OtoRhinoLaryngology by Sfakianakis G.Alexandros Sfakianakis G.Alexandros,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174
Δευτέρα 10 Απριλίου 2017
Factors affecting sound energy absorbance in acute otitis media model of chinchilla
Source:Hearing Research
Author(s): Xiying Guan, Thomas W. Seale, Rong Z. Gan
Acute otitis media (AOM) is a rapid-onset infection of the middle ear which results in middle ear pressure (MEP), middle ear effusion (MEE), and structural changes in middle ear tissues. Previous studies from our laboratory have identified that MEP, MEE, and middle ear structural changes are three factors affecting tympanic membrane (TM) mobility and hearing levels (Guan et al. 2014; 2013). Sound energy reflectance or absorbance (EA) is a diagnostic tool increasingly used in clinical settings for the identification of middle ear diseases. However, it is unclear whether EA can differentiate these three factors in an AOM ear. Here we report wideband EA measurements in the AOM model of chinchilla at three experimental stages: unopened, pressure released, and effusion removed. These correspond to the combined and individual effects of the three factors on sound energy transmission. AOM was produced by transbullar injection of Haemophilus influenzae in two treatment groups: 4 days (4D) and 8 days (8D) post inoculation. These time points represent the relatively early and later phase of AOM. In each group of chinchillas, EA at 250-8000 Hz was measured using a wideband tympanometer at three experimental stages. Results show that the effects of MEP, MEE, and tissue structural changes over the frequency range varied with the disease time course. MEP was the primary contributor to reduction of EA in 4D AOM ears and had a smaller effect in 8D ears. MEE reduced the EA at 6-8 kHz in 4D ears and 2-8 kHz in 8D ears and was responsible for the EA peak in both 4D and 8D ears. The residual EA loss due to structural changes was observed over the frequency range in 8D ears and only at high frequencies in 4D ears. The EA measurements were also compared with the published TM mobility loss in chinchilla AOM ears.
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Factors affecting sound energy absorbance in acute otitis media model of chinchilla
Source:Hearing Research
Author(s): Xiying Guan, Thomas W. Seale, Rong Z. Gan
Acute otitis media (AOM) is a rapid-onset infection of the middle ear which results in middle ear pressure (MEP), middle ear effusion (MEE), and structural changes in middle ear tissues. Previous studies from our laboratory have identified that MEP, MEE, and middle ear structural changes are three factors affecting tympanic membrane (TM) mobility and hearing levels (Guan et al. 2014; 2013). Sound energy reflectance or absorbance (EA) is a diagnostic tool increasingly used in clinical settings for the identification of middle ear diseases. However, it is unclear whether EA can differentiate these three factors in an AOM ear. Here we report wideband EA measurements in the AOM model of chinchilla at three experimental stages: unopened, pressure released, and effusion removed. These correspond to the combined and individual effects of the three factors on sound energy transmission. AOM was produced by transbullar injection of Haemophilus influenzae in two treatment groups: 4 days (4D) and 8 days (8D) post inoculation. These time points represent the relatively early and later phase of AOM. In each group of chinchillas, EA at 250-8000 Hz was measured using a wideband tympanometer at three experimental stages. Results show that the effects of MEP, MEE, and tissue structural changes over the frequency range varied with the disease time course. MEP was the primary contributor to reduction of EA in 4D AOM ears and had a smaller effect in 8D ears. MEE reduced the EA at 6-8 kHz in 4D ears and 2-8 kHz in 8D ears and was responsible for the EA peak in both 4D and 8D ears. The residual EA loss due to structural changes was observed over the frequency range in 8D ears and only at high frequencies in 4D ears. The EA measurements were also compared with the published TM mobility loss in chinchilla AOM ears.
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Calculating the Tumor Volumes in Vestibular Schwannomas: Are the ABC/2 and Volumetric Methods Comparable?.
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Effects of Early Smoking Habits on Young Adult Female Voices in Greece
Source:Journal of Voice
Author(s): Dionysios Tafiadis, Eugenia I. Toki, Kevin J. Miller, Nausica Ziavra
Cigarette use is a preventable cause of mortality and diseases. The World Health Organization states that Europe and especially Greece has the highest occurrence of smoking among adults. The prevalence of smoking among women in Greece was estimated to be over 30% in 2012. Smoking is a risk factor for many diseases. Studies have demonstrated the association between smoking and laryngeal pathologies as well as changes in voice characteristics. The purpose of this study was to estimate the effect of early smoking habit on young adult female voices and if they perceive any vocal changes using two assessment methods. The Voice Handicap Index and the acoustic analyses of voice measurements were used, with both serving as mini-assessment protocols. Two hundred and ten young females (110 smokers and 100 nonsmokers) attending the Technological Educational Institute of Epirus in the School of Health and Welfare were included. Statistically significant increases for physical and total scores of the Voice Handicap Index were found in the smokers group (P < 0.05). Significant changes were observed for the acoustic parameters between smoker and nonsmoker groups. The results of this study indicated observable signs of change in the voice acoustic characteristics of young adults with early smoking habits.
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Speech Rate Normalization and Phonemic Boundary Perception in Cochlear-Implant Users
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Normative Study of Wideband Acoustic Immittance Measures in Newborn Infants
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Speech Inconsistency in Children With Childhood Apraxia of Speech, Language Impairment, and Speech Delay: Depends on the Stimuli
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Efficacy of Visual–Acoustic Biofeedback Intervention for Residual Rhotic Errors: A Single-Subject Randomization Study
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Speech Rate Normalization and Phonemic Boundary Perception in Cochlear-Implant Users
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Normative Study of Wideband Acoustic Immittance Measures in Newborn Infants
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Speech Inconsistency in Children With Childhood Apraxia of Speech, Language Impairment, and Speech Delay: Depends on the Stimuli
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Efficacy of Visual–Acoustic Biofeedback Intervention for Residual Rhotic Errors: A Single-Subject Randomization Study
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Speech Rate Normalization and Phonemic Boundary Perception in Cochlear-Implant Users
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Normative Study of Wideband Acoustic Immittance Measures in Newborn Infants
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Speech Inconsistency in Children With Childhood Apraxia of Speech, Language Impairment, and Speech Delay: Depends on the Stimuli
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Efficacy of Visual–Acoustic Biofeedback Intervention for Residual Rhotic Errors: A Single-Subject Randomization Study
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Epilogue: Reading Comprehension Is Not a Single Ability–Implications for Assessment and Instruction
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Commentary on “Reading Comprehension Is Not a Single Ability”: Implications for Child Language Intervention
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Prologue: Reading Comprehension Is Not a Single Ability
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Introduction to the Clinical Forum: Reading Comprehension Is Not a Single Ability
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An Interactive View of Reading Comprehension: Implications for Assessment
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Comprehending Comprehension: Selected Possibilities for Clinical Practice Within a Multidimensional Model
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Beyond Comprehension Strategy Instruction: What's Next?
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Epilogue: Reading Comprehension Is Not a Single Ability–Implications for Assessment and Instruction
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Commentary on “Reading Comprehension Is Not a Single Ability”: Implications for Child Language Intervention
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Prologue: Reading Comprehension Is Not a Single Ability
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Introduction to the Clinical Forum: Reading Comprehension Is Not a Single Ability
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An Interactive View of Reading Comprehension: Implications for Assessment
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Comprehending Comprehension: Selected Possibilities for Clinical Practice Within a Multidimensional Model
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Beyond Comprehension Strategy Instruction: What's Next?
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Epilogue: Reading Comprehension Is Not a Single Ability–Implications for Assessment and Instruction
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Commentary on “Reading Comprehension Is Not a Single Ability”: Implications for Child Language Intervention
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Prologue: Reading Comprehension Is Not a Single Ability
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Introduction to the Clinical Forum: Reading Comprehension Is Not a Single Ability
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An Interactive View of Reading Comprehension: Implications for Assessment
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Comprehending Comprehension: Selected Possibilities for Clinical Practice Within a Multidimensional Model
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Beyond Comprehension Strategy Instruction: What's Next?
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On the role of ephrinA2 in auditory function.
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On the role of ephrinA2 in auditory function.
Hear Res. 2017 Apr 05;350:11-16
Authors: Ingham NJ, Steel KP, Drescher U
Abstract
Recent findings suggest that the manipulation of the EphA/ephrinA system can improve hearing threshold sensitivity in the auditory system (Yates et al., 2014). These results appear to open-up the possibility that pharmacological manipulation of this system could lead to the development of treatments to cure some types of hearing loss. As a first step towards this goal, we have performed a further series of auditory brainstem evoked potential recordings on ephrinA2 homozygous knockout mice and their wildtype littermates in order to replicate the previously reported findings. However, we found that ephrinA2 knockout mice had auditory threshold sensitivity for click and 3-42 kHz tone pip frequencies comparable to that of their wildtype littermates. Evoked potential wave amplitudes, latencies and inter-peak intervals were also comparable between ephrinA2 knockout mice and wild type control littermates. Thus in our experiments we could not replicate the findings of Yates et al. (2014). Whilst the EphA/ephrinA system may therefore play a role in the development of innervation of the cochlea and neural circuitry of the auditory brainstem, there appears to be a functional redundancy between members of this family such that loss of ephrinA2 function alone is insufficient to alter auditory function in the mouse.
PMID: 28390777 [PubMed - as supplied by publisher]
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The results of newborn hearing screening by means of transient otoacoustic emissions - has anything changed over 10 years?
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The results of newborn hearing screening by means of transient otoacoustic emissions - has anything changed over 10 years?
Int J Pediatr Otorhinolaryngol. 2017 May;96:4-10
Authors: Wroblewska-Seniuk K, Greczka G, Dabrowski P, Szyfter W, Mazela J
Abstract
OBJECTIVES: Universal newborn hearing screening (UNHS) has become the standard of care in many countries. The aim of this study was to evaluate the results of UNHS after ten years of the program in Poland and to compare them with the results of 2003.
METHODS: In the study, we analyze the results of UNHS in the University Hospital in Poznan, Poland. Between 01.01.2013 and 31.12.2013, 6827 children were examined by means of otoacoustic emissions.
RESULTS: Risk factors (RF) were identified in 772 (11.3%) newborns, which is significantly less than 10 years ago (p < 0.05). The most frequent RF were: ototoxic medications, treatment in neonatal intensive care unit (NICU) and prematurity < 33 weeks of gestation. In 2003, the most frequent were ototoxic medications and prematurity, less frequent was treatment in NICU and more common was low Apgar score. In 51 (6.6%) newborns with RF, the result of OAE was positive either unilaterally or bilaterally. In infants without RF the result was positive unilaterally in 22 (0.4%) and bilaterally in 14 (0.2%) patients. These results are significantly lower than in our former study. The relative risk of positive result was the highest in infants with complex congenital anomalies (RR = 44.99), craniofacial anomalies (RR = 17.46) and mechanical ventilation for > 5 days (RR = 10.69). In our previous study, the highest RR of positive test results was in infants with family history, congenital malformations and low Apgar score. We found that most predictive as to the final diagnosis was bilaterally positive OAE test. In most patients, the second check confirmed the diagnosis, independently of RF. The number of false positive tests at the 1st level of screening is significantly lower now than 10 years ago, probably due to better staff training.
CONCLUSIONS: Long term monitoring and the appropriate management of hearing deficit in children is essential. UNHS seems to be the most efficient way of finding children who require treatment of hearing impairment. The prevalence of most risk factors of hearing deficit has significantly changed over the years. The number of false positive results has significantly decreased over the years thanks to better staff training.
PMID: 28390612 [PubMed - in process]
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MYO15A splicing mutations in hearing loss: A review literature and report of a novel mutation.
Related Articles |
MYO15A splicing mutations in hearing loss: A review literature and report of a novel mutation.
Int J Pediatr Otorhinolaryngol. 2017 May;96:35-38
Authors: Motavaf M, Soveizi M, Maleki M, Mahdieh N
Abstract
Sensorineural hearing loss (SNHL) is the most prevalent genetic sensory defect in humans, affecting about 1 in 1000 newborns around the world. Non-syndromic SNHL accounts for nearly 70% of hereditary hearing loss and 80% of SNHL cases show an autosomal recessive mode of inheritance (ARNSHL). In the present study, we applied targeted-exome sequencing to a family with a single proband affected by congenital sensorineural hearing loss. 127 known genes were sequenced to find the causative mutation. One novel homozygous donor splice site mutation, c.4596 + 1G > A (IVS12 + 1G > A) was found in MYO15A gene. Analysis of this mutation within the family showed that the mutation segregates with hearing loss. New DNA sequencing technologies could lead to identification of the disease causing variants especially in highly heterogeneous disorders such as hearing loss.
PMID: 28390610 [PubMed - in process]
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