OtoRhinoLaryngology by Sfakianakis G.Alexandros Sfakianakis G.Alexandros,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174
Τετάρτη 11 Ιανουαρίου 2017
Voice Emotion Perception and Production in Cochlear Implant Users
Source:Hearing Research
Author(s): N.T. Jiam, M. Caldwell, M.L. Deroche, M. Chatterjee, C.J. Limb
Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants frequently demonstrate significant difficulty in recognizing voice emotions in comparison to their normal hearing counterparts. Cochlear implant-mediated perception and production of voice emotion is an important but relatively understudied area of research. However, a rich understanding of the voice emotion auditory processing offers opportunities to improve upon CI biomedical design and to develop training programs benefiting CI performance. In this review, we will address the issues, current literature, and future directions for improved voice emotion processing in cochlear implant users.
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Culture media-based selection of endothelial cells, pericytes, and perivascular-resident macrophage-like melanocytes from the young mouse vestibular system
Source:Hearing Research
Author(s): Jinhui Zhang, Songlin Chen, Jing Cai, Zhiqiang Hou, Xiaohan Wang, Allan Kachelmeier, Xiaorui Shi
The vestibular blood-labyrinth barrier (BLB) is comprised of perivascular-resident macrophage-like melanocytes (PVM/Ms) and pericytes (PCs), in addition to endothelial cells (ECs) and basement membrane (BM), and bears strong resemblance to the cochlear BLB in the stria vascularis. Over the past few decades, in vitro cell-based models have been widely used in blood-brain barrier (BBB) and blood-retina barrier (BRB) research, and have proved to be powerful tools for studying cell-cell interactions in their respective organs. Study of both the vestibular and strial BLB has been limited by the unavailability of primary culture cells from these barriers. To better understand how barrier component cells interact in the vestibular system to control BLB function, we developed a novel culture medium–based method for obtaining EC, PC, and PVM/M primary cells from tiny explants of the semicircular canal, sacculus, utriculus, and ampullae tissue of young mouse ears at post-natal age 8 - 12 d. Each phenotype is grown in a specific culture medium which selectively supports the phenotype in a mixed population of vestibular cell types. The unwanted phenotypes do not survive passaging. The protocol does not require additional equipment or special enzyme treatment. The harvesting process takes less than 2 h. Primary cell types are generated within 7 - 10 d. The primary culture ECs, PCs, and PVM/M shave consistent phenotypes more than 90% pure after two passages (∼ 3 weeks). The highly purified primary cell lines can be used for studying cell-cell interactions, barrier permeability, and angiogenesis.
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Voice Emotion Perception and Production in Cochlear Implant Users
Source:Hearing Research
Author(s): N.T. Jiam, M. Caldwell, M.L. Deroche, M. Chatterjee, C.J. Limb
Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants frequently demonstrate significant difficulty in recognizing voice emotions in comparison to their normal hearing counterparts. Cochlear implant-mediated perception and production of voice emotion is an important but relatively understudied area of research. However, a rich understanding of the voice emotion auditory processing offers opportunities to improve upon CI biomedical design and to develop training programs benefiting CI performance. In this review, we will address the issues, current literature, and future directions for improved voice emotion processing in cochlear implant users.
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Culture media-based selection of endothelial cells, pericytes, and perivascular-resident macrophage-like melanocytes from the young mouse vestibular system
Source:Hearing Research
Author(s): Jinhui Zhang, Songlin Chen, Jing Cai, Zhiqiang Hou, Xiaohan Wang, Allan Kachelmeier, Xiaorui Shi
The vestibular blood-labyrinth barrier (BLB) is comprised of perivascular-resident macrophage-like melanocytes (PVM/Ms) and pericytes (PCs), in addition to endothelial cells (ECs) and basement membrane (BM), and bears strong resemblance to the cochlear BLB in the stria vascularis. Over the past few decades, in vitro cell-based models have been widely used in blood-brain barrier (BBB) and blood-retina barrier (BRB) research, and have proved to be powerful tools for studying cell-cell interactions in their respective organs. Study of both the vestibular and strial BLB has been limited by the unavailability of primary culture cells from these barriers. To better understand how barrier component cells interact in the vestibular system to control BLB function, we developed a novel culture medium–based method for obtaining EC, PC, and PVM/M primary cells from tiny explants of the semicircular canal, sacculus, utriculus, and ampullae tissue of young mouse ears at post-natal age 8 - 12 d. Each phenotype is grown in a specific culture medium which selectively supports the phenotype in a mixed population of vestibular cell types. The unwanted phenotypes do not survive passaging. The protocol does not require additional equipment or special enzyme treatment. The harvesting process takes less than 2 h. Primary cell types are generated within 7 - 10 d. The primary culture ECs, PCs, and PVM/M shave consistent phenotypes more than 90% pure after two passages (∼ 3 weeks). The highly purified primary cell lines can be used for studying cell-cell interactions, barrier permeability, and angiogenesis.
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The path of a click stimulus from ear canal to umbo
Source:Hearing Research
Author(s): Mario Milazzo, Elika Fallah, Michael Carapezza, Nina S. Kumar, Jason H. Lei, Elizabeth S. Olson
The tympanic membrane (TM) has a key role in transmitting sounds to the inner ear, but a concise description of how the TM performs this function remains elusive. This paper probes TM operation by applying a free field click stimulus to the gerbil ear and exploring the consequent motions of the TM and umbo. Motions of the TM were measured both on radial tracks starting close to the umbo and on a grid distal and adjacent to the umbo. The experimental results confirmed the high fidelity of sound transmission from the ear canal to the umbo. A delay of 5–15 μs was seen in the onset of TM motion between points just adjacent to the umbo and mid-radial points. The TM responded with a ringing motion, with different locations possessing different primary ringing frequencies. A simple analytic model from the literature, treating the TM as a string, was used to explore the experimental results. The click-based experiments and analysis led to the following description of TM operation: A transient sound pressure on the TM causes a transient initial TM motion that is maximal ∼ at the TM's radial midpoints. Mechanical forces generated by this initial prominent TM distortion then pull the umbo inward, leading to a delayed umbo response. The initial TM deformation also gives rise to prolonged mechanical ringing on the TM that does not result in significant umbo motion, likely due to destructive interference from the range of ringing frequencies. Thus, the umbo's response is a high-fidelity representation of the transient stimulus. Because any sound can be considered as a consecutive series of clicks, this description is applicable to any sound stimulus.
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The path of a click stimulus from ear canal to umbo
Source:Hearing Research
Author(s): Mario Milazzo, Elika Fallah, Michael Carapezza, Nina S. Kumar, Jason H. Lei, Elizabeth S. Olson
The tympanic membrane (TM) has a key role in transmitting sounds to the inner ear, but a concise description of how the TM performs this function remains elusive. This paper probes TM operation by applying a free field click stimulus to the gerbil ear and exploring the consequent motions of the TM and umbo. Motions of the TM were measured both on radial tracks starting close to the umbo and on a grid distal and adjacent to the umbo. The experimental results confirmed the high fidelity of sound transmission from the ear canal to the umbo. A delay of 5–15 μs was seen in the onset of TM motion between points just adjacent to the umbo and mid-radial points. The TM responded with a ringing motion, with different locations possessing different primary ringing frequencies. A simple analytic model from the literature, treating the TM as a string, was used to explore the experimental results. The click-based experiments and analysis led to the following description of TM operation: A transient sound pressure on the TM causes a transient initial TM motion that is maximal ∼ at the TM's radial midpoints. Mechanical forces generated by this initial prominent TM distortion then pull the umbo inward, leading to a delayed umbo response. The initial TM deformation also gives rise to prolonged mechanical ringing on the TM that does not result in significant umbo motion, likely due to destructive interference from the range of ringing frequencies. Thus, the umbo's response is a high-fidelity representation of the transient stimulus. Because any sound can be considered as a consecutive series of clicks, this description is applicable to any sound stimulus.
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Voice Emotion Perception and Production in Cochlear Implant Users
Source:Hearing Research
Author(s): N.T. Jiam, M. Caldwell, M.L. Deroche, M. Chatterjee, C.J. Limb
Voice emotion is a fundamental component of human social interaction and social development. Unfortunately, cochlear implant users are often forced to interface with highly degraded prosodic cues as a result of device constraints in extraction, processing, and transmission. As such, individuals with cochlear implants frequently demonstrate significant difficulty in recognizing voice emotions in comparison to their normal hearing counterparts. Cochlear implant-mediated perception and production of voice emotion is an important but relatively understudied area of research. However, a rich understanding of the voice emotion auditory processing offers opportunities to improve upon CI biomedical design and to develop training programs benefiting CI performance. In this review, we will address the issues, current literature, and future directions for improved voice emotion processing in cochlear implant users.
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Culture media-based selection of endothelial cells, pericytes, and perivascular-resident macrophage-like melanocytes from the young mouse vestibular system
Source:Hearing Research
Author(s): Jinhui Zhang, Songlin Chen, Jing Cai, Zhiqiang Hou, Xiaohan Wang, Allan Kachelmeier, Xiaorui Shi
The vestibular blood-labyrinth barrier (BLB) is comprised of perivascular-resident macrophage-like melanocytes (PVM/Ms) and pericytes (PCs), in addition to endothelial cells (ECs) and basement membrane (BM), and bears strong resemblance to the cochlear BLB in the stria vascularis. Over the past few decades, in vitro cell-based models have been widely used in blood-brain barrier (BBB) and blood-retina barrier (BRB) research, and have proved to be powerful tools for studying cell-cell interactions in their respective organs. Study of both the vestibular and strial BLB has been limited by the unavailability of primary culture cells from these barriers. To better understand how barrier component cells interact in the vestibular system to control BLB function, we developed a novel culture medium–based method for obtaining EC, PC, and PVM/M primary cells from tiny explants of the semicircular canal, sacculus, utriculus, and ampullae tissue of young mouse ears at post-natal age 8 - 12 d. Each phenotype is grown in a specific culture medium which selectively supports the phenotype in a mixed population of vestibular cell types. The unwanted phenotypes do not survive passaging. The protocol does not require additional equipment or special enzyme treatment. The harvesting process takes less than 2 h. Primary cell types are generated within 7 - 10 d. The primary culture ECs, PCs, and PVM/M shave consistent phenotypes more than 90% pure after two passages (∼ 3 weeks). The highly purified primary cell lines can be used for studying cell-cell interactions, barrier permeability, and angiogenesis.
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The path of a click stimulus from ear canal to umbo
Source:Hearing Research
Author(s): Mario Milazzo, Elika Fallah, Michael Carapezza, Nina S. Kumar, Jason H. Lei, Elizabeth S. Olson
The tympanic membrane (TM) has a key role in transmitting sounds to the inner ear, but a concise description of how the TM performs this function remains elusive. This paper probes TM operation by applying a free field click stimulus to the gerbil ear and exploring the consequent motions of the TM and umbo. Motions of the TM were measured both on radial tracks starting close to the umbo and on a grid distal and adjacent to the umbo. The experimental results confirmed the high fidelity of sound transmission from the ear canal to the umbo. A delay of 5–15 μs was seen in the onset of TM motion between points just adjacent to the umbo and mid-radial points. The TM responded with a ringing motion, with different locations possessing different primary ringing frequencies. A simple analytic model from the literature, treating the TM as a string, was used to explore the experimental results. The click-based experiments and analysis led to the following description of TM operation: A transient sound pressure on the TM causes a transient initial TM motion that is maximal ∼ at the TM's radial midpoints. Mechanical forces generated by this initial prominent TM distortion then pull the umbo inward, leading to a delayed umbo response. The initial TM deformation also gives rise to prolonged mechanical ringing on the TM that does not result in significant umbo motion, likely due to destructive interference from the range of ringing frequencies. Thus, the umbo's response is a high-fidelity representation of the transient stimulus. Because any sound can be considered as a consecutive series of clicks, this description is applicable to any sound stimulus.
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Sound Retrains the Tinnitus Brain
Tinnitus is a poorly-understood medical condition that presents itself as an unpleasant, distressing, and sometimes outright painful ringing sound without cause. It can cause insomnia, frustration, difficulty hearing conversations, and a host of other conditions.
Causes of Tinnitus
Sometimes tinnitus symptoms are caused by an obvious external factor; a loud explosion or a long period in a loud environment, for example, can leave someone’s ears ringing for several days or even weeks. This kind of tinnitus frequently goes away in its own time.
The other common kind of tinnitus does not. It persists for years, and often accompanies the loss of hearing ability. You lose your ability to hear clearly, having it replaced by a constant, frustrating ringing sound. This kind of tinnitus is the least understood, and treatments are rarely effective in most cases. If it persists for two or more years, it is often considered permanent. This version is thought to be partially caused by the brain making new pathways to deal with the hearing loss, and the wiring essentially gets crossed somehow.
How To Treat It
Dealing with tinnitus is mostly a case of symptom management. In other words, how can you keep it from being so awful? It causes anxiety and pain to sufferers, so relieving that kind of pressure is vital.
One technique can be summed up in the phrase, “sound retrains the tinnitus brain.” That might sound odd, but it relies on the concept of neuroplasticity. In essence, new behaviors and habits can change the way the brain is wired, and the responses it has to situations. You would probably be scared the first time you go bungee jumping, but do it often enough as a hobby and it becomes thrilling rather than fearsome.
Sound Retrains the Tinnitus Brain
The treatment focuses on using computer software to create a customized, tailor made sound set to neutralize your perception of your tinnitus symptoms. Patients change between listening to the normal sound of their tinnitus, and listening to a sound produced by the software. They adjust the sound produced by the computer bit by bit until it matches the sound they perceive in their ears. The theory goes that by listening to an actual sound that matches the frequency of the tinnitus, you cancel the tinnitus out while listening. It can take the form of either music or so called white noise.
This is where the neuroplasticity comes in. The treatment argues that as you listen to the custom sound, your brain adapts to the perceived lower volume of the tinnitus it normally hears. This allows it to slowly turn down the apparent volume of the tinnitus, which hopefully means you notice it less. The goal is to make this altered perception permanent or at least long lasting through regular exposure. Once again, sound retrains the tinnitus brain.
Not So Weird
White noise generators are already a popular device to help people focus at work, or to provide a relaxing environment to allow people to sleep. Others report only being able to sleep with some soft music, a podcast, or similar sound playing. This is just a more specific version of the same technique, and it might just help people with a frustrating, anxiety-inducing invisible condition have some much needed relief.
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Dizziness and Falls in Obese Inpatients Undergoing Metabolic Rehabilitation
by Stefano Corna, Valentina Aspesi, Nicola Cau, Federica Scarpina, Natalia Gattini Valdés, Luigia Brugliera, Veronica Cimolin, Paolo Capodaglio
AimThe relationship between dizziness and falls in the obese population is a relatively unexplored issue. The aims of the present study were to define the 1-year prevalence of dizziness in an obese inpatient population undergoing metabolic rehabilitation and to investigate possible correlations with fall events.
Materials and MethodsWe recruited 329 obese subjects: 203 female (BMI 43,74 kg/m2 ± 0.5 SE; age 17–83 years, 58.33 ± 0.9 SE) and 126 male (BMI 44,27kg/m2 ± 0.7 DE age 27–79 years, 58.84 ± 1 SE). To assess dizziness we used the validated Italian version (38) of the Dizziness Handicap Inventory (DHI).
ResultsOut of the experimental sample, 100 subjects did not complain of dizziness and felt confident about their balance control, while 69.6% reported some degree of dizziness. Their mean DHI score was 22.3, which corresponds to mild dizziness. Twenty-one percent reported more severe dizziness (DHI score > 40). The majority of our sample reported minor dizziness and its perception appears to be independent from BMI: DHI scores were consistent across classes of obesity.
DiscussionThe rate of dizziness and falls (30.1%) in an this obese population was higher than that previously reported in a general matched population. However, obese subjects, in our sample, seem to underestimate their risk of fall and DHI score does not appear a reliable predictor of falls. Since complications associated with falls in obese persons generally require longer treatments than in lean individuals, our findings should be taken into account in order to identify other predictors, including cognitive and perceptual, of risk of fall and to implement fall prevention programs.
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The Acoustic Breathiness Index (ABI): A Multivariate Acoustic Model for Breathiness
Source:Journal of Voice
Author(s): Ben Barsties v. Latoszek, Youri Maryn, Ellen Gerrits, Marc De Bodt
ObjectiveThe evaluation of voice quality is a major component of voice assessment. The aim of the present study was to develop a new multivariate acoustic model for the evaluation of breathiness.MethodConcatenated voice samples of continuous speech and the sustained vowel [a:] from 970 subjects with dysphonia and 88 vocally healthy subjects were perceptually judged for breathiness severity. Acoustic analyses were conducted on the same concatenated voice samples after removal of the non-voiced segments of the continuous speech sample. The development of an acoustic model for breathiness was based on stepwise multiple linear regression analysis. Concurrent validity, diagnostic accuracy, and cross validation were statistically verified on the basis of the Spearman rank-order correlation coefficient (rs), several estimates of the receiver operating characteristics plus the likelihood ratio, and iterated internal cross correlations.ResultsRatings of breathiness from four experts with moderate reliability were used. Stepwise multiple regression analysis yielded a nine-variable acoustic model for the multiparametric measurement of breathiness (Acoustic Breathiness Index [ABI]). A strong correlation was found between ABI and auditory-perceptual rating (rs = 0.840, P = 0.000). The cross correlations confirmed a comparably high degree of association. Additionally, the receiver operating characteristics and likelihood ratio results showed the best diagnostic outcome at a threshold of ABI = 3.44 with a sensitivity of 82.4% and a specificity of 92.9%.ConclusionsThis study developed a new acoustic multivariate correlate for the evaluation of breathiness in voice. The ABI model showed valid and robust results and is therefore proposed as a new acoustic index for the evaluation of breathiness.
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Conversational Entrainment of Vocal Fry in Young Adult Female American English Speakers
Source:Journal of Voice
Author(s): Stephanie A. Borrie, Christine R. Delfino
ObjectiveConversational entrainment, the natural tendency for people to modify their behaviors to more closely match their communication partner, is examined as one possible mechanism modulating the prevalence of vocal fry in the speech of young American women engaged in spoken dialogue.MethodTwenty young adult female American English speakers engaged in two spoken dialogue tasks—one with a young adult female American English conversational partner who exhibited substantial vocal fry and one with a young adult female American English conversational partner who exhibited quantifiably less vocal fry. Dialogues were analyzed for proportion of vocal fry, by speaker, and two measures of communicative success (efficiency and enjoyment).ResultsParticipants employed significantly more vocal fry when conversing with the partner who exhibited substantial vocal fry than when conversing with the partner who exhibited quantifiably less vocal fry. Further, greater similarity between communication partners in their use of vocal fry tracked with higher scores of communicative efficiency and communicative enjoyment.ConclusionsConversational entrainment offers a mechanistic framework that may be used to explain, to some degree, the frequency with which vocal fry is employed by young American women engaged in spoken dialogue. Further, young American women who modulated their vocal patterns during dialogue to match those of their conversational partner gained more efficiency and enjoyment from their interactions, demonstrating the cognitive and social benefits of entrainment.
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Early Postoperative Imaging of the Labyrinth by Cone Beam CT After Stapes Surgery for Otosclerosis With Correlation to Audiovestibular Outcome
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“Long-term Outcomes After Middle Fossa Approach for Traumatic Facial Nerve Paralysis. Otology & Neurotology 2016;37: 799–804”
A Novel Mutation in SLC26A4 Causes Nonsyndromic Autosomal Recessive Hearing Impairment
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Activation of IGF1 Signaling in the Cochlea Induces the Transcription of Its Mediators During the Protection of Cochlear Hair Cells Against Aminoglycoside
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Effects of Intratympanic Dexamethasone on High-Dose Radiation Ototoxicity In Vivo
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Unilateral Hearing Loss Is Associated With Impaired Balance in Children: A Pilot Study: Erratum
Older Individuals Meeting Medicare Cochlear Implant Candidacy Criteria in Noise but Not in Quiet: Are These Patients Improved by Surgery?
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Reconstruction Outcomes Following Lateral Skull Base Resection
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Cochlear Implantation in Ménière's Disease With and Without Labyrinthectomy
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Steerable Robot-assisted Micromanipulation in the Middle Ear: Preliminary Feasibility Evaluation
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Tip Fold-over in Cochlear Implantation: Case Series
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“Neutrophil to Lymphocyte Ratio as a Predictive Marker of Vestibular Schwannoma Growth. Otology & Neurotology 2016;37: 580–5”
Successful Loading of a Bone-Anchored Hearing Implant at 1 Week After Surgery
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Initial Results of a Safety and Feasibility Study of Auditory Brainstem Implantation in Congenitally Deaf Children
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A Mysterious Role of Arginine Vasopressin Levels in Ménière's Disease—Meta-analysis of Clinical Studies
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First Report: Linear Incision for Placement of a Magnetically Coupled Bone-Anchored Hearing Implant
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Benefits of High-dose Steroid + Hespander + Mannitol Administration in the Treatment of Bell's Palsy
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The Weather and Ménière's Disease: A Longitudinal Analysis in the UK
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Skin Necrosis After Implantation With the BAHA Attract: A Case Report and Review of the Literature.
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Adverse Events Following Vestibular Schwannoma Surgery: A Comparison of Surgical Approach.
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Isosorbide-Induced Decompression Effect on the Scala Media: Participation of Plasma Osmolality and Plasma Arginine Vasopressin.
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Assessment of Cochlea Endolymphatic Hydrops Using 3-D FLAIR and 3-D Real IR Sequence in Guinea Pigs via 3T MRI After Intratympanic Gadolinium: A Histopathological Comparison.
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