Source:Hearing Research
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Σάββατο 8 Απριλίου 2017
Obituary for Professor Barbara Bohne
Source:Hearing Research
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Obituary for Professor Barbara Bohne
Source:Hearing Research
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Obituary for Professor Barbara Bohne
Source:Hearing Research
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Obituary for Professor Barbara Bohne
Publication date: Available online 8 April 2017
Source:Hearing Research
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Source:Hearing Research
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Obituary for Professor Barbara Bohne
Publication date: Available online 8 April 2017
Source:Hearing Research
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Source:Hearing Research
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The vestibular implant: A probe in orbit around the human balance system.
The vestibular implant: A probe in orbit around the human balance system.
J Vestib Res. 2017;27(1):51-61
Authors: Perez Fornos A, Cavuscens S, Ranieri M, van de Berg R, Stokroos R, Kingma H, Guyot JP, Guinand N
Abstract
The primary goal of the vestibular implant is to restore the vestibular function in patients with a disabling bilateral vestibular loss for whom there is currently no available treatment. The prototype developed by our team is a hybrid system consisting of a modified cochlear implant incorporating additional vestibular electrodes. Therefore, in addition of delivering sound information it is also capable of delivering motion information to the central nervous system using electrical stimulation. To date, thirteen patients have been implanted with such vestibular implant prototypes. For ethical reasons, only deaf ears were implanted and all patients experienced a clinical benefit from the hearing rehabilitation. The recent demonstration of partial restoration of the vestibulo-ocular and the vestibulo-collic reflexes in implanted patients suggests that gaze stabilization and postural control, fundamental functions of the balance system, can be artificially restored using a vestibular implant. This allows us to glimpse a useful clinical application in a near future. In parallel, we show how the vestibular implant provides a unique opportunity to explore the integration of the vestibular sensory input into the multisensory, multimodal balance system in humans, since it is able to selectively stimulate the vestibular system.
PMID: 28387690 [PubMed - in process]
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Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.
Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.
Nat Commun. 2017 Apr 07;8:14907
Authors: Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Geyser A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Rüttiger L, Forge A, Nürnberg B, Sans N, Montcouquiol M
Abstract
Mutations in GPSM2 cause Chudley-McCullough syndrome (CMCS), an autosomal recessive neurological disorder characterized by early-onset sensorineural deafness and brain anomalies. Here, we show that mutation of the mouse orthologue of GPSM2 affects actin-rich stereocilia elongation in auditory and vestibular hair cells, causing deafness and balance defects. The G-protein subunit Gαi3, a well-documented partner of Gpsm2, participates in the elongation process, and its absence also causes hearing deficits. We show that Gpsm2 defines an ∼200 nm nanodomain at the tips of stereocilia and this localization requires the presence of Gαi3, myosin 15 and whirlin. Using single-molecule tracking, we report that loss of Gpsm2 leads to decreased outgrowth and a disruption of actin dynamics in neuronal growth cones. Our results elucidate the aetiology of CMCS and highlight a new molecular role for Gpsm2/Gαi3 in the regulation of actin dynamics in epithelial and neuronal tissues.
PMID: 28387217 [PubMed - in process]
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The vestibular implant: A probe in orbit around the human balance system.
The vestibular implant: A probe in orbit around the human balance system.
J Vestib Res. 2017;27(1):51-61
Authors: Perez Fornos A, Cavuscens S, Ranieri M, van de Berg R, Stokroos R, Kingma H, Guyot JP, Guinand N
Abstract
The primary goal of the vestibular implant is to restore the vestibular function in patients with a disabling bilateral vestibular loss for whom there is currently no available treatment. The prototype developed by our team is a hybrid system consisting of a modified cochlear implant incorporating additional vestibular electrodes. Therefore, in addition of delivering sound information it is also capable of delivering motion information to the central nervous system using electrical stimulation. To date, thirteen patients have been implanted with such vestibular implant prototypes. For ethical reasons, only deaf ears were implanted and all patients experienced a clinical benefit from the hearing rehabilitation. The recent demonstration of partial restoration of the vestibulo-ocular and the vestibulo-collic reflexes in implanted patients suggests that gaze stabilization and postural control, fundamental functions of the balance system, can be artificially restored using a vestibular implant. This allows us to glimpse a useful clinical application in a near future. In parallel, we show how the vestibular implant provides a unique opportunity to explore the integration of the vestibular sensory input into the multisensory, multimodal balance system in humans, since it is able to selectively stimulate the vestibular system.
PMID: 28387690 [PubMed - in process]
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Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.
Defective Gpsm2/Gαi3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.
Nat Commun. 2017 Apr 07;8:14907
Authors: Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Geyser A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Rüttiger L, Forge A, Nürnberg B, Sans N, Montcouquiol M
Abstract
Mutations in GPSM2 cause Chudley-McCullough syndrome (CMCS), an autosomal recessive neurological disorder characterized by early-onset sensorineural deafness and brain anomalies. Here, we show that mutation of the mouse orthologue of GPSM2 affects actin-rich stereocilia elongation in auditory and vestibular hair cells, causing deafness and balance defects. The G-protein subunit Gαi3, a well-documented partner of Gpsm2, participates in the elongation process, and its absence also causes hearing deficits. We show that Gpsm2 defines an ∼200 nm nanodomain at the tips of stereocilia and this localization requires the presence of Gαi3, myosin 15 and whirlin. Using single-molecule tracking, we report that loss of Gpsm2 leads to decreased outgrowth and a disruption of actin dynamics in neuronal growth cones. Our results elucidate the aetiology of CMCS and highlight a new molecular role for Gpsm2/Gαi3 in the regulation of actin dynamics in epithelial and neuronal tissues.
PMID: 28387217 [PubMed - in process]
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Sudden sensorineural hearing loss.
| Related Articles |
Sudden sensorineural hearing loss.
CMAJ. 2017 Mar 20;189(11):E437-E438
Authors: Chin CJ, Dorman K
PMID: 28385715 [PubMed - in process]
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Signia Unveils New Made for iPhone Hearing Aid Delivering 'Better Than Normal Hearing'
Signia (http://ift.tt/29sqzaU) is taking a step towards smarter hearing health care with a recent announcement of its new product Signia Pure 13 BT. The new made for iPhone hearing aid delivers customized, high-quality sounds and allows audiologists to adjust hearing aid settings remotely. The IP67-rated Pure 13 BT is resistant to water, dust, and dirt. It combines binaural audio exchange and direct streaming using Signia's e2e wireless 3.0 and Bluetooth. It also uses iPhone's motion sensors to evaluate and adapt to different acoustic environments when the user is moving. Pure 13 BT automatically enables the most suitable setting based on the information it receives.
Users can remotely control the hearing aids through the myControl app, adjusting programs, volume, microphone directionality, and treble/bass during audio streaming. The device also functions like a fitness tracker for hearing, collecting daily hearing data and allowing users to monitor their noise exposure. Pure 13 BT also makes it easier for hearing care providers and hearing aid users to connect through Signia's new promax star platform and Signia TeleCare 2.0, which allows care providers to access real-time patient data remotely. Hearing care providers can then optimize users' hearing aid settings from afar and make other adjustments that would normally require an in-office visit.
The Signia Pure 13 BT will be available in May.
Published: 4/7/2017 3:09:00 PM
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Signia Unveils New Made for iPhone Hearing Aid Delivering 'Better Than Normal Hearing'
Signia (http://ift.tt/29sqzaU) is taking a step towards smarter hearing health care with a recent announcement of its new product Signia Pure 13 BT. The new made for iPhone hearing aid delivers customized, high-quality sounds and allows audiologists to adjust hearing aid settings remotely. The IP67-rated Pure 13 BT is resistant to water, dust, and dirt. It combines binaural audio exchange and direct streaming using Signia's e2e wireless 3.0 and Bluetooth. It also uses iPhone's motion sensors to evaluate and adapt to different acoustic environments when the user is moving. Pure 13 BT automatically enables the most suitable setting based on the information it receives.
Users can remotely control the hearing aids through the myControl app, adjusting programs, volume, microphone directionality, and treble/bass during audio streaming. The device also functions like a fitness tracker for hearing, collecting daily hearing data and allowing users to monitor their noise exposure. Pure 13 BT also makes it easier for hearing care providers and hearing aid users to connect through Signia's new promax star platform and Signia TeleCare 2.0, which allows care providers to access real-time patient data remotely. Hearing care providers can then optimize users' hearing aid settings from afar and make other adjustments that would normally require an in-office visit.
The Signia Pure 13 BT will be available in May.
Published: 4/7/2017 3:09:00 PM
from #Audiology via ola Kala on Inoreader http://ift.tt/2oiqdgV
via IFTTT
Signia Unveils New Made for iPhone Hearing Aid Delivering 'Better Than Normal Hearing'
Signia (http://ift.tt/29sqzaU) is taking a step towards smarter hearing health care with a recent announcement of its new product Signia Pure 13 BT. The new made for iPhone hearing aid delivers customized, high-quality sounds and allows audiologists to adjust hearing aid settings remotely. The IP67-rated Pure 13 BT is resistant to water, dust, and dirt. It combines binaural audio exchange and direct streaming using Signia's e2e wireless 3.0 and Bluetooth. It also uses iPhone's motion sensors to evaluate and adapt to different acoustic environments when the user is moving. Pure 13 BT automatically enables the most suitable setting based on the information it receives.
Users can remotely control the hearing aids through the myControl app, adjusting programs, volume, microphone directionality, and treble/bass during audio streaming. The device also functions like a fitness tracker for hearing, collecting daily hearing data and allowing users to monitor their noise exposure. Pure 13 BT also makes it easier for hearing care providers and hearing aid users to connect through Signia's new promax star platform and Signia TeleCare 2.0, which allows care providers to access real-time patient data remotely. Hearing care providers can then optimize users' hearing aid settings from afar and make other adjustments that would normally require an in-office visit.
The Signia Pure 13 BT will be available in May.
Published: 4/7/2017 3:09:00 PM
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