Objectives: Cochlear implantation surgery has been shown to result in trauma to inner ear sensory structures, resulting in loss of residual hearing. Localized therapeutic hypothermia has been shown in clinical care to be a neuroprotective intervention. Previously, we have shown in an experimental model that localized hypothermia protects cochlear hair cells and residual hearing function against surgical and cochlear implantation trauma. Using experimental temperature measurements carried out in human cadaver temporal bones and a finite element model of the inner ear, the present study examined the temperature distribution of a custom-designed hypothermia delivery system in the human inner ear organs. Design: The efficacy of the hypothermia probe and resulting heat distribution across human cochlea and surrounding tissues were modeled in three-dimensional in COMSOL. The geometry and dimensions of inner ear and temporal bones were derived from computed tomographic and magnetic resonance imaging images. Model predictions were compared with experimental observations from five human temporal bones. Results: In both the modeling and experimental studies, the cochlear temperature was lowered by 4 to 6 [degrees]C on the round window from a baseline of 37 [degrees]C within 16 to 18 minutes. The model simulations showed uniformly distributed cooling across the cochlea. This study provides insight for design, operation, and protocols for efficacious delivery of mild therapeutic hypothermia to the human cochlea that may significantly benefit patients undergoing surgical cochlear implantation by preserving residual hearing. Conclusion: There was a close correlation between the results of the numerical simulations and experimental observations in this study. Our custom-designed system is capable of effectively providing mild therapeutic hypothermia locally to the human cochlea. When combined with results from in vivo animal experiments, the present study suggests that the application of localized therapeutic hypothermia may hold potential for patients with an aim to preserve residual hearing after cochlear implantation. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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Παρασκευή 15 Δεκεμβρίου 2017
Theoretical Evaluation and Experimental Validation of Localized Therapeutic Hypothermia Application to Preserve Residual Hearing After Cochlear Implantation.
Objectives: Cochlear implantation surgery has been shown to result in trauma to inner ear sensory structures, resulting in loss of residual hearing. Localized therapeutic hypothermia has been shown in clinical care to be a neuroprotective intervention. Previously, we have shown in an experimental model that localized hypothermia protects cochlear hair cells and residual hearing function against surgical and cochlear implantation trauma. Using experimental temperature measurements carried out in human cadaver temporal bones and a finite element model of the inner ear, the present study examined the temperature distribution of a custom-designed hypothermia delivery system in the human inner ear organs. Design: The efficacy of the hypothermia probe and resulting heat distribution across human cochlea and surrounding tissues were modeled in three-dimensional in COMSOL. The geometry and dimensions of inner ear and temporal bones were derived from computed tomographic and magnetic resonance imaging images. Model predictions were compared with experimental observations from five human temporal bones. Results: In both the modeling and experimental studies, the cochlear temperature was lowered by 4 to 6 [degrees]C on the round window from a baseline of 37 [degrees]C within 16 to 18 minutes. The model simulations showed uniformly distributed cooling across the cochlea. This study provides insight for design, operation, and protocols for efficacious delivery of mild therapeutic hypothermia to the human cochlea that may significantly benefit patients undergoing surgical cochlear implantation by preserving residual hearing. Conclusion: There was a close correlation between the results of the numerical simulations and experimental observations in this study. Our custom-designed system is capable of effectively providing mild therapeutic hypothermia locally to the human cochlea. When combined with results from in vivo animal experiments, the present study suggests that the application of localized therapeutic hypothermia may hold potential for patients with an aim to preserve residual hearing after cochlear implantation. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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Theoretical Evaluation and Experimental Validation of Localized Therapeutic Hypothermia Application to Preserve Residual Hearing After Cochlear Implantation.
Objectives: Cochlear implantation surgery has been shown to result in trauma to inner ear sensory structures, resulting in loss of residual hearing. Localized therapeutic hypothermia has been shown in clinical care to be a neuroprotective intervention. Previously, we have shown in an experimental model that localized hypothermia protects cochlear hair cells and residual hearing function against surgical and cochlear implantation trauma. Using experimental temperature measurements carried out in human cadaver temporal bones and a finite element model of the inner ear, the present study examined the temperature distribution of a custom-designed hypothermia delivery system in the human inner ear organs. Design: The efficacy of the hypothermia probe and resulting heat distribution across human cochlea and surrounding tissues were modeled in three-dimensional in COMSOL. The geometry and dimensions of inner ear and temporal bones were derived from computed tomographic and magnetic resonance imaging images. Model predictions were compared with experimental observations from five human temporal bones. Results: In both the modeling and experimental studies, the cochlear temperature was lowered by 4 to 6 [degrees]C on the round window from a baseline of 37 [degrees]C within 16 to 18 minutes. The model simulations showed uniformly distributed cooling across the cochlea. This study provides insight for design, operation, and protocols for efficacious delivery of mild therapeutic hypothermia to the human cochlea that may significantly benefit patients undergoing surgical cochlear implantation by preserving residual hearing. Conclusion: There was a close correlation between the results of the numerical simulations and experimental observations in this study. Our custom-designed system is capable of effectively providing mild therapeutic hypothermia locally to the human cochlea. When combined with results from in vivo animal experiments, the present study suggests that the application of localized therapeutic hypothermia may hold potential for patients with an aim to preserve residual hearing after cochlear implantation. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
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Hearing Loss May Be a Risk Factor for Dementia and Cognitive Decline
Researchers found that hearing loss is significantly associated with dementia and other forms of cognitive decline in the first systematic review and meta-analysis of age-related hearing loss (ARHL) and cognitive decline using only pure-tone thresholds as the audiometric criteria ( JAMA Otolaryngol Head Neck Surg 2017. doi: 10.1001/jamaoto.2017.2513). Thirty-six unique studies found in PubMed, the Cochrane Library, EMBASE, and SCOPUS with about 20,264 participants were included in this study. The authors found a significant association between ARHL and dementia, and a small but statistically significant association between ARHL and all 10 cognitive domains that were investigated in this analyze, including global cognition, executive functions (attention, fluency, reasoning, and working memory), episodic memory (delayed and immediate recall), processing speed, semantic memory, and visuospatial ability. ARHL was also found to have a statistically significant association with cognitive impairment.
The authors said the causal mechanisms between ARHL and cognitive decline remain unclear, but one hypothesis is a common etiology like decline in the vascular system or a broader physiological decline. ARHL has been linked with multiple indicators of functional decline and is a biomarker for frailty syndrome, which has been causally linked to dementia. The authors also noted other hypotheses suggesting that ARHL may be causing cognitive decline through impaired speech perception. They recommended more randomized clinical trials exploring the cognitive benefit of hearing loss treatment and more research on whether treatment, alone or as part of a wider approach to risk factors, modifies dementia outcomes.
Published: 12/15/2017 12:15:00 PM
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Hearing Loss May Be a Risk Factor for Dementia and Cognitive Decline
Researchers found that hearing loss is significantly associated with dementia and other forms of cognitive decline in the first systematic review and meta-analysis of age-related hearing loss (ARHL) and cognitive decline using only pure-tone thresholds as the audiometric criteria ( JAMA Otolaryngol Head Neck Surg 2017. doi: 10.1001/jamaoto.2017.2513). Thirty-six unique studies found in PubMed, the Cochrane Library, EMBASE, and SCOPUS with about 20,264 participants were included in this study. The authors found a significant association between ARHL and dementia, and a small but statistically significant association between ARHL and all 10 cognitive domains that were investigated in this analyze, including global cognition, executive functions (attention, fluency, reasoning, and working memory), episodic memory (delayed and immediate recall), processing speed, semantic memory, and visuospatial ability. ARHL was also found to have a statistically significant association with cognitive impairment.
The authors said the causal mechanisms between ARHL and cognitive decline remain unclear, but one hypothesis is a common etiology like decline in the vascular system or a broader physiological decline. ARHL has been linked with multiple indicators of functional decline and is a biomarker for frailty syndrome, which has been causally linked to dementia. The authors also noted other hypotheses suggesting that ARHL may be causing cognitive decline through impaired speech perception. They recommended more randomized clinical trials exploring the cognitive benefit of hearing loss treatment and more research on whether treatment, alone or as part of a wider approach to risk factors, modifies dementia outcomes.
Published: 12/15/2017 12:15:00 PM
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Hearing Loss May Be a Risk Factor for Dementia and Cognitive Decline
Researchers found that hearing loss is significantly associated with dementia and other forms of cognitive decline in the first systematic review and meta-analysis of age-related hearing loss (ARHL) and cognitive decline using only pure-tone thresholds as the audiometric criteria ( JAMA Otolaryngol Head Neck Surg 2017. doi: 10.1001/jamaoto.2017.2513). Thirty-six unique studies found in PubMed, the Cochrane Library, EMBASE, and SCOPUS with about 20,264 participants were included in this study. The authors found a significant association between ARHL and dementia, and a small but statistically significant association between ARHL and all 10 cognitive domains that were investigated in this analyze, including global cognition, executive functions (attention, fluency, reasoning, and working memory), episodic memory (delayed and immediate recall), processing speed, semantic memory, and visuospatial ability. ARHL was also found to have a statistically significant association with cognitive impairment.
The authors said the causal mechanisms between ARHL and cognitive decline remain unclear, but one hypothesis is a common etiology like decline in the vascular system or a broader physiological decline. ARHL has been linked with multiple indicators of functional decline and is a biomarker for frailty syndrome, which has been causally linked to dementia. The authors also noted other hypotheses suggesting that ARHL may be causing cognitive decline through impaired speech perception. They recommended more randomized clinical trials exploring the cognitive benefit of hearing loss treatment and more research on whether treatment, alone or as part of a wider approach to risk factors, modifies dementia outcomes.
Published: 12/15/2017 12:15:00 PM
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Depth matters - Towards finding an objective neurophysiological measure of behavioral amplitude modulation detection based on neural threshold determination
Publication date: Available online 14 December 2017
Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
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Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
Graphical abstract
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Depth matters - Towards finding an objective neurophysiological measure of behavioral amplitude modulation detection based on neural threshold determination
Publication date: Available online 14 December 2017
Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
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Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
Graphical abstract
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Depth matters - Towards finding an objective neurophysiological measure of behavioral amplitude modulation detection based on neural threshold determination
Publication date: Available online 14 December 2017
Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
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Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
Graphical abstract
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Depth matters - Towards finding an objective neurophysiological measure of behavioral amplitude modulation detection based on neural threshold determination
Publication date: Available online 14 December 2017
Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
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Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
Graphical abstract
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Depth matters - Towards finding an objective neurophysiological measure of behavioral amplitude modulation detection based on neural threshold determination
Publication date: Available online 14 December 2017
Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
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Source:Hearing Research
Author(s): Saskia M. Waechter, Alejandro Lopez-Valdes, Cristina Simoes-Franklin, Laura Viani, Richard B. Reilly
With increasing numbers undergoing intervention for hearing impairment at a young age, the clinical need for objective assessment tools of auditory discrimination abilities is growing. Amplitude modulation (AM) sensitivity has been known to be an important factor for speech recognition particularly among cochlear implant (CI) users. It therefore would be useful to develop objective measures of AM detection for future clinical assessment of CI users; this study aimed to verify the feasibility of a neurophysiological approach studying a cohort of normal-hearing participants. The mismatch waveform (MMW) was evaluated as a potential objective measure of AM detection for a low modulation rate (8 Hz). This study also explored the relationship between behavioral AM detection and speech-in-noise recognition. The following measures were obtained for 15 young adults with no known hearing impairment: (1) psychoacoustic sinusoidal AM detection ability for a modulation rate of 8 Hz; (2) neural AM detection thresholds estimated from morphology weighted cortical auditory evoked potentials elicited to various AM depths; and (3) AzBio sentence scores for speech-in-noise recognition. No significant correlations were found between speech recognition and behavioral AM detection measures. Individual neural thresholds were obtained from MMW data and showed significant positive correlations with behavioral AM detection thresholds. Neural thresholds estimated from morphology weighted MMWs provide a novel, objective approach for assessing low-rate AM detection. The findings of this study encourage the continued investigation of the MMW as a neural correlate of low-rate AM detection in larger normal-hearing cohorts and subsequently in clinical cohorts such as cochlear implant users.
Graphical abstract
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Hearing from the Other Side: Understanding the Candidacy for SSD and Treatment Options
This course will provide professionals with an up-to-date overview about treatment options for patients with conductive hearing loss, mixed hearing loss and single-sided deafness. 
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Hearing from the Other Side: Understanding the Candidacy for SSD and Treatment Options
This course will provide professionals with an up-to-date overview about treatment options for patients with conductive hearing loss, mixed hearing loss and single-sided deafness.
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Hearing from the Other Side: Understanding the Candidacy for SSD and Treatment Options
This course will provide professionals with an up-to-date overview about treatment options for patients with conductive hearing loss, mixed hearing loss and single-sided deafness.
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