The PROfound study or the arrival of personalised medicine in the treatment of prostate cancer

xlomafota13 shared this article with you from Inoreader The PROfound study or the arrival of personalised medicine in the treatment of prostate cancer Via Association française pour l'étude du cancer Bull Cancer. 2021 Mar 12:S0007-4551(21)00042-4. doi: 10.1016/j.bulcan.2020.11.016. Online ahead of print. NO ABSTRACT PMID:33722378 | DOI:10.1016/j.bulcan.2020.11.016 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Adult non-Hodgkin bone lymphomas

xlomafota13 shared this article with you from Inoreader Adult non-Hodgkin bone lymphomas Via Association française pour l'étude du cancer Bull Cancer. 2021 Mar 12:S0007-4551(21)00070-9. doi: 10.1016/j.bulcan.2020.12.010. Online ahead of print. ABSTRACT Two forms of bone lymphomas can be distinguished: the primary bone lymphoma (PBL) and the secondary bone lymphoma (SBL). PBL is a rare disease with a good prognosis. Clinical manifestations and imaging findings are usually non-specific. Patient can present with pain, swelling of affected bone or pathologic fracture. Positron emission tomography-CT scan is a sensitive imaging modality and very useful for staging, restaging, surveillance of recurrence, and monitoring of treatment response of lymphoma. The diagnosis of PBL is often difficult and made after biopsy examination. Most patients have diffuse large B-cell lymphoma. Patients have been treated with radiotherapy, chemotherapy or combination of both. Localized disease, low IPI (International Prognostic Index) and complete remission after initial treatment were associate d with a better outcome. Management of late sequelae deserves particular attention. SBL is more common than PBL; this is a disseminated lymphoma with concomitant involvement of the skeleton. We review the clinical, imaging and pathologic features of bone lymphomas; and discuss therapeutic modalities as well as prognosis of these lymphomas in the era of immunochemotherapy. PMID:33722379 | DOI:10.1016/j.bulcan.2020.12.010 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Delayed facial palsy after cochlear implantation caused by reactivation of Herpesvirus: A case report and review of the literature

xlomafota13 shared this article with you from Inoreader Delayed facial palsy after cochlear implantation caused by reactivation of Herpesvirus: A case report and review of the literature Via Auris Nasus Larynx Publication date: Available online 15 March 2021 Source: Auris Nasus Larynx Author(s): Yui Ishikawa, Makoto Hosoya, Sho Kanzaki, Kaoru Ogawa View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The effects of residual parotid volume on symptom-specific quality of life and complications in patients undergoing parotid surgery

xlomafota13 shared this article with you from Inoreader The effects of residual parotid volume on symptom-specific quality of life and complications in patients undergoing parotid surgery Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 15. doi: 10.1007/s00405-021-06742-4. Online ahead of print. ABSTRACT PURPOSE: To measure postoperative residual parotid volumes in parotidectomy patients and to measure the effect of residual parotid volumes on the symptom-specific quality of life (SSQOL) and complications. METHODS: Between January 2010 and December 2016, 148 parotid gland surgeries were performed, and 74 patients were included in the study. Bilateral parotid gland volumes were measured by Magnetic Resonance Imaging (MRI). Parotidectomy Outcome Inventory-8 and aesthetic scale questionnaire were applied to the patients. The volumetric averages obtained were compared with the questions in the SSQOL scale, the aesthetic scale data, and complications. RESULTS: In the volumetric examination performed with MRI, the mean residual volumes of the operated parotid glands were 9.5 cm3, while the non-operated side was 28.8 cm3. The width of the surgery and the residual parotid tissue volume was inversely correlated. There was a statistically significant difference between the residual parotid gland volume and the pain related to the surgical area, depression in the surgical site, Frey's syndrome, incision scar, and numbness. As the residual parotid gland volumes decreased, the patients' cosmetic problems related to the surgical field increased significantly, and their SSQOL decreased. CONCLUSION: Postoperative residual parotid tissue volume could be an objective parameter to measure patients' SSQOL and complications. After parotidectomy, the maximum amount of disease-free tissue of the parotid gland should be left in place to increase patients' quality of life and minimize complications. PMID:33723622 | DOI:10.1007/s00405-021-06742-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Ring finger protein 126: a potential biomarker for colorectal cancer

xlomafota13 shared this article with you from Inoreader Ring finger protein 126: a potential biomarker for colorectal cancer Via Cellular and Molecular Biology Histol Histopathol. 2021 Mar 16:18328. doi: 10.14670/HH-18-328. Online ahead of print. ABSTRACT BACKGROUND: Colorectal cancer (CRC) is the most common cancer of the digestive system. However, effective therapeutic targets against CRC have not been found yet. Further, the relationship between the expression of ring finger protein 126 (RNF126) and CRC is not clear. MATERIAL AND METHODS: The expression level of RNF126 in CRC tissues and cell lines was detected by immunohistochemical staining and western blot. Subsequently, endogenous RNF126 expression was inhibited in a CRC cell line using a short hairpin RNA. Next, the effect of RNF126 on the properties of CRC cells was studied through different experimental methods. RESULTS: We found that the RNF126 protein was mainly localized in the cytoplasm. High RNF126 expression was observed to be an independent risk factor for poor prognosis in CRC patients. In vitro studies showed th at RNF126 was able to promote the proliferation, migration, and invasion ability of CRC cells. CONCLUSION: RNF126 acts as an oncogene during CRC development, and may serve as a novel target for CRC treatment. PMID:33724438 | DOI:10.14670/HH-18-328 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Differences between cancer patients and others who use medicinal Cannabis

xlomafota13 shared this article with you from Inoreader Differences between cancer patients and others who use medicinal Cannabis Via Head and neck cancers by Matthew M. Cousins, Mary Jannausch, Reshma Jagsi, Mark Ilgen Background Cancer patients have been at the forefront of policy discussions leading to legalization of medical Cannabis (marijuana). Unfortunately, Cannabis use among those with cancer is poorly understood. Methods A diverse group of patients seeking certification for medical Cannabis in the state of Michigan were surveyed at the time of their presentation to medical dispensaries. The survey assessed demographics, employment/disability, pain, physical functioning, mental health, mode of Cannabis use, and frequency/amount of Cannabis use. Chi-square and t-tests were performed to compare those who did and did not endorse cancer diagnosis. Results Analysis of data from 1485 adults pursuing medical Cannabis certification, including 72 (4.8%) reporting a cancer diagnosis, indicated that those with cancer were older [mean age 53.4 years (SD = 10.5) vs. 44.7 years (SD = 13.0); p Conclusions Patients with cancer who are seeking medical Cannabis are different from thos e seeking medical Cannabis without cancer, and they report using Cannabis differently. Further research to characterize the patterns and consequences of Cannabis use in cancer patients is needed. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is antibiotic prophylaxis expendable in parotid gland surgery? A retrospective analysis of surgical site infection rates

xlomafota13 shared this article with you from Inoreader Is antibiotic prophylaxis expendable in parotid gland surgery? A retrospective analysis of surgical site infection rates Via Clinical Otolaryngology Abstract Objectives To evaluate the rate of surgical site infection (SSI) and associated risk factors after parotid gland surgery including the impact of antibiotic prophylaxis. Design Retrospective single‐center clinical study. Setting Tertiary referral center for head and neck surgery Participants 754 patients who underwent parotid gland surgery at the University Hospital Heidelberg, Germany between 2007 and 2014 were enrolled in this study. Data on patient age, American Society of Anesthesiologists (ASA) classification system, smoking status, diabetes mellitus, operation time, and antibiotic prophylaxis were collected. Additionally, the National Healthcare Safety Network (NHSN) risk index was calculated. Association of these factors with SSI was evaluated in univariate analyses and a multivariate logistic regression model. Main outcome measures Rate of SSI. Results 24 patients (3.2%) had an SSI according to the NHSN definition. In univariate analyses, only smokers (p = 0.048) and male patients (p = 0.01) had a significantly higher rate of SSI. Since the majority of smokers were men (62.3%), the effect of male gender, smoking, together with the NHSN risk index were further investigated as predictors of SSI within a logistic regression model. All three predictors showed a significant effect on SSI. Conclusions Parotid gland surgery has a low rate of SSI. In our cohort, male gender, smoking, and high NHSN risk index scores were significantly associated with SSI, whereas antibiotic prophylaxis had no protective effect. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Diagnosis of isolated congenital anosmia using simultaneous functional magnetic resonance imaging and olfactory event‐related potentials: Our experience in six patients

xlomafota13 shared this article with you from Inoreader Diagnosis of isolated congenital anosmia using simultaneous functional magnetic resonance imaging and olfactory event‐related potentials: Our experience in six patients Via Clinical Otolaryngology Abstract ‐ Primary anosmia is usually associated with Kallmann syndrome, which is characterized by hormonal abnormalities such as hypogonadotropic hypogonadism. ‐ On very rare occasions, a primary anosmia presents as olfactory bulb agenesis without this associated syndrome. ‐ In previous studies of such cases, diagnosis is usually based on the absence of an olfactory bulb on structural MRI, rather than on objective functional measures. ‐ Simultaneous functional MRI and olfactory event‐related potential recordings can provide highly objective evidence of olfactory function. ‐ We examined both structural and functional MRI and olfactory event‐related potential data to diagnose primary anosmia with isolated olfactory bulb agenesis, gaining objective evidence of olfactory function. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Phonation Resistance Training Exercises (PhoRTE) With and Without Expiratory Muscle Strength Training (EMST) For Patients With Presbyphonia: A Noninferiority Randomized Clinical Trial

xlomafota13 shared this article with you from Inoreader Phonation Resistance Training Exercises (PhoRTE) With and Without Expiratory Muscle Strength Training (EMST) For Patients With Presbyphonia: A Noninferiority Randomized Clinical Trial Via Journal of Voice Presbyphonia negatively impacts quality of life in patients with age-related voice changes. A proof-of-concept study showed promise for high vocal intensity exercise to treat presbyphonia, which became the basis for a novel intervention for age-related voice changes known as Phonation Resistance Training Exercises (PhoRTE). Expiratory Muscle Strength Training (EMST) has also been proposed as an additional intervention to target and strengthen the aging respiratory system; however, EMST has undergone limited evaluation as an adjunct treatment for elderly patients undergoing voice therapy for presbyphonia. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Impact of Site, Size and Duration of Tympanic Membrane Perforation on Hearing Loss and Postsurgical Outcome

xlomafota13 shared this article with you from Inoreader Impact of Site, Size and Duration of Tympanic Membrane Perforation on Hearing Loss and Postsurgical Outcome Via Otolaryngology Indian Abstract This paper aims to assess correlation of site, size and duration of tympanic membrane perforation with hearing loss using pure tone audiogram and surgical outcome in terms of above parameters. The present study was conducted on 100 patients in Department of ENT and HNS, SMGS Hospital, Government Medical College Jammu during a time period of November 2018 to October 2019. All the patients with age 15–60 years who presented with tympanic membrane (pars tensa) perforation were included in the study. According to the size of perforation, mean pure tone threshold in group I was 20.87 ± 3.86 dB, in group II was 26.45 ± 6.08 dB and in group III was 32.6 ± 5.56 dB. The difference in hearing threshold between all the three groups was significant statistically. In terms of site, group E had maximum hearing threshold (34.67 ± 4.20 dB), followed by group B (32.71 ± 5.88 dB). Group A had the lowest hearing threshold of 24.99 ± 6.21 dB. The difference between hearing thresholds of group B perforations and group A perforations was statistically significant (p < 0.05). However, the difference between group E and group B was insignificant. This study has shown significant correlation between the size and the site of the perforation to the degree of hearing loss. The bigger the perforation, the greater the hearing loss. The central perforations were associated with more hearing loss than posterior perforations, thus refuting the hypothesis that site and size of a tympanic membrane perforation does not affect the degree of conductive hearing loss. This study did not show any correlation between duration of disease and degree of hearing loss. Surgical and audiometric results obtained in this study can be accepted as satisfactory and as expected by the literature. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Translation and validation of the Voice Handicap Index in Tamil language

xlomafota13 shared this article with you from Inoreader Translation and validation of the Voice Handicap Index in Tamil language Via Otolaryngology Indian Abstract Voice Handicap Index (VHI) is the most commonly used tool to assess the quality of life in voice disordered patients. A validated Tamil language version of VHI is not developed yet. Hence, this study was undertaken to translate and validate the Voice Handicap Index in Tamil language, which can potentially benefit Tamil speaking patients with voice disorders. This was a translation and tool validation study done at a tertiary care teaching hospital using an analytical, follow up design according to WHO guidelines. Dysphonic (Group A) and Normal (Group B) respondents were purposively invited to fill a self administered VHI-Tamil questionnaire. The content validity, response process validity, internal consistency and clinical validity of the questionnaire was calculated using appropriate statistical analysis methods using SPSS version 24.0 software. Out of 117 respondents, 61 respondents were dysphonic (Group A) and 56 respondents were normal (Group B). Overall inde x for content validation was over 0.84, and response process validation was 1.00 in all domains. Overall internal consistency was excellent, with Cronbach's alpha of 0.993. Excellent test–retest reliability was identified using the Spearman rank correlation coefficient (r = 0.96; p-value < 0.001). For clinical validity, a statistically significant difference between the dysphonic and the normal groups, for the overall VHI-Tamil scores and each of the three domain scores was noted. VHI-Tamil was found to be reliable and valid for assessing the quality of life in patients with voice disorders. It can be recommended for future use among Tamil speaking population. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hormonal influence on hearing

xlomafota13 shared this article with you from Inoreader Hormonal influence on hearing Via hno HNO. 2021 Mar 16. doi: 10.1007/s00106-021-01019-y. Online ahead of print. ABSTRACT BACKGROUND: Hearing loss leads to impairments in communication, social interactions, and cognitive functions. This renders early treatment particularly important. A causal therapy is not yet available. Human and animal studies have shown that certain hormones can have a positive effect on hearing. OBJECTIVE: This review provides an overview of the effects of various hormones on hearing a nd describes the potential benefit for future therapeutic approaches. MATERIALS AND METHODS: A systematic literature review of reviews dealing with the effects of various hormones on hearing in humans and animals published in PubMed between 2015 and 2020 was conducted. RESULTS: Hormones may mediate antiapoptotic effects on structure-relevant cells of the cochlea and auditory pathway, and may influence hair cell functionality or the electrolyte balance of the endo- and perilymph. Current research focuses on glucocorticoids; the mineral corticoid aldosterone; the sex hormones estrogen, progesterone, and testosterone; the growth hormones GH (growth hormone) and IGF‑1 (insulin-like growth factor 1); thyroid hormones; and insulin. Study results are still inconsistent at this time, but various hormones appear to represent a possible future treatment option for acute hearing loss. Long-term hormone treatment, which would be necessary particularly in the case of age-related he aring loss, does not currently represent a sensible course of action due to the side effect profile of the systemic treatment/lack of practicable topical application options. CONCLUSION: The mode of action of hormones is complex. Whether they can be used in the future for individualized treatment of patients with acute hearing impairment requires further investigation. PMID:33725160 | DOI:10.1007/s00106-021-01019-y View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.