Πέμπτη 8 Σεπτεμβρίου 2016

Tinnitus Habituation

Tinnitus is a problem where a person hears constant ringing, buzzing, humming or whistling in their ears that has nothing to do with outside noises. It can be incredibly distressing to those who suffer from it. While the condition isn’t life threatening, it is life altering. Sufferers can end up with depression, stress and constant agitation. Over 50 million people are afflicted with some form of tinnitus.

Becoming Habituated to Tinnitus

When you move into a new home close to a highway, you might be overwhelmed with the traffic sounds. After a few months though, you fail to notice the noise anymore. A friend might even visit and point out how loud the traffic is, and you’ll find that you’d tuned it out completely. You are habituated to other sensations and noises, so it’s possible to achieve tinnitus habituation too. It’s the same concept, but differs for every person who suffers.

When you hear your first humming, ringing or buzzing sounds, you’re hyper focused on them because you’re worried. Once you’re worried about the sounds, you might find that you can’t stop focusing on them, which can make them worse. After seeing a doctor to make sure there’s no underlying cause, you’ll have to find a way to achieve tinnitus habituation.

Relaxation for Habituation
Many people who suffer from tinnitus notice that it will get worse when they’re stressed. Worrying and being overwhelmed with tinnitus can actually make the symptoms worse. Relaxation techniques can bring some relief to those who suffer since it’ll lessen the symptoms.

Yoga and Massage
While yoga and massage might lean more towards relaxation techniques, they are great ways to take the focus off the sounds you’re experiencing. While relaxing, performing yoga or getting a massage, it’s best to avoid silence. Play some soft music in the background.

Sound Therapy
Choosing a sound that counteracts the tinnitus is often a part of sound therapy and tinnitus habituation. Some people like the sounds of the beach. Others like rainfall in a forest. You’ll have to experiment with sounds to find what best suits your needs.

Some people use a variety of sounds like the television during the day and soothing sounds at night, so they can sleep. The noise you pick to counteract the tinnitus should not be irritating or annoying, since that will defeat the purpose.

It can take weeks to months to become habituated to the sounds of tinnitus. That’s after weeks of trying to find the right sounds to soothe and mask the sounds generated in your ears. While it takes some, it’s definitely possible.



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Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.

Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.

Clin Epigenetics. 2016;8:91

Authors: Kernohan KD, Cigana Schenkel L, Huang L, Smith A, Pare G, Ainsworth P, Care4Rare Canada Consortium, Boycott KM, Warman-Chardon J, Sadikovic B

Abstract
BACKGROUND: DNA methylation is an essential epigenetic mark, controlled by DNA methyltransferase (DNMT) proteins, which regulates chromatin structure and gene expression throughout the genome. In this study, we describe a family with adult-onset autosomal dominant cerebellar ataxia with deafness and narcolepsy (ADCA-DN) caused by mutations in the maintenance methyltransferase DNMT1 and assess the DNA methylation profile of these individuals.
RESULTS: We report a family with six individuals affected with ADCA-DN; specifically, patients first developed hearing loss and ataxia, followed by narcolepsy, and cognitive decline. We identified a heterozygous DNMT1 variant, c.1709C>T [p.Ala570Val] by Sanger sequencing, which had been previously reported as pathogenic for ADCA-DN and segregated with disease in the family. DNA methylation analysis by high-resolution genome-wide DNA methylation array identified a decrease in CpGs with 0-10 % methylation and 80-95 % methylation and a concomitant increase in sites with 10-30 % methylation and >95 % methylation. This pattern suggests an increase in methylation of normally unmethylated regions, such as promoters and CpG islands, as well as further methylation of highly methylated gene bodies and intergenic regions. Furthermore, a regional analysis identified 82 hypermethylated loci with consistent robust differences across ≥5 consecutive probes compared to our large reference cohort.
CONCLUSIONS: This report identifies robust changes in the DNA methylation patterns in ADCA-DN patients, which is an important step towards elucidating disease pathogenesis.

PMID: 27602171 [PubMed - in process]



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Delayed diagnosis of MYH-9–related disorder and the role of light microscopy in congenital macrothrombocytopenias.

http:--highwire.stanford.edu-icons-exter Related Articles

Delayed diagnosis of MYH-9–related disorder and the role of light microscopy in congenital macrothrombocytopenias.

Blood. 2016 Apr 14;127(15):1940

Authors: Perez Botero J, Patnaik MM

PMID: 27540618 [PubMed - indexed for MEDLINE]



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Logopedia en paciente con mapeo cortical intraoperatorio

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Publication date: Available online 7 September 2016
Source:Revista de Logopedia, Foniatría y Audiología
Author(s): José Luis Acevedo Pérez, Amalia Sánchez López, Concepción Núñez Núñez
El mapeo cortical intraoperatorio es una técnica segura y de alta fiabilidad para la resección de tumores en el área elocuente sensitivo-motriz sin producir más déficit. Cada día se está implantando en más hospitales. Se necesita de un equipo multidisciplinar con profesionales altamente cualificados. La incorporación del médico foniatra y del logopeda a este equipo puede ser clave en cualquiera de sus fases. Durante la cirugía el paciente se mantiene despierto y colabora de forma activa cuando se trata de resecciones en áreas del lenguaje. Antes de extirpar se realiza el mapeo aplicando estimulación eléctrica cortical mientras se va explorando continuamente el lenguaje con el fin de minimizar secuelas. Finalizada la exéresis se vuelve a explorar lingüísticamente al paciente antes de dormirle para el cierre. El postoperatorio suele transcurrir sin complicaciones y el control con resonancia magnética postoperatoria confirma si la extirpación ha sido completa o no. Posteriormente se evalúa al paciente en planta y en consultas externas y se plantea un tratamiento precoz que identifique, recupere y/o compense los posibles déficits lingüísticos diagnosticados. El tratamiento de logopedia es de menor duración y con mejor pronóstico. La labor del servicio de foniatría-logopedia se torna relevante para colaborar antes, durante y después de la cirugía. Es importante conocer en profundidad esta técnica para abordar al paciente con mejores resultados. En el presente artículo se ilustra la técnica de mapeo cerebral intraoperatorio y la posterior rehabilitación a partir de un caso clínico.The intraoperative cortical mapping is a safe and highly reliable technique for tumor resection in the eloquent sensorimotor cortex. This technique is currently being implemented in hospitals worldwide. For its implementation, a multidisciplinary team of highly qualified professionals is required and the incorporation of a phoniatrician and a speech therapist into this team may be crucial in any of its stages. During the surgical procedure, the patient remains awake and actively collaborates when it comes to language areas resections. While the mapping is applied, the patient performs a language test in order to minimize sequelae. Once the excision is complete, the patient is re-evaluated linguistically before putting to sleep in order to perform the closure of the craniotomy. Postoperative complications are rare and MRI controls can confirm whether the removal was complete or not. Eventually, the patient must be checked for any superimposed neurological deficits during admission or outpatient visits. Early treatment must be applied to identify, recover and/or compensates the possible linguistic deficits previously diagnosed. The speech and language therapy is shorter and with a better prognosis. The role of the phoniatry and speech therapy are significant before, during and after the surgical procedure. It is important to profoundly know this technique in order to treat the patient with better results. This article illustrates the intraoperative brain mapping technique and the subsequent rehabilitation process with phoniatry and speech therapy based on a clinical case.



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Logopedia en paciente con mapeo cortical intraoperatorio

alertIcon.gif

Publication date: Available online 7 September 2016
Source:Revista de Logopedia, Foniatría y Audiología
Author(s): José Luis Acevedo Pérez, Amalia Sánchez López, Concepción Núñez Núñez
El mapeo cortical intraoperatorio es una técnica segura y de alta fiabilidad para la resección de tumores en el área elocuente sensitivo-motriz sin producir más déficit. Cada día se está implantando en más hospitales. Se necesita de un equipo multidisciplinar con profesionales altamente cualificados. La incorporación del médico foniatra y del logopeda a este equipo puede ser clave en cualquiera de sus fases. Durante la cirugía el paciente se mantiene despierto y colabora de forma activa cuando se trata de resecciones en áreas del lenguaje. Antes de extirpar se realiza el mapeo aplicando estimulación eléctrica cortical mientras se va explorando continuamente el lenguaje con el fin de minimizar secuelas. Finalizada la exéresis se vuelve a explorar lingüísticamente al paciente antes de dormirle para el cierre. El postoperatorio suele transcurrir sin complicaciones y el control con resonancia magnética postoperatoria confirma si la extirpación ha sido completa o no. Posteriormente se evalúa al paciente en planta y en consultas externas y se plantea un tratamiento precoz que identifique, recupere y/o compense los posibles déficits lingüísticos diagnosticados. El tratamiento de logopedia es de menor duración y con mejor pronóstico. La labor del servicio de foniatría-logopedia se torna relevante para colaborar antes, durante y después de la cirugía. Es importante conocer en profundidad esta técnica para abordar al paciente con mejores resultados. En el presente artículo se ilustra la técnica de mapeo cerebral intraoperatorio y la posterior rehabilitación a partir de un caso clínico.The intraoperative cortical mapping is a safe and highly reliable technique for tumor resection in the eloquent sensorimotor cortex. This technique is currently being implemented in hospitals worldwide. For its implementation, a multidisciplinary team of highly qualified professionals is required and the incorporation of a phoniatrician and a speech therapist into this team may be crucial in any of its stages. During the surgical procedure, the patient remains awake and actively collaborates when it comes to language areas resections. While the mapping is applied, the patient performs a language test in order to minimize sequelae. Once the excision is complete, the patient is re-evaluated linguistically before putting to sleep in order to perform the closure of the craniotomy. Postoperative complications are rare and MRI controls can confirm whether the removal was complete or not. Eventually, the patient must be checked for any superimposed neurological deficits during admission or outpatient visits. Early treatment must be applied to identify, recover and/or compensates the possible linguistic deficits previously diagnosed. The speech and language therapy is shorter and with a better prognosis. The role of the phoniatry and speech therapy are significant before, during and after the surgical procedure. It is important to profoundly know this technique in order to treat the patient with better results. This article illustrates the intraoperative brain mapping technique and the subsequent rehabilitation process with phoniatry and speech therapy based on a clinical case.



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Logopedia en paciente con mapeo cortical intraoperatorio

alertIcon.gif

Publication date: Available online 7 September 2016
Source:Revista de Logopedia, Foniatría y Audiología
Author(s): José Luis Acevedo Pérez, Amalia Sánchez López, Concepción Núñez Núñez
El mapeo cortical intraoperatorio es una técnica segura y de alta fiabilidad para la resección de tumores en el área elocuente sensitivo-motriz sin producir más déficit. Cada día se está implantando en más hospitales. Se necesita de un equipo multidisciplinar con profesionales altamente cualificados. La incorporación del médico foniatra y del logopeda a este equipo puede ser clave en cualquiera de sus fases. Durante la cirugía el paciente se mantiene despierto y colabora de forma activa cuando se trata de resecciones en áreas del lenguaje. Antes de extirpar se realiza el mapeo aplicando estimulación eléctrica cortical mientras se va explorando continuamente el lenguaje con el fin de minimizar secuelas. Finalizada la exéresis se vuelve a explorar lingüísticamente al paciente antes de dormirle para el cierre. El postoperatorio suele transcurrir sin complicaciones y el control con resonancia magnética postoperatoria confirma si la extirpación ha sido completa o no. Posteriormente se evalúa al paciente en planta y en consultas externas y se plantea un tratamiento precoz que identifique, recupere y/o compense los posibles déficits lingüísticos diagnosticados. El tratamiento de logopedia es de menor duración y con mejor pronóstico. La labor del servicio de foniatría-logopedia se torna relevante para colaborar antes, durante y después de la cirugía. Es importante conocer en profundidad esta técnica para abordar al paciente con mejores resultados. En el presente artículo se ilustra la técnica de mapeo cerebral intraoperatorio y la posterior rehabilitación a partir de un caso clínico.The intraoperative cortical mapping is a safe and highly reliable technique for tumor resection in the eloquent sensorimotor cortex. This technique is currently being implemented in hospitals worldwide. For its implementation, a multidisciplinary team of highly qualified professionals is required and the incorporation of a phoniatrician and a speech therapist into this team may be crucial in any of its stages. During the surgical procedure, the patient remains awake and actively collaborates when it comes to language areas resections. While the mapping is applied, the patient performs a language test in order to minimize sequelae. Once the excision is complete, the patient is re-evaluated linguistically before putting to sleep in order to perform the closure of the craniotomy. Postoperative complications are rare and MRI controls can confirm whether the removal was complete or not. Eventually, the patient must be checked for any superimposed neurological deficits during admission or outpatient visits. Early treatment must be applied to identify, recover and/or compensates the possible linguistic deficits previously diagnosed. The speech and language therapy is shorter and with a better prognosis. The role of the phoniatry and speech therapy are significant before, during and after the surgical procedure. It is important to profoundly know this technique in order to treat the patient with better results. This article illustrates the intraoperative brain mapping technique and the subsequent rehabilitation process with phoniatry and speech therapy based on a clinical case.



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Τετάρτη 7 Σεπτεμβρίου 2016

The Influence of Cochlear Mechanical Dysfunction, Temporal Processing Deficits, and Age on the Intelligibility of Audible Speech in Noise for Hearing-Impaired Listeners

The aim of this study was to assess the relative importance of cochlear mechanical dysfunction, temporal processing deficits, and age on the ability of hearing-impaired listeners to understand speech in noisy backgrounds. Sixty-eight listeners took part in the study. They were provided with linear, frequency-specific amplification to compensate for their audiometric losses, and intelligibility was assessed for speech-shaped noise (SSN) and a time-reversed two-talker masker (R2TM). Behavioral estimates of cochlear gain loss and residual compression were available from a previous study and were used as indicators of cochlear mechanical dysfunction. Temporal processing abilities were assessed using frequency modulation detection thresholds. Age, audiometric thresholds, and the difference between audiometric threshold and cochlear gain loss were also included in the analyses. Stepwise multiple linear regression models were used to assess the relative importance of the various factors for intelligibility. Results showed that (a) cochlear gain loss was unrelated to intelligibility, (b) residual cochlear compression was related to intelligibility in SSN but not in a R2TM, (c) temporal processing was strongly related to intelligibility in a R2TM and much less so in SSN, and (d) age per se impaired intelligibility. In summary, all factors affected intelligibility, but their relative importance varied across maskers.



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