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OtoRhinoLaryngology by Sfakianakis G.Alexandros Sfakianakis G.Alexandros,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174
Tinnitus is a condition often described as a “ringing” or “buzzing” sound in the ears. Tinnitus can be continuous or intermittent, and the sound may be loud or soft and subtle. The condition is fairly common, and many people simply adjust to the ongoing sounds in their ears without huge difficulty. For some people, however, the condition can be very loud and extreme. It can interfere with normal hearing, even though the Tinnitus is not necessarily causing the hearing loss.
Searching For Relief
Tinnitus can appear for many reasons. The top cause is exposure to loud noise, like gunshots or loud machinery. Infections and ear blockages can also bring on the condition. Some medications, including aspirin and antidepressants, can bring on Tinnitus. For some people the sound can be continuous and go on through the night, causing sleep loss. This can bring on a vicious circle, as fatigue and stress are also thought to be linked to Tinnitus.
There is no known cure for Tinnitus at this time, but some people have found relief by listening to another sound that helps block the sound. This is called a “masking sound.” The best masking sound for Tinnitus may vary for different people, but here are a few sounds that are said to work well to alleviate the symptoms of tinnitus.
Sound Therapies
Finding the best masking sound for Tinnitus is an important part of therapy for this condition. The best masking sound for Tinnitus, whether it is the sound of rainfall, a relaxing ocean surf sound, or the quiet sound of general “white noise,” can work in several ways to ease the anxiety that Tinnitus can bring on in a patient.
The best masking sound for Tinnitus is one that can completely cover the sound inside the ear, or at least enough to be a distraction. The element of distraction is important as it can ease symptoms of the condition immediately. The sound masking treatment also helps to train the patient’s brain in a way that makes it tune out the Tinnitus sound. The American Tinnitus Association calls this brain training a way of “classifying” the sound as an “unimportant” (and thus easier to ignore) sound. The ATA also refers to a neuromodulation effect that comes with sound masking, as the masking sounds can help relieve hyperactivity in the brain that is also thought to bring on Tinnitus.
Today there are many options for masking sounds, ranging from peaceful ocean sounds to nature sounds to white noise, or white noise without high frequencies. Masking sounds can be played from a special player or even put in ear pieces.
The good news is that masking sounds do bring relief and they bring it in a way that is low cost and has no side effects. That’s a great bit of news for Tinnitus sufferers everywhere, to be sure.
A wave expansion method is proposed in this work, based on measurements with a spherical microphone array, and formulated in the framework provided by Compressive Sensing. The method promotes sparse solutions via ℓ1-norm minimization, so that the measured data are represented by few basis functions. This results in fine spatial resolution and accuracy. This publication covers the theoretical background of the method, including experimental results that illustrate some of the fundamental differences with the “conventional” least-squares approach. The proposed methodology is relevant for source localization, sound field reconstruction, and sound fieldanalysis.
The frequency following response (FFR) arises from the sustained neural activity of a population of neurons that are phase locked to periodic acoustic stimuli. Determining the source of the FFR noninvasively may be useful for understanding the function of phase locking in the auditory pathway to the temporal envelope and fine structure of sounds. The current study compared the FFR recorded with a horizontally aligned (mastoid-to-mastoid) electrode montage and a vertically aligned (forehead-to-neck) electrode montage. Unlike previous studies, envelope and fine structure latencies were derived simultaneously from the same narrowband stimuli to minimize differences in cochlear delay. Stimuli were five amplitude-modulated tones centered at 576 Hz, each with a different modulation rate, resulting in different side-band frequencies across stimulus conditions. Changes in response phase across modulation frequency and side-band frequency (group delay) were used to determine the latency of the FFR reflecting phase locking to the envelope and temporal fine structure, respectively. For the FFR reflecting phase locking to the temporal fine structure, the horizontal montage had a shorter group delay than the vertical montage, suggesting an earlier generation source within the auditory pathway. For the FFR reflecting phase locking to the envelope, group delay was longer than that for the fine structure FFR, and no significant difference in group delay was found between montages. However, it is possible that multiple sources of FFR (including the cochlear microphonic) were recorded by each montage, complicating interpretations of the group delay.
A wave expansion method is proposed in this work, based on measurements with a spherical microphone array, and formulated in the framework provided by Compressive Sensing. The method promotes sparse solutions via ℓ1-norm minimization, so that the measured data are represented by few basis functions. This results in fine spatial resolution and accuracy. This publication covers the theoretical background of the method, including experimental results that illustrate some of the fundamental differences with the “conventional” least-squares approach. The proposed methodology is relevant for source localization, sound field reconstruction, and sound fieldanalysis.
Noise- and sine-carrier vocoders are often used to acoustically simulate the information transmitted by a cochlear implant(CI). However, sine-waves fail to mimic the broad spread of excitation produced by a CI and noise-bands contain intrinsic modulations that are absent in CIs. The present study proposes pulse-spreading harmonic complexes (PSHCs) as an alternative acoustic carrier in vocoders. Sentence-in-noise recognition was measured in 12 normal-hearing subjects for noise-, sine-, and PSHC-vocoders. Consistent with the amount of intrinsic modulations present in each vocoder condition, the average speech reception threshold obtained with the PSHC-vocoder was higher than with sine-vocoding but lower than with noise-vocoding.
Beyond what the eye can see.
Surv Ophthalmol. 2016 Feb 24;
Authors: Ahmad KE, Fraser CL, Sue CM, Barton JJ
Abstract
A 45 year old woman presented with acute sequential optic neuropathy resulting in bilateral complete blindness. No significant visual recovery occurred. Past medical history was relevant for severe pre-eclampsia with resultant renal failure, diabetes mellitus, and sudden bilateral hearing loss when she was. There was a family history of diabetes mellitus in her mother. Testing for common causes of bilateral optic neuropathy did not reveal a diagnosis for her illness. The maternal history of diabetes, and personal history of diabetes and deafness prompted testing for mitochondrial disease. The three primary mitochondrial DNA mutations responsible for Leber Hereditary Optic Neuropathy (LHON), but the patient was subsequently found to have a disease causing mitochondrial DNA mutation, m.13513G>A. The case illustrates the importance of early testing for mitochondrial disease, and demonstrates that LHON like presentations may be missed if testing is limited to the three primary mutations.
PMID: 26921807 [PubMed - as supplied by publisher]
Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation.
Cell Death Differ. 2016 Feb 26;
Authors: Chen JR, Tang ZH, Zheng J, Shi HS, Ding J, Qian XD, Zhang C, Chen JL, Wang CC, Li L, Chen JZ, Yin SK, Shao JZ, Huang TS, Chen P, Guan MX, Wang JF
Abstract
Deafness or hearing loss is a major issue in human health. Inner ear hair cells are the main sensory receptors responsible for hearing. Defects in hair cells are one of the major causes of deafness. A combination of induced pluripotent stem cell (iPSC) technology with genome-editing technology may provide an attractive cell-based strategy to regenerate hair cells and treat hereditary deafness in humans. Here, we report the generation of iPSCs from members of a Chinese family carrying MYO15A c.4642G>A and c.8374G>A mutations and the induction of hair cell-like cells from those iPSCs. The compound heterozygous MYO15A mutations resulted in abnormal morphology and dysfunction of the derived hair cell-like cells. We used a CRISPR/Cas9 approach to genetically correct the MYO15A mutation in the iPSCs and rescued the morphology and function of the derived hair cell-like cells. Our data demonstrate the feasibility of generating inner ear hair cells from human iPSCs and the functional rescue of gene mutation-based deafness by using genetic correction.Cell Death and Differentiation advance online publication, 26 February 2016; doi:10.1038/cdd.2016.16.
PMID: 26915297 [PubMed - as supplied by publisher]
Related Articles |
Vestibular Assessment and Rehabilitation: Ten-Year Survey Trends of Audiologists' Opinions and Practice.
J Am Acad Audiol. 2016 Feb;27(2):126-40
Authors: Nelson MD, Akin FW, Riska KM, Andresen K, Mondelli SS
Abstract
BACKGROUND: The past decade has yielded changes in the education and training of audiologists and technological advancements that have become widely available for clinical balance function testing. It is unclear if recent advancements in vestibular instrumentation or the transition to an AuD degree have affected audiologists' vestibular clinical practice or opinions.
PURPOSE: The purpose of this study was to examine predominant opinions and practices for vestibular assessment (VA) and vestibular rehabilitation (VR) over the past decade and between master's- and AuD-level audiologists.
METHOD: A 31-question survey was administered to audiologists via U.S. mail in 2003 (N = 7,500) and electronically in 2014 (N = 9,984) with a response rate of 12% and 10%, respectively.
RESULTS: There was an increase in the number of audiologists providing vestibular services in the past decade. Most respondents agreed that audiologists were the most qualified professionals to conduct VA. Less than half of the surveyed audiologists felt that graduate training was adequate for VA. AuD-level audiologists were more satisfied with graduate training and felt more comfortable performing VA compared to master's-level audiologists. Few respondents agreed that audiologists were the most qualified professionals to conduct VR or that graduate training prepared them to conduct VR. The basic vestibular test battery was unchanged across surveys and included: calorics, smooth pursuit, saccades, search for spontaneous, positional, gaze and optokinetic nystagmus, Dix-Hallpike, case history, and hearing evaluation. There was a trend toward greater use of air (versus water) calorics, videonystagmography (versus electronystagmography), and additional tests of vestibular and balance function.
CONCLUSIONS: VA is a growing specialty area in the field of audiology. Better training opportunities are needed to increase audiologists' knowledge and skills for providing vestibular services. The basic tests performed during VA have remained relatively unchanged over the past 10 yr.
PMID: 26905532 [PubMed - in process]
A Distributed Network for Social Cognition Enriched for Oxytocin Receptors.
J Neurosci. 2016 Feb 24;36(8):2517-35
Authors: Mitre M, Marlin BJ, Schiavo JK, Morina E, Norden SE, Hackett TA, Aoki CJ, Chao MV, Froemke RC
Abstract
UNLABELLED: Oxytocin is a neuropeptide important for social behaviors such as maternal care and parent-infant bonding. It is believed that oxytocin receptor signaling in the brain is critical for these behaviors, but it is unknown precisely when and where oxytocin receptors are expressed or which neural circuits are directly sensitive to oxytocin. To overcome this challenge, we generated specific antibodies to the mouse oxytocin receptor and examined receptor expression throughout the brain. We identified a distributed network of female mouse brain regions for maternal behaviors that are especially enriched for oxytocin receptors, including the piriform cortex, the left auditory cortex, and CA2 of the hippocampus. Electron microscopic analysis of the cerebral cortex revealed that oxytocin receptors were mainly expressed at synapses, as well as on axons and glial processes. Functionally, oxytocin transiently reduced synaptic inhibition in multiple brain regions and enabled long-term synaptic plasticity in the auditory cortex. Thus modulation of inhibition may be a general mechanism by which oxytocin can act throughout the brain to regulate parental behaviors and social cognition.
SIGNIFICANCE STATEMENT: Oxytocin is an important peptide hormone involved in maternal behavior and social cognition, but it has been unclear what elements of neural circuits express oxytocin receptors due to the paucity of suitable antibodies. Here, we developed new antibodies to the mouse oxytocin receptor. Oxytocin receptors were found in discrete brain regions and at cortical synapses for modulating excitatory-inhibitory balance and plasticity. These antibodies should be useful for future studies of oxytocin and social behavior.
PMID: 26911697 [PubMed - in process]
Related Articles |
Vestibular Assessment and Rehabilitation: Ten-Year Survey Trends of Audiologists' Opinions and Practice.
J Am Acad Audiol. 2016 Feb;27(2):126-40
Authors: Nelson MD, Akin FW, Riska KM, Andresen K, Mondelli SS
Abstract
BACKGROUND: The past decade has yielded changes in the education and training of audiologists and technological advancements that have become widely available for clinical balance function testing. It is unclear if recent advancements in vestibular instrumentation or the transition to an AuD degree have affected audiologists' vestibular clinical practice or opinions.
PURPOSE: The purpose of this study was to examine predominant opinions and practices for vestibular assessment (VA) and vestibular rehabilitation (VR) over the past decade and between master's- and AuD-level audiologists.
METHOD: A 31-question survey was administered to audiologists via U.S. mail in 2003 (N = 7,500) and electronically in 2014 (N = 9,984) with a response rate of 12% and 10%, respectively.
RESULTS: There was an increase in the number of audiologists providing vestibular services in the past decade. Most respondents agreed that audiologists were the most qualified professionals to conduct VA. Less than half of the surveyed audiologists felt that graduate training was adequate for VA. AuD-level audiologists were more satisfied with graduate training and felt more comfortable performing VA compared to master's-level audiologists. Few respondents agreed that audiologists were the most qualified professionals to conduct VR or that graduate training prepared them to conduct VR. The basic vestibular test battery was unchanged across surveys and included: calorics, smooth pursuit, saccades, search for spontaneous, positional, gaze and optokinetic nystagmus, Dix-Hallpike, case history, and hearing evaluation. There was a trend toward greater use of air (versus water) calorics, videonystagmography (versus electronystagmography), and additional tests of vestibular and balance function.
CONCLUSIONS: VA is a growing specialty area in the field of audiology. Better training opportunities are needed to increase audiologists' knowledge and skills for providing vestibular services. The basic tests performed during VA have remained relatively unchanged over the past 10 yr.
PMID: 26905532 [PubMed - in process]
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Related Articles |
Higher prevalence of autoimmune diseases and longer spells of vertigo in patients affected with familial Ménière's disease: A clinical comparison of familial and sporadic Ménière's disease.
Am J Audiol. 2014 Jun;23(2):232-7
Authors: Hietikko E, Sorri M, Männikkö M, Kotimäki J
Abstract
PURPOSE This study compared clinical features, predisposing factors, and concomitant diseases between sporadic and familial Ménière's disease (MD). METHOD Retrospective chart review and postal questionnaire were used. Participants were 250 definite patients with MD (sporadic, n =149; familial, n = 101) who fulfilled the American Academy of Otorhinolaryngology-Head and Neck Surgery (1995) criteria. RESULTS On average, familial patients were affected 5.6 years earlier than sporadic patients, and they suffered from significantly longer spells of vertigo (p = .007). The prevalence of rheumatoid arthritis (p = .002) and other autoimmune diseases (p = .046) was higher among the familial patients, who also had more migraine (p = .036) and hearing impairment (p = .002) in their families. CONCLUSION The clinical features of familial and sporadic MD are very similar in general, but some differences do exist. Familial MD patients are affected earlier and suffer from longer spells of vertigo.
PMID: 24686733 [PubMed - indexed for MEDLINE]