Medicine by Alexandros G. SfakianakisInternational Journal of Molecular Sciences IJMS, Vol. 20, Pages 4775: Epigenetics of Urological Cancers...International Journal of Molecular SciencesIJMS, Vol. 20, Pages 4775: Epigenetics of Urological CancersIJMS, Vol. 20, Pages 4775: Epigenetics of Urological Cancers International Journal of Molecular Sciences doi: 10.3390/ijms20194775 Authors: Wolfgang A. Schulz Karina D. Sørensen The major urological cancers comprise prostate adenocarcinoma, urinary bladder...
Thu Sep 26, 2019 10:14
Piloquinone, potent cytotoxic compound from Egyptian Streptomyces pilosus SBG-NRC-216Mohamed I Abo-Alkasem, Ahmed A El-Beih, Tarek E Mazeed, Enas M Mostafa, Hassan M Awad, Samia A Ahmed, Saadia M Easa, Fawkia M El-Beih, Ahmed I El-DiwanyEgyptian Pharmaceutical Journal 2019 18(3):179-187Background and objective Piloquinone shows biological activity as an anticancer and antitrypanosomal agent, and it acts as an inhibitor for monoamine oxidase, the main causative factor of Alzheimer's disease. The aim...
Thu Sep 26, 2019 10:10
How to Help Students Strategically Prepare for the MCAT Exam and Learn Foundational Knowledge Needed for Medical SchoolNo abstract availableFirst They Came for the Socialists… Commentary on "First They Came for the Socialists…"No abstract availableThe Architecture of an Internal, Scientific, Pre-Submission Review Program Designed to Increase the Impact and Success of Grant Proposals and ManuscriptsSecuring extramural grant funding and publishing in peer-reviewed journals are key indicators of success...
Thu Sep 26, 2019 10:09
Medicine by Alexandros G. SfakianakisInternational Journal of Molecular Sciences IJMS, Vol. 20, Pages 4775: Epigenetics of Urological Cancers...International Journal of Molecular SciencesIJMS, Vol. 20, Pages 4775: Epigenetics of Urological CancersIJMS, Vol. 20, Pages 4775: Epigenetics of Urological Cancers International Journal of Molecular Sciences doi: 10.3390/ijms20194775 Authors: Wolfgang A. Schulz Karina D. Sørensen The major urological cancers comprise prostate adenocarcinoma, urinary bladder...
Thu Sep 26, 2019 10:14
Diagnostic accuracy of computed tomography coronary angiography in patients presenting with heart failure of unknown etiology in the middle eastAhmed Fathala, Dhaifallah Shwaihi, Mohamamed M Shoukri, Mashael K AlrujaibHeart Views 2019 20(3):77-82Objectives: The purpose of this study is to assess the diagnostic performance of coronary artery calcium score (CACS), computed tomography coronary angiography (CTCA), and the prevalence of coronary artery disease (CAD) as etiology of heart failure (HF) in...
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Quantitative HBsAg: Not helpful to evaluate fibrosis in HBeAg-negative chronic hepatitis B patientsDimitri Loureiro, Abdellah Mansouri, Tarik AsselahSaudi Journal of Gastroenterology 2019 25(5):269-271Endoscopic robotic suturing: The way forwardHung Leng Kaan, Khek Yu HoSaudi Journal of Gastroenterology 2019 25(5):272-276Traditionally, suturing is performed in open surgery using a needle holder and forceps. The aim is to achieve accurate approximation of both edges of the wound and to tie a secure...
09:28
A prospective study to determine the clinical profile of patients suspected to have acute intestinal obstruction in the emergency departmentB Kirubagaran, Kundavaram Paul Prabhakar Abhilash, Srujan Lam SharmaCurrent Medical Issues 2019 17(3):49-54Background: Acute intestinal obstruction (AIO) is a surgical emergency, with its varied symptomatology and presentation, and diagnosing it is always a challenge to the emergency physician. This study was done to understand the prevalence, various etiologies,...
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A new prognostic factor of breast cancer: High carboxyl ester lipase expression related to poor survivalPublication date: November 2019Source: Cancer Genetics, Volume 239Author(s): Yingnan Cui, Yan Jiao, Keren Wang, Miao He, Zhaoying YangAbstractObjectiveThe enzyme carboxyl ester lipase (CEL), known as bile salt-dependent lipase (BSDL) or bile salt-stimulated lipase (BSSL), is mainly expressed in pancreatic acinar cells and lactating mammary glands. To investigate the link between CEL expression...
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American Journal of Roentgenology,Women's Imaging,Dense Breast Ultrasound Screening After Digital Mammography Versus After Digital Breast TomosynthesisElizabeth H. Dibble, et al. | American Journal of Roentgenology | Sep 25, 2019Ahead of PrintMusculoskeletal ImagingImpact of Dual-Energy CT Postprocessing Protocol for the Detection of Gouty Arthritis and Quantification of Tophi in Patients Presenting With Podagra: Comparison With UltrasoundSylvia Strobl, et al. | American Journal of Roentgenology...
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Neural crest derived stem cells from dental pulp and tooth-associated stem cells for peripheral nerve regenerationAlessandra Pisciotta, Laura Bertoni, Antonio Vallarola, Giulia Bertani, Daniela Mecugni, Gianluca CarnevaleNeural Regeneration Research 2020 15(3):373-381The peripheral nerve injuries, representing some of the most common types of traumatic lesions affecting the nervous system, are highly invalidating for the patients besides being a huge social burden. Although peripheral nervous system...
09:25
Mattress Suture Technique for Caudal Septum Dislocations in Open and Endonasal Septoplasty: Which Approach is Better?Objectives: Various techniques have been described to correct caudal septum dislocations but the issue has not been resolved conclusively. This study aimed to describe a suture technique that can be used to correct and stabilize the caudal septum on the maxillary spine and also to evaluate the effects on patientsymptoms. Methods: Fifty-two patients with caudal septal dislocation were...
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An online wideband acoustic immittance (WAI) database and corresponding website.No abstract availableDiscrepancies in Hearing Thresholds between Pure-Tone Audiometry and Auditory Steady-State Response in Non-MalingerersObjectives: To evaluate discrepancies between pure-tone audiometry (PTA) and auditory steady state response (ASSR) tests in non-malingerers and investigate brain lesions that may explain the discrepancies, especially in cases where the PTA threshold was worse than the estimated ASSR...
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Effect of subconjunctival bevacizumab injection before primary pterygium excision: a clinical and immunohistochemical studyAbd Elmagid M Tag Eldin, Mona M Aly, Marwa A El KholyDelta Journal of Ophthalmology 2019 20(3):95-99Purpose The aim of this study was to evaluate the effect of preoperative subconjunctival bevacizumab injection on the clinical and immunohistochemical analysis of primary pterygium. Patients and methods A total of 10 eyes of 10 patients with primary pterygium received a subconjunctival...
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Prevention of malnutrition in cystic fibrosisPurpose of review Malnutrition is one of the major burdens of disease in cystic fibrosis. The prevention of malnutrition remains a priority throughout the life of a patient with cystic fibrosis. Literature and guidelines on the management of nutrition in cystic fibrosis have been published; however, here we review updated findings in cystic fibrosis nutrition as well as the role of novel treatments. Recent findings We review the latest studies on the importance...
09:23
Analysis of the treatment results of localized conventional radiotherapy for early- and advanced-stage cutaneous T-cell lymphoma refractory to other skin-directed therapiesJaehyeon Park, Jong-Hun Kim, Jin Park, Sun Young LeeDermatologica Sinica 2019 37(3):117-122Background: Radiotherapy treatment was used as a skin-directed therapy for early- and advanced-stage cutaneous T-cell lymphoma (CTCL) refractory to other skin-directed or systemic therapies. Materials and Methods: From January 1990 to January...
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Toward Increased Understanding of the Steroid Controversy in Septic ShockNo abstract availablePromoting Family Engagement in the ICU: Experience From a National Collaborative of 63 ICUsObjectives: As part of an improvement program targeting ICU, a national collaborative was launched to help hospitals implement patient- and family-centered care engagement initiatives. Design: Ten-month quality improvement collaborative. Setting: Guided by a national patient and family advisory group, participating...
09:15
Pedicle lengthening with traction vasculogenesis: Axial and perforator abdominal island flap model in ratCagil Meric Erenoglu, Yigit Ozer Tiftikcioglu, Bilgen Katipoglu ErenogluTurkish Journal of Plastic Surgery 2019 27(4):151-155Background: Functional vessel elongation is possible with traction vasculogenesis technique. This study questions the effect of traction on pedicle length and flap viability of rat abdominal superficial epigastric and cephalic epigastric perforator flaps. Method: 28 Wistar-Albino...
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Pediatric diffuse intrinsic pontine gliomasHuber Said Padilla-Zambrano, Ezequiel Garcia-Ballestas, Amit Agrawal, Maximiliano Paez-Nova, Alfonso I Pacheco-Hernandez, Luis Rafael Moscote-SalazarGlioma 2019 2(3):127-132Historically, brainstem gliomas have been one of the most difficult types of neoplasms to treat. They comprise 10%–20% of pediatric tumors of the central nervous system. The average age of diagnosis is 7–9 years, without a predilection for gender. The advent of magnetic resonance imaging...
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Providing evidence for effective prevention and control of rabies in IndiaMysore Kalappa Sudarshan, Doddabele Hanumanthaiah Ashwath NarayanaIndian Journal of Public Health 2019 63(5):1-1Time for India to move towards rabies elimination by 2030!Gyanendra GongalIndian Journal of Public Health 2019 63(5):2-2Appraisal of surveillance of human rabies and animal bites in seven states of IndiaMysore Kalappa Sudarshan, Doddabele Hanumanthaiah Ashwath NarayanaIndian Journal of Public Health 2019 63(5):3-8Background:...
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Demographic profile and pattern of fatal firearm injuries in an urban city in south-South NigeriaObiora Jude Uchendu, Nkadi Francis Nwachokor, Eseroghene Arthur IjomoneSahel Medical Journal 2019 22(3):109-113Background: Recurrent war, agitation, and terrorism in West African sub region have encouraged access to both local and imported firearm with a consequent increase in circulating firearm in Nigeria. Objective: This study aims to describe the demographic profile and pattern of firearm injuries...
09:13
6-minute walking test: a useful tool in the management of heart failure patients? by Sophia Giannitsi et al.The place of ARBs in heart failure therapy: is aldosterone suppression the key? by Uma Markan et al.Influence of model-predicted rivaroxaban exposure and patient characteristics on efficacy and safety outcomes in patients with acute coronary syndrome by Liping Zhang et al.Therapeutic Advances in Cardiovascular Disease is a peer-reviewed open access journal which focuses on pioneering efforts...
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Socioeconomic predictors of suicide risk among cancer patients in the United States: A population-based studyPublication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Omar Abdel-RahmanAbstractObjectiveTo assess the socioeconomic predictors of suicide risk among cancer patients in the United States.MethodsCancer patients available within Surveillance, Epidemiology and End Results (SEER) database who were diagnosed between 2000–2010 have been reviewed. Linkage analysis to Census...
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Outcomes of Infants Supported With Extracorporeal Membrane Oxygenation Using Centrifugal Versus Roller Pumps: An Analysis From the Extracorporeal Life Support Organization RegistryObjectives: To determine whether mortality differs between roller and centrifugal pumps used during extracorporeal membrane oxygenation in infants weighing less than 10 kg. Design: Retrospective propensity-matched cohort study. Setting: All extracorporeal membrane oxygenation centers reporting to the Extracorporeal Life...
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Vanderbilt Leans on BioVU as it Builds 'All of Us' Database, InfrastructurePublished on Sep 26, 2019 A-Alpha Bio Raises $2.8 million in Seed Financing to Develop NGS-Based Protein Interaction TechPublished on Sep 26, 2019 Chinese Biotech Startup Looks to Develop CRISPR-Based TB DiagnosticPublished on Sep 25, 2019 IPO Window Wide Open for Dx, Genomics CompaniesPublished on Sep 25, 2019Identify Autoimmune Biomarkers from Stimulated Whole BloodThis application note from NanoString details a reproducible...
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Vanderbilt Leans on BioVU as it Builds 'All of Us' Database, InfrastructurePublished on Sep 26, 2019 A-Alpha Bio Raises $2.8 million in Seed Financing to Develop NGS-Based Protein Interaction TechPublished on Sep 26, 2019 Chinese Biotech Startup Looks to Develop CRISPR-Based TB DiagnosticPublished on Sep 25, 2019 IPO Window Wide Open for Dx, Genomics CompaniesPublished on Sep 25, 2019Identify Autoimmune Biomarkers from Stimulated Whole BloodThis application note from NanoString details a reproducible...
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Αμοργός: 6 υπέροχα χωριά της Πατήστε εδώΤο καλύτερο road trip που μπορείτε να κάνετε το 2019Θεσσαλονίκη: Τα καλύτερα μαγαζιά για ψάρι και θαλασσινάΠατήστε εδώΠατήστε εδώΜεσόγειος: 10 άγνωστοι θησαυροί τηςΠατήστε εδώ
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Population-Based Active Surveillance for Culture-Confirmed Candidemia — Four Sites, United States, 2012–2016Mitsuru Toda, PhD; Sabrina R. Williams, MPH; Elizabeth L. Berkow, PhD; et al.Candidemia is a fungal infection that can cause serious illness and death.MMWR Weekly (No. 38)PDF of Weekly issueSevere Silicosis in Engineered Stone Fabrication Workers — California, Colorado, Texas, and Washington, 2017–2019Cecile Rose, MD; Amy Heinzerling, MD; Ketki Patel, MD, PhD; et al.Prescription Opioid Use...
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Policy for Genetic GenealogyPublished on Sep 26, 2019The Justice Department has issued an interim policy governing the use of genetic genealogy, according to CNET. Read more >To Get Them EnrolledPublished on Sep 26, 2019Direct-to-consumer genetic testing company 23andMe is partnering with clinical trial firm TrialSpark to address low recruitment into clinical trials. Read more >A Growth Field?Published on Sep 26, 2019Reuters reports on the growth of genetic testing fraud in the US that targets...
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Food Allergy,Food allergies can be very difficult for those living with the allergy and their families. Read more about NIH's commitment to food allergy research. (From NIH's NIAID)Gene Identified In People Who Need Little SleepScientists identified a gene that causes people to naturally sleep less than six and a half hours each night without any apparent ill effects. (From NIH Research Matters)Dilated Eye ExamA dilated eye exam is the best thing you can do for your eye health. Discover why. (From...
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Preventing Falls,Each year millions of Americans, especially older adults, go to the emergency department after an injury from a fall. Learn what you can do to prevent falls. (From NIH News in Health)
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Mental Health Advocacy Groups Appeal to FDA to Reconsider PGx Enforcement ActivityPublished on Sep 26, 2019 Sherlock Biosciences Lands $2M DOD Contract to Develop Rapid DiagnosticsPublished on Sep 26, 2019 NSIGHT2 Trial Finds Whole-Genome Sequencing Has High Analytical PerformancePublished on Sep 26, 2019 Human Kidney Immune Cell Map Reveals Multiple Infection Protection ZonesPublished on Sep 26, 2019 PetaGene Enters Indian Market With Distribution DealPublished on Sep 26, 2019Featured in Depth Natera...
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CDC Travelers' Health UpdatePlanning to study abroad, but don't know how to start preparing for your trip? We've got a travel guide for you. Full article.Before you go1. Use our destination tool and check the health risks for your host country. You can also find country-specific vaccine, medication, and health advice.2. Make an appointment with a healthcare provider at least a month before you go.3. Pack a travel health kit.4. Enroll in STEP with the US Department of State.5. Consider getting travel...
08:57
Prevalence and Trends of Developmental Disabilities among Children in the United States: 2009–2017Benjamin Zablotsky, Lindsey I. Black, Matthew J. Maenner, Laura A. Schieve, Melissa L. Danielson, Rebecca H. Bitsko, Stephen J. Blumberg, Michael D. Kogan and Coleen A. BoyleCommentaryIncreasing Prevalence of Developmental Disabilities Among Children in the US: A Sign of Progress?Maureen S. Durkin
08:23
Association between iron deficiency and prevalence of thyroid autoimmunity in pregnant and non-pregnant women of childbearing age: a cross-sectional studyBackground: Thyroid autoimmunity (TAI) is prevalent among women of reproductive age and associated with adverse pregnancy outcomes. This study aimed to investigate the association between iron nutritional status and the prevalence of TAI in women during the first trimester of pregnancy and in non-pregnant women of childbearing age. Methods: Cross-sectional...
08:23
Eating disorder animal modelPurpose of review The aim of this review is to describe animal models that simulate the features of eating disorders. The literature pertaining to animal models that are of relevance for clinical eating disorders and the possible underpinning mechanisms was reviewed using PubMed, Ovid database and Google Scholar. Recent findings New refinements of the circuits regulated by neurotransmitters and neuropeptides which instigate eating behaviours and the various feedback pathways...
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Emergency Department Use After Outpatient Surgery Among Dually Enrolled VA and Medicare PatientsBackground: Emergency department (ED) use following outpatient surgery may be associated with a surgery-related patient safety problem. We characterized ED use within 7 days of general, urology, orthopedic, ear/nose/throat, and podiatry surgical procedures and assessed factors associated with these visits by specialty. Methods: We calculated the 2011-2013 postoperative ED visit rate for Veterans older...
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Clinical Approach to Lactose IntoleranceDejan Micic, MD; Vijaya L. Rao, MD; David T. Rubin, MDWomen's HealthTreatment of Vulvovaginal AtrophyCarolyn J. Crandall, MD, MSTRENDING NOW ON JAMA NETWORK OPENA National Survey of Marijuana Use Among US Adults With Medical Conditions, 2016-2017Concordance Between Electronic Clinical Documentation and Physicians' Observed BehaviorPrevalence of Screening for Social Needs by US Physician Practices and HospitalsEffect of Electronic Medication Reconciliation Intervention...
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Mechanisms of cetyltrimethyl ammonium chloride-induced toxicity to photosystem II oxygen evolution complex of Chlorella vulgaris F1068Publication date: 5 February 2020Source: Journal of Hazardous Materials, Volume 383Author(s): Na Liu, Han Zhang, Jinfeng Zhao, Yin Xu, Fei GeAbstractMicroalgae photosynthesis is sensitive to coexisted contaminates in aquatic environment, thereby causes adverse effect on algal growth and nutrients uptake. Here, we investigated the photosynthetic toxicity mechanism of...
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Exploring the science of healthcare deliveryNo abstract availableTreating patients with opioid use disorderNo abstract availableOverview of breast cancerEach year, more than 250,000 women in the United States are diagnosed with invasive breast cancer. Although overall mortality for breast cancer patients has declined, it is still the second most common cause of cancer death in women. This article provides an overview of nonmetastatic breast cancer in women, including general features, diagnostic...
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A Goal-directed Quality Improvement Initiative to Reduce Opioid Prescriptions After Orthopaedic ProceduresIntroduction: Orthopaedic surgeons are increasingly aware of deleterious effects of the opioid epidemic and the association between overprescription and diversion toward nonmedical opioid use or substance abuse. Opiate prescriptions at the time of hospital discharge have been identified as target for intervention. This study describes the successful outcome of a goal-directed intervention aimed...
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A Matched-Pair Analysis of Prepectoral with Subpectoral Breast Reconstruction: Is There a Difference in Postoperative Complication Rate?Background: The development of acellular dermal matrices has revolutionized implant-based breast reconstruction. The most recent development has been the introduction of prepectoral breast reconstruction. However, concerns have been expressed related to the quality of soft-tissue coverage and infectious complications. Thus, the authors felt it prudent to perform...
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Impact of Diffuse Idiopathic Skeletal Hyperostosis on Sagittal Spinal Alignment in the General Elderly Population: A Japanese Cohort Survey Randomly Sampled from a Basic Resident RegistryBackground: Interest is mounting regarding diffuse idiopathic skeletal hyperostosis (DISH) as the rate in the elderly increases. Although some studies have demonstrated an effect of DISH on sagittal spinal alignment, the pathogenetic mechanism remains unknown. Random sampling from the basic resident registry of a...
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To focus on pain or not to focus? WHEN is the questionNo abstract availableGetting closer to the other's worldNo abstract availableReading and writing: the evolution of molecular pain geneticsNo abstract availableBeyond pain: can antidepressants improve depressive symptoms and quality of life in patients with neuropathic pain? A systematic review and meta-analysisNeuropathic pain can be a predictor of severe emotional distress, up to full-blown depressive states. In these patients, it is important...
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A Diagnostic Challenge: Changes in Histopathologic Tumor Diagnosis of Atypical Squamous Proliferations After Surgical RemovalBACKGROUND Biopsy-proven "atypical squamous proliferations" (ASPs) may prove difficult to diagnose histologically because of partial sampling, lack of complete criteria for definitive diagnosis, or overlap of histopathological features with other neoplasms. There are no guidelines concerning the management of ASPs. OBJECTIVE To retrospectively clarify the diagnosis of biopsy-proven...
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In Memoriam: Arsen Pankovich, MD (1930–2019)No abstract availableShort Versus Long Cephalomedullary Nails for Pertrochanteric Hip Fractures: A Randomized Prospective StudyObjective: To compare functional and clinical outcomes in patients with pertrochanteric hip fractures treated with either a short (SN) or long (LN) cephalomedullary nail. Design: Prospective, randomized. Setting: Clinical investigation was performed at the Mayo Clinic's Level 1 Trauma Center in Rochester, MN. Patients/Participants:...
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Detection and classification of systemic sclerosis-related interstitial lung disease: a reviewPurpose of review Systemic sclerosis (SSc) is a heterogeneous disease with a variable disease course. Interstitial lung disease (ILD) is one of the leading causes of morbidity and mortality in patients with SSc. The present review highlights recent advances in the classification, diagnosis, and early detection of SSc-associated ILD (SSc-ILD). Recent findings Risk stratification through measurement of disease...
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Evaluation of Hypoglossal Nerve Stimulation Treatment in Obstructive Sleep ApneaDavid T. Kent, MD; Kelly A. Carden, MD; Li Wang, MS; et al.Dysphagia After Primary Transoral Robotic Surgery With Neck Dissection vs Nonsurgical Therapy in Patients With Low- to Intermediate-Risk Oropharyngeal CancerKatherine A. Hutcheson, PhD; Carla L. Warneke, MS; Christopher M. K. L. Yao, MD; et al.OBSERVATIONGiant Pituitary Adenoma With Inferior Petrosal Sinus, Jugular Foramen, and Hypoglossal Canal ExtensionAnderson...
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Royal Society Publishing—Table of Contents AlertProceedings of the Royal Society BVol. 286, No. 1911, (September 2019) The above issue is now available online at:https://royalsocietypublishing.org/toc/rspb/2019/286/1911?ai=aqlf&ui=cbwb&af=HClick the links below to view the abstract for each article, or click the link above to view all Just Released articles for this journal.Review articlesReview articles: Evolution of ageing as a tangle of trade-offs: energy versus functionAlexei A. Maklakov and Tracey...
Thu Sep 26, 2019 10:16
Medicine by Alexandros G. SfakianakisInternational Journal of Molecular Sciences IJMS, Vol. 20, Pages 4775: Epigenetics of Urological Cancers...International Journal of Molecular SciencesIJMS, Vol. 20, Pages 4775: Epigenetics of Urological CancersIJMS, Vol. 20, Pages 4775: Epigenetics of Urological Cancers International Journal of Molecular Sciences doi: 10.3390/ijms20194775 Authors: Wolfgang A. Schulz Karina D. Sørensen The major urological cancers comprise prostate adenocarcinoma, urinary bladder...
Thu Sep 26, 2019 10:14
