Παρασκευή 20 Απριλίου 2018
AAA 2018 Explores New Frontiers in Music Perception of Cochlear Implant Users
It was a full house at the Judith S. Gravel Annual Vanderbilt Lecture by Charles Limb, MD, at this week's American Academy of Audiology coneference in Nashville, TN. Limb is the Francis A. Sooy Professor of Otolaryngology-Head and Neck Surgery and the chief of the Division of Otology, Neurotology, and Skull Base Surgery at University of California in San Francisco.
Limb gave a fascinating presentation on the challenges affecting children with cochlear impants in the area o musicperception. Despite the adavcen in CIs, Limb's research has sound significant limitations of this technology in enabling users to have extensive epxerience of sound. However, he presented his creative an donoging work so identifu new frontiers in improving the music percenption of this patient popylation. "I'm most excited that were starting to identify things that could be improved. We've spent the last 10 to 15 years of the field just showing how bad everyhing was without actually being able to improve anything," Limb told The Hearing Journal after his presentation. "So we're starting to find things that might actually imporive music perception—and that's pretty exciting to me."
At the lecture, Limb showed videos of CI users with music abilities—testaments to the musicality of children who may have hearing difficulties but benefit from the use of CIs.
Limb cited some exciting areas of advancement. "For example, some of the sutides on tuning in cochlear implant is starting to show some promise in temrs sof pitch percepton, and others have worked on on pitch processing strategies that are promising so maybe we're getting closer to more accurate pitch."
But to optimize this progress in research, it's important to address critical issues like access to CIs.
"Sadly, there are still many people who need our services but dont get access to them, and the system thatd in place to give people access to these services is pretty daunting," Limb stated.
"I think that we to acceot as a comunity, as a people, as a goverment that hearig loss is not acceptable to just persist in our world world. if tehre treatments out there, it should be our right to get that treatment. So all of us need to get better."
Published: 4/20/2018 10:14:00 AM
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AAA 2018 Explores New Frontiers in Music Perception of Cochlear Implant Users
It was a full house at the Judith S. Gravel Annual Vanderbilt Lecture by Charles Limb, MD, at this week's American Academy of Audiology coneference in Nashville, TN. Limb is the Francis A. Sooy Professor of Otolaryngology-Head and Neck Surgery and the chief of the Division of Otology, Neurotology, and Skull Base Surgery at University of California in San Francisco.
Limb gave a fascinating presentation on the challenges affecting children with cochlear impants in the area o musicperception. Despite the adavcen in CIs, Limb's research has sound significant limitations of this technology in enabling users to have extensive epxerience of sound. However, he presented his creative an donoging work so identifu new frontiers in improving the music percenption of this patient popylation. "I'm most excited that were starting to identify things that could be improved. We've spent the last 10 to 15 years of the field just showing how bad everyhing was without actually being able to improve anything," Limb told The Hearing Journal after his presentation. "So we're starting to find things that might actually imporive music perception—and that's pretty exciting to me."
At the lecture, Limb showed videos of CI users with music abilities—testaments to the musicality of children who may have hearing difficulties but benefit from the use of CIs.
Limb cited some exciting areas of advancement. "For example, some of the sutides on tuning in cochlear implant is starting to show some promise in temrs sof pitch percepton, and others have worked on on pitch processing strategies that are promising so maybe we're getting closer to more accurate pitch."
But to optimize this progress in research, it's important to address critical issues like access to CIs.
"Sadly, there are still many people who need our services but dont get access to them, and the system thatd in place to give people access to these services is pretty daunting," Limb stated.
"I think that we to acceot as a comunity, as a people, as a goverment that hearig loss is not acceptable to just persist in our world world. if tehre treatments out there, it should be our right to get that treatment. So all of us need to get better."
Published: 4/20/2018 10:14:00 AM
from #Audiology via ola Kala on Inoreader https://ift.tt/2HEhekd
via IFTTT
AAA 2018 Explores New Frontiers in Music Perception of Cochlear Implant Users
It was a full house at the Judith S. Gravel Annual Vanderbilt Lecture by Charles Limb, MD, at this week's American Academy of Audiology coneference in Nashville, TN. Limb is the Francis A. Sooy Professor of Otolaryngology-Head and Neck Surgery and the chief of the Division of Otology, Neurotology, and Skull Base Surgery at University of California in San Francisco.
Limb gave a fascinating presentation on the challenges affecting children with cochlear impants in the area o musicperception. Despite the adavcen in CIs, Limb's research has sound significant limitations of this technology in enabling users to have extensive epxerience of sound. However, he presented his creative an donoging work so identifu new frontiers in improving the music percenption of this patient popylation. "I'm most excited that were starting to identify things that could be improved. We've spent the last 10 to 15 years of the field just showing how bad everyhing was without actually being able to improve anything," Limb told The Hearing Journal after his presentation. "So we're starting to find things that might actually imporive music perception—and that's pretty exciting to me."
At the lecture, Limb showed videos of CI users with music abilities—testaments to the musicality of children who may have hearing difficulties but benefit from the use of CIs.
Limb cited some exciting areas of advancement. "For example, some of the sutides on tuning in cochlear implant is starting to show some promise in temrs sof pitch percepton, and others have worked on on pitch processing strategies that are promising so maybe we're getting closer to more accurate pitch."
But to optimize this progress in research, it's important to address critical issues like access to CIs.
"Sadly, there are still many people who need our services but dont get access to them, and the system thatd in place to give people access to these services is pretty daunting," Limb stated.
"I think that we to acceot as a comunity, as a people, as a goverment that hearig loss is not acceptable to just persist in our world world. if tehre treatments out there, it should be our right to get that treatment. So all of us need to get better."
Published: 4/20/2018 10:14:00 AM
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Hearing loss and social support in urban and rural communities.
| Related Articles |
Hearing loss and social support in urban and rural communities.
Int J Audiol. 2018 Apr 19;:1-8
Authors: Hay-McCutcheon MJ, Hyams A, Yang X, Parton J
Abstract
OBJECTIVE: Perceived social support and hearing handicap were assessed in adults with and without hearing loss who lived in different geographical regions of Alabama.
DESIGN: The Hearing Handicap Inventory for Adults (HHIA) assessed emotional and social consequences of hearing loss. The Medical Outcomes Study (MOS) Social Support Survey and the Social Functioning, Role Emotional and Mental Health scales of the SF-36 were administered.
STUDY SAMPLE: Data were collected from 71 study participants with hearing loss and from 45 adults without hearing loss.
RESULTS: Degree of hearing loss and outcomes from the HHIA did not differ between adults who lived in rural or urban settings. Tangible support was poorer for adults with hearing loss who lived in rural settings compared to those who lived in urban settings. For adults without hearing loss, residency was not associated with tangible support. For these adults, income was associated with other types of social support (i.e. informational support, affection, positive social interaction).
CONCLUSIONS: Adults with hearing loss living in rural areas had poor perceived tangible support. The provision of support to address a hearing loss could be worse for these adults compared to adults who lived in urban settings.
PMID: 29671659 [PubMed - as supplied by publisher]
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The role of communication partners in the audiological rehabilitation.
| Related Articles |
The role of communication partners in the audiological rehabilitation.
Int J Audiol. 2018 Apr 19;:1
Authors: Danermark B
PMID: 29671651 [PubMed - as supplied by publisher]
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Hearing loss and social support in urban and rural communities.
| Related Articles |
Hearing loss and social support in urban and rural communities.
Int J Audiol. 2018 Apr 19;:1-8
Authors: Hay-McCutcheon MJ, Hyams A, Yang X, Parton J
Abstract
OBJECTIVE: Perceived social support and hearing handicap were assessed in adults with and without hearing loss who lived in different geographical regions of Alabama.
DESIGN: The Hearing Handicap Inventory for Adults (HHIA) assessed emotional and social consequences of hearing loss. The Medical Outcomes Study (MOS) Social Support Survey and the Social Functioning, Role Emotional and Mental Health scales of the SF-36 were administered.
STUDY SAMPLE: Data were collected from 71 study participants with hearing loss and from 45 adults without hearing loss.
RESULTS: Degree of hearing loss and outcomes from the HHIA did not differ between adults who lived in rural or urban settings. Tangible support was poorer for adults with hearing loss who lived in rural settings compared to those who lived in urban settings. For adults without hearing loss, residency was not associated with tangible support. For these adults, income was associated with other types of social support (i.e. informational support, affection, positive social interaction).
CONCLUSIONS: Adults with hearing loss living in rural areas had poor perceived tangible support. The provision of support to address a hearing loss could be worse for these adults compared to adults who lived in urban settings.
PMID: 29671659 [PubMed - as supplied by publisher]
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The role of communication partners in the audiological rehabilitation.
| Related Articles |
The role of communication partners in the audiological rehabilitation.
Int J Audiol. 2018 Apr 19;:1
Authors: Danermark B
PMID: 29671651 [PubMed - as supplied by publisher]
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High-level heteroplasmy for the m.7445A>G mitochondrial DNA mutation can cause progressive sensorineural hearing loss in infancy.
 |
Related Articles |
High-level heteroplasmy for the m.7445A>G mitochondrial DNA mutation can cause progressive sensorineural hearing loss in infancy.
Int J Pediatr Otorhinolaryngol. 2018 May;108:125-131
Authors: Matsushima K, Nakano A, Arimoto Y, Mutai H, Yamazawa K, Murayama K, Matsunaga T
Abstract
OBJECTIVE: Hearing loss caused by mutation of mitochondrial DNA typically develops in late childhood or early adulthood, but rarely in infancy. We report the investigation of a patient to determine the cause of his early onset hearing loss.
MATERIALS AND METHODS: The proband was a boy aged 1 year and 2 months at presentation. Newborn hearing screening test by automated auditory brainstem response generated "pass" results for both ears. His reaction to sound deteriorated by 9 months. Average pure tone threshold at 0.5, 1, and 2 kHz was 55 dB by conditioned orientation response audiometry. His father had congenital hearing loss, and his mother had progressive hearing loss since childhood. Invader assays and Sanger sequencing were performed to investigate genetic causes of the hearing loss in the proband, and heteroplasmy was assessed by PCR-restriction fragment length polymorphism, Sanger sequencing, and pyrosequencing. Additionally, mitochondrial function was evaluated by measurement of the oxygen consumption rate of patient skin fibroblasts.
RESULTS: An m.7445A > G mitochondrial DNA mutation and a heterozygous c.235delC (p.L79Cfs*3) mutation of GJB2 were detected in the proband. His mother carried the m.7445A > G mitochondrial DNA mutation, and his father was a compound heterozygote for GJB2 mutations (c.[235delC]; [134G > A; 408C > A]). Tissue samples from both the proband and his mother exhibited a high degree of heteroplasmy. Fibroblasts from the proband exhibited markedly reduced oxygen consumption rates. These data indicate that the proband had impaired mitochondrial function, resulting in hearing loss.
CONCLUSION: This research demonstrates that hearing loss in a proband who presented in infancy and that of his mother resulted from a high level of heteroplasmy for the m.7445A > G mitochondrial DNA mutation, indicating that this alteration can cause hearing loss in infancy.
PMID: 29605341 [PubMed - indexed for MEDLINE]
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High-level heteroplasmy for the m.7445A>G mitochondrial DNA mutation can cause progressive sensorineural hearing loss in infancy.
|
Related Articles |
High-level heteroplasmy for the m.7445A>G mitochondrial DNA mutation can cause progressive sensorineural hearing loss in infancy.
Int J Pediatr Otorhinolaryngol. 2018 May;108:125-131
Authors: Matsushima K, Nakano A, Arimoto Y, Mutai H, Yamazawa K, Murayama K, Matsunaga T
Abstract
OBJECTIVE: Hearing loss caused by mutation of mitochondrial DNA typically develops in late childhood or early adulthood, but rarely in infancy. We report the investigation of a patient to determine the cause of his early onset hearing loss.
MATERIALS AND METHODS: The proband was a boy aged 1 year and 2 months at presentation. Newborn hearing screening test by automated auditory brainstem response generated "pass" results for both ears. His reaction to sound deteriorated by 9 months. Average pure tone threshold at 0.5, 1, and 2 kHz was 55 dB by conditioned orientation response audiometry. His father had congenital hearing loss, and his mother had progressive hearing loss since childhood. Invader assays and Sanger sequencing were performed to investigate genetic causes of the hearing loss in the proband, and heteroplasmy was assessed by PCR-restriction fragment length polymorphism, Sanger sequencing, and pyrosequencing. Additionally, mitochondrial function was evaluated by measurement of the oxygen consumption rate of patient skin fibroblasts.
RESULTS: An m.7445A > G mitochondrial DNA mutation and a heterozygous c.235delC (p.L79Cfs*3) mutation of GJB2 were detected in the proband. His mother carried the m.7445A > G mitochondrial DNA mutation, and his father was a compound heterozygote for GJB2 mutations (c.[235delC]; [134G > A; 408C > A]). Tissue samples from both the proband and his mother exhibited a high degree of heteroplasmy. Fibroblasts from the proband exhibited markedly reduced oxygen consumption rates. These data indicate that the proband had impaired mitochondrial function, resulting in hearing loss.
CONCLUSION: This research demonstrates that hearing loss in a proband who presented in infancy and that of his mother resulted from a high level of heteroplasmy for the m.7445A > G mitochondrial DNA mutation, indicating that this alteration can cause hearing loss in infancy.
PMID: 29605341 [PubMed - indexed for MEDLINE]
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Hearing loss and social support in urban and rural communities.
| Related Articles |
Hearing loss and social support in urban and rural communities.
Int J Audiol. 2018 Apr 19;:1-8
Authors: Hay-McCutcheon MJ, Hyams A, Yang X, Parton J
Abstract
OBJECTIVE: Perceived social support and hearing handicap were assessed in adults with and without hearing loss who lived in different geographical regions of Alabama.
DESIGN: The Hearing Handicap Inventory for Adults (HHIA) assessed emotional and social consequences of hearing loss. The Medical Outcomes Study (MOS) Social Support Survey and the Social Functioning, Role Emotional and Mental Health scales of the SF-36 were administered.
STUDY SAMPLE: Data were collected from 71 study participants with hearing loss and from 45 adults without hearing loss.
RESULTS: Degree of hearing loss and outcomes from the HHIA did not differ between adults who lived in rural or urban settings. Tangible support was poorer for adults with hearing loss who lived in rural settings compared to those who lived in urban settings. For adults without hearing loss, residency was not associated with tangible support. For these adults, income was associated with other types of social support (i.e. informational support, affection, positive social interaction).
CONCLUSIONS: Adults with hearing loss living in rural areas had poor perceived tangible support. The provision of support to address a hearing loss could be worse for these adults compared to adults who lived in urban settings.
PMID: 29671659 [PubMed - as supplied by publisher]
from #Audiology via ola Kala on Inoreader https://ift.tt/2HiRqe4
via IFTTT
The role of communication partners in the audiological rehabilitation.
| Related Articles |
The role of communication partners in the audiological rehabilitation.
Int J Audiol. 2018 Apr 19;:1
Authors: Danermark B
PMID: 29671651 [PubMed - as supplied by publisher]
from #Audiology via ola Kala on Inoreader https://ift.tt/2qNOJ9C
via IFTTT
Hearing loss and social support in urban and rural communities.
| Related Articles |
Hearing loss and social support in urban and rural communities.
Int J Audiol. 2018 Apr 19;:1-8
Authors: Hay-McCutcheon MJ, Hyams A, Yang X, Parton J
Abstract
OBJECTIVE: Perceived social support and hearing handicap were assessed in adults with and without hearing loss who lived in different geographical regions of Alabama.
DESIGN: The Hearing Handicap Inventory for Adults (HHIA) assessed emotional and social consequences of hearing loss. The Medical Outcomes Study (MOS) Social Support Survey and the Social Functioning, Role Emotional and Mental Health scales of the SF-36 were administered.
STUDY SAMPLE: Data were collected from 71 study participants with hearing loss and from 45 adults without hearing loss.
RESULTS: Degree of hearing loss and outcomes from the HHIA did not differ between adults who lived in rural or urban settings. Tangible support was poorer for adults with hearing loss who lived in rural settings compared to those who lived in urban settings. For adults without hearing loss, residency was not associated with tangible support. For these adults, income was associated with other types of social support (i.e. informational support, affection, positive social interaction).
CONCLUSIONS: Adults with hearing loss living in rural areas had poor perceived tangible support. The provision of support to address a hearing loss could be worse for these adults compared to adults who lived in urban settings.
PMID: 29671659 [PubMed - as supplied by publisher]
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via IFTTT
The role of communication partners in the audiological rehabilitation.
| Related Articles |
The role of communication partners in the audiological rehabilitation.
Int J Audiol. 2018 Apr 19;:1
Authors: Danermark B
PMID: 29671651 [PubMed - as supplied by publisher]
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TMTC2 variant associated with sensorineural hearing loss and auditory neuropathy spectrum disorder in a family dyad.
| Related Articles |
TMTC2 variant associated with sensorineural hearing loss and auditory neuropathy spectrum disorder in a family dyad.
Mol Genet Genomic Med. 2018 Apr 19;:
Authors: Guillen-Ahlers H, Erbe CB, Chevalier FD, Montoya MJ, Zimmerman KD, Langefeld CD, Olivier M, Runge CL
Abstract
BACKGROUND: Sensorineural hearing loss (SNHL) is a common form of hearing loss that can be inherited or triggered by environmental insults; auditory neuropathy spectrum disorder (ANSD) is a SNHL subtype with unique diagnostic criteria. The genetic factors associated with these impairments are vast and diverse, but causal genetic factors are rarely characterized.
METHODS: A family dyad, both cochlear implant recipients, presented with a hearing history of bilateral, progressive SNHL, and ANSD. Whole-exome sequencing was performed to identify coding sequence variants shared by both family members, and screened against genes relevant to hearing loss and variants known to be associated with SNHL and ANSD.
RESULTS: Both family members are successful cochlear implant users, demonstrating effective auditory nerve stimulation with their devices. Genetic analyses revealed a mutation (rs35725509) in the TMTC2 gene, which has been reported previously as a likely genetic cause of SNHL in another family of Northern European descent.
CONCLUSION: This study represents the first confirmation of the rs35725509 variant in an independent family as a likely cause for the complex hearing loss phenotype (SNHL and ANSD) observed in this family dyad.
PMID: 29671961 [PubMed - as supplied by publisher]
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