRI has immense potential for detection of ligamentous injury at the craniovertebral junction, standardized algorithms for its use and interpretation need to be developed. | ||
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 | On the linear sizes of vertebrae and intervertebral discs of children in the beginning of puberty | p. 246 |
| Mikhail Dudin, Yuri Baloshin, Igor Popov, Nikita Lisitsa, Stepan Bober DOI:10.4103/jcvjs.JCVJS_91_18 Study Design: We collected experimental data concerning vertebrae sizes and performed an investigation of these data for different patient ages by methods of mathematical statistics. Purpose: The standard dimensions of vertebrae and intervertebral discs are of major importance for obtaining a comprehensive understanding of spine diseases and their successful treatment. The purpose is to study these sizes for children at the age of 9–14 years.Overview of Literature: Unfortunately, this issue is poorly presented in the corresponding literature. There are no systematic results. Only particular cases are presented. Materials and Methods: Experimental is based on the: results of X-ray investigations of children spines. Theoretical background is given by methods of mathematical statistics. Results: Systematic description of vertebrae sizes for children of age 9–14 is given. This specific age interval is the most common period of initiation of various pathological deformations of human spine.Conclusions: The acquired data both reflect the process of spine growth and can serve for building correct mathematical models of a healthful or diseased spine. | ||
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 | A novel technique for the subfascial insertion of magnetically controlled growing rods – The Alder Hey technique | p. 250 |
| Sudarshan Munigangaiah, Phil Brown, Mohamed Mohamed, Colin E Bruce, Jayesh M Trivedi, Neil T Davidson DOI:10.4103/jcvjs.JCVJS_105_18 Purpose: In this study, we would like to describe a novel technique for subfascial insertion of magnetically controlled growing rods using chest drain during surgery for early-onset scoliosis. Materials and Methods:Posterior approach, surgical dissection to the spine is performed exposing the relevant anatomy to allow placement of pedicle screws always in the distal construct and pedicle screws or hooks in the proximal construct. To allow easy passage of the Magnetic Expansion Control (MAGEC) rod, as well as easy maneuvering of the rod in either the cranial to caudal direction, we use a chest drain of size 24 French diameter as a tunnel. This allows surgeons to fit the nonflexible part of MAGEC rod in the middle of the deformity and cut to length passed through the chest drain from a cranial to caudal position and then chest drain is removed. Results: A total of 40 children with early-onset scoliosis had insertion of MAGEC rods using this technique. There were 21 female and 19 male patients. Early-onset scoliosis etiology is idiopathic in 20 patients, neuromuscular in 16 patients, and others in 4 patients. Median age across all groups was 7 years (range 4–13) at the time of surgery. Follow-up ranged from 11 to 56 months with a median of 24 months. Conclusion: The use of a chest drain during subfascial passage of magnetically controlled growing rod is a safe, reliable, reproducible novel technique. This shortens overall time of surgery in our experience. | ||
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 | Clinical and radiological union rate evaluation of type 2 odontoid fractures: A comparison between anterior screw fixation and halo vest in elderly patients | p. 254 |
| Massimo Girardo, Alessandro Rava, Giosuè Gargiulo, Angela Coniglio, Stefano Artiaco, Alessandro Massè, Federico Fusini DOI:10.4103/jcvjs.JCVJS_93_18 Purpose: Odontoid fracture is a very common cervical injury, especially in elderly patients. Despite the high frequency, the appropriate management is still debated. The aim of this study is to evaluate clinical and radiological outcomes after anterior screw fixation or halo vest (HV) in type II odontoid fracture in elderly patients.Materials and Methods: Between January 2013 and December 2015, 135 consecutive patients affected by odontoid process were found. According to inclusion and exclusion criteria, 57 patients were included in the study. Patients were evaluated with visual analog scale (VAS), Smiley–Webster Scale (SWS), Italian Version of the Neck Disability Index (NDI), and patient satisfaction during follow-up. Furthermore, radiological data were evaluated for bone healing. Student's t-test or Fisher's exact test was used between groups, analyzing radiological and clinical results, and level of statistical significance was set at P < 0.05. Results: Seventeen patients were female and 40 were male. Twenty-seven patients were included in surgical group (SG) while 30 were included in HV group with a mean follow-up of 37.74 ± 10.52 months. A significant difference (P < 0.05) between groups was found for pseudoarthrosis, with a lower rate for SG. No significant differences in term of VAS, NDI, and SWS were found between groups (P > 0.05); SG reached higher satisfaction than HV group (P = 0.0271). Conclusions: Both treatments are equivalent in terms of clinical outcomes, and they are a valuable choice in the management of type II odontoid fracture. However, it must be considered that patients could slightly tolerate HV and may need a change of treatment. | ||
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 | Recurrent lumbar disc herniation: Is there a correlation with the surgical technique? A multivariate analysis | p. 260 |
| Alessandro Landi, Giovanni Grasso, Cristina Mancarella, Demo Eugenio Dugoni, Fabrizio Gregori, Giorgia Iacopino, Harrison Xiao Bai, Nicola Marotta, Andrea Iaquinandi, Roberto Delfini DOI:10.4103/jcvjs.JCVJS_94_18 Purpose: The recurrence of a lumbar disc herniation (LDH) is a common cause of poor outcome following lumbar discectomy. The aim of this study was to assess a potential relationship between the incidence of recurrent LDH and the surgical technique used. Furthermore, we tried to define the best surgical technique for the treatment of recurrent LDH to limit subsequent recurrences. Materials and Methods: A retrospective study was conducted on 979 consecutive patients treated for LDH. A multivariate analysis tried to identify a possible correlation between (1) the surgical technique used to treat the primary LDH and its recurrence; (2) technique used to treat the recurrence of LDH and the second recurrence; and (3) incidence of recurrence and clinical outcome. Data were analyzed with the Pearson's Chi-square test for its significance. Results: In 582 cases (59.4%), a discectomy was performed, while in 381 (40.6%), a herniectomy was undertaken. In 16 cases, a procedure marked as "other" was performed. Among all patients, 110 (11.2%) had a recurrence. Recurrent LDH was observed in 55 patients following discectomy (9.45%), in 45 following herniectomy (11.8%), and in 10 (62.5%) following other surgery. Our data showed that 90.5% of discectomies and 88.2% of the herniectomies had a good clinical outcome, whereas other surgeries presented a recurrence rate of 62.5% (Pearson's χ2 < 0.001). No statistical differences were observed between discectomy or herniectomy, for the treatment of the recurrence, and the incidence for the second recurrences (P > 0.05). A significant statistical correlation emerged between the use of other techniques and the incidence for the second recurrences (P < 0.05). Conclusions: The recurrence of an LDH is one of the most feared complications following surgery. Although the standard discectomy has been considered more protective toward the recurrence compared to herniectomy, our data suggest that there is no significant correlation between the surgical technique and the risk of LDH recurrence. | ||
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| CASE REPORTS | | |
 | The repair using a fibular graft of cervical vertebral collapse due to renal cell carcinoma: Late results with a case report | p. 267 |
| Vaner Koksal, Hüseyin Eren, Hasan Güçer DOI:10.4103/jcvjs.JCVJS_32_18 The most common cause of spinal tumors is metastases, but the cervical vertebra is the least common region of spinal metastasis, and relatively, little is published about surgery in metastasis to the cervical vertebra. While spinal metastasis is most often caused by neoplasms originating from the lung, breast, and prostate, renal cell carcinoma (RCC) metastasis is very rare. A 47-year-old patient introduced here presented with severe pain spontaneously on his neck and in his arm. In the radiology of the patient without neurological deficit, a pathologic vertebral collapse was detected in the C6 vertebral corpus. The patient underwent anterior cervical corpectomy. The fibula graft taken from his right leg was implanted in the emptied area and supported by an anterior plaque, and restoration of physiological cervical lordosis was established. From the pathological tissue that was taken, it was determined that the cause of the lysis was an RCC metastasis. After surgical repair of the cervical spine, a primary pathology with a diameter of 10 cm was detected in the patient's kidney, and a radical nephrectomy was performed. After 6 years of follow-up, there was no recurrence, and the patient continued his normal daily life. Radiologically between the autologous fibula graft and its own vertebral body was observed to achieve very good fusion. In this study, we emphasized the importance of resection of metastasis together with a primary tumor in a metastatic RCC case to cure the patient and provide the desired quality of life. | ||
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 | Transthoracic approach for ventrally situated paraspinal extradural hydatid cyst of the dorsal spine | p. 271 |
| Mohnish P Dighe, Srikant Balasubramaniam, Trimurti D Nadkarni DOI:10.4103/jcvjs.JCVJS_71_18 A 40-year-old female presented with back pain without any neurological deficits. Radiological investigations revealed a ventrally situated paraspinal lesion causing widening of the right D4 neural foramen. She underwent a right posterolateral thoracotomy and excision of the lesion in toto, which was reported as a hydatid cyst on histology. Ventrally situated paraspinal extradural hydatid cysts are rare. A Transthoracic surgical exposure offers a direct approach for complete excision of the lesion, minimizing the chances of rupture and spillage. | ||
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 | Autostabilization of neglected high-grade fracture–dislocation in the cervical spine | p. 274 |
| Kunal Shah, Akshay Gadiya, Abhay Nene DOI:10.4103/jcvjs.JCVJS_92_18 Neglected cervical spine trauma is rare with very few case series reported in literature. There are no clear guidelines for its treatment. If operative treatment is sought, the role of skull traction, type of approach (anterior only, posterior only, or combined), sequence of surgery, type of instrumentation, etc., have to be considered. Hence, the treatment is challenging. Autostabilization has been described in the natural history of degenerative lumbar spondylolisthesis. As a result, many patients are treated nonoperatively, obviating need of surgery. We report two cases of neglected/untreated fracture–dislocation at subaxial cervical spine. They presented with exertional neck pain. Computed tomography scan showed bony fusion at involved level. The patient was treated nonsurgically with favorable outcome at long-term follow-up. Our cases depict autostabilization in a case of neglected traumatic cervical spine injury, which is never been reported. Such patients do well with nonsurgical treatment, thus obviating need for extensive deformity correction. | ||
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 | Performing the screw fixation from C3 to odontoid process in a patient with Klippel-Feil syndrome and type II odontoid fracture | p. 277 |
| Mustafa Ogden, Ulas Yuksel, Ibrahim Akkurt, Bulent Bakar DOI:10.4103/jcvjs.JCVJS_54_18 A 56-year-old female patient was admitted with a history of pain during neck movements after cervical injury. Computerized tomography scan revealed type II odontoid fracture and fusion anomaly between C2 and C3 vertebrae. At surgery, the anteroinferior part of C2 vertebra corpus could not be reached; therefore, transodontoid screw was advanced from C3 vertebra toward odontoid process. At follow-up examination, the complaints of the patient had recovered, and fracture line was completely fused. Advancing screw from C3 to odontoid process via anterior cervical approach could be thought an alternative treatment option in the patient with short neck caused from vertebra fusion anomaly and/or obesity. | ||
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 | Unprecedented complication of odontoid regeneration after transoral odontoidectomy | p. 280 |
| Manish Garg, MS Sridhar, Saurabh Verma, Jitendra Bhadoria DOI:10.4103/jcvjs.JCVJS_98_18 Transoral odontoidectomy followed by occipitocervical fixation is a widely used approach to relieve ventral compressions at the craniovertebral junction. Despite the large amount of literature on this approach and its complications, odontoid process regeneration and causing the worsening of symptoms of brainstem dysfunction and upper cervical cord were not found in the English literature. We report the case of odontoid regeneration in a 12-year-old girl. She presented with torticollis and symptoms of brainstem dysfunction and upper cervical cord compression with syringohydromyelia and underwent transoral resection of dens and posterior occipitocervical fusion at the age of 7 years. Post surgery, clinically and radiologically, the resolution was evident till the age of 11 years when the child started to have relapse and worsening of the previous symptoms. The computed tomography/magnetic resonance imaging shows regeneration of the odontoid process compressing the brain stem with an increase in syringohydromyelia. We suggest that there is a need for the removal of the complete odontoid process with periosteum and also beyond the dentocentral synchondrosis to prevent late recurrences of odontoid regeneration. | ||
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 | Isolated enchondroma of the atlas | p. 283 |
| Necati Ucler DOI:10.4103/jcvjs.JCVJS_101_18 Periosteal enchondromas located in the spine are rare. We reported an even more infrequent occurrence of a periosteal enchondroma in the cervical spine of a 19-year-old girl. During the operation, a giant (>8 cm × 5.5 cm × 5 cm) ossified periosteal enchondroma with involvement of posterior structures and muscles of the axis was resected. The pathological examination revealed that the tumor consisted of enchondroid tissue with typical chondrocytes, confirming the diagnosis of periosteal enchondroma. Early identification of the initial lesion should be coupled with total surgical resection, as a definitive treatment, to prevent malignant transformation. Enchondromas grow in an expanding manner which makes easy total resection. | ||
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| LETTER TO EDITOR | | |
| Giant cell glioblastoma with spinal and spinal leptomeningeal metastasis in a child: A rare presentation of a rare tumor | p. 286 | |
| Mahmood Dhahir Al-Mendalawi DOI:10.4103/jcvjs.JCVJS_97_18 | ||
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Δευτέρα 21 Ιανουαρίου 2019
Craniovertebral Junction and Spine
Regulation of Virus Replication and T Cell Homeostasis by N 6 -Methyladenosine
Abstract
RNA modifications are abundant in eukaryotes, bacteria, and archaea. N6-methyladenosine (m6A), a type of RNA modification mainly found in messenger RNA (mRNA), has significant effects on the metabolism and function of mRNAs. This modification is governed by three types of proteins, namely methyltransferases as "writers", demethylases as "erasers", and specific m6A-binding proteins (YTHDF1-3) as "readers". Further, it is important for the regulation of cell fate and has a critical function in many biological processes including virus replication, stem cell differentiation, and cancer development, and exerts its effect by controlling gene expression. Herein, we summarize recent advances in research on m6A in virus replication and T cell regulation, which is a rapidly emerging field that will facilitate the development of antiviral therapies and the study of innate immunity.
http://bit.ly/2FRdTxe
Brexpiprazole: A Review in Schizophrenia
Abstract
Brexpiprazole (Rxulti®, Rexulti®) is an oral atypical antipsychotic agent approved for the treatment of schizophrenia in the EU (in adult patients) and the USA, as well as in some other countries, including Japan. Like aripiprazole, it is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors and an antagonist at serotonin 5-HT2A receptors. However, brexpiprazole displays less intrinsic activity at D2 receptors and, coupled with actions at 5HT1A, 5HT2A and noradrenaline α1B receptors that are at least as potent as its action at D2 receptors, is predicted to demonstrate a lower propensity for activating adverse events and extrapyramidal symptoms than aripiprazole. Brexpiprazole 2–4 mg/day produced statistically significant and clinically meaningful improvements in overall symptomatology and psychosocial functioning compared with placebo in adults with acute exacerbation of schizophrenia. As maintenance treatment, brexpiprazole 1–4 mg/day significantly delayed the time to relapse compared with placebo in patients who were already stabilized on the drug and was associated with stabilization or continued improvement in patients' symptoms and functioning. Brexpiprazole was generally well tolerated, exhibiting an adverse event profile characterized by a relatively low incidence of activating and sedating adverse effects, small changes in QT interval and metabolic parameters that were not clinically significant, and moderate weight gain. Clinical evidence to date suggests it usefully extends the range of therapeutic options for schizophrenia.
http://bit.ly/2U9lTNT
MCH Workforce Capacity: Maximizing Opportunities Afforded by a Changing Public Health System
Abstract
Objectives A skilled workforce is essential to advancing maternal and child health (MCH) in a rapidly changing public health system. Little is known about the MCH workforce's existing capacity to maximize opportunities afforded by ongoing change. We assessed MCH workforce capacity in three areas: Systems Integration, Evidence-Based Decision-Making, and Change Management/Adaptive Leadership. We then examined associations between workforce capacity and modifiable workforce development strategies/resources. Methods Data are from the Public Health Workforce Interests and Needs Survey (PH WINS). The present study was limited to employees working in MCH programs (weighted N = 3062). Workforce capacity was operationalized as self-reported awareness of public health trends and proficiency to perform related skills in the three areas. Survey-weighted generalized estimating equations were used to fit logistic regression models accounting for employee clustering within states. Results While awareness of public health trends was low, the majority of employees (> 70% in each area) reported proficiency to perform skills related to these trends. Capacity was lowest in Systems Integration. Employee engagement in academic partnerships and higher state contributions to MCH program budgets were the strategies/resources most consistently associated with higher capacity. Workplace support was the strongest correlate of capacity in Change Management/Adaptive Leadership. Conclusions for Practice Although employees lacked familiarity with specific public health trends, they were proficient in skills needed to engage in related work. Still, areas for improvement remain. Results provide a baseline against which future training efforts can be evaluated. Academic partnerships and MCH program funding may be useful to prioritize in the context of health transformation.
http://bit.ly/2Dq5eQu
Gene structure and expression patterns of Acdaf-1 , a TGF-β type I receptor in Ancylostoma caninum
Abstract
The components of the transforming growth factor β (TGF-β) signaling pathway in parasitic nematodes remain unknown. In this research, a type I receptor for TGF-β was isolated from the hookworm Ancylostoma caninum. The new gene was designated as Acdaf-1, a Caenorhabditis elegans daf-1 homolog. The full-length cDNA of Acdaf-1 encodes a 595-amino-acid protein with an NH2-terminal signal peptide. This protein has a cytoplasm tail (209-595aa region) which corresponds to the type 1a membrane topology. Between amino acid position 295–500, the protein contains the ATP binding site, substrate binding sites, and PKC-kinase-like domain. Real-time RT-PCR showed that the transcript was expressed in three main stages of A. caninum. It reached the maximal level in the female adult worm stage with lower transcript level in the first and second larvae (L1/L2) and intermediate level in L3 stages as well as in the male worms. After serum activation, the activity of Acdaf-1 was decreased in L3 larvae. These data implied that Acdaf-1 might relate to the infection ability of the larvae. Immunolocalization revealed that AcDAF-1 was present in eggs, intestine, and epidermis cells of larvae (L1, L2, and L3 stages) with strong signal in primordium of the gonads in L3 and was abundant in epidermis, intestine, and ovary of adult worm. These results suggested that Acdaf-1 might be involved in the interaction of the parasite and host relationship and provide a potential target for parasite control.
http://bit.ly/2RJqcmc
Gout and healthcare utilization and complications after hip arthroplasty: a cohort study using the US National Inpatient Sample (NIS)
Abstract
Little is known about the effect of gout on in-hospital complications and healthcare utilization after total hip arthroplasty (THA). We used the 1998-2014 U.S. National Inpatient Sample (NIS) to examine this question using cohort study design. Multivariable-adjusted Cox regression analyses included age, race, gender, underlying diagnosis, Deyo-Romano comorbidity index, insurance payer, and income. In adjusted analyses, we found that gout was associated with 9-20% higher healthcare utilization and 6% higher hazard of transfusion after primary THA. These findings can inform surgeons and patients of gout-associated complications post-THA.
http://bit.ly/2S4Hjy8
Match Running Performance in Young Soccer Players: A Systematic Review
Abstract
Background
To date, athletic performance has been extensively assessed in youth soccer players through laboratory and field testing. Only recently has running performance via time–motion analysis been assessed during match play. Match running data are often useful in a practical context to aid game understanding and decision making regarding training content and prescriptions. A plethora of previous reviews have collated and appraised the literature on time–motion analysis in professional senior players, but none have solely examined youth players.
Objective
The aim of the present systematic review was to provide a critical appraisal and summary of the original research articles that have evaluated match running performance in young male soccer players.
Methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, literature searches were performed in four databases: PubMed, ISI Web of Science, SPORTDiscus and SciELO. We used the following descriptors: soccer, football, young, youth, junior, physical performance, running performance, match running performance, movement patterns, time–motion analysis, distances covered, activity profile, work rate, match analysis, and match performance. Articles were included only if they were original articles written in the English language, studied populations of male children and/or adolescents (aged ≤ 20 years), were published/ahead of print on or before 31 December 2017 and showed at least one outcome measure regarding match running performance, such as total distance covered, peak game speed or indicators of activities performed at established speed thresholds.
Results
A total of 5801 records were found. After duplicates were removed and exclusion and inclusion criteria applied, 50 articles were included (n = 2615 participants). Their outcome measures were extracted and findings were synthesized. The majority of the reviewed papers covered the European continent (62%) and used global positioning systems (GPS) (64%). Measurement error of the tools used to obtain position data and running metrics was systematically overlooked among the studies. The main aims of studies were to examine differences across playing positions (20%), age groups (26%) and match halves (36%). Consistent findings pointed to the existence of positional role and age effects on match running output (using fixed running speed thresholds), but there was no clear consensus about reductions in activity over the course of match play. Congested schedules negatively affected players' running performance. While over 32% of all studies assessed the relationships between match running performance and physical capacity, biochemical markers and body composition, ~ 70% of these did not account for playing position.
Conclusions
This review collated scientific evidence that can aid soccer conditioning professionals in understanding external match loads across youth categories. Coaches working with youth development programs should consider that data derived from a given population may not be relevant for other populations, since game rules, match format and configuration are essentially unstandardized among studies for age-matched players. Despite limited evidence, periodization training emphasizing technical-tactical content can improve match running performance. Occurrence of acute and residual impairments in the running performance of young soccer players is common. Prescription of postmatch recovery strategies, such as cold water immersion and spa treatment, can potentially help reduce these declines, although additional research is warranted. This review also highlighted areas requiring further investigation, such as the possible influence of environmental and contextual constraints and a more integrative approach combining tactical and technical data.
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