Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480
Τρίτη 23 Μαΐου 2017
Curcumin attenuates lipopolysaccharide/d-galactosamine-induced acute liver injury
Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480
Hearing Preservation in Pediatric Cochlear Implantation.
Objective: Currently, there is a paucity of literature evaluating hearing preservation outcomes in children following cochlear implantation. The objective of the current study is to report pediatric hearing preservation results following cochlear implantation with conventional full-length electrodes. Study Design: Retrospective review (2000-2016). Setting: Tertiary referral center. Patients: All pediatric patients with a
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An Assessment of the Clinical Acceptability of Direct Acoustic Cochlear Implantation for Adults With Advanced Otosclerosis in the United Kingdom.
Hypothesis: Assess the clinical acceptability of direct acoustic cochlear implantation for patients with advanced otosclerosis and the support for conducting a controlled trial of its effectiveness in the United Kingdom. Background: Emerging evidence supports the efficacy of direct acoustic cochlear implantation in patients with advanced otosclerosis whose needs cannot be managed using the combination of stapes surgery and hearing aids. A controlled trial would provide evidence for its effectiveness and cost-effectiveness to healthcare commissioners. Methods: An online survey of clinical professionals was constructed to characterize current standard of care for patients with advanced otosclerosis and to assess whether clinicians would be willing to refer patients into a trial to evaluate direct acoustic cochlear implantation. A consensus process was conducted to define inclusion criteria for the future trial. Results: No survey respondent considered direct acoustic cochlear implantation to be inappropriate with a majority indicating that they would refer patients into a future trial. The consensus was that there is a lack of available treatment options for those patients with bone conduction thresholds worse than 55 dB HL and who did not meet current criteria for cochlear implantation. Conclusion: The present study confirms that a controlled trial to evaluate the effectiveness of direct acoustic cochlear implantation would have the support of clinicians in the United Kingdom. A feasibility study would be required to determine whether patients who meet the inclusion criteria could be recruited in a timely manner and in sufficient numbers to conduct a formal evaluation of effectiveness. Copyright (C) 2017 by Otology & Neurotology, Inc. Image copyright (C) 2010 Wolters Kluwer Health/Anatomical Chart Company
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Progression of Unilateral Hearing Loss in Children With and Without Ipsilateral Cochlear Nerve Canal Stenosis: A Hazard Analysis.
Objective: To investigate the risk of hearing loss progression in each ear among children with unilateral hearing loss associated with ipsilateral bony cochlear nerve canal (BCNC) stenosis. Setting: Tertiary pediatric referral center. Patients: Children diagnosed with unilateral hearing loss who had undergone temporal bone computed tomography imaging and had at least 6 months of follow-up audiometric testing were identified from a prospective audiological database. Interventions: Two pediatric radiologists blinded to affected ear evaluated imaging for temporal bone anomalies and measured bony cochlear canal width independently. All available audiograms were reviewed, and air conduction thresholds were documented. Main Outcome Measure: Progression of hearing loss was defined by a 10 dB increase in air conduction pure-tone average. Results: One hundred twenty eight children met inclusion criteria. Of these, 54 (42%) had a temporal bone anomaly, and 22 (17%) had ipsilateral BCNC stenosis. At 12 months, rates of progression in the ipsilateral ear were as follows: 12% among those without a temporal bone anomaly, 13% among those with a temporal bone anomaly, and 17% among those with BCNC stenosis. Children with BCNC stenosis had a significantly greater risk of progression in their ipsilateral ear compared with children with no stenosis: hazard ratio (HR) 2.17, 95% confidence interval (CI) (1.01, 4.66), p value 0.046. When we compared children with BCNC stenosis to those with normal temporal bone imaging, we found that the children with stenosis had nearly two times greater risk estimate for progression, but this difference did not reach significance, HR 1.9, CI (0.8, 4.3), p = 0.1. No children with BCNC stenosis developed hearing loss in their contralateral year by 12 months of follow-up. Conclusion: Children with bony cochlear nerve canal stenosis may be at increased risk for progression in their ipsilateral ear. Audiometric and medical follow-up for these children should be considered. Copyright (C) 2017 by Otology & Neurotology, Inc. Image copyright (C) 2010 Wolters Kluwer Health/Anatomical Chart Company
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Foreign Body Response to Silicone in Cochlear Implant Electrodes in the Human.
Hypothesis: Silicone as part of a cochlear implant electrode may be responsible for a foreign body response in the human. Background: Clinical evidence of a foreign body response to a cochlear implant has been reported. In a previous study, particulate material found within the fibrous sheath and within macrophages surrounding a cochlear implant has been identified as being consistent with platinum. However, to date, there has been no histologic evidence of a role for silicone in this cellular immune response. Methods: A total of 44 temporal bone specimens from 36 patients were reviewed by light microscopy for evidence of presumed platinum and/or silicone foreign bodies in an extracellular or intracellular location. Identification of cell type involved in phagocytosis of foreign body material was accomplished using CD163 immunostaining. The identity and source of the foreign body material was confirmed using energy-dispersive X-ray spectroscopy and scanning electron microscopy. Results: Evidence for both platinum and silicone was found in all 44 specimens. In three patients, anti-CD 163 immunostaining demonstrated phagocytized platinum and silicone foreign bodies. In five specimens, energy-dispersive X-ray spectroscopy demonstrated that the birefringent foreign bodies were consistent with silicone. Scanning electron microscopy of two electrodes removed from temporal bones demonstrated small cracks, fragmentation, and small circular defects in the silicone carrier. Conclusion: Histologic evidence of a foreign body response to the presence of platinum and silicone in a cochlear implant has been demonstrated and may be responsible for some reported delayed failures or extrusion. Copyright (C) 2017 by Otology & Neurotology, Inc. Image copyright (C) 2010 Wolters Kluwer Health/Anatomical Chart Company
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Efficacy of Intratympanic Gentamicin in Meniere's Disease With and Without Migraine.
Objective: To compare the efficacy of intratympanic gentamicin injection (ITG) on vertigo control, drop attacks, and functional level in Meniere's disease patients with and without a history of migraine. Patients: Meniere's disease patients (patients with migraine and age- and sex-matched control patients without migraine) treated from 2002 to 2012 who failed medical management and received ITG, with a minimum 2-year follow up. Intervention: ITG. Main Outcome Measures: Vertigo control, drop attack prevalence, and change in functional level. Results: Twenty-eight Meniere's disease patients were included in this study (14 with migraine and 14 matched patients without migraine). There were three men and 11 women in each groups, with a mean age of 53 +/- 8.9 years. Baseline characteristics (Meniere's stage, vertigo frequency, drop attack prevalence, and functional level) before ITG were not significantly different between the two groups. Two years after ITG, 71% of Meniere's disease with migraine patients and 78% of Meniere's disease without migraine patients had class A, B, or C vertigo control (p > 0.999). Change in prevalence of drop attacks (43-7% versus 50-0%, respectively) was also similar (p > 0.999). However, significantly fewer vertigo control class A, B, and C migraine patients achieved functional level 1 or 2 (40%) compared with non-migraine patients (91%) (p = 0.007). Conclusions: Although ITG appears equally effective in treating vertigo and drop attacks in Meniere's disease with and without migraine, patients with migraine derive significantly less benefit in terms of functional improvement. Copyright (C) 2017 by Otology & Neurotology, Inc. Image copyright (C) 2010 Wolters Kluwer Health/Anatomical Chart Company
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Dichotic Listening Deficit Associated With Solvent Exposure.
Hypothesis: A significant left ear deficit can be observed in solvent-exposed individuals using the dichotic digit test. Background: Solvents are ubiquitous in global industrial processes. Due to their lipophilic nature, solvents can adversely affect large white matter tracks such as the corpus callosum. Previous investigations reveal that long-term workplace exposure to solvents is also deleterious to various auditory processes. Investigations in exposed populations suggest a decreased performance for dichotic listening. Methods: In this present study, we examined the lateralization of a dichotic digit test score for 49 solvent-exposed individuals along with 49 age- and sex-matched controls. We evaluated group differences between test scores and the right ear advantage using a laterality index (LI). Results: Individual ear results suggest that long-term workplace solvent exposure is associated with a significantly lower dichotic listening score for the left ear. A binaural compound score analysis using a laterality index supports this left-ear deficit. Conclusion: These results provide an insight on the effects of solvent exposure on dichotic listening abilities. Further research should investigate the importance of using dichotic listening tasks to screen for solvent-induced auditory dysfunction in exposed individuals. Copyright (C) 2017 by Otology & Neurotology, Inc. Image copyright (C) 2010 Wolters Kluwer Health/Anatomical Chart Company
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Typicality Effect and Category Structure in Spanish–English Bilingual Children and Adults
Purpose
The study examines the typicality effect in Spanish–English bilingual children and adults in their 2 languages.
Method
Two studies were conducted using a category-generation task to compare the typical items generated by children with those generated by adults. Children in the 1st study differed orthogonally with respect to age (older, younger) and language use (higher Spanish use, higher English use). In the 2nd study, the older and younger children were matched with adults on their current Spanish use to delineate the influence of test language and age.
Results
Children with higher English use generated more typical items, and these occurred earlier in their word lists in English than in Spanish. Participants at all levels of Spanish experience generated fewer typical items in Spanish than in English. Thus, there was less convergence of items considered typical among participants in Spanish. Older and younger children did not differ in the number of typical items generated. However, when participants were matched for language use, older children produced typical items earlier in their word lists than did younger children.
Conclusion
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Typicality Effect and Category Structure in Spanish–English Bilingual Children and Adults
Purpose
The study examines the typicality effect in Spanish–English bilingual children and adults in their 2 languages.
Method
Two studies were conducted using a category-generation task to compare the typical items generated by children with those generated by adults. Children in the 1st study differed orthogonally with respect to age (older, younger) and language use (higher Spanish use, higher English use). In the 2nd study, the older and younger children were matched with adults on their current Spanish use to delineate the influence of test language and age.
Results
Children with higher English use generated more typical items, and these occurred earlier in their word lists in English than in Spanish. Participants at all levels of Spanish experience generated fewer typical items in Spanish than in English. Thus, there was less convergence of items considered typical among participants in Spanish. Older and younger children did not differ in the number of typical items generated. However, when participants were matched for language use, older children produced typical items earlier in their word lists than did younger children.
Conclusion
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Typicality Effect and Category Structure in Spanish–English Bilingual Children and Adults
Purpose
The study examines the typicality effect in Spanish–English bilingual children and adults in their 2 languages.
Method
Two studies were conducted using a category-generation task to compare the typical items generated by children with those generated by adults. Children in the 1st study differed orthogonally with respect to age (older, younger) and language use (higher Spanish use, higher English use). In the 2nd study, the older and younger children were matched with adults on their current Spanish use to delineate the influence of test language and age.
Results
Children with higher English use generated more typical items, and these occurred earlier in their word lists in English than in Spanish. Participants at all levels of Spanish experience generated fewer typical items in Spanish than in English. Thus, there was less convergence of items considered typical among participants in Spanish. Older and younger children did not differ in the number of typical items generated. However, when participants were matched for language use, older children produced typical items earlier in their word lists than did younger children.
Conclusion
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Tinnitus With No Hearing Loss
Tinnitus is a condition that may cause someone to hear continuous hissing, buzzing or humming noises even in quiet or silent environments. The constant noise may lead to depression, anxiety or irritability, and it could also lead to sleep deprivation if the sounds occur at night. While tinnitus may lead to hearing loss, this is not always the case.
Tinnitus With No Hearing Loss May Be Temporary
In many cases, tinnitus is a result of damage to the inner ear. However, if there is no damage to the inner ear, it is possible that the hissing or buzzing noises one hears will go away on their own. In many cases, the condition is caused by temporary exposure to loud music at a rock concert or being too close to an alarm at the fire station.
Tinnitus With No Hearing Loss May Only Impact One Ear
It is possible that those who have tinnitus without any hearing loss may only have the condition in one ear. Again, this signifies that the condition may only be temporary and could be avoided by wearing better ear protection. For instance, someone who is subject to loud noises at work may want to wear ear guards while walking through a factory or when mowing the lawn outside of an apartment complex.
Tinnitus With No Hearing Loss May Not Be Medically Significant
Temporary ringing, buzzing or hissing sounds may be a sign of a mild form of tinnitus. Assuming that these noises go away on their own, it is unlikely that the condition is a significant cause for concern from a medical perspective. However, it will still be a good idea for those who have even passing symptoms to get a hearing test done and to limit exposure to loud noises going forward.
How Can You Overcome Tinnitus Symptoms?
There are several factors that may increase the risk of tinnitus or exasperate existing symptoms. Ideally, those who have the condition will refrain from excess caffeine or sugar, will get at least eight hours of sleep at night and will start to eat better and exercise more often.
If you have tinnitus, it may be a good idea to talk to a doctor about how to manage or eliminate symptoms. Regardless of whether or not you have the condition, it is in your best interest to limit your exposure to loud noises to avoid gradual hearing loss or other potential injuries to the ear.
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Bottom of an iceberg: undiagnosed aortic aneurysm masquerading as vocal cord palsy
http://otorhinolaryngology-crete.blogspot.com/2017/05/undiagnosed-aortic-aneurysm.html
από Rao, V. U. S., Chatterjee, S., Swamy, S. S. στο BMJ Case Reports Last 6 Issues Μετάφραση άρθρου Description A previously healthy woman aged 60 years was referred to a tertiary referral cancer centre with change of voice for 1 week suspecting neoplastic aetiology on account of her tobacco chewing habit of more than 20 years. No history of voice abuse, fever or cough was there preceding the onset of the change of voice. She did not have any previous history of hospitalisation or diagnosed comorbidities. On clinical examination, her pulse rate was 82 bpm; blood pressure was 130/90 mm Hg and respiratory rate was 12/min. Video laryngoscopy examination revealed left vocal cord palsy with no obvious lesion. A whole-body F18 FDG PET–CT scan revealed the presence of 6.6x4.8x6.7 cm lobulated sacullar aneurysm arising from the aortic arch between the origins of the left common carotid and subclavian arteries (figures 1 and 2). The likely mycotic aneurysm caused significant surrounding metabolically active inflammatory changes (figure 3).
Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480
Gamma Knife Radiosurgery for Vestibular Schwannomas and Quality of Life Evaluation.
Gamma Knife Radiosurgery for Vestibular Schwannomas and Quality of Life Evaluation.
Stereotact Funct Neurosurg. 2017 May 23;95(3):166-173
Authors: Berkowitz O, Han YY, Talbott EO, Iyer AK, Kano H, Kondziolka D, Brown MA, Lunsford LD
Abstract
BACKGROUND: Further investigation is needed to look at the impact of vestibular schwannoma (VS) on the health-related quality of life (QOL) of participants who undergo Gamma Knife® radiosurgery (GKRS).
OBJECTIVES: Investigators compared the QOL for VS participants to reported US population norms in order to evaluate disease burden and long-term QOL several years after GKRS.
METHODS: This cross-sectional study surveyed participants to assess hearing status, tinnitus, imbalance, vertigo, as well as the Short-Form 36-item Health Questionnaire (SF-36). The data were normalized, age adjusted, and functional status was correlated to determine clinically significant differences.
RESULTS: A total of 353 participants who underwent GKRS between 1997 and 2007 were included in this study with a median postoperative period of 5 years. SF-36 scores were very similar to population norms, and age-adjusted scores for participants followed the US population curve. Frequent vertigo and balance problems had the largest statistically and clinically significant effect on physical and mental component summary scores followed by nonuseful hearing in the tumor ear.
CONCLUSIONS: Participants reported a good long-term QOL that was very similar to the QOL of US population norms. Of the common VS symptoms, vertigo had the greatest impact on QOL followed by imbalance and then hearing loss.
PMID: 28531896 [PubMed - as supplied by publisher]
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Utricular hypofunction in patients with type 2 diabetes mellitus.
Utricular hypofunction in patients with type 2 diabetes mellitus.
Acta Otorhinolaryngol Ital. 2017 May 22;:
Authors: Jáuregui-Renaud K, Aranda-Moreno C, Herrera-Rangel A
Abstract
The aim of this study was to assess the function of the utricle and horizontal semicircular canals in patients with type 2 diabetes mellitus receiving primary health care, with/without a history of falls. 101 patients with type 2 diabetes mellitus, 34 to 84 years old (26 with and 75 without a history of falls) and 51 healthy volunteers (40-83 years old) accepted to participate. They denied having a history of dizziness, vertigo, unsteadiness, hearing loss or neurological disorders. None of them were seeking care due to sensory or balance decline. After a clinical evaluation and report of symptoms related to balance using a standardised questionnaire, lateral canal function was assessed by sinusoidal rotation at 0.16 Hz and 1.28 Hz (60°/sec peak velocity), otolith function was assessed by static visual vertical (average of 10 trials) and dynamic visual vertical during unilateral centrifugation (300°/sec at 3.5 cm) and static posturography was performed on hard/ soft surface with eyes open/closed. Compared to healthy volunteers, patients showed decreased responses to unilateral centrifugation, but similar responses to horizontal canal stimuli (independently of age, peripheral neuropathy or a history of falls) (ANCoVA p < 0.05) and a larger sway area with a lengthier sway path. Compared to patients with no falls, patients with falls had a higher female/male ratio and a higher frequency of score ≥ 4 on the questionnaire of symptoms related to balance, but similar age, body mass index and frequency of peripheral neuropathy. In patients with type 2 diabetes mellitus, receiving primary healthcare who are not seeking care due to sensory or balance decline, utricular function may be impaired even in the absence of horizontal canal dysfunction or a history of falls.
PMID: 28530263 [PubMed - as supplied by publisher]
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Gamma Knife Radiosurgery for Vestibular Schwannomas and Quality of Life Evaluation.
Gamma Knife Radiosurgery for Vestibular Schwannomas and Quality of Life Evaluation.
Stereotact Funct Neurosurg. 2017 May 23;95(3):166-173
Authors: Berkowitz O, Han YY, Talbott EO, Iyer AK, Kano H, Kondziolka D, Brown MA, Lunsford LD
Abstract
BACKGROUND: Further investigation is needed to look at the impact of vestibular schwannoma (VS) on the health-related quality of life (QOL) of participants who undergo Gamma Knife® radiosurgery (GKRS).
OBJECTIVES: Investigators compared the QOL for VS participants to reported US population norms in order to evaluate disease burden and long-term QOL several years after GKRS.
METHODS: This cross-sectional study surveyed participants to assess hearing status, tinnitus, imbalance, vertigo, as well as the Short-Form 36-item Health Questionnaire (SF-36). The data were normalized, age adjusted, and functional status was correlated to determine clinically significant differences.
RESULTS: A total of 353 participants who underwent GKRS between 1997 and 2007 were included in this study with a median postoperative period of 5 years. SF-36 scores were very similar to population norms, and age-adjusted scores for participants followed the US population curve. Frequent vertigo and balance problems had the largest statistically and clinically significant effect on physical and mental component summary scores followed by nonuseful hearing in the tumor ear.
CONCLUSIONS: Participants reported a good long-term QOL that was very similar to the QOL of US population norms. Of the common VS symptoms, vertigo had the greatest impact on QOL followed by imbalance and then hearing loss.
PMID: 28531896 [PubMed - as supplied by publisher]
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Utricular hypofunction in patients with type 2 diabetes mellitus.
Utricular hypofunction in patients with type 2 diabetes mellitus.
Acta Otorhinolaryngol Ital. 2017 May 22;:
Authors: Jáuregui-Renaud K, Aranda-Moreno C, Herrera-Rangel A
Abstract
The aim of this study was to assess the function of the utricle and horizontal semicircular canals in patients with type 2 diabetes mellitus receiving primary health care, with/without a history of falls. 101 patients with type 2 diabetes mellitus, 34 to 84 years old (26 with and 75 without a history of falls) and 51 healthy volunteers (40-83 years old) accepted to participate. They denied having a history of dizziness, vertigo, unsteadiness, hearing loss or neurological disorders. None of them were seeking care due to sensory or balance decline. After a clinical evaluation and report of symptoms related to balance using a standardised questionnaire, lateral canal function was assessed by sinusoidal rotation at 0.16 Hz and 1.28 Hz (60°/sec peak velocity), otolith function was assessed by static visual vertical (average of 10 trials) and dynamic visual vertical during unilateral centrifugation (300°/sec at 3.5 cm) and static posturography was performed on hard/ soft surface with eyes open/closed. Compared to healthy volunteers, patients showed decreased responses to unilateral centrifugation, but similar responses to horizontal canal stimuli (independently of age, peripheral neuropathy or a history of falls) (ANCoVA p < 0.05) and a larger sway area with a lengthier sway path. Compared to patients with no falls, patients with falls had a higher female/male ratio and a higher frequency of score ≥ 4 on the questionnaire of symptoms related to balance, but similar age, body mass index and frequency of peripheral neuropathy. In patients with type 2 diabetes mellitus, receiving primary healthcare who are not seeking care due to sensory or balance decline, utricular function may be impaired even in the absence of horizontal canal dysfunction or a history of falls.
PMID: 28530263 [PubMed - as supplied by publisher]
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Genetics of human Bardet-Biedl syndrome, an updates.
 |
Related Articles |
Genetics of human Bardet-Biedl syndrome, an updates.
Clin Genet. 2016 Jul;90(1):3-15
Authors: Khan SA, Muhammad N, Khan MA, Kamal A, Rehman ZU, Khan S
Abstract
Bardet-Biedl syndrome (BBS) is an autosomal recessive multisystemic human genetic disorder characterized by six major defects including obesity, mental retardation, renal anomalies, polydactyly, retinal degeneration and hypogenitalism. In several cases of BBS, few other features such as metabolic defects, cardiovascular anomalies, speech deficits, hearing loss, hypertension, hepatic defects and high incidence of diabetes mellitus have been reported as well. The BBS displays extensive genetic heterogeneity. To date, 19 genes have been mapped on different chromosomes causing BBS phenotypes having varied mutational load of each BBS gene. In this review, we have discussed clinical spectrum and genetics of BBS. This report presents a concise overview of the current knowledge on clinical data and its molecular genetics progress upto date.
PMID: 26762677 [PubMed - indexed for MEDLINE]
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Sensory loss and its consequences for couples' psychosocial and relational wellbeing: an integrative review.
 |
Related Articles |
Sensory loss and its consequences for couples' psychosocial and relational wellbeing: an integrative review.
Aging Ment Health. 2017 Apr;21(4):337-347
Authors: Lehane CM, Dammeyer J, Elsass P
Abstract
OBJECTIVES: Previous research has shown that marital communication is key to couples' successful illness adjustment. However, little is known about couples' experiences of health conditions characterised by communication difficulties such as acquired hearing, vision, and dual-sensory loss. The aim of this review was to identify the effect of sensory loss, and associated communication difficulties, on couples' relational and psychosocial adjustment.
METHOD: A systematic search was conducted to identify studies investigating the social, psychological, and relational impact of sensory loss on couples.
RESULTS: Twenty-four articles met the criteria for inclusion in the review. Significant heterogeneity in the measurements and design of the quantitative studies prevented statistical data synthesis. All but two studies reported some effect of sensory loss on couples' psychosocial or relational wellbeing. Higher levels of marital satisfaction were found to buffer against adverse psychological outcomes. Results of quantitative and qualitative studies were synthesised to form an integrative model illustrating the associations between sensory loss and couples' relational and psychosocial wellbeing.
CONCLUSIONS: Although this review reports an association between sensory loss and couples' relational and psychosocial wellbeing, the results should be viewed with caution given that relatively few studies on couples' experiences of acquired sensory loss exist, and many have methodological limitations.
PMID: 26739709 [PubMed - indexed for MEDLINE]
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Vibroplasty in Severe Congenital or Acquired Meatal Stenosis by Coupling an Active Middle Ear Implant to the Short Process of the Incus.
Objective: To evaluate the safety and effectiveness of coupling an active middle ear implant to the short process of the incus in subjects with meatal pathologies. Study Design: Retrospective study. Setting: Tertiary referral center. Patients: Twelve patients suffering from either congenital aural atresia or acquired meatal fibrosis. Intervention: Implantation of an active middle ear implant with coupling of the actuator to the short process of the incus. Main Outcome Measures: Evaluation of the air conduction and bone conduction hearing thresholds pre- and postoperatively, aided warble-tone hearing thresholds, unaided and aided speech recognition in quiet and noise. Questionnaires on subjective benefit and quality of life. Results: Mean unaided postoperative air conduction and bone conduction thresholds did not vary significantly from preoperative values (p = 0.55 and 0.082, respectively). The mean functional gain amounted to 42.1 +/- 8.8 dB, the mean aided sound field threshold of the implanted ear was 28.6 +/- 8.6 dB. No significant difference in functional gain but a close to significant difference in postoperative aided thresholds (p = 0.053) were found between subjects with congenital atresia and acquired fibrosis. Subjective benefit assessed by the global score of the Abbreviated Profile of Hearing Aid Benefit questionnaire revealed an improvement of 31 to 42%. Conclusion: Coupling of the actuator to the short process of the incus is a safe and clinically promising procedure in cases where the standard application to the long process is not feasible. In pure conductive hearing loss the benefit is comparable to long incus process coupling, whereas in mixed hearing loss slightly worse results were observed. Copyright (C) 2017 by Otology & Neurotology, Inc. Image copyright (C) 2010 Wolters Kluwer Health/Anatomical Chart Company
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