Effectiveness of Audiologist-Delivered Cognitive Behavioral Therapy for Tinnitus and Hyperacusis Rehabilitation: Outcomes for Patients Treated in Routine Practice

Objective

The aim was to assess the effectiveness of cognitive behavioral therapy (CBT) for tinnitus and/or hyperacusis delivered by audiologists working in the National Health Service in the United Kingdom.

Design

This was a retrospective study, based on questionnaires assessing tinnitus and hyperacusis and insomnia before and after CBT.

Study Sample

Data were gathered for 68 consecutive patients (average age = 52.5 years) who enrolled for CBT.

Results

All measures showed significant improvements after CBT. Effect sizes for patients who completed CBT were 1.13 for Tinnitus Handicap Inventory scores; 0.76 for Hyperacusis Questionnaire scores; 0.71, 0.95, and 0.93 for tinnitus loudness, annoyance, and effect on life, respectively, measured using the Visual Analog Scale; and 0.94 for the Insomnia Severity Index score. An analysis including those who dropped out also showed significant improvements for all measures.

Conclusion

Audiologist-delivered CBT led to significant improvements in self-report measures of tinnitus and hyperacusis handicap and insomnia. The methods described here may be used when designing future randomized controlled trials of efficacy.

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Effectiveness of Audiologist-Delivered Cognitive Behavioral Therapy for Tinnitus and Hyperacusis Rehabilitation: Outcomes for Patients Treated in Routine Practice

Objective

The aim was to assess the effectiveness of cognitive behavioral therapy (CBT) for tinnitus and/or hyperacusis delivered by audiologists working in the National Health Service in the United Kingdom.

Design

This was a retrospective study, based on questionnaires assessing tinnitus and hyperacusis and insomnia before and after CBT.

Study Sample

Data were gathered for 68 consecutive patients (average age = 52.5 years) who enrolled for CBT.

Results

All measures showed significant improvements after CBT. Effect sizes for patients who completed CBT were 1.13 for Tinnitus Handicap Inventory scores; 0.76 for Hyperacusis Questionnaire scores; 0.71, 0.95, and 0.93 for tinnitus loudness, annoyance, and effect on life, respectively, measured using the Visual Analog Scale; and 0.94 for the Insomnia Severity Index score. An analysis including those who dropped out also showed significant improvements for all measures.

Conclusion

Audiologist-delivered CBT led to significant improvements in self-report measures of tinnitus and hyperacusis handicap and insomnia. The methods described here may be used when designing future randomized controlled trials of efficacy.

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Erratum

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The Mandarin Version of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) and Its Reliability

Purpose

The purpose of this study is to develop the Mandarin version of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) and evaluate its reliability compared with the Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS).

Method

The Mandarin version of the CAPE-V tool was translated from the validated English version with phonemic adaptations, content adjustment, and scale modification. Sixty dysphonic, 20 normal, and 20 repeated voice samples were included in this study. Ten of these were used for preassessment training; the remaining 90 were evaluated using the Mandarin CAPE-V and GRBAS for comparison of their interrater and intrarater reliabilities.

Results

Intrarater reliability was measured by Pearson r for the CAPE-V and Spearman rho for the GRBAS. Average CAPE-V Pearson r ranged from 0.80 for strain to 0.91 for overall severity, compared with average GRBAS Spearman rho of 0.83 for strain to 0.89 for asthenia. Interrater reliability was measured by an intraclass coefficient (ICC). Average CAPE-V ICCs ranged from .57 for pitch to .81 for overall severity, compared with average GRBAS ICCs of .60 for asthenia to .83 for grade.

Conclusions

The Mandarin CAPE-V addresses some limits of the English version. It also demonstrates good intrarater and interrater reliability, comparable to those of GRBAS.

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Erratum

from #Audiology via ola Kala on Inoreader https://ift.tt/2D7hkQC
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The Mandarin Version of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) and Its Reliability

Purpose

The purpose of this study is to develop the Mandarin version of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) and evaluate its reliability compared with the Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS).

Method

The Mandarin version of the CAPE-V tool was translated from the validated English version with phonemic adaptations, content adjustment, and scale modification. Sixty dysphonic, 20 normal, and 20 repeated voice samples were included in this study. Ten of these were used for preassessment training; the remaining 90 were evaluated using the Mandarin CAPE-V and GRBAS for comparison of their interrater and intrarater reliabilities.

Results

Intrarater reliability was measured by Pearson r for the CAPE-V and Spearman rho for the GRBAS. Average CAPE-V Pearson r ranged from 0.80 for strain to 0.91 for overall severity, compared with average GRBAS Spearman rho of 0.83 for strain to 0.89 for asthenia. Interrater reliability was measured by an intraclass coefficient (ICC). Average CAPE-V ICCs ranged from .57 for pitch to .81 for overall severity, compared with average GRBAS ICCs of .60 for asthenia to .83 for grade.

Conclusions

The Mandarin CAPE-V addresses some limits of the English version. It also demonstrates good intrarater and interrater reliability, comparable to those of GRBAS.

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Gout Associated with Higher Risk of Hearing Loss in Older Adults

​Adults 65 and older with gout have a 44 percent higher risk of developing hearing loss independent of demographic, comorbidities, and use of common medications, according to a new study (BMJ Open. 2018 Aug 20;8(8):e022854). Researchers from the University of Alabama at Birmingham School of Medicine examined 5% Medicare claims from 2006 to 2012 and identified cases of incident hearing impairment among patients with existing gout. Of the 1.71 million people included, 89,409 developed incident hearing impairment. Compared with the people without, people with hearing impairment were older, less likely to be black, and had higher medical comorbidity. The crude incidence rates of incident hearing impairment in people with and without gout were 16.9 v. 8.7 per 1,000 person-years. The association between gout and hearing loss has long been suspected because they share similar pathological processes, but the authors said this is the first study to investigate this relationship. The authors also said that the hypothesis that hyperuricaemia-related inflammation and oxidative stress pathways potentially link gout to the risk of hearing loss in older adults should be tested in future studies, which should reveal which factors contribute to this increased risk and to what extent. ​

Published: 9/14/2018 10:47:00 AM

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Gout Associated with Higher Risk of Hearing Loss in Older Adults

​Adults 65 and older with gout have a 44 percent higher risk of developing hearing loss independent of demographic, comorbidities, and use of common medications, according to a new study (BMJ Open. 2018 Aug 20;8(8):e022854). Researchers from the University of Alabama at Birmingham School of Medicine examined 5% Medicare claims from 2006 to 2012 and identified cases of incident hearing impairment among patients with existing gout. Of the 1.71 million people included, 89,409 developed incident hearing impairment. Compared with the people without, people with hearing impairment were older, less likely to be black, and had higher medical comorbidity. The crude incidence rates of incident hearing impairment in people with and without gout were 16.9 v. 8.7 per 1,000 person-years. The association between gout and hearing loss has long been suspected because they share similar pathological processes, but the authors said this is the first study to investigate this relationship. The authors also said that the hypothesis that hyperuricaemia-related inflammation and oxidative stress pathways potentially link gout to the risk of hearing loss in older adults should be tested in future studies, which should reveal which factors contribute to this increased risk and to what extent. ​

Published: 9/14/2018 10:47:00 AM

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The peroxisome: an update on mysteries 2.0.

The peroxisome: an update on mysteries 2.0.

Histochem Cell Biol. 2018 Sep 15;:

Authors: Islinger M, Voelkl A, Fahimi HD, Schrader M

Abstract
Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, e.g. the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular redox balance. Peroxisomal dysfunction has been linked to severe metabolic disorders in man, but peroxisomes are now also recognized as protective organelles with a wider significance in human health and potential impact on a large number of globally important human diseases such as neurodegeneration, obesity, cancer, and age-related disorders. Therefore, the interest in peroxisomes and their physiological functions has significantly increased in recent years. In this review, we intend to highlight recent discoveries, advancements and trends in peroxisome research, and present an update as well as a continuation of two former review articles addressing the unsolved mysteries of this astonishing organelle. We summarize novel findings on the biological functions of peroxisomes, their biogenesis, formation, membrane dynamics and division, as well as on peroxisome-organelle contacts and cooperation. Furthermore, novel peroxisomal proteins and machineries at the peroxisomal membrane are discussed. Finally, we address recent findings on the role of peroxisomes in the brain, in neurological disorders, and in the development of cancer.

PMID: 30219925 [PubMed - as supplied by publisher]

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The peroxisome: an update on mysteries 2.0.

The peroxisome: an update on mysteries 2.0.

Histochem Cell Biol. 2018 Sep 15;:

Authors: Islinger M, Voelkl A, Fahimi HD, Schrader M

Abstract
Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, e.g. the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular redox balance. Peroxisomal dysfunction has been linked to severe metabolic disorders in man, but peroxisomes are now also recognized as protective organelles with a wider significance in human health and potential impact on a large number of globally important human diseases such as neurodegeneration, obesity, cancer, and age-related disorders. Therefore, the interest in peroxisomes and their physiological functions has significantly increased in recent years. In this review, we intend to highlight recent discoveries, advancements and trends in peroxisome research, and present an update as well as a continuation of two former review articles addressing the unsolved mysteries of this astonishing organelle. We summarize novel findings on the biological functions of peroxisomes, their biogenesis, formation, membrane dynamics and division, as well as on peroxisome-organelle contacts and cooperation. Furthermore, novel peroxisomal proteins and machineries at the peroxisomal membrane are discussed. Finally, we address recent findings on the role of peroxisomes in the brain, in neurological disorders, and in the development of cancer.

PMID: 30219925 [PubMed - as supplied by publisher]

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