The Oxidant-Antioxidant Equilibrium and Inflammatory Process Indicators after an Exercise Test on the AlterG Antigravity Treadmill in Young Amateur Female Athletes.

Related Articles

The Oxidant-Antioxidant Equilibrium and Inflammatory Process Indicators after an Exercise Test on the AlterG Antigravity Treadmill in Young Amateur Female Athletes.

Oxid Med Cell Longev. 2018;2018:3484159

Authors: Sielski Ł, Sutkowy P, Skopowska A, Pawlak-Osińska K, Augustyńska Z, Hewelt K, Drapała R, Woźniak A

Abstract
The AlterG antigravity treadmill allows running with a considerable weight reduction. Physical exercise practiced on this treadmill is an innovative method supporting the treatment of injuries in sports and rehabilitation of patients. The aim of the study was to investigate the effect of a 30 min run on the AlterG treadmill with 80% body weight reduction comparing the effect to the similar effort on the classic treadmill on the redox equilibrium and the activity of selected lysosomal enzymes and a serine protease inhibitor in the blood of amateur minor female volleyball players. Venous blood samples were taken before the exercise and 30 minutes and 24 hours after its completion. The obtained results were analysed using Tukey's test and Pearson's linear correlations were calculated. 24 h after the running test on classic treadmill, the erythrocytic superoxide dismutase activity was higher than before and 30 min after it, as well as compared to the run on AlterG treadmill (p < 0.001). The erythrocytic-conjugated diene concentration 24 h after the exercise on the classic treadmill was meaningly higher compared to that after the exercise on the AlterG treadmill (p < 0.001). The cathepsin D activity was significantly lower after the exercise in AlterG conditions compared to the baseline value and that measured after the exercise on classic treadmill (p < 0.001). It seems that the exercise on the AlterG treadmill keeps the oxidant-antioxidant equilibrium and stabilizes lysosomal membranes in young, physically active women in contrast to the exercise on the classic treadmill. This trial is registered with CTRI/2018/01/011344.

PMID: 29765494 [PubMed - in process]

from #Audiology via ola Kala on Inoreader https://ift.tt/2L89pSZ
via IFTTT

Evaluation of a multi-channel algorithm for reducing transient sounds.

Related Articles

Evaluation of a multi-channel algorithm for reducing transient sounds.

Int J Audiol. 2018 May 15;:1-8

Authors: Keshavarzi M, Baer T, Moore BCJ

Abstract
OBJECTIVE: The objective was to evaluate and select appropriate parameters for a multi-channel transient reduction (MCTR) algorithm for detecting and attenuating transient sounds in speech.
DESIGN: In each trial, the same sentence was played twice. A transient sound was presented in both sentences, but its level varied across the two depending on whether or not it had been processed by the MCTR and on the "strength" of the processing. The participant indicated their preference for which one was better and by how much in terms of the balance between the annoyance produced by the transient and the audibility of the transient (they were told that the transient should still be audible).
STUDY SAMPLE: Twenty English-speaking participants were tested, 10 with normal hearing and 10 with mild-to-moderate hearing-impairment. Frequency-dependent linear amplification was provided for the latter.
RESULTS: The results for both participant groups indicated that sounds processed using the MCTR were preferred over the unprocessed sounds. For the hearing-impaired participants, the medium and strong settings of the MCTR were preferred over the weak setting.
CONCLUSIONS: The medium and strong settings of the MCTR reduced the annoyance produced by the transients while maintaining their audibility.

PMID: 29764254 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2k64ohA
via IFTTT

The Oxidant-Antioxidant Equilibrium and Inflammatory Process Indicators after an Exercise Test on the AlterG Antigravity Treadmill in Young Amateur Female Athletes.

Related Articles

The Oxidant-Antioxidant Equilibrium and Inflammatory Process Indicators after an Exercise Test on the AlterG Antigravity Treadmill in Young Amateur Female Athletes.

Oxid Med Cell Longev. 2018;2018:3484159

Authors: Sielski Ł, Sutkowy P, Skopowska A, Pawlak-Osińska K, Augustyńska Z, Hewelt K, Drapała R, Woźniak A

Abstract
The AlterG antigravity treadmill allows running with a considerable weight reduction. Physical exercise practiced on this treadmill is an innovative method supporting the treatment of injuries in sports and rehabilitation of patients. The aim of the study was to investigate the effect of a 30 min run on the AlterG treadmill with 80% body weight reduction comparing the effect to the similar effort on the classic treadmill on the redox equilibrium and the activity of selected lysosomal enzymes and a serine protease inhibitor in the blood of amateur minor female volleyball players. Venous blood samples were taken before the exercise and 30 minutes and 24 hours after its completion. The obtained results were analysed using Tukey's test and Pearson's linear correlations were calculated. 24 h after the running test on classic treadmill, the erythrocytic superoxide dismutase activity was higher than before and 30 min after it, as well as compared to the run on AlterG treadmill (p < 0.001). The erythrocytic-conjugated diene concentration 24 h after the exercise on the classic treadmill was meaningly higher compared to that after the exercise on the AlterG treadmill (p < 0.001). The cathepsin D activity was significantly lower after the exercise in AlterG conditions compared to the baseline value and that measured after the exercise on classic treadmill (p < 0.001). It seems that the exercise on the AlterG treadmill keeps the oxidant-antioxidant equilibrium and stabilizes lysosomal membranes in young, physically active women in contrast to the exercise on the classic treadmill. This trial is registered with CTRI/2018/01/011344.

PMID: 29765494 [PubMed - in process]

from #Audiology via ola Kala on Inoreader https://ift.tt/2L89pSZ
via IFTTT

Evaluation of a multi-channel algorithm for reducing transient sounds.

Related Articles

Evaluation of a multi-channel algorithm for reducing transient sounds.

Int J Audiol. 2018 May 15;:1-8

Authors: Keshavarzi M, Baer T, Moore BCJ

Abstract
OBJECTIVE: The objective was to evaluate and select appropriate parameters for a multi-channel transient reduction (MCTR) algorithm for detecting and attenuating transient sounds in speech.
DESIGN: In each trial, the same sentence was played twice. A transient sound was presented in both sentences, but its level varied across the two depending on whether or not it had been processed by the MCTR and on the "strength" of the processing. The participant indicated their preference for which one was better and by how much in terms of the balance between the annoyance produced by the transient and the audibility of the transient (they were told that the transient should still be audible).
STUDY SAMPLE: Twenty English-speaking participants were tested, 10 with normal hearing and 10 with mild-to-moderate hearing-impairment. Frequency-dependent linear amplification was provided for the latter.
RESULTS: The results for both participant groups indicated that sounds processed using the MCTR were preferred over the unprocessed sounds. For the hearing-impaired participants, the medium and strong settings of the MCTR were preferred over the weak setting.
CONCLUSIONS: The medium and strong settings of the MCTR reduced the annoyance produced by the transients while maintaining their audibility.

PMID: 29764254 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2k64ohA
via IFTTT

Evaluation of a multi-channel algorithm for reducing transient sounds.

Related Articles

Evaluation of a multi-channel algorithm for reducing transient sounds.

Int J Audiol. 2018 May 15;:1-8

Authors: Keshavarzi M, Baer T, Moore BCJ

Abstract
OBJECTIVE: The objective was to evaluate and select appropriate parameters for a multi-channel transient reduction (MCTR) algorithm for detecting and attenuating transient sounds in speech.
DESIGN: In each trial, the same sentence was played twice. A transient sound was presented in both sentences, but its level varied across the two depending on whether or not it had been processed by the MCTR and on the "strength" of the processing. The participant indicated their preference for which one was better and by how much in terms of the balance between the annoyance produced by the transient and the audibility of the transient (they were told that the transient should still be audible).
STUDY SAMPLE: Twenty English-speaking participants were tested, 10 with normal hearing and 10 with mild-to-moderate hearing-impairment. Frequency-dependent linear amplification was provided for the latter.
RESULTS: The results for both participant groups indicated that sounds processed using the MCTR were preferred over the unprocessed sounds. For the hearing-impaired participants, the medium and strong settings of the MCTR were preferred over the weak setting.
CONCLUSIONS: The medium and strong settings of the MCTR reduced the annoyance produced by the transients while maintaining their audibility.

PMID: 29764254 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2k64ohA
via IFTTT

Response properties of the human frequency-following response (FFR) to speech and non-speech sounds: level dependence, adaptation and phase-locking limits.

Related Articles

Response properties of the human frequency-following response (FFR) to speech and non-speech sounds: level dependence, adaptation and phase-locking limits.

Int J Audiol. 2018 May 15;:1-8

Authors: Bidelman G, Powers L

Abstract
OBJECTIVE: The frequency-following response (FFR) is a neurophonic potential used to assess auditory neural encoding at subcortical stages. Despite the FFR's empirical and clinical utility, basic response properties of this evoked potential remain undefined.
DESIGN: We measured FFRs to speech and nonspeech (pure tone, chirp sweeps) stimuli to quantify three key properties of this potential: level-dependence (I/O functions), adaptation and the upper limit of neural phase-locking.
STUDY SAMPLE: n = 13 normal-hearing listeners.
RESULTS: I/O functions showed FFR amplitude increased with increasing stimulus presentation level between 25 and 80 dB SPL; FFR growth was steeper for tones than speech when measured at the same frequency. FFR latency decreased 4-5 ms with decreasing presentation level from 25 and 80 dB SPL but responses were ∼2 ms earlier for speech than tones. FFR amplitudes showed a 50% reduction over 6 min of recording with the strongest adaptation in the first 60 s (250 trials). Estimates of neural synchronisation revealed FFRs contained measurable phase-locking up to ∼1200-1300 Hz, slightly higher than the single neuron limit reported in animal models.
CONCLUSIONS: Findings detail fundamental response properties that will be important for using FFRs in clinical and empirical applications.

PMID: 29764252 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2IPAWdq
via IFTTT

Horizontal sound localisation accuracy in individuals with conductive hearing loss: effect of the bone conduction implant.

Related Articles

Horizontal sound localisation accuracy in individuals with conductive hearing loss: effect of the bone conduction implant.

Int J Audiol. 2018 May 15;:1-8

Authors: Asp F, Reinfeldt S

Abstract
OBJECTIVE: The objective of this study is to quantify the effect of the Bone Conduction Implant (BCI) on sound localisation accuracy in subjects with conductive hearing loss (CHL).
DESIGN: The subjects were tested in a horizontal sound localisation task in which localisation responses were objectively obtained by eye-tracking, in a prospective, cross-sectional design. The tests were performed unaided and unilaterally aided. The stimulus used had a spectrum similar to female speech and was presented at 63 and 73 dB SPL. The main outcome measure was the error index (EI), ranging from 0 to 1 (perfect to random performance).
STUDY SAMPLE: Eleven subjects (aged 21-75 years, five females) with BCI participated in the study. Their mixed/conductive hearing loss was either unilateral (n = 5) or bilateral (n = 6).
RESULTS: Three of five subjects (60%) with unilateral CHL, and four of six subjects (67%) with bilateral CHL showed significantly improved sound localisation when using a unilateral BCI (p < .05). For the subjects with bilateral CHL, a distinct linear relation between aided sound localisation and hearing thresholds in the non-implant ear existed at 73 dB SPL (18% decrease in the EI per 10 dB decrease in pure-tone average, r = 0.98, p < .001).
CONCLUSIONS: Individuals with mixed/conductive hearing loss may benefit from a unilateral BCI in sound localisation.

PMID: 29764239 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2rQpt2M
via IFTTT

Evaluation of a multi-channel algorithm for reducing transient sounds.

Related Articles

Evaluation of a multi-channel algorithm for reducing transient sounds.

Int J Audiol. 2018 May 15;:1-8

Authors: Keshavarzi M, Baer T, Moore BCJ

Abstract
OBJECTIVE: The objective was to evaluate and select appropriate parameters for a multi-channel transient reduction (MCTR) algorithm for detecting and attenuating transient sounds in speech.
DESIGN: In each trial, the same sentence was played twice. A transient sound was presented in both sentences, but its level varied across the two depending on whether or not it had been processed by the MCTR and on the "strength" of the processing. The participant indicated their preference for which one was better and by how much in terms of the balance between the annoyance produced by the transient and the audibility of the transient (they were told that the transient should still be audible).
STUDY SAMPLE: Twenty English-speaking participants were tested, 10 with normal hearing and 10 with mild-to-moderate hearing-impairment. Frequency-dependent linear amplification was provided for the latter.
RESULTS: The results for both participant groups indicated that sounds processed using the MCTR were preferred over the unprocessed sounds. For the hearing-impaired participants, the medium and strong settings of the MCTR were preferred over the weak setting.
CONCLUSIONS: The medium and strong settings of the MCTR reduced the annoyance produced by the transients while maintaining their audibility.

PMID: 29764254 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2k64ohA
via IFTTT

Response properties of the human frequency-following response (FFR) to speech and non-speech sounds: level dependence, adaptation and phase-locking limits.

Related Articles

Response properties of the human frequency-following response (FFR) to speech and non-speech sounds: level dependence, adaptation and phase-locking limits.

Int J Audiol. 2018 May 15;:1-8

Authors: Bidelman G, Powers L

Abstract
OBJECTIVE: The frequency-following response (FFR) is a neurophonic potential used to assess auditory neural encoding at subcortical stages. Despite the FFR's empirical and clinical utility, basic response properties of this evoked potential remain undefined.
DESIGN: We measured FFRs to speech and nonspeech (pure tone, chirp sweeps) stimuli to quantify three key properties of this potential: level-dependence (I/O functions), adaptation and the upper limit of neural phase-locking.
STUDY SAMPLE: n = 13 normal-hearing listeners.
RESULTS: I/O functions showed FFR amplitude increased with increasing stimulus presentation level between 25 and 80 dB SPL; FFR growth was steeper for tones than speech when measured at the same frequency. FFR latency decreased 4-5 ms with decreasing presentation level from 25 and 80 dB SPL but responses were ∼2 ms earlier for speech than tones. FFR amplitudes showed a 50% reduction over 6 min of recording with the strongest adaptation in the first 60 s (250 trials). Estimates of neural synchronisation revealed FFRs contained measurable phase-locking up to ∼1200-1300 Hz, slightly higher than the single neuron limit reported in animal models.
CONCLUSIONS: Findings detail fundamental response properties that will be important for using FFRs in clinical and empirical applications.

PMID: 29764252 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2IPAWdq
via IFTTT

Horizontal sound localisation accuracy in individuals with conductive hearing loss: effect of the bone conduction implant.

Related Articles

Horizontal sound localisation accuracy in individuals with conductive hearing loss: effect of the bone conduction implant.

Int J Audiol. 2018 May 15;:1-8

Authors: Asp F, Reinfeldt S

Abstract
OBJECTIVE: The objective of this study is to quantify the effect of the Bone Conduction Implant (BCI) on sound localisation accuracy in subjects with conductive hearing loss (CHL).
DESIGN: The subjects were tested in a horizontal sound localisation task in which localisation responses were objectively obtained by eye-tracking, in a prospective, cross-sectional design. The tests were performed unaided and unilaterally aided. The stimulus used had a spectrum similar to female speech and was presented at 63 and 73 dB SPL. The main outcome measure was the error index (EI), ranging from 0 to 1 (perfect to random performance).
STUDY SAMPLE: Eleven subjects (aged 21-75 years, five females) with BCI participated in the study. Their mixed/conductive hearing loss was either unilateral (n = 5) or bilateral (n = 6).
RESULTS: Three of five subjects (60%) with unilateral CHL, and four of six subjects (67%) with bilateral CHL showed significantly improved sound localisation when using a unilateral BCI (p < .05). For the subjects with bilateral CHL, a distinct linear relation between aided sound localisation and hearing thresholds in the non-implant ear existed at 73 dB SPL (18% decrease in the EI per 10 dB decrease in pure-tone average, r = 0.98, p < .001).
CONCLUSIONS: Individuals with mixed/conductive hearing loss may benefit from a unilateral BCI in sound localisation.

PMID: 29764239 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2rQpt2M
via IFTTT

Evaluation of a multi-channel algorithm for reducing transient sounds.

Related Articles

Evaluation of a multi-channel algorithm for reducing transient sounds.

Int J Audiol. 2018 May 15;:1-8

Authors: Keshavarzi M, Baer T, Moore BCJ

Abstract
OBJECTIVE: The objective was to evaluate and select appropriate parameters for a multi-channel transient reduction (MCTR) algorithm for detecting and attenuating transient sounds in speech.
DESIGN: In each trial, the same sentence was played twice. A transient sound was presented in both sentences, but its level varied across the two depending on whether or not it had been processed by the MCTR and on the "strength" of the processing. The participant indicated their preference for which one was better and by how much in terms of the balance between the annoyance produced by the transient and the audibility of the transient (they were told that the transient should still be audible).
STUDY SAMPLE: Twenty English-speaking participants were tested, 10 with normal hearing and 10 with mild-to-moderate hearing-impairment. Frequency-dependent linear amplification was provided for the latter.
RESULTS: The results for both participant groups indicated that sounds processed using the MCTR were preferred over the unprocessed sounds. For the hearing-impaired participants, the medium and strong settings of the MCTR were preferred over the weak setting.
CONCLUSIONS: The medium and strong settings of the MCTR reduced the annoyance produced by the transients while maintaining their audibility.

PMID: 29764254 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2k64ohA
via IFTTT

Response properties of the human frequency-following response (FFR) to speech and non-speech sounds: level dependence, adaptation and phase-locking limits.

Related Articles

Response properties of the human frequency-following response (FFR) to speech and non-speech sounds: level dependence, adaptation and phase-locking limits.

Int J Audiol. 2018 May 15;:1-8

Authors: Bidelman G, Powers L

Abstract
OBJECTIVE: The frequency-following response (FFR) is a neurophonic potential used to assess auditory neural encoding at subcortical stages. Despite the FFR's empirical and clinical utility, basic response properties of this evoked potential remain undefined.
DESIGN: We measured FFRs to speech and nonspeech (pure tone, chirp sweeps) stimuli to quantify three key properties of this potential: level-dependence (I/O functions), adaptation and the upper limit of neural phase-locking.
STUDY SAMPLE: n = 13 normal-hearing listeners.
RESULTS: I/O functions showed FFR amplitude increased with increasing stimulus presentation level between 25 and 80 dB SPL; FFR growth was steeper for tones than speech when measured at the same frequency. FFR latency decreased 4-5 ms with decreasing presentation level from 25 and 80 dB SPL but responses were ∼2 ms earlier for speech than tones. FFR amplitudes showed a 50% reduction over 6 min of recording with the strongest adaptation in the first 60 s (250 trials). Estimates of neural synchronisation revealed FFRs contained measurable phase-locking up to ∼1200-1300 Hz, slightly higher than the single neuron limit reported in animal models.
CONCLUSIONS: Findings detail fundamental response properties that will be important for using FFRs in clinical and empirical applications.

PMID: 29764252 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2IPAWdq
via IFTTT

Horizontal sound localisation accuracy in individuals with conductive hearing loss: effect of the bone conduction implant.

Related Articles

Horizontal sound localisation accuracy in individuals with conductive hearing loss: effect of the bone conduction implant.

Int J Audiol. 2018 May 15;:1-8

Authors: Asp F, Reinfeldt S

Abstract
OBJECTIVE: The objective of this study is to quantify the effect of the Bone Conduction Implant (BCI) on sound localisation accuracy in subjects with conductive hearing loss (CHL).
DESIGN: The subjects were tested in a horizontal sound localisation task in which localisation responses were objectively obtained by eye-tracking, in a prospective, cross-sectional design. The tests were performed unaided and unilaterally aided. The stimulus used had a spectrum similar to female speech and was presented at 63 and 73 dB SPL. The main outcome measure was the error index (EI), ranging from 0 to 1 (perfect to random performance).
STUDY SAMPLE: Eleven subjects (aged 21-75 years, five females) with BCI participated in the study. Their mixed/conductive hearing loss was either unilateral (n = 5) or bilateral (n = 6).
RESULTS: Three of five subjects (60%) with unilateral CHL, and four of six subjects (67%) with bilateral CHL showed significantly improved sound localisation when using a unilateral BCI (p < .05). For the subjects with bilateral CHL, a distinct linear relation between aided sound localisation and hearing thresholds in the non-implant ear existed at 73 dB SPL (18% decrease in the EI per 10 dB decrease in pure-tone average, r = 0.98, p < .001).
CONCLUSIONS: Individuals with mixed/conductive hearing loss may benefit from a unilateral BCI in sound localisation.

PMID: 29764239 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2rQpt2M
via IFTTT

Evaluation of a multi-channel algorithm for reducing transient sounds.

Related Articles

Evaluation of a multi-channel algorithm for reducing transient sounds.

Int J Audiol. 2018 May 15;:1-8

Authors: Keshavarzi M, Baer T, Moore BCJ

Abstract
OBJECTIVE: The objective was to evaluate and select appropriate parameters for a multi-channel transient reduction (MCTR) algorithm for detecting and attenuating transient sounds in speech.
DESIGN: In each trial, the same sentence was played twice. A transient sound was presented in both sentences, but its level varied across the two depending on whether or not it had been processed by the MCTR and on the "strength" of the processing. The participant indicated their preference for which one was better and by how much in terms of the balance between the annoyance produced by the transient and the audibility of the transient (they were told that the transient should still be audible).
STUDY SAMPLE: Twenty English-speaking participants were tested, 10 with normal hearing and 10 with mild-to-moderate hearing-impairment. Frequency-dependent linear amplification was provided for the latter.
RESULTS: The results for both participant groups indicated that sounds processed using the MCTR were preferred over the unprocessed sounds. For the hearing-impaired participants, the medium and strong settings of the MCTR were preferred over the weak setting.
CONCLUSIONS: The medium and strong settings of the MCTR reduced the annoyance produced by the transients while maintaining their audibility.

PMID: 29764254 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2k64ohA
via IFTTT

Response properties of the human frequency-following response (FFR) to speech and non-speech sounds: level dependence, adaptation and phase-locking limits.

Related Articles

Response properties of the human frequency-following response (FFR) to speech and non-speech sounds: level dependence, adaptation and phase-locking limits.

Int J Audiol. 2018 May 15;:1-8

Authors: Bidelman G, Powers L

Abstract
OBJECTIVE: The frequency-following response (FFR) is a neurophonic potential used to assess auditory neural encoding at subcortical stages. Despite the FFR's empirical and clinical utility, basic response properties of this evoked potential remain undefined.
DESIGN: We measured FFRs to speech and nonspeech (pure tone, chirp sweeps) stimuli to quantify three key properties of this potential: level-dependence (I/O functions), adaptation and the upper limit of neural phase-locking.
STUDY SAMPLE: n = 13 normal-hearing listeners.
RESULTS: I/O functions showed FFR amplitude increased with increasing stimulus presentation level between 25 and 80 dB SPL; FFR growth was steeper for tones than speech when measured at the same frequency. FFR latency decreased 4-5 ms with decreasing presentation level from 25 and 80 dB SPL but responses were ∼2 ms earlier for speech than tones. FFR amplitudes showed a 50% reduction over 6 min of recording with the strongest adaptation in the first 60 s (250 trials). Estimates of neural synchronisation revealed FFRs contained measurable phase-locking up to ∼1200-1300 Hz, slightly higher than the single neuron limit reported in animal models.
CONCLUSIONS: Findings detail fundamental response properties that will be important for using FFRs in clinical and empirical applications.

PMID: 29764252 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2IPAWdq
via IFTTT

Horizontal sound localisation accuracy in individuals with conductive hearing loss: effect of the bone conduction implant.

Related Articles

Horizontal sound localisation accuracy in individuals with conductive hearing loss: effect of the bone conduction implant.

Int J Audiol. 2018 May 15;:1-8

Authors: Asp F, Reinfeldt S

Abstract
OBJECTIVE: The objective of this study is to quantify the effect of the Bone Conduction Implant (BCI) on sound localisation accuracy in subjects with conductive hearing loss (CHL).
DESIGN: The subjects were tested in a horizontal sound localisation task in which localisation responses were objectively obtained by eye-tracking, in a prospective, cross-sectional design. The tests were performed unaided and unilaterally aided. The stimulus used had a spectrum similar to female speech and was presented at 63 and 73 dB SPL. The main outcome measure was the error index (EI), ranging from 0 to 1 (perfect to random performance).
STUDY SAMPLE: Eleven subjects (aged 21-75 years, five females) with BCI participated in the study. Their mixed/conductive hearing loss was either unilateral (n = 5) or bilateral (n = 6).
RESULTS: Three of five subjects (60%) with unilateral CHL, and four of six subjects (67%) with bilateral CHL showed significantly improved sound localisation when using a unilateral BCI (p < .05). For the subjects with bilateral CHL, a distinct linear relation between aided sound localisation and hearing thresholds in the non-implant ear existed at 73 dB SPL (18% decrease in the EI per 10 dB decrease in pure-tone average, r = 0.98, p < .001).
CONCLUSIONS: Individuals with mixed/conductive hearing loss may benefit from a unilateral BCI in sound localisation.

PMID: 29764239 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader https://ift.tt/2rQpt2M
via IFTTT

Sequencing of exons 4, 5, 12 of COCH gene in patients with postlingual sensorineural hearing loss accompanied by vestibular lesion.

Related Articles

Sequencing of exons 4, 5, 12 of COCH gene in patients with postlingual sensorineural hearing loss accompanied by vestibular lesion.

Arch Med Sci. 2018 Apr;14(3):625-628

Authors: Mielczarek M, Olszewski J, Pietkiewicz P

Abstract
Introduction: Mutations at the DFNA9 locus on chromosome 14q12 are the third most common form of DFNA hearing loss, which is clinically characterized by late onset (in adulthood) progressive sensorineural hearing loss accompanied by vestibular dysfunction. The aim of the study was to search for COCH gene mutations (P51S, V66G, G87W, G88E, V104del, I109N, W117R, A119T, M512T, C542Y) in patients with severe or profound sensorineural hearing loss accompanied by a vestibular lesion.
Material and methods: The study was based on a group of 30 patients. Qualification criteria comprised the presence of progressive postlingual, severe to profound sensorineural hearing loss with tinnitus, early age of sensorineural hearing loss onset, before the 40th year of life, and a positive family history of early onset hearing loss. All patients were diagnosed with peripheral vestibular lesions.
Results: The authors did not find P51S, V66G, G87W, G88E, V104del, I109N, W117R, A119T, M512T, or C542Y mutations in the COCH gene in the tested group (no differences were found in the nucleotide sequences of exomes 4, 5 and 12 when compared to the published cDNA sequence of the COCH gene).
Conclusions: No cochlin mutations were found in the group of patients with severe to profound sensorineural hearing impairment accompanied by a vestibular lesion. The COCH gene needs further exploration and analysis of genotype-phenotype correlations.

PMID: 29765451 [PubMed]

from #Audiology via xlomafota13 on Inoreader https://ift.tt/2IvOaIQ
via IFTTT