Single cell analysis of the inner ear sensory organs.

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Single cell analysis of the inner ear sensory organs.

Int J Dev Biol. 2017;61(3-4-5):205-213

Authors: Yizhar-Barnea O, Avraham KB

Abstract
The inner ear is composed of a complex mixture of cells, which together allow organisms to hear and maintain balance. The cells in the inner ear, which undergo an extraordinary process of development, have only recently begun to be studied on an individual level. As it has recently become clear that individual cells, previously considered to be of uniform character, may differ dramatically from each other, the need to study cell-to-cell variation, along with distinct transcriptional and regulatory signatures, has taken hold in the scientific community. In conjunction with high-throughput technologies, attempts are underway to dissect the inter- and intra-cellular variability of different cell types and developmental states of the inner ear from a novel perspective. Single cell analysis of the inner ear sensory organs holds the promise of providing a significant boost in building an omics network that translates into a comprehensive understanding of the mechanisms of hearing and balance. These networks may uncover critical elements for trans-differentiation, regeneration and/or reprogramming, providing entry points for therapeutics of deafness and vestibular pathologies.

PMID: 28621418 [PubMed - in process]

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Single cell analysis of the inner ear sensory organs.

Related Articles

Single cell analysis of the inner ear sensory organs.

Int J Dev Biol. 2017;61(3-4-5):205-213

Authors: Yizhar-Barnea O, Avraham KB

Abstract
The inner ear is composed of a complex mixture of cells, which together allow organisms to hear and maintain balance. The cells in the inner ear, which undergo an extraordinary process of development, have only recently begun to be studied on an individual level. As it has recently become clear that individual cells, previously considered to be of uniform character, may differ dramatically from each other, the need to study cell-to-cell variation, along with distinct transcriptional and regulatory signatures, has taken hold in the scientific community. In conjunction with high-throughput technologies, attempts are underway to dissect the inter- and intra-cellular variability of different cell types and developmental states of the inner ear from a novel perspective. Single cell analysis of the inner ear sensory organs holds the promise of providing a significant boost in building an omics network that translates into a comprehensive understanding of the mechanisms of hearing and balance. These networks may uncover critical elements for trans-differentiation, regeneration and/or reprogramming, providing entry points for therapeutics of deafness and vestibular pathologies.

PMID: 28621418 [PubMed - in process]

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Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic.

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Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic.

Int J Audiol. 2017 Jun 16;:1-8

Authors: Aazh H, Moore BCJ

Abstract
OBJECTIVES: The aims were as follows: (1) to explore patterns of uncomfortable loudness levels (ULLs) across frequency and their associated factors for patients with tinnitus and hyperacusis, and (2) to re-evaluate the criteria for diagnosing hyperacusis based on ULLs and scores for the Hyperacusis Questionnaire (HQ).
DESIGN: This was a retrospective cross-sectional study.
STUDY SAMPLE: 573 consecutive patients for whom ULLs had been measured were included.
RESULTS: A good correspondence between the diagnosis of hyperacusis based on the across-frequency average ULL for the ear with the lowest ULLs (ULLmin) and hyperacusis handicap based on HQ scores was obtained with cut-off values of ULLmin ≤77 dB HL and HQ score ≥ 22. A regression model showed significant relationships between ULLmin and the score on the HQ and age. The mean HQ score for patients with a large interaural asymmetry in ULLs was significantly higher than for the remainder. Hyperacusis handicap was associated with strong across-frequency variations in ULLs.
CONCLUSIONS: Appropriate cut-off values for diagnosing hyperacusis are ULLmin ≤77 dB HL and HQ score ≥22. Large interaural asymmetry and large across-frequency variations in ULLs are associated with higher HQ scores.

PMID: 28622055 [PubMed - as supplied by publisher]

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via IFTTT

Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic.

Related Articles

Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic.

Int J Audiol. 2017 Jun 16;:1-8

Authors: Aazh H, Moore BCJ

Abstract
OBJECTIVES: The aims were as follows: (1) to explore patterns of uncomfortable loudness levels (ULLs) across frequency and their associated factors for patients with tinnitus and hyperacusis, and (2) to re-evaluate the criteria for diagnosing hyperacusis based on ULLs and scores for the Hyperacusis Questionnaire (HQ).
DESIGN: This was a retrospective cross-sectional study.
STUDY SAMPLE: 573 consecutive patients for whom ULLs had been measured were included.
RESULTS: A good correspondence between the diagnosis of hyperacusis based on the across-frequency average ULL for the ear with the lowest ULLs (ULLmin) and hyperacusis handicap based on HQ scores was obtained with cut-off values of ULLmin ≤77 dB HL and HQ score ≥ 22. A regression model showed significant relationships between ULLmin and the score on the HQ and age. The mean HQ score for patients with a large interaural asymmetry in ULLs was significantly higher than for the remainder. Hyperacusis handicap was associated with strong across-frequency variations in ULLs.
CONCLUSIONS: Appropriate cut-off values for diagnosing hyperacusis are ULLmin ≤77 dB HL and HQ score ≥22. Large interaural asymmetry and large across-frequency variations in ULLs are associated with higher HQ scores.

PMID: 28622055 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader http://ift.tt/2rEr8eF
via IFTTT

Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic.

Related Articles

Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic.

Int J Audiol. 2017 Jun 16;:1-8

Authors: Aazh H, Moore BCJ

Abstract
OBJECTIVES: The aims were as follows: (1) to explore patterns of uncomfortable loudness levels (ULLs) across frequency and their associated factors for patients with tinnitus and hyperacusis, and (2) to re-evaluate the criteria for diagnosing hyperacusis based on ULLs and scores for the Hyperacusis Questionnaire (HQ).
DESIGN: This was a retrospective cross-sectional study.
STUDY SAMPLE: 573 consecutive patients for whom ULLs had been measured were included.
RESULTS: A good correspondence between the diagnosis of hyperacusis based on the across-frequency average ULL for the ear with the lowest ULLs (ULLmin) and hyperacusis handicap based on HQ scores was obtained with cut-off values of ULLmin ≤77 dB HL and HQ score ≥ 22. A regression model showed significant relationships between ULLmin and the score on the HQ and age. The mean HQ score for patients with a large interaural asymmetry in ULLs was significantly higher than for the remainder. Hyperacusis handicap was associated with strong across-frequency variations in ULLs.
CONCLUSIONS: Appropriate cut-off values for diagnosing hyperacusis are ULLmin ≤77 dB HL and HQ score ≥22. Large interaural asymmetry and large across-frequency variations in ULLs are associated with higher HQ scores.

PMID: 28622055 [PubMed - as supplied by publisher]

from #Audiology via ola Kala on Inoreader http://ift.tt/2rEr8eF
via IFTTT

Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic.

Related Articles

Factors related to uncomfortable loudness levels for patients seen in a tinnitus and hyperacusis clinic.

Int J Audiol. 2017 Jun 16;:1-8

Authors: Aazh H, Moore BCJ

Abstract
OBJECTIVES: The aims were as follows: (1) to explore patterns of uncomfortable loudness levels (ULLs) across frequency and their associated factors for patients with tinnitus and hyperacusis, and (2) to re-evaluate the criteria for diagnosing hyperacusis based on ULLs and scores for the Hyperacusis Questionnaire (HQ).
DESIGN: This was a retrospective cross-sectional study.
STUDY SAMPLE: 573 consecutive patients for whom ULLs had been measured were included.
RESULTS: A good correspondence between the diagnosis of hyperacusis based on the across-frequency average ULL for the ear with the lowest ULLs (ULLmin) and hyperacusis handicap based on HQ scores was obtained with cut-off values of ULLmin ≤77 dB HL and HQ score ≥ 22. A regression model showed significant relationships between ULLmin and the score on the HQ and age. The mean HQ score for patients with a large interaural asymmetry in ULLs was significantly higher than for the remainder. Hyperacusis handicap was associated with strong across-frequency variations in ULLs.
CONCLUSIONS: Appropriate cut-off values for diagnosing hyperacusis are ULLmin ≤77 dB HL and HQ score ≥22. Large interaural asymmetry and large across-frequency variations in ULLs are associated with higher HQ scores.

PMID: 28622055 [PubMed - as supplied by publisher]

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