Recovery of Online Sentence Processing in Aphasia: Eye Movement Changes Resulting From Treatment of Underlying Forms

Purpose

The present study tested whether (and how) language treatment changed online sentence processing in individuals with aphasia.

Method

Participants with aphasia (n = 10) received a 12-week program of Treatment of Underlying Forms (Thompson & Shapiro, 2005) focused on production and comprehension of passive sentences. Before and after treatment, participants performed a sentence-picture matching task with active and passive sentences as eye movements were tracked. Twelve age-matched controls also performed the task once each.

Results

In the age-matched group, eye movements indicated agent-first predictive processing after hearing the subject noun, followed by rapid thematic reanalysis after hearing the verb form. Pretreatment eye movements in the participants with aphasia showed no predictive agent-first processing, and more accurate thematic analysis in active compared to passive sentences. After treatment, which resulted in improved offline passive sentence production and comprehension, participants were more likely to respond correctly when they made agent-first eye movements early in the sentence, showed equally reliable thematic analysis in active and passive sentences, and were less likely to use a spatially based alternative response strategy.

Conclusions

These findings suggest that treatment focused on improving sentence production and comprehension supports the emergence of more normal-like sentence comprehension processes.

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Recovery of Online Sentence Processing in Aphasia: Eye Movement Changes Resulting From Treatment of Underlying Forms

Purpose

The present study tested whether (and how) language treatment changed online sentence processing in individuals with aphasia.

Method

Participants with aphasia (n = 10) received a 12-week program of Treatment of Underlying Forms (Thompson & Shapiro, 2005) focused on production and comprehension of passive sentences. Before and after treatment, participants performed a sentence-picture matching task with active and passive sentences as eye movements were tracked. Twelve age-matched controls also performed the task once each.

Results

In the age-matched group, eye movements indicated agent-first predictive processing after hearing the subject noun, followed by rapid thematic reanalysis after hearing the verb form. Pretreatment eye movements in the participants with aphasia showed no predictive agent-first processing, and more accurate thematic analysis in active compared to passive sentences. After treatment, which resulted in improved offline passive sentence production and comprehension, participants were more likely to respond correctly when they made agent-first eye movements early in the sentence, showed equally reliable thematic analysis in active and passive sentences, and were less likely to use a spatially based alternative response strategy.

Conclusions

These findings suggest that treatment focused on improving sentence production and comprehension supports the emergence of more normal-like sentence comprehension processes.

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Recovery of Online Sentence Processing in Aphasia: Eye Movement Changes Resulting From Treatment of Underlying Forms

Purpose

The present study tested whether (and how) language treatment changed online sentence processing in individuals with aphasia.

Method

Participants with aphasia (n = 10) received a 12-week program of Treatment of Underlying Forms (Thompson & Shapiro, 2005) focused on production and comprehension of passive sentences. Before and after treatment, participants performed a sentence-picture matching task with active and passive sentences as eye movements were tracked. Twelve age-matched controls also performed the task once each.

Results

In the age-matched group, eye movements indicated agent-first predictive processing after hearing the subject noun, followed by rapid thematic reanalysis after hearing the verb form. Pretreatment eye movements in the participants with aphasia showed no predictive agent-first processing, and more accurate thematic analysis in active compared to passive sentences. After treatment, which resulted in improved offline passive sentence production and comprehension, participants were more likely to respond correctly when they made agent-first eye movements early in the sentence, showed equally reliable thematic analysis in active and passive sentences, and were less likely to use a spatially based alternative response strategy.

Conclusions

These findings suggest that treatment focused on improving sentence production and comprehension supports the emergence of more normal-like sentence comprehension processes.

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Reliability of center of pressure measures for assessing the development of sitting postural control through the stages of sitting

Publication date: July 2017
Source:Gait & Posture, Volume 56
Author(s): Jordan Wickstrom, Nick Stergiou, Anastasia Kyvelidou
Cerebral palsy (CP) impairs an individual’s ability to move and control one’s posture. Unfortunately, the signs and symptoms of CP may not be apparent before age two. Evaluating sitting posture is a potential way to assess the developing mechanisms that contribute to CP. The purpose of this project was to determine the reliability of linear and nonlinear measures, including inter- and intrastage reliability, when used to analyze the center of pressure (COP) time series during the stages of sitting development in children with typical development (TD) and with/at-risk for cerebral palsy (CP). We hypothesized that nonlinear tools would be more reliable than linear tools in assessing childrens’ sitting development, and reliability would increase with development. COP data was recorded for three trials at eight sessions. Linear parameters used were root mean square, range of sway for the anterior-posterior (AP) and medial-lateral (ML) directions, and sway path. Nonlinear parameters used were Approximate Entropy, the largest Lyapunov Exponent, and Correlation Dimension for the AP and ML direction. Participants consisted of 33 children with TD and 26 children with/at-risk for CP. Our results determined that COP is a moderately reliable method for assessing the development of sitting postural control in stages in both groups. Thus, clinicians may be able to use measures from COP data across stages to assess the efficacy of therapeutic interventions that are intended to improve sitting postural abilities in children with/at-risk for CP.



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Force-velocity relationship of leg muscles assessed with motorized treadmill tests: two-velocity method

Publication date: Available online 4 May 2017
Source:Gait & Posture
Author(s): Slobodanka Dobrijevic, Vladimir Ilic, Sasa Djuric, Slobodan Jaric
Linear regression models applied on force (F) and velocity (V) data obtained from loaded multi-joint functional movement tasks have often been used to assess mechanical capacities of the tested muscles. The present study aimed to explore the properties of the F-V relationship of leg muscles exerting the maximum pulling F at a wide range of V on a standard motorized treadmill. Young and physically active male and female subjects (N=13+15) were tested on their maximum pulling F exerted horizontally while walking or running on a treadmill set to 8 different velocities (1.4–3.3m/s). Both the individual (median R=0.935) and averaged across the subjects F-V relationships (R=0.994) proved to be approximately linear and exceptionally strong, while their parameters depicting the leg muscle capacities for producing maximum F, V, and power (P; proportional to the product of F and V) were highly reliable (0.84<ICC<0.97). In addition, the same F-V relationship parameters obtained from only the highest and lowest treadmill V (i.e., the ‘two-velocity method') revealed a strong relationship (0.89<R<0.99), and there were no meaningful differences regarding the magnitudes of the same parameters obtained from all 8 V’s of the treadmill. We conclude that the F-V relationship of leg muscles tested through a wide range of treadmill V could be strong, linear, and reliable. Moreover, the relatively quick and fatigue-free two-velocity method could provide reliable and ecologically valid indices of F, V, and P producing capacities of leg muscles and, therefore, should be considered for future routine testing.



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Influence of both cutaneous input from the foot soles and visual information on the control of postural stability in dyslexic children

Publication date: Available online 4 May 2017
Source:Gait & Posture
Author(s): Nathalie Goulème, Philippe Villeneuve, Christophe-Loïc Gérard, Maria Pia Bucci
Dyslexic children show impaired in postural stability. The aim of our study was to test the influence of foot soles and visual information on the postural control of dyslexic children, compared to non-dyslexic children. Postural stability was evaluated with TechnoConcept^® platform in twenty-four dyslexic children (mean age: 9.3±0.29years) and in twenty-four non-dyslexic children, gender- and age-matched, in two postural conditions (with and without foam: a 4-mm foam was put under their feet or not) and in two visual conditions (eyes open and eyes closed). We measured the surface area, the length and the mean velocity of the center of pressure (CoP). Moreover, we calculated the Romberg Quotient (RQ). Our results showed that the surface area, length and mean velocity of the CoP were significantly greater in the dyslexic children compared to the non-dyslexic children, particularly with foam and eyes closed. Furthermore, the RQ was significantly smaller in the dyslexic children and significantly greater without foam than with foam. All these findings suggest that dyslexic children are not able to compensate with other available inputs when sensorial inputs are less informative (with foam, or eyes closed), which results in poor postural stability. We suggest that the impairment of the cerebellar integration of all the sensorial inputs is responsible for the postural deficits observed in dyslexic children.



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Control of locomotor stability in stabilizing and destabilizing environments

Publication date: June 2017
Source:Gait & Posture, Volume 55
Author(s): Mengnan/Mary Wu, Geoffrey Brown, Keith E. Gordon
To develop effective interventions targeting locomotor stability, it is crucial to understand how people control and modify gait in response to changes in stabilization requirements. Our purpose was to examine how individuals with and without incomplete spinal cord injury (iSCI) control lateral stability in haptic walking environments that increase or decrease stabilization demands. We hypothesized that people would adapt to walking in a predictable, stabilizing viscous force field and unpredictable destabilizing force field by increasing and decreasing feedforward control of lateral stability, respectively. Adaptations in feedforward control were measured using after-effects when fields were removed. Both groups significantly (p<0.05) decreased step width in the stabilizing field. When the stabilizing field was removed, narrower steps persisted in both groups and subjects with iSCI significantly increased movement variability (p<0.05). The after-effect of walking in the stabilizing field was a suppression of ongoing general stabilization mechanisms. In the destabilizing field, subjects with iSCI took faster steps and increased lateral margins of stability (p<0.05). Step frequency increases persisted when the destabilizing field was removed (p<0.05), suggesting that subjects with iSCI made feedforward adaptions to increase control of lateral stability. In contrast, in the destabilizing field, non-impaired subjects increased movement variability (p<0.05) and did not change step width, step frequency, or lateral margin of stability (p>0.05). When the destabilizing field was removed, increases in movement variability persisted (p<0.05), suggesting that non-impaired subjects made feedforward decreases in resistance to perturbations.



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Leg stiffness during sprinting in transfemoral amputees with running-specific prosthesis

Publication date: Available online 4 May 2017
Source:Gait & Posture
Author(s): Yoko Sano, Atsushi Makimoto, Satoru Hashizume, Akihiko Murai, Yoshiyuki Kobayashi, Hiroshi Takemura, Hiroaki Hobara
Carbon fiber running-specific prostheses are designed to reproduce the spring-like stepping behavior of individuals similar to springs loaded by the entire body mass (i.e. spring-mass model). The aim of this study was to test whether leg stiffness would be modulated differently between intact and prosthetic legs in transfemoral amputees wearing RSP during sprinting. Eight unilateral transfemoral amputees performed maximum sprinting along an indoor overground runway. Leg stiffness was calculated from kinetic and kinematic data in intact and prosthetic legs. The results showed that leg stiffness was for the prosthetic limb approximately 12% decreased compared to the intact limb. Although there was no difference in leg compression between the legs, maximal vertical ground reaction force was significantly greater in the intact leg than in the prosthetic one. These results indicate that asymmetric modulation of leg stiffness in transfemoral amputees with running-specific prostheses is mainly associated with asymmetric ground reaction force.



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Reliability of center of pressure measures for assessing the development of sitting postural control through the stages of sitting

Publication date: July 2017
Source:Gait & Posture, Volume 56
Author(s): Jordan Wickstrom, Nick Stergiou, Anastasia Kyvelidou
Cerebral palsy (CP) impairs an individual’s ability to move and control one’s posture. Unfortunately, the signs and symptoms of CP may not be apparent before age two. Evaluating sitting posture is a potential way to assess the developing mechanisms that contribute to CP. The purpose of this project was to determine the reliability of linear and nonlinear measures, including inter- and intrastage reliability, when used to analyze the center of pressure (COP) time series during the stages of sitting development in children with typical development (TD) and with/at-risk for cerebral palsy (CP). We hypothesized that nonlinear tools would be more reliable than linear tools in assessing childrens’ sitting development, and reliability would increase with development. COP data was recorded for three trials at eight sessions. Linear parameters used were root mean square, range of sway for the anterior-posterior (AP) and medial-lateral (ML) directions, and sway path. Nonlinear parameters used were Approximate Entropy, the largest Lyapunov Exponent, and Correlation Dimension for the AP and ML direction. Participants consisted of 33 children with TD and 26 children with/at-risk for CP. Our results determined that COP is a moderately reliable method for assessing the development of sitting postural control in stages in both groups. Thus, clinicians may be able to use measures from COP data across stages to assess the efficacy of therapeutic interventions that are intended to improve sitting postural abilities in children with/at-risk for CP.



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Force-velocity relationship of leg muscles assessed with motorized treadmill tests: two-velocity method

Publication date: Available online 4 May 2017
Source:Gait & Posture
Author(s): Slobodanka Dobrijevic, Vladimir Ilic, Sasa Djuric, Slobodan Jaric
Linear regression models applied on force (F) and velocity (V) data obtained from loaded multi-joint functional movement tasks have often been used to assess mechanical capacities of the tested muscles. The present study aimed to explore the properties of the F-V relationship of leg muscles exerting the maximum pulling F at a wide range of V on a standard motorized treadmill. Young and physically active male and female subjects (N=13+15) were tested on their maximum pulling F exerted horizontally while walking or running on a treadmill set to 8 different velocities (1.4–3.3m/s). Both the individual (median R=0.935) and averaged across the subjects F-V relationships (R=0.994) proved to be approximately linear and exceptionally strong, while their parameters depicting the leg muscle capacities for producing maximum F, V, and power (P; proportional to the product of F and V) were highly reliable (0.84<ICC<0.97). In addition, the same F-V relationship parameters obtained from only the highest and lowest treadmill V (i.e., the ‘two-velocity method') revealed a strong relationship (0.89<R<0.99), and there were no meaningful differences regarding the magnitudes of the same parameters obtained from all 8 V’s of the treadmill. We conclude that the F-V relationship of leg muscles tested through a wide range of treadmill V could be strong, linear, and reliable. Moreover, the relatively quick and fatigue-free two-velocity method could provide reliable and ecologically valid indices of F, V, and P producing capacities of leg muscles and, therefore, should be considered for future routine testing.



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Influence of both cutaneous input from the foot soles and visual information on the control of postural stability in dyslexic children

Publication date: Available online 4 May 2017
Source:Gait & Posture
Author(s): Nathalie Goulème, Philippe Villeneuve, Christophe-Loïc Gérard, Maria Pia Bucci
Dyslexic children show impaired in postural stability. The aim of our study was to test the influence of foot soles and visual information on the postural control of dyslexic children, compared to non-dyslexic children. Postural stability was evaluated with TechnoConcept^® platform in twenty-four dyslexic children (mean age: 9.3±0.29years) and in twenty-four non-dyslexic children, gender- and age-matched, in two postural conditions (with and without foam: a 4-mm foam was put under their feet or not) and in two visual conditions (eyes open and eyes closed). We measured the surface area, the length and the mean velocity of the center of pressure (CoP). Moreover, we calculated the Romberg Quotient (RQ). Our results showed that the surface area, length and mean velocity of the CoP were significantly greater in the dyslexic children compared to the non-dyslexic children, particularly with foam and eyes closed. Furthermore, the RQ was significantly smaller in the dyslexic children and significantly greater without foam than with foam. All these findings suggest that dyslexic children are not able to compensate with other available inputs when sensorial inputs are less informative (with foam, or eyes closed), which results in poor postural stability. We suggest that the impairment of the cerebellar integration of all the sensorial inputs is responsible for the postural deficits observed in dyslexic children.



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Control of locomotor stability in stabilizing and destabilizing environments

Publication date: June 2017
Source:Gait & Posture, Volume 55
Author(s): Mengnan/Mary Wu, Geoffrey Brown, Keith E. Gordon
To develop effective interventions targeting locomotor stability, it is crucial to understand how people control and modify gait in response to changes in stabilization requirements. Our purpose was to examine how individuals with and without incomplete spinal cord injury (iSCI) control lateral stability in haptic walking environments that increase or decrease stabilization demands. We hypothesized that people would adapt to walking in a predictable, stabilizing viscous force field and unpredictable destabilizing force field by increasing and decreasing feedforward control of lateral stability, respectively. Adaptations in feedforward control were measured using after-effects when fields were removed. Both groups significantly (p<0.05) decreased step width in the stabilizing field. When the stabilizing field was removed, narrower steps persisted in both groups and subjects with iSCI significantly increased movement variability (p<0.05). The after-effect of walking in the stabilizing field was a suppression of ongoing general stabilization mechanisms. In the destabilizing field, subjects with iSCI took faster steps and increased lateral margins of stability (p<0.05). Step frequency increases persisted when the destabilizing field was removed (p<0.05), suggesting that subjects with iSCI made feedforward adaptions to increase control of lateral stability. In contrast, in the destabilizing field, non-impaired subjects increased movement variability (p<0.05) and did not change step width, step frequency, or lateral margin of stability (p>0.05). When the destabilizing field was removed, increases in movement variability persisted (p<0.05), suggesting that non-impaired subjects made feedforward decreases in resistance to perturbations.



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Leg stiffness during sprinting in transfemoral amputees with running-specific prosthesis

Publication date: Available online 4 May 2017
Source:Gait & Posture
Author(s): Yoko Sano, Atsushi Makimoto, Satoru Hashizume, Akihiko Murai, Yoshiyuki Kobayashi, Hiroshi Takemura, Hiroaki Hobara
Carbon fiber running-specific prostheses are designed to reproduce the spring-like stepping behavior of individuals similar to springs loaded by the entire body mass (i.e. spring-mass model). The aim of this study was to test whether leg stiffness would be modulated differently between intact and prosthetic legs in transfemoral amputees wearing RSP during sprinting. Eight unilateral transfemoral amputees performed maximum sprinting along an indoor overground runway. Leg stiffness was calculated from kinetic and kinematic data in intact and prosthetic legs. The results showed that leg stiffness was for the prosthetic limb approximately 12% decreased compared to the intact limb. Although there was no difference in leg compression between the legs, maximal vertical ground reaction force was significantly greater in the intact leg than in the prosthetic one. These results indicate that asymmetric modulation of leg stiffness in transfemoral amputees with running-specific prostheses is mainly associated with asymmetric ground reaction force.



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Reliability of center of pressure measures for assessing the development of sitting postural control through the stages of sitting

Publication date: July 2017
Source:Gait & Posture, Volume 56
Author(s): Jordan Wickstrom, Nick Stergiou, Anastasia Kyvelidou
Cerebral palsy (CP) impairs an individual’s ability to move and control one’s posture. Unfortunately, the signs and symptoms of CP may not be apparent before age two. Evaluating sitting posture is a potential way to assess the developing mechanisms that contribute to CP. The purpose of this project was to determine the reliability of linear and nonlinear measures, including inter- and intrastage reliability, when used to analyze the center of pressure (COP) time series during the stages of sitting development in children with typical development (TD) and with/at-risk for cerebral palsy (CP). We hypothesized that nonlinear tools would be more reliable than linear tools in assessing childrens’ sitting development, and reliability would increase with development. COP data was recorded for three trials at eight sessions. Linear parameters used were root mean square, range of sway for the anterior-posterior (AP) and medial-lateral (ML) directions, and sway path. Nonlinear parameters used were Approximate Entropy, the largest Lyapunov Exponent, and Correlation Dimension for the AP and ML direction. Participants consisted of 33 children with TD and 26 children with/at-risk for CP. Our results determined that COP is a moderately reliable method for assessing the development of sitting postural control in stages in both groups. Thus, clinicians may be able to use measures from COP data across stages to assess the efficacy of therapeutic interventions that are intended to improve sitting postural abilities in children with/at-risk for CP.



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Force-velocity relationship of leg muscles assessed with motorized treadmill tests: two-velocity method

Publication date: Available online 4 May 2017
Source:Gait & Posture
Author(s): Slobodanka Dobrijevic, Vladimir Ilic, Sasa Djuric, Slobodan Jaric
Linear regression models applied on force (F) and velocity (V) data obtained from loaded multi-joint functional movement tasks have often been used to assess mechanical capacities of the tested muscles. The present study aimed to explore the properties of the F-V relationship of leg muscles exerting the maximum pulling F at a wide range of V on a standard motorized treadmill. Young and physically active male and female subjects (N=13+15) were tested on their maximum pulling F exerted horizontally while walking or running on a treadmill set to 8 different velocities (1.4–3.3m/s). Both the individual (median R=0.935) and averaged across the subjects F-V relationships (R=0.994) proved to be approximately linear and exceptionally strong, while their parameters depicting the leg muscle capacities for producing maximum F, V, and power (P; proportional to the product of F and V) were highly reliable (0.84<ICC<0.97). In addition, the same F-V relationship parameters obtained from only the highest and lowest treadmill V (i.e., the ‘two-velocity method') revealed a strong relationship (0.89<R<0.99), and there were no meaningful differences regarding the magnitudes of the same parameters obtained from all 8 V’s of the treadmill. We conclude that the F-V relationship of leg muscles tested through a wide range of treadmill V could be strong, linear, and reliable. Moreover, the relatively quick and fatigue-free two-velocity method could provide reliable and ecologically valid indices of F, V, and P producing capacities of leg muscles and, therefore, should be considered for future routine testing.



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Influence of both cutaneous input from the foot soles and visual information on the control of postural stability in dyslexic children

Publication date: Available online 4 May 2017
Source:Gait & Posture
Author(s): Nathalie Goulème, Philippe Villeneuve, Christophe-Loïc Gérard, Maria Pia Bucci
Dyslexic children show impaired in postural stability. The aim of our study was to test the influence of foot soles and visual information on the postural control of dyslexic children, compared to non-dyslexic children. Postural stability was evaluated with TechnoConcept^® platform in twenty-four dyslexic children (mean age: 9.3±0.29years) and in twenty-four non-dyslexic children, gender- and age-matched, in two postural conditions (with and without foam: a 4-mm foam was put under their feet or not) and in two visual conditions (eyes open and eyes closed). We measured the surface area, the length and the mean velocity of the center of pressure (CoP). Moreover, we calculated the Romberg Quotient (RQ). Our results showed that the surface area, length and mean velocity of the CoP were significantly greater in the dyslexic children compared to the non-dyslexic children, particularly with foam and eyes closed. Furthermore, the RQ was significantly smaller in the dyslexic children and significantly greater without foam than with foam. All these findings suggest that dyslexic children are not able to compensate with other available inputs when sensorial inputs are less informative (with foam, or eyes closed), which results in poor postural stability. We suggest that the impairment of the cerebellar integration of all the sensorial inputs is responsible for the postural deficits observed in dyslexic children.



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Control of locomotor stability in stabilizing and destabilizing environments

Publication date: June 2017
Source:Gait & Posture, Volume 55
Author(s): Mengnan/Mary Wu, Geoffrey Brown, Keith E. Gordon
To develop effective interventions targeting locomotor stability, it is crucial to understand how people control and modify gait in response to changes in stabilization requirements. Our purpose was to examine how individuals with and without incomplete spinal cord injury (iSCI) control lateral stability in haptic walking environments that increase or decrease stabilization demands. We hypothesized that people would adapt to walking in a predictable, stabilizing viscous force field and unpredictable destabilizing force field by increasing and decreasing feedforward control of lateral stability, respectively. Adaptations in feedforward control were measured using after-effects when fields were removed. Both groups significantly (p<0.05) decreased step width in the stabilizing field. When the stabilizing field was removed, narrower steps persisted in both groups and subjects with iSCI significantly increased movement variability (p<0.05). The after-effect of walking in the stabilizing field was a suppression of ongoing general stabilization mechanisms. In the destabilizing field, subjects with iSCI took faster steps and increased lateral margins of stability (p<0.05). Step frequency increases persisted when the destabilizing field was removed (p<0.05), suggesting that subjects with iSCI made feedforward adaptions to increase control of lateral stability. In contrast, in the destabilizing field, non-impaired subjects increased movement variability (p<0.05) and did not change step width, step frequency, or lateral margin of stability (p>0.05). When the destabilizing field was removed, increases in movement variability persisted (p<0.05), suggesting that non-impaired subjects made feedforward decreases in resistance to perturbations.



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Leg stiffness during sprinting in transfemoral amputees with running-specific prosthesis

Publication date: Available online 4 May 2017
Source:Gait & Posture
Author(s): Yoko Sano, Atsushi Makimoto, Satoru Hashizume, Akihiko Murai, Yoshiyuki Kobayashi, Hiroshi Takemura, Hiroaki Hobara
Carbon fiber running-specific prostheses are designed to reproduce the spring-like stepping behavior of individuals similar to springs loaded by the entire body mass (i.e. spring-mass model). The aim of this study was to test whether leg stiffness would be modulated differently between intact and prosthetic legs in transfemoral amputees wearing RSP during sprinting. Eight unilateral transfemoral amputees performed maximum sprinting along an indoor overground runway. Leg stiffness was calculated from kinetic and kinematic data in intact and prosthetic legs. The results showed that leg stiffness was for the prosthetic limb approximately 12% decreased compared to the intact limb. Although there was no difference in leg compression between the legs, maximal vertical ground reaction force was significantly greater in the intact leg than in the prosthetic one. These results indicate that asymmetric modulation of leg stiffness in transfemoral amputees with running-specific prostheses is mainly associated with asymmetric ground reaction force.



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Epiglottitis as the Presenting Sign of Mucous Membranous Pemphigoid: A Case Report

Publication date: Available online 4 May 2017
Source:Journal of Voice
Author(s): Narin Nard Carmel-Neiderman, Ilana Kaplan, Yael Oestreicher-Kedem
Mucous membranous pemphigoid (MMP) is an autoimmune disease of the mucous membranes characterized by formation of subepithelial blisters. MMP commonly involves the ocular and oral mucosa. Laryngeal MMP is very rare, estimated as occurring in 1 of 10 million persons in the general population. It mostly affects the supraglottis, but may also involve other laryngeal sites as well as extralaryngeal areas. This report describes the clinical picture, workup to diagnosis, and differential diagnosis of an isolated epiglottic process in an elderly female who presented with isolated, long-standing, nonresolving epiglottitis, later diagnosed as MMP with epiglottal and oral involvement.



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Novel compound heterozygous MYO7A mutations in Moroccan families with autosomal recessive non-syndromic hearing loss

by Amina Bakhchane, Majida Charif, Amale Bousfiha, Redouane Boulouiz, Halima Nahili, Hassan Rouba, Hicham Charoute, Guy Lenaers, Abdelhamid Barakat

The MYO7A gene encodes a protein belonging to the unconventional myosin super family. Mutations within MYO7A can lead to either non syndromic hearing loss or to the Usher syndrome type 1B (USH1B). Here, we report the results of genetic analyses performed on Moroccan families with autosomal recessive non syndromic hearing loss that identified two families with compound heterozygous MYO7A mutations. Five mutations (c.6025delG, c.6229T>A, c.3500T>A, c.5617C>T and c.4487C>A) were identified in these families, the latter presenting two differently affected branches. Multiple bioinformatics programs and molecular modelling predicted the pathogenic effect of these mutations. In conclusion, the absence of vestibular and retinal symptom in the affected patients suggests that these families have the isolated non-syndromic hearing loss DFNB2 (nonsyndromic autosomal recessive hearing loss) presentation, instead of USH1B.

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Transient evoked otoacoustic emissions in rock musicians

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Transient evoked otoacoustic emissions in rock musicians

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Transient evoked otoacoustic emissions in rock musicians

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Transient evoked otoacoustic emissions in rock musicians

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Transient evoked otoacoustic emissions in rock musicians

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UK bone conduction hearing device consensus workshop: Narrative summary.

UK bone conduction hearing device consensus workshop: Narrative summary.

Cochlear Implants Int. 2017 May 03;:1-5

Authors: Mandavia R, Dimitriadis PA, Monksfield P, Hall A, Ray J, Schilder AGM

Abstract
OBJECTIVES: To identify United Kingdom (UK)-specific research priorities in the field of bone conduction hearing devices (BCHDs).
METHOD: Narrative summary of the discussions and outcomes of a UK BCHD research workshop. The workshop was organized on 8 September 2016 under the auspices of the National Institute for Health Research (NIHR) Clinical Research Network (CRN) ENT Specialty group and Royal College of Surgeons (RCS) Clinical Research Initiative. Representatives from a wide range of patient and professional groups from the UK and abroad were invited to attend. Main outcome measures were research priorities and approaches in the field of BCHDs.
RESULTS: Key research questions in the field of BCHDs are as follows: (1) What are the existing national BCHD practices? (2) What are the patient information and support needs on BCHDs? (3) Which outcomes should be measured across clinical studies in the field of BCHDs? The workshop suggested the following approaches to address these priorities: (1) a service evaluation of current UK BCHD practice; development of a national registry of BCHDs; (2) qualitative research to understand patient information and support needs; development of patient decision support tools; (3) development of core outcome sets for BCHDs.
DISCUSSION: Building upon the framework of the recent UK Research Agenda for ENT, Hearing and Balance, patients and professionals defined key UK-specific research priorities and approaches in the field of BCHDs. This approach promotes engagement, buy-in, national collaboration and thereby value of future BCHD research.

PMID: 28466683 [PubMed - as supplied by publisher]

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UK bone conduction hearing device consensus workshop: Narrative summary.

UK bone conduction hearing device consensus workshop: Narrative summary.

Cochlear Implants Int. 2017 May 03;:1-5

Authors: Mandavia R, Dimitriadis PA, Monksfield P, Hall A, Ray J, Schilder AGM

Abstract
OBJECTIVES: To identify United Kingdom (UK)-specific research priorities in the field of bone conduction hearing devices (BCHDs).
METHOD: Narrative summary of the discussions and outcomes of a UK BCHD research workshop. The workshop was organized on 8 September 2016 under the auspices of the National Institute for Health Research (NIHR) Clinical Research Network (CRN) ENT Specialty group and Royal College of Surgeons (RCS) Clinical Research Initiative. Representatives from a wide range of patient and professional groups from the UK and abroad were invited to attend. Main outcome measures were research priorities and approaches in the field of BCHDs.
RESULTS: Key research questions in the field of BCHDs are as follows: (1) What are the existing national BCHD practices? (2) What are the patient information and support needs on BCHDs? (3) Which outcomes should be measured across clinical studies in the field of BCHDs? The workshop suggested the following approaches to address these priorities: (1) a service evaluation of current UK BCHD practice; development of a national registry of BCHDs; (2) qualitative research to understand patient information and support needs; development of patient decision support tools; (3) development of core outcome sets for BCHDs.
DISCUSSION: Building upon the framework of the recent UK Research Agenda for ENT, Hearing and Balance, patients and professionals defined key UK-specific research priorities and approaches in the field of BCHDs. This approach promotes engagement, buy-in, national collaboration and thereby value of future BCHD research.

PMID: 28466683 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader http://ift.tt/2pKu0Vj
via IFTTT