Janet Clarke: It is my honor to speak to you today about the Nucleus 22 implant upgrade to the Nucleus 6 sound processor. There are several handouts available for you. Please make sure that you download those. They are also be available on myCochlear.com. The learning objectives are to ensure that we can perform these upgrades in an efficient manner to optimize patient outcomes.
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Κυριακή 7 Φεβρουαρίου 2016
From Pioneer to Modern Day: The Nucleus 22 Implant Upgrade to the Nucleus 6 System
Janet Clarke: It is my honor to speak to you today about the Nucleus 22 implant upgrade to the Nucleus 6 sound processor. There are several handouts available for you. Please make sure that you download those. They are also be available on myCochlear.com. The learning objectives are to ensure that we can perform these upgrades in an efficient manner to optimize patient outcomes.
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Minimally Invasive Ponto Surgery - A New Perspective on Bone Anchored Surgery
Dr. Holmberg: Today’s course will focus on why we have developed minimally invasive Ponto surgery (MIPS), how it is done, the preclinical clinical results, as well as patient benefits. We’ll start with indications and benefits of bone anchored hearing implants. Then, we will discuss the MIPS in detail, why it's done, review the new instrumentation and components, and show how surgery is performed. It may be helpful for you to explain this to patients that might be anxious about undergoing surgery. I will also go over results from the development work and clinical work we've been doing for the past two years, and I’ll save time for questions and answers at the end. 
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20Q: Tinnitus and Hyperacusis - Reassessment of an Old Problem
I seem to be hearing more and more about tinnitus research. Is there really that much more to learn?It’s certainly true that tinnitus has been studied for some time, but yes, there still is much more to learn and much that we already know, but perhaps forgotten. Patients with tinnitus react in a complex manner involving many brain regions with different functions. The brain networks responsible for tinnitus and their relative weights create unique characteristics for each patient. The better we understand this relationship, the better we can offer assistance and treatment strategies. 
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From Pioneer to Modern Day: The Nucleus 22 Implant Upgrade to the Nucleus 6 System
Janet Clarke: It is my honor to speak to you today about the Nucleus 22 implant upgrade to the Nucleus 6 sound processor. There are several handouts available for you. Please make sure that you download those. They are also be available on myCochlear.com. The learning objectives are to ensure that we can perform these upgrades in an efficient manner to optimize patient outcomes.
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HEI-OC1 Cells as a Model for Investigating Prestin Function
Publication date: Available online 6 February 2016
Source:Hearing Research
Author(s): Channy Park, Pru Thein, Gilda Kalinec, Federico Kalinec
The House Ear Institute–Organ of Corti 1 (HEI-OC1) is a mouse auditory cell line that endogenously express, among other several markers of cochlear hair cells, the motor protein prestin (SLC26A5). Since its discovery fifteen years ago, and because of the difficulties associated with working with outer hair cells, prestin studies have been performed mostly by expressing it exogenously in non-specific systems such as HEK293 and TSA201, embryonic kidney cells from human origin, or Chinese Hamster Ovary (CHO) cells. Here, we report flow cytometry and confocal laser scanning microscopy studies on the pattern of prestin expression, as well as nonlinear capacitance (NLC) and whole cell-patch clamping studies on prestin motor function, in HEI-OC1 cells cultured at permissive and non-permissive conditions. Our results indicate that both total prestin expression and plasma membrane localization increase in a time-dependent manner when HEI-OC1 cells differentiate under non-permissive culture conditions. In addition, we demonstrate that HEI-OC1 cells have a robust NLC associated to prestin motor function, which decreases when the density of prestin molecules present at the plasma membrane increases. Altogether, our results show that the response of endogenously expressed prestin in HEI-OC1 cells is different from the response of prestin expressed exogenously in non-auditory cells, and suggest that the HEI-OC1 cell line may be an important additional tool for investigating prestin function.
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Source:Hearing Research
Author(s): Channy Park, Pru Thein, Gilda Kalinec, Federico Kalinec
The House Ear Institute–Organ of Corti 1 (HEI-OC1) is a mouse auditory cell line that endogenously express, among other several markers of cochlear hair cells, the motor protein prestin (SLC26A5). Since its discovery fifteen years ago, and because of the difficulties associated with working with outer hair cells, prestin studies have been performed mostly by expressing it exogenously in non-specific systems such as HEK293 and TSA201, embryonic kidney cells from human origin, or Chinese Hamster Ovary (CHO) cells. Here, we report flow cytometry and confocal laser scanning microscopy studies on the pattern of prestin expression, as well as nonlinear capacitance (NLC) and whole cell-patch clamping studies on prestin motor function, in HEI-OC1 cells cultured at permissive and non-permissive conditions. Our results indicate that both total prestin expression and plasma membrane localization increase in a time-dependent manner when HEI-OC1 cells differentiate under non-permissive culture conditions. In addition, we demonstrate that HEI-OC1 cells have a robust NLC associated to prestin motor function, which decreases when the density of prestin molecules present at the plasma membrane increases. Altogether, our results show that the response of endogenously expressed prestin in HEI-OC1 cells is different from the response of prestin expressed exogenously in non-auditory cells, and suggest that the HEI-OC1 cell line may be an important additional tool for investigating prestin function.
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HEI-OC1 Cells as a Model for Investigating Prestin Function
Publication date: Available online 6 February 2016
Source:Hearing Research
Author(s): Channy Park, Pru Thein, Gilda Kalinec, Federico Kalinec
The House Ear Institute–Organ of Corti 1 (HEI-OC1) is a mouse auditory cell line that endogenously express, among other several markers of cochlear hair cells, the motor protein prestin (SLC26A5). Since its discovery fifteen years ago, and because of the difficulties associated with working with outer hair cells, prestin studies have been performed mostly by expressing it exogenously in non-specific systems such as HEK293 and TSA201, embryonic kidney cells from human origin, or Chinese Hamster Ovary (CHO) cells. Here, we report flow cytometry and confocal laser scanning microscopy studies on the pattern of prestin expression, as well as nonlinear capacitance (NLC) and whole cell-patch clamping studies on prestin motor function, in HEI-OC1 cells cultured at permissive and non-permissive conditions. Our results indicate that both total prestin expression and plasma membrane localization increase in a time-dependent manner when HEI-OC1 cells differentiate under non-permissive culture conditions. In addition, we demonstrate that HEI-OC1 cells have a robust NLC associated to prestin motor function, which decreases when the density of prestin molecules present at the plasma membrane increases. Altogether, our results show that the response of endogenously expressed prestin in HEI-OC1 cells is different from the response of prestin expressed exogenously in non-auditory cells, and suggest that the HEI-OC1 cell line may be an important additional tool for investigating prestin function.
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Source:Hearing Research
Author(s): Channy Park, Pru Thein, Gilda Kalinec, Federico Kalinec
The House Ear Institute–Organ of Corti 1 (HEI-OC1) is a mouse auditory cell line that endogenously express, among other several markers of cochlear hair cells, the motor protein prestin (SLC26A5). Since its discovery fifteen years ago, and because of the difficulties associated with working with outer hair cells, prestin studies have been performed mostly by expressing it exogenously in non-specific systems such as HEK293 and TSA201, embryonic kidney cells from human origin, or Chinese Hamster Ovary (CHO) cells. Here, we report flow cytometry and confocal laser scanning microscopy studies on the pattern of prestin expression, as well as nonlinear capacitance (NLC) and whole cell-patch clamping studies on prestin motor function, in HEI-OC1 cells cultured at permissive and non-permissive conditions. Our results indicate that both total prestin expression and plasma membrane localization increase in a time-dependent manner when HEI-OC1 cells differentiate under non-permissive culture conditions. In addition, we demonstrate that HEI-OC1 cells have a robust NLC associated to prestin motor function, which decreases when the density of prestin molecules present at the plasma membrane increases. Altogether, our results show that the response of endogenously expressed prestin in HEI-OC1 cells is different from the response of prestin expressed exogenously in non-auditory cells, and suggest that the HEI-OC1 cell line may be an important additional tool for investigating prestin function.
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Fitting recommendations and clinical benefit associated with use of the NAL-NL2 hearing-aid prescription in Nucleus cochlear implant recipients
10.3109/14992027.2015.1133936<br/>Ruth English
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Normative data on audiovisual speech integration using sentence recognition and capacity measures
10.3109/14992027.2015.1120895<br/>Nicholas Altieri
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Fitting recommendations and clinical benefit associated with use of the NAL-NL2 hearing-aid prescription in Nucleus cochlear implant recipients
10.3109/14992027.2015.1133936<br/>Ruth English
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Normative data on audiovisual speech integration using sentence recognition and capacity measures
10.3109/14992027.2015.1120895<br/>Nicholas Altieri
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Light finger contact concurrently reduces postural sway and enhances signal detection performance in children with developmental coordination disorder
Publication date: Available online 6 February 2016
Source:Gait & Posture
Author(s): Fu-Chen Chen, Chia-Liang Tsai
The current study examined the effects of light finger touch on postural sway and signal detection performance in children with developmental coordination disorder (DCD). Children with DCD (n=30; 18 boys, 12 girls; age=11.87±0.48 years) and typically developing children (n=30; 14 boys, 16 girls; age=11.73±0.52 years) were recruited from schools in Pintung County, Taiwan. Participants completed a signal detection task under no finger touch (NT) and light finger touch (LT) conditions, while postural sway in both anteroposterior (AP) and mediolateral (ML) axes was recorded. In both conditions, children with DCD exhibited significantly higher levels of postural sway (p<0.05) and lower signal detection performances (p<0.05) than TDC. Additionally, both groups significantly reduced postural sway (p<0.05) and enhanced signal detection performance (p<0.05) when engaged in light finger touch compared with no finger touch. While the effect of LT on postural sway was greater among TDC relative to children with DCD (p<0.05), the effect of LT on signal detection was greater in children with DCD compared with TDC (p<0.05). These results suggest that light finger touch is effective in concurrently reducing postural sway and enhancing signal detection in both groups.
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Source:Gait & Posture
Author(s): Fu-Chen Chen, Chia-Liang Tsai
The current study examined the effects of light finger touch on postural sway and signal detection performance in children with developmental coordination disorder (DCD). Children with DCD (n=30; 18 boys, 12 girls; age=11.87±0.48 years) and typically developing children (n=30; 14 boys, 16 girls; age=11.73±0.52 years) were recruited from schools in Pintung County, Taiwan. Participants completed a signal detection task under no finger touch (NT) and light finger touch (LT) conditions, while postural sway in both anteroposterior (AP) and mediolateral (ML) axes was recorded. In both conditions, children with DCD exhibited significantly higher levels of postural sway (p<0.05) and lower signal detection performances (p<0.05) than TDC. Additionally, both groups significantly reduced postural sway (p<0.05) and enhanced signal detection performance (p<0.05) when engaged in light finger touch compared with no finger touch. While the effect of LT on postural sway was greater among TDC relative to children with DCD (p<0.05), the effect of LT on signal detection was greater in children with DCD compared with TDC (p<0.05). These results suggest that light finger touch is effective in concurrently reducing postural sway and enhancing signal detection in both groups.
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Unilateral hip osteoarthritis: Its effects on preoperative lower limb muscle activation and intramuscular coordination patterns
Publication date: Available online 6 February 2016
Source:Gait & Posture
Author(s): André Schmidt, Felix Stief, Katharina Lenarz, Dara Froemel, Frederick Lutz, John Barker, Andrea Meurer
The objective of this study was to test if patients with unilateral hip osteoarthritis (OA) show greater muscle activity asymmetry between their affected and non-affected limbs than healthy controls between their left and right limbs. Seventeen patients with unilateral hip OA (7 females, 10 males) and 17 age-matched healthy controls (7 females, 10 males) participated in this study. Both groups performed instrumented gait analysis at comparable speeds. Muscle activity was recorded simultaneously for the tibialis anterior (TA), gastrocnemius medialis (GM), vastus lateralis (VL), semitendinosus (ST), tensor fasciae latae (TFL), and gluteus medius (GLM) muscles. In hip OA patients, EMG data showed greater activity of the TA muscle in the non-affected limb, and greater TFL muscle activity in the affected limb. Compared to healthy controls, greater asymmetries between paired limbs were observed for the TA and GM muscles. Finally, the TFL muscle of the affected limb contributed more to the total limb muscle activity than did the non-affected limb. The observed alterations in TA and GM muscle activity in hip OA patients may be due to the greater peak braking and peak vertical forces measured in the non-affected limb. Contrary to this, greater TLF muscle activity of the affected limb indicates the demands put on stabilizing the hip during stance phase. Further studies are necessary to test whether leg length discrepancy affects muscle activation alterations between the affected and non-affected limb in unilateral hip OA patients.
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Source:Gait & Posture
Author(s): André Schmidt, Felix Stief, Katharina Lenarz, Dara Froemel, Frederick Lutz, John Barker, Andrea Meurer
The objective of this study was to test if patients with unilateral hip osteoarthritis (OA) show greater muscle activity asymmetry between their affected and non-affected limbs than healthy controls between their left and right limbs. Seventeen patients with unilateral hip OA (7 females, 10 males) and 17 age-matched healthy controls (7 females, 10 males) participated in this study. Both groups performed instrumented gait analysis at comparable speeds. Muscle activity was recorded simultaneously for the tibialis anterior (TA), gastrocnemius medialis (GM), vastus lateralis (VL), semitendinosus (ST), tensor fasciae latae (TFL), and gluteus medius (GLM) muscles. In hip OA patients, EMG data showed greater activity of the TA muscle in the non-affected limb, and greater TFL muscle activity in the affected limb. Compared to healthy controls, greater asymmetries between paired limbs were observed for the TA and GM muscles. Finally, the TFL muscle of the affected limb contributed more to the total limb muscle activity than did the non-affected limb. The observed alterations in TA and GM muscle activity in hip OA patients may be due to the greater peak braking and peak vertical forces measured in the non-affected limb. Contrary to this, greater TLF muscle activity of the affected limb indicates the demands put on stabilizing the hip during stance phase. Further studies are necessary to test whether leg length discrepancy affects muscle activation alterations between the affected and non-affected limb in unilateral hip OA patients.
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Multiple Sclerosis Influences the Precision of the Ankle Plantarflexon Muscular Force Production
Publication date: Available online 6 February 2016
Source:Gait & Posture
Author(s): David J. Arpin, Brenda L. Davies, Max J. Kurz
The primary aim of this investigation was to quantify the precision of the steady-state isometric control of the ankle plantarflexors musculature of individuals with multiple sclerosis (MS), and to evaluate if the precision is related to the mobility impairments. Individuals with MS and healthy adults performed a submaximal steady-state isometric contraction with the ankle plantarflexors. The coefficient of variation was used to assess the amount of variability or error in the precision of the torques generated by the ankle plantarflexor musculature. The participants also walked across a digital mat at their preferred and fast-as-possible walking speeds, which recorded their spatiotemporal gait kinematics. The results of this investigation were that the individuals with MS: 1) had reduced maximal voluntary torques at the ankle, 2) a greater amount of variability in the precision of the isometric ankle torques, 3) altered and more variable spatiotemporal gait kinematics, and 4) a greater amount of variability in the isometric ankle torques were related to a slower walking speed and cadence, shorter step length and a greater amount of gait variability. These results further fuels the impression that a reduction in control of the ankle joint musculature may be a key factor in the mobility and balance impairments seen in individuals with MS.
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Source:Gait & Posture
Author(s): David J. Arpin, Brenda L. Davies, Max J. Kurz
The primary aim of this investigation was to quantify the precision of the steady-state isometric control of the ankle plantarflexors musculature of individuals with multiple sclerosis (MS), and to evaluate if the precision is related to the mobility impairments. Individuals with MS and healthy adults performed a submaximal steady-state isometric contraction with the ankle plantarflexors. The coefficient of variation was used to assess the amount of variability or error in the precision of the torques generated by the ankle plantarflexor musculature. The participants also walked across a digital mat at their preferred and fast-as-possible walking speeds, which recorded their spatiotemporal gait kinematics. The results of this investigation were that the individuals with MS: 1) had reduced maximal voluntary torques at the ankle, 2) a greater amount of variability in the precision of the isometric ankle torques, 3) altered and more variable spatiotemporal gait kinematics, and 4) a greater amount of variability in the isometric ankle torques were related to a slower walking speed and cadence, shorter step length and a greater amount of gait variability. These results further fuels the impression that a reduction in control of the ankle joint musculature may be a key factor in the mobility and balance impairments seen in individuals with MS.
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