OtoRhinoLaryngology by Sfakianakis G.Alexandros Sfakianakis G.Alexandros,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174
Πέμπτη 27 Ιουλίου 2017
Electrophysiological Evidence for the Sources of the Masking Level Difference
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Influences of Phonological Context on Tense Marking in Spanish–English Dual Language Learners
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Electrophysiological Evidence for the Sources of the Masking Level Difference
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Influences of Phonological Context on Tense Marking in Spanish–English Dual Language Learners
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Electrophysiological Evidence for the Sources of the Masking Level Difference
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Influences of Phonological Context on Tense Marking in Spanish–English Dual Language Learners
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Erratum to: A Modeling Study of the Responses of the Lateral Superior Olive to Ipsilateral Sinusoidally Amplitude-Modulated Tones
Otoliths - Accelerometer and seismometer; Implications in Vestibular Evoked Myogenic Potential (VEMP)
Source:Hearing Research
Author(s): Wally Grant, Ian Curthoys
Vestibular otolithic organs are recognized as transducers of head acceleration and they function as such up to their corner frequency or undamped natural frequency. It is well recognized that these organs respond to frequencies above their corner frequency up to the 2–3 kHz range (Curthoys et al., 2016). A mechanics model for the transduction of these organs is developed that predicts the response below the undamped natural frequency as an accelerometer and above that frequency as a seismometer. The model is converted to a transfer function using hair cell bundle deflection. Measured threshold acceleration stimuli are used along with threshold deflections for threshold transfer function values. These are compared to model predicted values, both below and above their undamped natural frequency. Threshold deflection values are adjusted to match the model transfer function. The resulting threshold deflection values were well within in measure threshold bundle deflections. Vestibular Evoked Myogenic Potentials (VEMP) today routinely uses stimulus frequencies of 500 and 1000 Hz, and otoliths have been established incontrovertibly by clinical and neural evidence as the stimulus source. The mechanism for stimulus at these frequencies above the undamped natural frequency of otoliths is presented where otoliths are utilizing a seismometer mode of response for VEMPS transduction.
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Changes of metabolism and functional connectivity in late-onset deafness: Evidence from cerebral 18F-FDG-PET
Source:Hearing Research
Author(s): Antoine Verger, Stephane Roman, Rose-May Chaudat, Olivier Felician, Mathieu Ceccaldi, Mira Didic, Eric Guedj
Hearing loss is known to impact brain function. The aim of this study was to characterize cerebral metabolic Positron Emission Tomography (PET) changes in elderly patients fulfilling criteria for cochlear implant and investigate the impact of hearing loss on functional connectivity. Statistical Parametric Mapping-T-scores-maps comparisons of 18F-FDG-PET of 27 elderly patients fulfilling criteria for cochlear implant for hearing loss (best-aided speech intelligibility lower or equal to 50%) and 27 matched healthy subjects (p < 0.005, corrected for volume extent) were performed. Metabolic connectivity was evaluated through interregional correlation analysis. Patients were found to have decreased metabolism within the right associative auditory cortex, while increased metabolism was found in prefrontal areas, pre- and post-central areas, the cingulum and the left inferior parietal gyrus. The right associative auditory cortex was integrated into a network of increased metabolic connectivity that included pre- and post-central areas, the cingulum, the right inferior parietal gyrus, as well as the striatum on both sides. Metabolic values of the right associative auditory cortex and left inferior parietal gyrus were positively correlated with performance on neuropsychological test scores. These findings provide further insight into the reorganization of the connectome through sensory loss and compensatory mechanisms in elderly patients with severe hearing loss.
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Detecting temporal changes in acoustic scenes: The variable benefit of selective attention
Source:Hearing Research
Author(s): Laurent Demany, Yann Bayle, Emilie Puginier, Catherine Semal
Four experiments investigated change detection in acoustic scenes consisting of a sum of five amplitude-modulated pure tones. As the tones were about 0.7 octave apart and were amplitude-modulated with different frequencies (in the range 2–32 Hz), they were perceived as separate streams. Listeners had to detect a change in the frequency (experiments 1 and 2) or the shape (experiments 3 and 4) of the modulation of one of the five tones, in the presence of an informative cue orienting selective attention either before the scene (pre-cue) or after it (post-cue). The changes left intensity unchanged and were not detectable in the spectral (tonotopic) domain. Performance was much better with pre-cues than with post-cues. Thus, change deafness was manifest in the absence of an appropriate focusing of attention when the change occurred, even though the streams and the changes to be detected were acoustically very simple (in contrast to the conditions used in previous demonstrations of change deafness). In one case, the results were consistent with a model based on the assumption that change detection was possible if and only if attention was endogenously focused on a single tone. However, it was also found that changes resulting in a steepening of amplitude rises were to some extent able to draw attention exogenously. Change detection was not markedly facilitated when the change produced a discontinuity in the modulation domain, contrary to what could be expected from the perspective of predictive coding.
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In vivo recording of the vestibular microphonic in mammals
Source:Hearing Research
Author(s): C.J. Pastras, I.S. Curthoys, D.J. Brown
BackgroundThe Vestibular Microphonic (VM) has only featured in a handful of publications, mostly involving non-mammalian and ex vivo models. The VM is the extracellular analogue of the vestibular hair cell receptor current, and offers a tool to monitor vestibular hair cell activity in vivo.ObjectiveTo characterise features of the VM measured in vivo in guinea pigs, using a relatively simple experimental setup.MethodsThe VM, evoked by bone-conducted vibration (BCV), was recorded from the basal surface of either the utricular or saccular macula after surgical removal of the cochlea, in 27 guinea pigs.ResultsThe VM remained after vestibular nerve blockade, but was abolished following end-organ destruction or death. The VM reversed polarity as the recording electrode tracked across the utricular or saccular macula surface, or through the utricular macula. The VM could be evoked by BCV stimuli of frequencies between 100 Hz and 5 kHz, and was largest to vibrations between 600 Hz and 800 Hz. Experimental manipulations demonstrated a reduction in the VM amplitude with maculae displacement, or rupture of the utricular membrane.ConclusionsResults mirror those obtained in previous ex vivo studies, and further demonstrate that vestibular hair cells are sensitive to vibrations of several kilohertz. Changes in the VM with maculae displacement or rupture suggest utricular hydrops may alter vestibular hair cell sensitivity due to either mechanical or ionic changes.
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Tympanic membrane pressure buffering function at quasi-static and low-frequency pressure variations
Source:Hearing Research
Author(s): Wasil H.M. Salih, Pieter G.G. Muyshondt, Joris J.J. Dirckx
Deformation of the tympanic membrane is known to contribute to the pressure regulation processes in the middle ear cleft. In this paper we investigated pressure variations in the rabbit middle ear in response to sinusoidal varying pressures applied to the ear canal, with frequencies ranging from 0.5 Hz to 50 Hz and pressure amplitudes ranging between 0.25 kPa and 1 kPa. The transtympanic pressure difference was found to be smallest in the quasi-static range, and quickly increased as a function of frequency. The response curves showed asymmetry, with larger transtympanic pressures when positive pressures were applied in the ear canal. Normalized transtympanic pressure amplitudes remained fairly constant as a function of input pressure, with values in the range of 60%–70% relative to the applied pressure. The total harmonic distortion of the middle ear pressure signal was calculated and was found to be very small (≤2%) for low-pressure amplitudes and low frequencies. For pressure amplitudes in the order of 0.25 kPa–0.5 kPa, it increased to about 10% at 50 Hz. When a 1 kPa pressure amplitude was applied, variation between animals became large and distortion values up to 30% at 50 Hz were observed. The results showed that pressure buffering due to tympanic membrane displacement was most effective for compensating small transtympanic pressure loads at low frequencies.
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Otoliths - Accelerometer and seismometer; Implications in Vestibular Evoked Myogenic Potential (VEMP)
Source:Hearing Research
Author(s): Wally Grant, Ian Curthoys
Vestibular otolithic organs are recognized as transducers of head acceleration and they function as such up to their corner frequency or undamped natural frequency. It is well recognized that these organs respond to frequencies above their corner frequency up to the 2–3 kHz range (Curthoys et al., 2016). A mechanics model for the transduction of these organs is developed that predicts the response below the undamped natural frequency as an accelerometer and above that frequency as a seismometer. The model is converted to a transfer function using hair cell bundle deflection. Measured threshold acceleration stimuli are used along with threshold deflections for threshold transfer function values. These are compared to model predicted values, both below and above their undamped natural frequency. Threshold deflection values are adjusted to match the model transfer function. The resulting threshold deflection values were well within in measure threshold bundle deflections. Vestibular Evoked Myogenic Potentials (VEMP) today routinely uses stimulus frequencies of 500 and 1000 Hz, and otoliths have been established incontrovertibly by clinical and neural evidence as the stimulus source. The mechanism for stimulus at these frequencies above the undamped natural frequency of otoliths is presented where otoliths are utilizing a seismometer mode of response for VEMPS transduction.
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Changes of metabolism and functional connectivity in late-onset deafness: Evidence from cerebral 18F-FDG-PET
Source:Hearing Research
Author(s): Antoine Verger, Stephane Roman, Rose-May Chaudat, Olivier Felician, Mathieu Ceccaldi, Mira Didic, Eric Guedj
Hearing loss is known to impact brain function. The aim of this study was to characterize cerebral metabolic Positron Emission Tomography (PET) changes in elderly patients fulfilling criteria for cochlear implant and investigate the impact of hearing loss on functional connectivity. Statistical Parametric Mapping-T-scores-maps comparisons of 18F-FDG-PET of 27 elderly patients fulfilling criteria for cochlear implant for hearing loss (best-aided speech intelligibility lower or equal to 50%) and 27 matched healthy subjects (p < 0.005, corrected for volume extent) were performed. Metabolic connectivity was evaluated through interregional correlation analysis. Patients were found to have decreased metabolism within the right associative auditory cortex, while increased metabolism was found in prefrontal areas, pre- and post-central areas, the cingulum and the left inferior parietal gyrus. The right associative auditory cortex was integrated into a network of increased metabolic connectivity that included pre- and post-central areas, the cingulum, the right inferior parietal gyrus, as well as the striatum on both sides. Metabolic values of the right associative auditory cortex and left inferior parietal gyrus were positively correlated with performance on neuropsychological test scores. These findings provide further insight into the reorganization of the connectome through sensory loss and compensatory mechanisms in elderly patients with severe hearing loss.
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Detecting temporal changes in acoustic scenes: The variable benefit of selective attention
Source:Hearing Research
Author(s): Laurent Demany, Yann Bayle, Emilie Puginier, Catherine Semal
Four experiments investigated change detection in acoustic scenes consisting of a sum of five amplitude-modulated pure tones. As the tones were about 0.7 octave apart and were amplitude-modulated with different frequencies (in the range 2–32 Hz), they were perceived as separate streams. Listeners had to detect a change in the frequency (experiments 1 and 2) or the shape (experiments 3 and 4) of the modulation of one of the five tones, in the presence of an informative cue orienting selective attention either before the scene (pre-cue) or after it (post-cue). The changes left intensity unchanged and were not detectable in the spectral (tonotopic) domain. Performance was much better with pre-cues than with post-cues. Thus, change deafness was manifest in the absence of an appropriate focusing of attention when the change occurred, even though the streams and the changes to be detected were acoustically very simple (in contrast to the conditions used in previous demonstrations of change deafness). In one case, the results were consistent with a model based on the assumption that change detection was possible if and only if attention was endogenously focused on a single tone. However, it was also found that changes resulting in a steepening of amplitude rises were to some extent able to draw attention exogenously. Change detection was not markedly facilitated when the change produced a discontinuity in the modulation domain, contrary to what could be expected from the perspective of predictive coding.
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In vivo recording of the vestibular microphonic in mammals
Source:Hearing Research
Author(s): C.J. Pastras, I.S. Curthoys, D.J. Brown
BackgroundThe Vestibular Microphonic (VM) has only featured in a handful of publications, mostly involving non-mammalian and ex vivo models. The VM is the extracellular analogue of the vestibular hair cell receptor current, and offers a tool to monitor vestibular hair cell activity in vivo.ObjectiveTo characterise features of the VM measured in vivo in guinea pigs, using a relatively simple experimental setup.MethodsThe VM, evoked by bone-conducted vibration (BCV), was recorded from the basal surface of either the utricular or saccular macula after surgical removal of the cochlea, in 27 guinea pigs.ResultsThe VM remained after vestibular nerve blockade, but was abolished following end-organ destruction or death. The VM reversed polarity as the recording electrode tracked across the utricular or saccular macula surface, or through the utricular macula. The VM could be evoked by BCV stimuli of frequencies between 100 Hz and 5 kHz, and was largest to vibrations between 600 Hz and 800 Hz. Experimental manipulations demonstrated a reduction in the VM amplitude with maculae displacement, or rupture of the utricular membrane.ConclusionsResults mirror those obtained in previous ex vivo studies, and further demonstrate that vestibular hair cells are sensitive to vibrations of several kilohertz. Changes in the VM with maculae displacement or rupture suggest utricular hydrops may alter vestibular hair cell sensitivity due to either mechanical or ionic changes.
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Tympanic membrane pressure buffering function at quasi-static and low-frequency pressure variations
Source:Hearing Research
Author(s): Wasil H.M. Salih, Pieter G.G. Muyshondt, Joris J.J. Dirckx
Deformation of the tympanic membrane is known to contribute to the pressure regulation processes in the middle ear cleft. In this paper we investigated pressure variations in the rabbit middle ear in response to sinusoidal varying pressures applied to the ear canal, with frequencies ranging from 0.5 Hz to 50 Hz and pressure amplitudes ranging between 0.25 kPa and 1 kPa. The transtympanic pressure difference was found to be smallest in the quasi-static range, and quickly increased as a function of frequency. The response curves showed asymmetry, with larger transtympanic pressures when positive pressures were applied in the ear canal. Normalized transtympanic pressure amplitudes remained fairly constant as a function of input pressure, with values in the range of 60%–70% relative to the applied pressure. The total harmonic distortion of the middle ear pressure signal was calculated and was found to be very small (≤2%) for low-pressure amplitudes and low frequencies. For pressure amplitudes in the order of 0.25 kPa–0.5 kPa, it increased to about 10% at 50 Hz. When a 1 kPa pressure amplitude was applied, variation between animals became large and distortion values up to 30% at 50 Hz were observed. The results showed that pressure buffering due to tympanic membrane displacement was most effective for compensating small transtympanic pressure loads at low frequencies.
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Otoliths - Accelerometer and seismometer; Implications in Vestibular Evoked Myogenic Potential (VEMP)
Source:Hearing Research
Author(s): Wally Grant, Ian Curthoys
Vestibular otolithic organs are recognized as transducers of head acceleration and they function as such up to their corner frequency or undamped natural frequency. It is well recognized that these organs respond to frequencies above their corner frequency up to the 2–3 kHz range (Curthoys et al., 2016). A mechanics model for the transduction of these organs is developed that predicts the response below the undamped natural frequency as an accelerometer and above that frequency as a seismometer. The model is converted to a transfer function using hair cell bundle deflection. Measured threshold acceleration stimuli are used along with threshold deflections for threshold transfer function values. These are compared to model predicted values, both below and above their undamped natural frequency. Threshold deflection values are adjusted to match the model transfer function. The resulting threshold deflection values were well within in measure threshold bundle deflections. Vestibular Evoked Myogenic Potentials (VEMP) today routinely uses stimulus frequencies of 500 and 1000 Hz, and otoliths have been established incontrovertibly by clinical and neural evidence as the stimulus source. The mechanism for stimulus at these frequencies above the undamped natural frequency of otoliths is presented where otoliths are utilizing a seismometer mode of response for VEMPS transduction.
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Changes of metabolism and functional connectivity in late-onset deafness: Evidence from cerebral 18F-FDG-PET
Source:Hearing Research
Author(s): Antoine Verger, Stephane Roman, Rose-May Chaudat, Olivier Felician, Mathieu Ceccaldi, Mira Didic, Eric Guedj
Hearing loss is known to impact brain function. The aim of this study was to characterize cerebral metabolic Positron Emission Tomography (PET) changes in elderly patients fulfilling criteria for cochlear implant and investigate the impact of hearing loss on functional connectivity. Statistical Parametric Mapping-T-scores-maps comparisons of 18F-FDG-PET of 27 elderly patients fulfilling criteria for cochlear implant for hearing loss (best-aided speech intelligibility lower or equal to 50%) and 27 matched healthy subjects (p < 0.005, corrected for volume extent) were performed. Metabolic connectivity was evaluated through interregional correlation analysis. Patients were found to have decreased metabolism within the right associative auditory cortex, while increased metabolism was found in prefrontal areas, pre- and post-central areas, the cingulum and the left inferior parietal gyrus. The right associative auditory cortex was integrated into a network of increased metabolic connectivity that included pre- and post-central areas, the cingulum, the right inferior parietal gyrus, as well as the striatum on both sides. Metabolic values of the right associative auditory cortex and left inferior parietal gyrus were positively correlated with performance on neuropsychological test scores. These findings provide further insight into the reorganization of the connectome through sensory loss and compensatory mechanisms in elderly patients with severe hearing loss.
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via IFTTT
Detecting temporal changes in acoustic scenes: The variable benefit of selective attention
Source:Hearing Research
Author(s): Laurent Demany, Yann Bayle, Emilie Puginier, Catherine Semal
Four experiments investigated change detection in acoustic scenes consisting of a sum of five amplitude-modulated pure tones. As the tones were about 0.7 octave apart and were amplitude-modulated with different frequencies (in the range 2–32 Hz), they were perceived as separate streams. Listeners had to detect a change in the frequency (experiments 1 and 2) or the shape (experiments 3 and 4) of the modulation of one of the five tones, in the presence of an informative cue orienting selective attention either before the scene (pre-cue) or after it (post-cue). The changes left intensity unchanged and were not detectable in the spectral (tonotopic) domain. Performance was much better with pre-cues than with post-cues. Thus, change deafness was manifest in the absence of an appropriate focusing of attention when the change occurred, even though the streams and the changes to be detected were acoustically very simple (in contrast to the conditions used in previous demonstrations of change deafness). In one case, the results were consistent with a model based on the assumption that change detection was possible if and only if attention was endogenously focused on a single tone. However, it was also found that changes resulting in a steepening of amplitude rises were to some extent able to draw attention exogenously. Change detection was not markedly facilitated when the change produced a discontinuity in the modulation domain, contrary to what could be expected from the perspective of predictive coding.
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In vivo recording of the vestibular microphonic in mammals
Source:Hearing Research
Author(s): C.J. Pastras, I.S. Curthoys, D.J. Brown
BackgroundThe Vestibular Microphonic (VM) has only featured in a handful of publications, mostly involving non-mammalian and ex vivo models. The VM is the extracellular analogue of the vestibular hair cell receptor current, and offers a tool to monitor vestibular hair cell activity in vivo.ObjectiveTo characterise features of the VM measured in vivo in guinea pigs, using a relatively simple experimental setup.MethodsThe VM, evoked by bone-conducted vibration (BCV), was recorded from the basal surface of either the utricular or saccular macula after surgical removal of the cochlea, in 27 guinea pigs.ResultsThe VM remained after vestibular nerve blockade, but was abolished following end-organ destruction or death. The VM reversed polarity as the recording electrode tracked across the utricular or saccular macula surface, or through the utricular macula. The VM could be evoked by BCV stimuli of frequencies between 100 Hz and 5 kHz, and was largest to vibrations between 600 Hz and 800 Hz. Experimental manipulations demonstrated a reduction in the VM amplitude with maculae displacement, or rupture of the utricular membrane.ConclusionsResults mirror those obtained in previous ex vivo studies, and further demonstrate that vestibular hair cells are sensitive to vibrations of several kilohertz. Changes in the VM with maculae displacement or rupture suggest utricular hydrops may alter vestibular hair cell sensitivity due to either mechanical or ionic changes.
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Tympanic membrane pressure buffering function at quasi-static and low-frequency pressure variations
Source:Hearing Research
Author(s): Wasil H.M. Salih, Pieter G.G. Muyshondt, Joris J.J. Dirckx
Deformation of the tympanic membrane is known to contribute to the pressure regulation processes in the middle ear cleft. In this paper we investigated pressure variations in the rabbit middle ear in response to sinusoidal varying pressures applied to the ear canal, with frequencies ranging from 0.5 Hz to 50 Hz and pressure amplitudes ranging between 0.25 kPa and 1 kPa. The transtympanic pressure difference was found to be smallest in the quasi-static range, and quickly increased as a function of frequency. The response curves showed asymmetry, with larger transtympanic pressures when positive pressures were applied in the ear canal. Normalized transtympanic pressure amplitudes remained fairly constant as a function of input pressure, with values in the range of 60%–70% relative to the applied pressure. The total harmonic distortion of the middle ear pressure signal was calculated and was found to be very small (≤2%) for low-pressure amplitudes and low frequencies. For pressure amplitudes in the order of 0.25 kPa–0.5 kPa, it increased to about 10% at 50 Hz. When a 1 kPa pressure amplitude was applied, variation between animals became large and distortion values up to 30% at 50 Hz were observed. The results showed that pressure buffering due to tympanic membrane displacement was most effective for compensating small transtympanic pressure loads at low frequencies.
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Otoliths - Accelerometer and seismometer; Implications in Vestibular Evoked Myogenic Potential (VEMP)
Source:Hearing Research
Author(s): Wally Grant, Ian Curthoys
Vestibular otolithic organs are recognized as transducers of head acceleration and they function as such up to their corner frequency or undamped natural frequency. It is well recognized that these organs respond to frequencies above their corner frequency up to the 2–3 kHz range (Curthoys et al., 2016). A mechanics model for the transduction of these organs is developed that predicts the response below the undamped natural frequency as an accelerometer and above that frequency as a seismometer. The model is converted to a transfer function using hair cell bundle deflection. Measured threshold acceleration stimuli are used along with threshold deflections for threshold transfer function values. These are compared to model predicted values, both below and above their undamped natural frequency. Threshold deflection values are adjusted to match the model transfer function. The resulting threshold deflection values were well within in measure threshold bundle deflections. Vestibular Evoked Myogenic Potentials (VEMP) today routinely uses stimulus frequencies of 500 and 1000 Hz, and otoliths have been established incontrovertibly by clinical and neural evidence as the stimulus source. The mechanism for stimulus at these frequencies above the undamped natural frequency of otoliths is presented where otoliths are utilizing a seismometer mode of response for VEMPS transduction.
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Changes of metabolism and functional connectivity in late-onset deafness: Evidence from cerebral 18F-FDG-PET
Source:Hearing Research
Author(s): Antoine Verger, Stephane Roman, Rose-May Chaudat, Olivier Felician, Mathieu Ceccaldi, Mira Didic, Eric Guedj
Hearing loss is known to impact brain function. The aim of this study was to characterize cerebral metabolic Positron Emission Tomography (PET) changes in elderly patients fulfilling criteria for cochlear implant and investigate the impact of hearing loss on functional connectivity. Statistical Parametric Mapping-T-scores-maps comparisons of 18F-FDG-PET of 27 elderly patients fulfilling criteria for cochlear implant for hearing loss (best-aided speech intelligibility lower or equal to 50%) and 27 matched healthy subjects (p < 0.005, corrected for volume extent) were performed. Metabolic connectivity was evaluated through interregional correlation analysis. Patients were found to have decreased metabolism within the right associative auditory cortex, while increased metabolism was found in prefrontal areas, pre- and post-central areas, the cingulum and the left inferior parietal gyrus. The right associative auditory cortex was integrated into a network of increased metabolic connectivity that included pre- and post-central areas, the cingulum, the right inferior parietal gyrus, as well as the striatum on both sides. Metabolic values of the right associative auditory cortex and left inferior parietal gyrus were positively correlated with performance on neuropsychological test scores. These findings provide further insight into the reorganization of the connectome through sensory loss and compensatory mechanisms in elderly patients with severe hearing loss.
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via IFTTT
Detecting temporal changes in acoustic scenes: The variable benefit of selective attention
Source:Hearing Research
Author(s): Laurent Demany, Yann Bayle, Emilie Puginier, Catherine Semal
Four experiments investigated change detection in acoustic scenes consisting of a sum of five amplitude-modulated pure tones. As the tones were about 0.7 octave apart and were amplitude-modulated with different frequencies (in the range 2–32 Hz), they were perceived as separate streams. Listeners had to detect a change in the frequency (experiments 1 and 2) or the shape (experiments 3 and 4) of the modulation of one of the five tones, in the presence of an informative cue orienting selective attention either before the scene (pre-cue) or after it (post-cue). The changes left intensity unchanged and were not detectable in the spectral (tonotopic) domain. Performance was much better with pre-cues than with post-cues. Thus, change deafness was manifest in the absence of an appropriate focusing of attention when the change occurred, even though the streams and the changes to be detected were acoustically very simple (in contrast to the conditions used in previous demonstrations of change deafness). In one case, the results were consistent with a model based on the assumption that change detection was possible if and only if attention was endogenously focused on a single tone. However, it was also found that changes resulting in a steepening of amplitude rises were to some extent able to draw attention exogenously. Change detection was not markedly facilitated when the change produced a discontinuity in the modulation domain, contrary to what could be expected from the perspective of predictive coding.
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via IFTTT
In vivo recording of the vestibular microphonic in mammals
Source:Hearing Research
Author(s): C.J. Pastras, I.S. Curthoys, D.J. Brown
BackgroundThe Vestibular Microphonic (VM) has only featured in a handful of publications, mostly involving non-mammalian and ex vivo models. The VM is the extracellular analogue of the vestibular hair cell receptor current, and offers a tool to monitor vestibular hair cell activity in vivo.ObjectiveTo characterise features of the VM measured in vivo in guinea pigs, using a relatively simple experimental setup.MethodsThe VM, evoked by bone-conducted vibration (BCV), was recorded from the basal surface of either the utricular or saccular macula after surgical removal of the cochlea, in 27 guinea pigs.ResultsThe VM remained after vestibular nerve blockade, but was abolished following end-organ destruction or death. The VM reversed polarity as the recording electrode tracked across the utricular or saccular macula surface, or through the utricular macula. The VM could be evoked by BCV stimuli of frequencies between 100 Hz and 5 kHz, and was largest to vibrations between 600 Hz and 800 Hz. Experimental manipulations demonstrated a reduction in the VM amplitude with maculae displacement, or rupture of the utricular membrane.ConclusionsResults mirror those obtained in previous ex vivo studies, and further demonstrate that vestibular hair cells are sensitive to vibrations of several kilohertz. Changes in the VM with maculae displacement or rupture suggest utricular hydrops may alter vestibular hair cell sensitivity due to either mechanical or ionic changes.
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Tympanic membrane pressure buffering function at quasi-static and low-frequency pressure variations
Source:Hearing Research
Author(s): Wasil H.M. Salih, Pieter G.G. Muyshondt, Joris J.J. Dirckx
Deformation of the tympanic membrane is known to contribute to the pressure regulation processes in the middle ear cleft. In this paper we investigated pressure variations in the rabbit middle ear in response to sinusoidal varying pressures applied to the ear canal, with frequencies ranging from 0.5 Hz to 50 Hz and pressure amplitudes ranging between 0.25 kPa and 1 kPa. The transtympanic pressure difference was found to be smallest in the quasi-static range, and quickly increased as a function of frequency. The response curves showed asymmetry, with larger transtympanic pressures when positive pressures were applied in the ear canal. Normalized transtympanic pressure amplitudes remained fairly constant as a function of input pressure, with values in the range of 60%–70% relative to the applied pressure. The total harmonic distortion of the middle ear pressure signal was calculated and was found to be very small (≤2%) for low-pressure amplitudes and low frequencies. For pressure amplitudes in the order of 0.25 kPa–0.5 kPa, it increased to about 10% at 50 Hz. When a 1 kPa pressure amplitude was applied, variation between animals became large and distortion values up to 30% at 50 Hz were observed. The results showed that pressure buffering due to tympanic membrane displacement was most effective for compensating small transtympanic pressure loads at low frequencies.
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Otoliths - Accelerometer and seismometer; Implications in Vestibular Evoked Myogenic Potential (VEMP)
Source:Hearing Research
Author(s): Wally Grant, Ian Curthoys
Vestibular otolithic organs are recognized as transducers of head acceleration and they function as such up to their corner frequency or undamped natural frequency. It is well recognized that these organs respond to frequencies above their corner frequency up to the 2–3 kHz range (Curthoys et al., 2016). A mechanics model for the transduction of these organs is developed that predicts the response below the undamped natural frequency as an accelerometer and above that frequency as a seismometer. The model is converted to a transfer function using hair cell bundle deflection. Measured threshold acceleration stimuli are used along with threshold deflections for threshold transfer function values. These are compared to model predicted values, both below and above their undamped natural frequency. Threshold deflection values are adjusted to match the model transfer function. The resulting threshold deflection values were well within in measure threshold bundle deflections. Vestibular Evoked Myogenic Potentials (VEMP) today routinely uses stimulus frequencies of 500 and 1000 Hz, and otoliths have been established incontrovertibly by clinical and neural evidence as the stimulus source. The mechanism for stimulus at these frequencies above the undamped natural frequency of otoliths is presented where otoliths are utilizing a seismometer mode of response for VEMPS transduction.
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Changes of metabolism and functional connectivity in late-onset deafness: Evidence from cerebral 18F-FDG-PET
Source:Hearing Research
Author(s): Antoine Verger, Stephane Roman, Rose-May Chaudat, Olivier Felician, Mathieu Ceccaldi, Mira Didic, Eric Guedj
Hearing loss is known to impact brain function. The aim of this study was to characterize cerebral metabolic Positron Emission Tomography (PET) changes in elderly patients fulfilling criteria for cochlear implant and investigate the impact of hearing loss on functional connectivity. Statistical Parametric Mapping-T-scores-maps comparisons of 18F-FDG-PET of 27 elderly patients fulfilling criteria for cochlear implant for hearing loss (best-aided speech intelligibility lower or equal to 50%) and 27 matched healthy subjects (p < 0.005, corrected for volume extent) were performed. Metabolic connectivity was evaluated through interregional correlation analysis. Patients were found to have decreased metabolism within the right associative auditory cortex, while increased metabolism was found in prefrontal areas, pre- and post-central areas, the cingulum and the left inferior parietal gyrus. The right associative auditory cortex was integrated into a network of increased metabolic connectivity that included pre- and post-central areas, the cingulum, the right inferior parietal gyrus, as well as the striatum on both sides. Metabolic values of the right associative auditory cortex and left inferior parietal gyrus were positively correlated with performance on neuropsychological test scores. These findings provide further insight into the reorganization of the connectome through sensory loss and compensatory mechanisms in elderly patients with severe hearing loss.
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Detecting temporal changes in acoustic scenes: The variable benefit of selective attention
Source:Hearing Research
Author(s): Laurent Demany, Yann Bayle, Emilie Puginier, Catherine Semal
Four experiments investigated change detection in acoustic scenes consisting of a sum of five amplitude-modulated pure tones. As the tones were about 0.7 octave apart and were amplitude-modulated with different frequencies (in the range 2–32 Hz), they were perceived as separate streams. Listeners had to detect a change in the frequency (experiments 1 and 2) or the shape (experiments 3 and 4) of the modulation of one of the five tones, in the presence of an informative cue orienting selective attention either before the scene (pre-cue) or after it (post-cue). The changes left intensity unchanged and were not detectable in the spectral (tonotopic) domain. Performance was much better with pre-cues than with post-cues. Thus, change deafness was manifest in the absence of an appropriate focusing of attention when the change occurred, even though the streams and the changes to be detected were acoustically very simple (in contrast to the conditions used in previous demonstrations of change deafness). In one case, the results were consistent with a model based on the assumption that change detection was possible if and only if attention was endogenously focused on a single tone. However, it was also found that changes resulting in a steepening of amplitude rises were to some extent able to draw attention exogenously. Change detection was not markedly facilitated when the change produced a discontinuity in the modulation domain, contrary to what could be expected from the perspective of predictive coding.
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In vivo recording of the vestibular microphonic in mammals
Source:Hearing Research
Author(s): C.J. Pastras, I.S. Curthoys, D.J. Brown
BackgroundThe Vestibular Microphonic (VM) has only featured in a handful of publications, mostly involving non-mammalian and ex vivo models. The VM is the extracellular analogue of the vestibular hair cell receptor current, and offers a tool to monitor vestibular hair cell activity in vivo.ObjectiveTo characterise features of the VM measured in vivo in guinea pigs, using a relatively simple experimental setup.MethodsThe VM, evoked by bone-conducted vibration (BCV), was recorded from the basal surface of either the utricular or saccular macula after surgical removal of the cochlea, in 27 guinea pigs.ResultsThe VM remained after vestibular nerve blockade, but was abolished following end-organ destruction or death. The VM reversed polarity as the recording electrode tracked across the utricular or saccular macula surface, or through the utricular macula. The VM could be evoked by BCV stimuli of frequencies between 100 Hz and 5 kHz, and was largest to vibrations between 600 Hz and 800 Hz. Experimental manipulations demonstrated a reduction in the VM amplitude with maculae displacement, or rupture of the utricular membrane.ConclusionsResults mirror those obtained in previous ex vivo studies, and further demonstrate that vestibular hair cells are sensitive to vibrations of several kilohertz. Changes in the VM with maculae displacement or rupture suggest utricular hydrops may alter vestibular hair cell sensitivity due to either mechanical or ionic changes.
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Tympanic membrane pressure buffering function at quasi-static and low-frequency pressure variations
Source:Hearing Research
Author(s): Wasil H.M. Salih, Pieter G.G. Muyshondt, Joris J.J. Dirckx
Deformation of the tympanic membrane is known to contribute to the pressure regulation processes in the middle ear cleft. In this paper we investigated pressure variations in the rabbit middle ear in response to sinusoidal varying pressures applied to the ear canal, with frequencies ranging from 0.5 Hz to 50 Hz and pressure amplitudes ranging between 0.25 kPa and 1 kPa. The transtympanic pressure difference was found to be smallest in the quasi-static range, and quickly increased as a function of frequency. The response curves showed asymmetry, with larger transtympanic pressures when positive pressures were applied in the ear canal. Normalized transtympanic pressure amplitudes remained fairly constant as a function of input pressure, with values in the range of 60%–70% relative to the applied pressure. The total harmonic distortion of the middle ear pressure signal was calculated and was found to be very small (≤2%) for low-pressure amplitudes and low frequencies. For pressure amplitudes in the order of 0.25 kPa–0.5 kPa, it increased to about 10% at 50 Hz. When a 1 kPa pressure amplitude was applied, variation between animals became large and distortion values up to 30% at 50 Hz were observed. The results showed that pressure buffering due to tympanic membrane displacement was most effective for compensating small transtympanic pressure loads at low frequencies.
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Synchronised vestibular signals increase the P300 event-related potential elicited by auditory oddballs.
Related Articles |
Synchronised vestibular signals increase the P300 event-related potential elicited by auditory oddballs.
Brain Res. 2016 Oct 01;1648(Pt A):224-31
Authors: Schmidt-Kassow M, Wilkinson D, Denby E, Ferguson H
Abstract
The perception of beat within an auditory rhythm can be facilitated when accompanied by synchronised movements. Electrophysiological investigation shows that this facilitatory effect is associated with a larger P300 amplitude. It has remained unclear, however, which movement-related processes drive this P300 effect. To investigate whether vestibular signals play a role, we administered alternating, sub-sensory (mean=.3mA) galvanic current to the vestibular nerves of participants while they counted the number of oddballs presented in a stream of tones played at a rate of 1Hz. Consistent with a vestibular effect, the P300 elicited by the oddballs was increased during stimulation relative to a sham condition, but only when the frequency of the alternating current matched that at which the tones were played. This finding supports the general idea that the vestibular system is involved in audio-motor synchronisation and is the first to show by electrophysiological means that it influences cognitive processes involved in beat perception.
PMID: 27423517 [PubMed - indexed for MEDLINE]
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Synchronised vestibular signals increase the P300 event-related potential elicited by auditory oddballs.
Related Articles |
Synchronised vestibular signals increase the P300 event-related potential elicited by auditory oddballs.
Brain Res. 2016 Oct 01;1648(Pt A):224-31
Authors: Schmidt-Kassow M, Wilkinson D, Denby E, Ferguson H
Abstract
The perception of beat within an auditory rhythm can be facilitated when accompanied by synchronised movements. Electrophysiological investigation shows that this facilitatory effect is associated with a larger P300 amplitude. It has remained unclear, however, which movement-related processes drive this P300 effect. To investigate whether vestibular signals play a role, we administered alternating, sub-sensory (mean=.3mA) galvanic current to the vestibular nerves of participants while they counted the number of oddballs presented in a stream of tones played at a rate of 1Hz. Consistent with a vestibular effect, the P300 elicited by the oddballs was increased during stimulation relative to a sham condition, but only when the frequency of the alternating current matched that at which the tones were played. This finding supports the general idea that the vestibular system is involved in audio-motor synchronisation and is the first to show by electrophysiological means that it influences cognitive processes involved in beat perception.
PMID: 27423517 [PubMed - indexed for MEDLINE]
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Symbolic Play and Novel Noun Learning in Deaf and Hearing Children: Longitudinal Effects of Access to Sound on Early Precursors of Language.
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Symbolic Play and Novel Noun Learning in Deaf and Hearing Children: Longitudinal Effects of Access to Sound on Early Precursors of Language.
PLoS One. 2016;11(5):e0155964
Authors: Quittner AL, Cejas I, Wang NY, Niparko JK, Barker DH
Abstract
In the largest, longitudinal study of young, deaf children before and three years after cochlear implantation, we compared symbolic play and novel noun learning to age-matched hearing peers. Participants were 180 children from six cochlear implant centers and 96 hearing children. Symbolic play was measured during five minutes of videotaped, structured solitary play. Play was coded as "symbolic" if the child used substitution (e.g., a wooden block as a bed). Novel noun learning was measured in 10 trials using a novel object and a distractor. Cochlear implant vs. normal hearing children were delayed in their use of symbolic play, however, those implanted before vs. after age two performed significantly better. Children with cochlear implants were also delayed in novel noun learning (median delay 1.54 years), with minimal evidence of catch-up growth. Quality of parent-child interactions was positively related to performance on the novel noun learning, but not symbolic play task. Early implantation was beneficial for both achievement of symbolic play and novel noun learning. Further, maternal sensitivity and linguistic stimulation by parents positively affected noun learning skills, although children with cochlear implants still lagged in comparison to hearing peers.
PMID: 27228032 [PubMed - indexed for MEDLINE]
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Using the International Classification of Functioning, Disability and Health in Assessment and Intervention of School-Aged Children With Language Impairments
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English Verb Accuracy of Bilingual Cantonese–English Preschoolers
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Tense Marking in the English Narrative Retells of Dual Language Preschoolers
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Language Assessment With Children Who Speak Nonmainstream Dialects: Examining the Effects of Scoring Modifications in Norm-Referenced Assessment
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Language, Speech, and Hearing Services in Schools : A Journal of Research and Practice Affecting Educational Settings
Resources for LSHSS Authors
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Using the International Classification of Functioning, Disability and Health in Assessment and Intervention of School-Aged Children With Language Impairments
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Sampling Utterances and Grammatical Analysis Revised (SUGAR): New Normative Values for Language Sample Analysis Measures
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English Verb Accuracy of Bilingual Cantonese–English Preschoolers
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Tense Marking in the English Narrative Retells of Dual Language Preschoolers
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Language Assessment With Children Who Speak Nonmainstream Dialects: Examining the Effects of Scoring Modifications in Norm-Referenced Assessment
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Language, Speech, and Hearing Services in Schools : A Journal of Research and Practice Affecting Educational Settings
Resources for LSHSS Authors
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Using the International Classification of Functioning, Disability and Health in Assessment and Intervention of School-Aged Children With Language Impairments
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Sampling Utterances and Grammatical Analysis Revised (SUGAR): New Normative Values for Language Sample Analysis Measures
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English Verb Accuracy of Bilingual Cantonese–English Preschoolers
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Tense Marking in the English Narrative Retells of Dual Language Preschoolers
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Language Assessment With Children Who Speak Nonmainstream Dialects: Examining the Effects of Scoring Modifications in Norm-Referenced Assessment
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