| Related Articles |
Promoting global action on hearing loss: World hearing day.
Int J Audiol. 2017 Mar;56(3):145-147
Authors: Chadha S, Cieza A
PMID: 28262049 [PubMed - in process]
| Related Articles |
Promoting global action on hearing loss: World hearing day.
Int J Audiol. 2017 Mar;56(3):145-147
Authors: Chadha S, Cieza A
PMID: 28262049 [PubMed - in process]
| Related Articles |
Promoting global action on hearing loss: World hearing day.
Int J Audiol. 2017 Mar;56(3):145-147
Authors: Chadha S, Cieza A
PMID: 28262049 [PubMed - in process]
| Related Articles |
Promoting global action on hearing loss: World hearing day.
Int J Audiol. 2017 Mar;56(3):145-147
Authors: Chadha S, Cieza A
PMID: 28262049 [PubMed - in process]
Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice.
Elife. 2017 Mar 06;6:
Authors: Bucks SA, Cox BC, Vlosich BA, Manning JP, Nguyen TB, Stone JS
Abstract
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates. However, there is no definitive evidence that this process occurs in mammals. We used fate-mapping and other methods to demonstrate that utricular type II vestibular hair cells undergo turnover in adult mice under normal conditions. We found that supporting cells phagocytose both type I and II hair cells. Plp1-CreER(T2)-expressing supporting cells replace type II hair cells. Type I hair cells are not restored by Plp1-CreER(T2)-expressing supporting cells or by Atoh1-CreER(TM)-expressing type II hair cells. Destruction of hair cells causes supporting cells to generate 6 times as many type II hair cells compared to normal conditions. These findings expand our understanding of sensorineural plasticity in adult vestibular organs and further elucidate the roles that supporting cells serve during homeostasis and after injury.
PMID: 28263708 [PubMed - in process]
Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice.
Elife. 2017 Mar 06;6:
Authors: Bucks SA, Cox BC, Vlosich BA, Manning JP, Nguyen TB, Stone JS
Abstract
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates. However, there is no definitive evidence that this process occurs in mammals. We used fate-mapping and other methods to demonstrate that utricular type II vestibular hair cells undergo turnover in adult mice under normal conditions. We found that supporting cells phagocytose both type I and II hair cells. Plp1-CreER(T2)-expressing supporting cells replace type II hair cells. Type I hair cells are not restored by Plp1-CreER(T2)-expressing supporting cells or by Atoh1-CreER(TM)-expressing type II hair cells. Destruction of hair cells causes supporting cells to generate 6 times as many type II hair cells compared to normal conditions. These findings expand our understanding of sensorineural plasticity in adult vestibular organs and further elucidate the roles that supporting cells serve during homeostasis and after injury.
PMID: 28263708 [PubMed - in process]
 |
Related Articles |
MYH9-related disorder, a probable May-Hegglin anomaly case series: A tertiary care experience.
Hematol Oncol Stem Cell Ther. 2016 Dec;9(4):137-140
Authors: Kamath V, Gnanasekaran KK, Mammen J
Abstract
OBJECTIVE/BACKGROUND: May-Hegglin anomaly (MHA) is a rare familial bleeding disorder characterized by a triad of thrombocytopenia, giant platelets, and Döhle-like inclusion bodies within the leukocytes. The clinical spectrum as well as the pathophysiology of this entity is not well defined. The objective of this work is to present a series of three cases of MHA diagnosed in our hospital, where the patients presented with variable bleeding manifestations, thrombocytopenia, and giant platelets.
MATERIALS AND METHODS: We studied three cases of possible MHA. In addition to the clinical examination, complete hemogram, and peripheral blood smear examination, these patients were also subjected to coagulation studies. Although bleeding symptoms varied among these patients, platelet aggregation tests with various agonists showed a normal response.
RESULTS: Consistent findings of this entity noted in our patients were mild-to-moderate thrombocytopenia, giant platelets, and Döhle-like inclusions within the leukocytes.
CONCLUSION: A diagnosis of MHA could be made based on a thorough peripheral blood smear examination, which also helps to avoid a misdiagnosis of immune thrombocytopenia.
PMID: 27614228 [PubMed - indexed for MEDLINE]
