OtoRhinoLaryngology by Sfakianakis G.Alexandros Sfakianakis G.Alexandros,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174
Κυριακή 25 Ιουνίου 2017
Professional Ethics: Making the Right Decision
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Vanderbilt Audiology Journal Club - Research Examining Benefit of Hearing Aid Features
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Professional Ethics: Making the Right Decision
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Vanderbilt Audiology Journal Club - Research Examining Benefit of Hearing Aid Features
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Professional Ethics: Making the Right Decision
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Vanderbilt Audiology Journal Club - Research Examining Benefit of Hearing Aid Features
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Age-related plantar centre of pressure trajectory changes during barefoot walking
Source:Gait & Posture, Volume 57
Author(s): Gisela Sole, Todd Pataky, Christopher C. Sole, Leigh Hale, Stephan Milosavljevic
Plantar centre of pressure (COP) variables during gait have been used to predict risk of injury, or consequences thereof. The aim of this study was to determine the effect of age on the COP trajectory during barefoot gait at a self-selected speed. 287 participants (aged 18–80year, 163 women) walked barefoot at self-selected speed across a Footscan® force platform, completing five trials for each side. COP trajectories were extracted and trajectory-level canonical correlation analysis was used to test their correlation with age. Post hoc linear regressions were performed on the medio-lateral (COPx) and anterior-posterior (COPy) components. The test statistic trajectory exceeded the critical threshold for the left (p=0.001) and right foot (p=0.003). Post hoc analyses showed positive correlation between age and COPx in late stance, placed more laterally with increasing age, while no significant correlation was found for COPy. While no significant correlations were observed for the test statistic trajectory during heel strike and mid-stance, post hoc analysis indicated that the COPx component was placed more laterally at heel strike for the left foot with increasing age (p=0.016). The findings suggest that older individuals tend to push-off with less metatarso-phalangeal dorsiflexion. These results do not necessarily imply that ageing itself causes the observed correlation. Further evidence is needed to determine whether the laterally placed COP during roll-off may be a useful factor for determining risk for falling in the older population, or as a risk for future injuries or overuse disorders.
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Age-related plantar centre of pressure trajectory changes during barefoot walking
Source:Gait & Posture, Volume 57
Author(s): Gisela Sole, Todd Pataky, Christopher C. Sole, Leigh Hale, Stephan Milosavljevic
Plantar centre of pressure (COP) variables during gait have been used to predict risk of injury, or consequences thereof. The aim of this study was to determine the effect of age on the COP trajectory during barefoot gait at a self-selected speed. 287 participants (aged 18–80year, 163 women) walked barefoot at self-selected speed across a Footscan® force platform, completing five trials for each side. COP trajectories were extracted and trajectory-level canonical correlation analysis was used to test their correlation with age. Post hoc linear regressions were performed on the medio-lateral (COPx) and anterior-posterior (COPy) components. The test statistic trajectory exceeded the critical threshold for the left (p=0.001) and right foot (p=0.003). Post hoc analyses showed positive correlation between age and COPx in late stance, placed more laterally with increasing age, while no significant correlation was found for COPy. While no significant correlations were observed for the test statistic trajectory during heel strike and mid-stance, post hoc analysis indicated that the COPx component was placed more laterally at heel strike for the left foot with increasing age (p=0.016). The findings suggest that older individuals tend to push-off with less metatarso-phalangeal dorsiflexion. These results do not necessarily imply that ageing itself causes the observed correlation. Further evidence is needed to determine whether the laterally placed COP during roll-off may be a useful factor for determining risk for falling in the older population, or as a risk for future injuries or overuse disorders.
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Age-related plantar centre of pressure trajectory changes during barefoot walking
Source:Gait & Posture, Volume 57
Author(s): Gisela Sole, Todd Pataky, Christopher C. Sole, Leigh Hale, Stephan Milosavljevic
Plantar centre of pressure (COP) variables during gait have been used to predict risk of injury, or consequences thereof. The aim of this study was to determine the effect of age on the COP trajectory during barefoot gait at a self-selected speed. 287 participants (aged 18–80year, 163 women) walked barefoot at self-selected speed across a Footscan® force platform, completing five trials for each side. COP trajectories were extracted and trajectory-level canonical correlation analysis was used to test their correlation with age. Post hoc linear regressions were performed on the medio-lateral (COPx) and anterior-posterior (COPy) components. The test statistic trajectory exceeded the critical threshold for the left (p=0.001) and right foot (p=0.003). Post hoc analyses showed positive correlation between age and COPx in late stance, placed more laterally with increasing age, while no significant correlation was found for COPy. While no significant correlations were observed for the test statistic trajectory during heel strike and mid-stance, post hoc analysis indicated that the COPx component was placed more laterally at heel strike for the left foot with increasing age (p=0.016). The findings suggest that older individuals tend to push-off with less metatarso-phalangeal dorsiflexion. These results do not necessarily imply that ageing itself causes the observed correlation. Further evidence is needed to determine whether the laterally placed COP during roll-off may be a useful factor for determining risk for falling in the older population, or as a risk for future injuries or overuse disorders.
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Effects of Acute Altered Gravity During Parabolic Flight and/or Vestibular Loss on Cell Proliferation in the Rat Dentate Gyrus.
Related Articles |
Effects of Acute Altered Gravity During Parabolic Flight and/or Vestibular Loss on Cell Proliferation in the Rat Dentate Gyrus.
Neurosci Lett. 2017 Jun 20;:
Authors: Zheng Y, Gliddon CM, Aitken P, Stiles L, Machado ML, Philoxene B, Denise P, Smith PF, Besnard S
Abstract
Both parabolic flight, i.e. a condition of altered gravity, and loss of vestibular function, have been suggested to affect spatial learning and memory, which is known to be influenced by neurogenesis in the hippocampus. In this study we investigated whether short alternated micro- and hyper-gravity stimulations during parabolic flight and/or loss of vestibular function, would alter cell proliferation in the hippocampal dentate gyrus of rats, by measuring the number of bromodeoxyuridine (BrdU)-incorporated cells. Rats were randomly allocated to the following experimental groups: (1) sham transtympanic saline injection only (n=5); (2) bilateral vestibular deafferentation (BVD) by sodium arsanilate transtympanic injection only (n=5); (3) sham treatment and parabolic flight (n=5); (4) BVD and parabolic flight (n=6). Forty-two days following transtympanic injection, the animals were subjected to parabolic flight in an awake restrained condition after habituation. A modified Airbus A300 aircraft was flown on a parabolic path, creating 20 secs of 1.8G during both climbing and descending and 22 secs of 0G at the apex of each parabola. The no flight animals were subjected to the same housing for the same duration. Immediately after the parabolic flight or control ground condition, animals were injected with BrdU (300mg/kg, i.p). Twenty-four hs after BrdU injection, rats were sacrificed. BrdU immunolabelling was performed and the number of BrdU(+ve) cells in the dentate gyrus of the hippocampus was quantified using a modified fractionator method. BVD caused a large and significant reduction in the number of BrdU-positive cells compared to sham animals (P≤0.0001); however, flight and all interactions were non-significant. These results indicate that BVD significantly decreased cell proliferation irrespective of the short exposure to altered/modified gravity.
PMID: 28645788 [PubMed - as supplied by publisher]
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Effects of Acute Altered Gravity During Parabolic Flight and/or Vestibular Loss on Cell Proliferation in the Rat Dentate Gyrus.
Related Articles |
Effects of Acute Altered Gravity During Parabolic Flight and/or Vestibular Loss on Cell Proliferation in the Rat Dentate Gyrus.
Neurosci Lett. 2017 Jun 20;:
Authors: Zheng Y, Gliddon CM, Aitken P, Stiles L, Machado ML, Philoxene B, Denise P, Smith PF, Besnard S
Abstract
Both parabolic flight, i.e. a condition of altered gravity, and loss of vestibular function, have been suggested to affect spatial learning and memory, which is known to be influenced by neurogenesis in the hippocampus. In this study we investigated whether short alternated micro- and hyper-gravity stimulations during parabolic flight and/or loss of vestibular function, would alter cell proliferation in the hippocampal dentate gyrus of rats, by measuring the number of bromodeoxyuridine (BrdU)-incorporated cells. Rats were randomly allocated to the following experimental groups: (1) sham transtympanic saline injection only (n=5); (2) bilateral vestibular deafferentation (BVD) by sodium arsanilate transtympanic injection only (n=5); (3) sham treatment and parabolic flight (n=5); (4) BVD and parabolic flight (n=6). Forty-two days following transtympanic injection, the animals were subjected to parabolic flight in an awake restrained condition after habituation. A modified Airbus A300 aircraft was flown on a parabolic path, creating 20 secs of 1.8G during both climbing and descending and 22 secs of 0G at the apex of each parabola. The no flight animals were subjected to the same housing for the same duration. Immediately after the parabolic flight or control ground condition, animals were injected with BrdU (300mg/kg, i.p). Twenty-four hs after BrdU injection, rats were sacrificed. BrdU immunolabelling was performed and the number of BrdU(+ve) cells in the dentate gyrus of the hippocampus was quantified using a modified fractionator method. BVD caused a large and significant reduction in the number of BrdU-positive cells compared to sham animals (P≤0.0001); however, flight and all interactions were non-significant. These results indicate that BVD significantly decreased cell proliferation irrespective of the short exposure to altered/modified gravity.
PMID: 28645788 [PubMed - as supplied by publisher]
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