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Seeking a quiet cafe to discuss business or chat with a friend? The new iHEARu mobile app can help.
The iHEARu mobile app uses crowd-sourcing to help individuals find locations with noise levels that suit your needs. Whether seeking a quiet eatery or lively bar with loud music, the iHEARu GPS will help you find it. By combining decibel data gathered from smartphone users in real-life environments, iHEARu provides the data to change the world…one ear-friendly place at a time.
Founded and inspired by world-renowned neuroscientists and audiologists from the University of Washington Dr. Kelly Tremblay and Dr. Charles Limb of the University of California, San Francisco (UCSF), the iHEARu app helps people collect decibel data in public spaces. The iHEARu team has partnered with the UCSF Sound and Music Perception Lab, headed by Dr. Limb, to help San Francisco's hearing-challenged community find ear-friendly places to visit. The team is calling on all citizen scientists to join the movement by downloading the free app and taking data readings across the city. For each data reading during Restaurant Week (January 22–31), the iHEARu team will make a contribution to the Hearing Loss Association of America and CHEFSGIVING.
Why create an ear-friendly movement? Consider:
The app can be downloaded for FREE via the App Store or Google Play. Learn more about iHearu from Dr. Tremblay's article .
Seeking a quiet cafe to discuss business or chat with a friend? The new iHEARu mobile app can help.
The iHEARu mobile app uses crowd-sourcing to help individuals find locations with noise levels that suit your needs. Whether seeking a quiet eatery or lively bar with loud music, the iHEARu GPS will help you find it. By combining decibel data gathered from smartphone users in real-life environments, iHEARu provides the data to change the world…one ear-friendly place at a time.
Founded and inspired by world-renowned neuroscientists and audiologists from the University of Washington Dr. Kelly Tremblay and Dr. Charles Limb of the University of California, San Francisco (UCSF), the iHEARu app helps people collect decibel data in public spaces. The iHEARu team has partnered with the UCSF Sound and Music Perception Lab, headed by Dr. Limb, to help San Francisco's hearing-challenged community find ear-friendly places to visit. The team is calling on all citizen scientists to join the movement by downloading the free app and taking data readings across the city. For each data reading during Restaurant Week (January 22–31), the iHEARu team will make a contribution to the Hearing Loss Association of America and CHEFSGIVING.
Why create an ear-friendly movement? Consider:
The app can be downloaded for FREE via the App Store or Google Play. Learn more about iHearu from Dr. Tremblay's article .
Seeking a quiet cafe to discuss business or chat with a friend? The new iHEARu mobile app can help.
The iHEARu mobile app uses crowd-sourcing to help individuals find locations with noise levels that suit your needs. Whether seeking a quiet eatery or lively bar with loud music, the iHEARu GPS will help you find it. By combining decibel data gathered from smartphone users in real-life environments, iHEARu provides the data to change the world…one ear-friendly place at a time.
Founded and inspired by world-renowned neuroscientists and audiologists from the University of Washington Dr. Kelly Tremblay and Dr. Charles Limb of the University of California, San Francisco (UCSF), the iHEARu app helps people collect decibel data in public spaces. The iHEARu team has partnered with the UCSF Sound and Music Perception Lab, headed by Dr. Limb, to help San Francisco's hearing-challenged community find ear-friendly places to visit. The team is calling on all citizen scientists to join the movement by downloading the free app and taking data readings across the city. For each data reading during Restaurant Week (January 22–31), the iHEARu team will make a contribution to the Hearing Loss Association of America and CHEFSGIVING.
Why create an ear-friendly movement? Consider:
The app can be downloaded for FREE via the App Store or Google Play. Learn more about iHearu from Dr. Tremblay's article .
A recently published study, "Establishing a mental lexicon with cochlear implants: an ERP study with young children," conducted by researchers at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) in Leipzig and the University Medical Centre Dresden, reported that hearing-impaired children with cochlear implants (CI) pick up words faster compared with normal-hearing children. The study aimed to examine the lexical-semantic development of profoundly hearing-impaired and deaf children with CI using the N400 effect, which is an event-related potential (ERP) that reflects semantic processing, as its marker.
The study briefly explains that natural hearing is different from hearing through CI: the implant yields only limited frequency discrimination and dynamic range resulting in more hearing difficulty in hearing especially in noisy environments. The research points out that—especially in cases of children with congenital or acquired sensorineural deafness— infants' brains develop without any auditory input for a considerable amount of time. This means that even with implantation at about 12 months, which is considered as early implantation, congenitally hearing-impaired children will only have their first auditory input experience at a time when children with normal hearing will already have explored language to an extent that allows them to produce their first words.
Test subjects were 36 hearing-impaired children with bilateral CIs. However, due to excessive artefacts, six were excluded from further analysis. 13 subjects had severe hearing loss with some residual hearing prior to implantation; the remaining 19 had congenital bilateral deafness. Following their cochlear implantation, the children underwent a rehabilitation program where they received bimonthly fitting of the speech processor and multidisciplinary speech and language therapy for up to three years. Electroencephalogram (EEG) recordings were performed 12, 18 and 24 months after first implant activation.
Niki Vavatzanidis, one of the authors of the research, in a press release from Max Planck Institute, said "We observed that when deaf children get their implants, they learn words faster than those with normal hearing. Consequently, they build up certain word pools faster." Study leader Angela D. Friederici, head of MPI CBS, further explained that "children with cochlear implants could help us understand the general processes of language acquisition and determine which single steps are age-dependent."
A recently published study, "Establishing a mental lexicon with cochlear implants: an ERP study with young children," conducted by researchers at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) in Leipzig and the University Medical Centre Dresden, reported that hearing-impaired children with cochlear implants (CI) pick up words faster compared with normal-hearing children. The study aimed to examine the lexical-semantic development of profoundly hearing-impaired and deaf children with CI using the N400 effect, which is an event-related potential (ERP) that reflects semantic processing, as its marker.
The study briefly explains that natural hearing is different from hearing through CI: the implant yields only limited frequency discrimination and dynamic range resulting in more hearing difficulty in hearing especially in noisy environments. The research points out that—especially in cases of children with congenital or acquired sensorineural deafness— infants' brains develop without any auditory input for a considerable amount of time. This means that even with implantation at about 12 months, which is considered as early implantation, congenitally hearing-impaired children will only have their first auditory input experience at a time when children with normal hearing will already have explored language to an extent that allows them to produce their first words.
Test subjects were 36 hearing-impaired children with bilateral CIs. However, due to excessive artefacts, six were excluded from further analysis. 13 subjects had severe hearing loss with some residual hearing prior to implantation; the remaining 19 had congenital bilateral deafness. Following their cochlear implantation, the children underwent a rehabilitation program where they received bimonthly fitting of the speech processor and multidisciplinary speech and language therapy for up to three years. Electroencephalogram (EEG) recordings were performed 12, 18 and 24 months after first implant activation.
Niki Vavatzanidis, one of the authors of the research, in a press release from Max Planck Institute, said "We observed that when deaf children get their implants, they learn words faster than those with normal hearing. Consequently, they build up certain word pools faster." Study leader Angela D. Friederici, head of MPI CBS, further explained that "children with cochlear implants could help us understand the general processes of language acquisition and determine which single steps are age-dependent."
A recently published study, "Establishing a mental lexicon with cochlear implants: an ERP study with young children," conducted by researchers at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) in Leipzig and the University Medical Centre Dresden, reported that hearing-impaired children with cochlear implants (CI) pick up words faster compared with normal-hearing children. The study aimed to examine the lexical-semantic development of profoundly hearing-impaired and deaf children with CI using the N400 effect, which is an event-related potential (ERP) that reflects semantic processing, as its marker.
The study briefly explains that natural hearing is different from hearing through CI: the implant yields only limited frequency discrimination and dynamic range resulting in more hearing difficulty in hearing especially in noisy environments. The research points out that—especially in cases of children with congenital or acquired sensorineural deafness— infants' brains develop without any auditory input for a considerable amount of time. This means that even with implantation at about 12 months, which is considered as early implantation, congenitally hearing-impaired children will only have their first auditory input experience at a time when children with normal hearing will already have explored language to an extent that allows them to produce their first words.
Test subjects were 36 hearing-impaired children with bilateral CIs. However, due to excessive artefacts, six were excluded from further analysis. 13 subjects had severe hearing loss with some residual hearing prior to implantation; the remaining 19 had congenital bilateral deafness. Following their cochlear implantation, the children underwent a rehabilitation program where they received bimonthly fitting of the speech processor and multidisciplinary speech and language therapy for up to three years. Electroencephalogram (EEG) recordings were performed 12, 18 and 24 months after first implant activation.
Niki Vavatzanidis, one of the authors of the research, in a press release from Max Planck Institute, said "We observed that when deaf children get their implants, they learn words faster than those with normal hearing. Consequently, they build up certain word pools faster." Study leader Angela D. Friederici, head of MPI CBS, further explained that "children with cochlear implants could help us understand the general processes of language acquisition and determine which single steps are age-dependent."
It is well known that there is communication between the auditory and the visual system. Audiologists frequently take advantage of this relationship in balance system diagnostics as related to the vestibular-ocular reflex (VOR). Yet, new findings suggest this relationship is not limited to the inner ear.
InnerScope Hearing Technologies (http://www.innd.com/) now offers purchase options and hearing resources to personal sound amplifier products (PSAPs) consumers on its direct-to-consumer e-commerce site, Hearingbenefit.com. They can sign up to receive an e-book produced by InnerScope called The Senior Medical Controversy on Hearingbenefit.com to learn about the consequences of untreated hearing loss, including cognitive issues such as Alzheimer's and dementia. InnerScope has also created a separate landing page (http://www.howtohearbetter.com/) to assist consumers through the evaluation and decision phase of choosing a device. Matthew Moore, CEO of InnerScope, said once people click onto their e-commerce store, it is easy for them to navigate and make a decision to purchase. "We have taken the stress off the buying process, by offering easy payments with zero down and zero interest. We know that for years the tens of millions of hearing impaired people have been an underserved market… We offer these people through our Hearingbenefit.com website easy and simple access to hearing products that can help improve their hearing immediately without hurting their pocketbook, and even a money back guarantee," Moore said.
InnerScope Hearing Technologies (http://www.innd.com/) now offers purchase options and hearing resources to personal sound amplifier products (PSAPs) consumers on its direct-to-consumer e-commerce site, Hearingbenefit.com. They can sign up to receive an e-book produced by InnerScope called The Senior Medical Controversy on Hearingbenefit.com to learn about the consequences of untreated hearing loss, including cognitive issues such as Alzheimer's and dementia. InnerScope has also created a separate landing page (http://www.howtohearbetter.com/) to assist consumers through the evaluation and decision phase of choosing a device. Matthew Moore, CEO of InnerScope, said once people click onto their e-commerce store, it is easy for them to navigate and make a decision to purchase. "We have taken the stress off the buying process, by offering easy payments with zero down and zero interest. We know that for years the tens of millions of hearing impaired people have been an underserved market… We offer these people through our Hearingbenefit.com website easy and simple access to hearing products that can help improve their hearing immediately without hurting their pocketbook, and even a money back guarantee," Moore said.
InnerScope Hearing Technologies (http://www.innd.com/) now offers purchase options and hearing resources to personal sound amplifier products (PSAPs) consumers on its direct-to-consumer e-commerce site, Hearingbenefit.com. They can sign up to receive an e-book produced by InnerScope called The Senior Medical Controversy on Hearingbenefit.com to learn about the consequences of untreated hearing loss, including cognitive issues such as Alzheimer's and dementia. InnerScope has also created a separate landing page (http://www.howtohearbetter.com/) to assist consumers through the evaluation and decision phase of choosing a device. Matthew Moore, CEO of InnerScope, said once people click onto their e-commerce store, it is easy for them to navigate and make a decision to purchase. "We have taken the stress off the buying process, by offering easy payments with zero down and zero interest. We know that for years the tens of millions of hearing impaired people have been an underserved market… We offer these people through our Hearingbenefit.com website easy and simple access to hearing products that can help improve their hearing immediately without hurting their pocketbook, and even a money back guarantee," Moore said.
Related Articles |
Novel frameshift mutation in the KCNQ1 gene responsible for Jervell and Lange-Nielsen syndrome.
Iran J Basic Med Sci. 2018 Jan;21(1):108-111
Authors: Amirian A, Dalili SM, Zafari Z, Saber S, Karimipoor M, Akbari V, Fazelifar AF, Zeinali S
Abstract
Objectives: Jervell and Lange-Nielsen syndrome is an autosomal recessive disorder caused by mutations in KCNQ1 or KCNE1 genes. The disease is characterized by sensorineural hearing loss and long QT syndrome.
Materials and Methods: Here we present a 3.5-year-old female patient, an offspring of consanguineous marriage, who had a history of recurrent syncope and congenital sensorineural deafness. The patient and the family members were screened for mutations in KCNQ1 gene by linkage analysis and DNA sequencing.
Results: DNA sequencing showed a c.1532_1534delG (p. A512Pfs*81) mutation in the KCNQ1 gene in homozygous form. The results of short tandem repeat (STR) markers showed that the disease in the family is linked to the KCNQ1 gene. The mutation was confirmed in the parents in heterozygous form.
Conclusion: This is the first report of this variant in KCNQ1 gene in an Iranian family. The data of this study could be used for early diagnosis of the condition in the family and genetic counseling.
PMID: 29372044 [PubMed]
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Gene therapy for inherited retinal and optic nerve degenerations.
Expert Opin Biol Ther. 2018 Jan;18(1):37-49
Authors: Moore NA, Morral N, Ciulla TA, Bracha P
Abstract
INTRODUCTION: The eye is a target for investigational gene therapy due to the monogenic nature of many inherited retinal and optic nerve degenerations (IRD), its accessibility, tight blood-ocular barrier, the ability to non-invasively monitor for functional and anatomic outcomes, as well as its relative immune privileged state.Vectors currently used in IRD clinical trials include adeno-associated virus (AAV), small single-stranded DNA viruses, and lentivirus, RNA viruses of the retrovirus family. Both can transduce non-dividing cells, but AAV are non-integrating, while lentivirus integrate into the host cell genome, and have a larger transgene capacity. Areas covered: This review covers Leber's congenital amaurosis, choroideremia, retinitis pigmentosa, Usher syndrome, Stargardt disease, Leber's hereditary optic neuropathy, Achromatopsia, and X-linked retinoschisis. Expert opinion: Despite great potential, gene therapy for IRD raises many questions, including the potential for less invasive intravitreal versus subretinal delivery, efficacy, safety, and longevity of response, as well as acceptance of novel study endpoints by regulatory bodies, patients, clinicians, and payers. Also, ultimate adoption of gene therapy for IRD will require widespread genetic screening to identify and diagnose patients based on genotype instead of phenotype.
PMID: 29057663 [PubMed - indexed for MEDLINE]
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A Guerilla Guide to Common Problems in 'Neurostatistics': Essential Statistical Topics in Neuroscience.
J Undergrad Neurosci Educ. 2017;16(1):R1-R12
Authors: Smith PF
Abstract
Effective inferential statistical analysis is essential for high quality studies in neuroscience. However, recently, neuroscience has been criticised for the poor use of experimental design and statistical analysis. Many of the statistical issues confronting neuroscience are similar to other areas of biology; however, there are some that occur more regularly in neuroscience studies. This review attempts to provide a succinct overview of some of the major issues that arise commonly in the analyses of neuroscience data. These include: the non-normal distribution of the data; inequality of variance between groups; extensive correlation in data for repeated measurements across time or space; excessive multiple testing; inadequate statistical power due to small sample sizes; pseudo-replication; and an over-emphasis on binary conclusions about statistical significance as opposed to effect sizes. Statistical analysis should be viewed as just another neuroscience tool, which is critical to the final outcome of the study. Therefore, it needs to be done well and it is a good idea to be proactive and seek help early, preferably before the study even begins.
PMID: 29371855 [PubMed]
Related Articles |
A Guerilla Guide to Common Problems in 'Neurostatistics': Essential Statistical Topics in Neuroscience.
J Undergrad Neurosci Educ. 2017;16(1):R1-R12
Authors: Smith PF
Abstract
Effective inferential statistical analysis is essential for high quality studies in neuroscience. However, recently, neuroscience has been criticised for the poor use of experimental design and statistical analysis. Many of the statistical issues confronting neuroscience are similar to other areas of biology; however, there are some that occur more regularly in neuroscience studies. This review attempts to provide a succinct overview of some of the major issues that arise commonly in the analyses of neuroscience data. These include: the non-normal distribution of the data; inequality of variance between groups; extensive correlation in data for repeated measurements across time or space; excessive multiple testing; inadequate statistical power due to small sample sizes; pseudo-replication; and an over-emphasis on binary conclusions about statistical significance as opposed to effect sizes. Statistical analysis should be viewed as just another neuroscience tool, which is critical to the final outcome of the study. Therefore, it needs to be done well and it is a good idea to be proactive and seek help early, preferably before the study even begins.
PMID: 29371855 [PubMed]
InnerScope Hearing Technologies (http://www.innd.com/) now offers purchase options and hearing resources to personal sound amplifier products (PSAPs) consumers on its direct-to-consumer e-commerce site, Hearingbenefit.com. They can sign up to receive an e-book produced by InnerScope called The Senior Medical Controversy on Hearingbenefit.com to learn about the consequences of untreated hearing loss, including cognitive issues such as Alzheimer's and dementia. InnerScope has also created a separate landing page (http://www.howtohearbetter.com/) to assist consumers through the evaluation and decision phase of choosing a device. Matthew Moore, CEO of InnerScope, said once people click onto their e-commerce store, it is easy for them to navigate and make a decision to purchase. "We have taken the stress off the buying process, by offering easy payments with zero down and zero interest. We know that for years the tens of millions of hearing impaired people have been an underserved market… We offer these people through our Hearingbenefit.com website easy and simple access to hearing products that can help improve their hearing immediately without hurting their pocketbook, and even a money back guarantee," Moore said.
InnerScope Hearing Technologies (http://www.innd.com/) now offers purchase options and hearing resources to personal sound amplifier products (PSAPs) consumers on its direct-to-consumer e-commerce site, Hearingbenefit.com. They can sign up to receive an e-book produced by InnerScope called The Senior Medical Controversy on Hearingbenefit.com to learn about the consequences of untreated hearing loss, including cognitive issues such as Alzheimer's and dementia. InnerScope has also created a separate landing page (http://www.howtohearbetter.com/) to assist consumers through the evaluation and decision phase of choosing a device. Matthew Moore, CEO of InnerScope, said once people click onto their e-commerce store, it is easy for them to navigate and make a decision to purchase. "We have taken the stress off the buying process, by offering easy payments with zero down and zero interest. We know that for years the tens of millions of hearing impaired people have been an underserved market… We offer these people through our Hearingbenefit.com website easy and simple access to hearing products that can help improve their hearing immediately without hurting their pocketbook, and even a money back guarantee," Moore said.
InnerScope Hearing Technologies (http://www.innd.com/) now offers purchase options and hearing resources to personal sound amplifier products (PSAPs) consumers on its direct-to-consumer e-commerce site, Hearingbenefit.com. They can sign up to receive an e-book produced by InnerScope called The Senior Medical Controversy on Hearingbenefit.com to learn about the consequences of untreated hearing loss, including cognitive issues such as Alzheimer's and dementia. InnerScope has also created a separate landing page (http://www.howtohearbetter.com/) to assist consumers through the evaluation and decision phase of choosing a device. Matthew Moore, CEO of InnerScope, said once people click onto their e-commerce store, it is easy for them to navigate and make a decision to purchase. "We have taken the stress off the buying process, by offering easy payments with zero down and zero interest. We know that for years the tens of millions of hearing impaired people have been an underserved market… We offer these people through our Hearingbenefit.com website easy and simple access to hearing products that can help improve their hearing immediately without hurting their pocketbook, and even a money back guarantee," Moore said.