An assessment of bone-seeking radionuclides for palliation of metastatic bone pain in a vertebral model

Abstract

Objective

Bone-seeking radiopharmaceuticals have the main role in the treatment of painful bone metastases. The aim of this study was to dosimetrically compare radiopharmaceuticals in use for bone pain palliation therapy and bone scan.

Methods

The MCNPX code was used to simulate the radiation transport in a vertebral phantom. Absorbed fractions were calculated for monoenergetic electrons, photons and alpha particles. S values were obtained for radionuclides ³²P, ³³P, ⁸⁹Sr, ⁹⁰Y, ^99mTc, ^117mSn, ¹⁵³Sm, ¹⁶⁶Ho, ¹⁶⁹Er, ¹⁷⁷Lu, ¹⁸⁶Re, ¹⁸⁸Re, ²²³Ra, ²²⁴Ra and their progenies for target regions including the active marrow and the bone endosteum.

Results

The results demonstrated the dependence of dosimetric parameters on the source or target size, particle energy and location of the source. The electron emitters including ³³P, ^117mSn, ¹⁶⁹Er and ¹⁷⁷Lu and ²²³Ra as an α-emitter gave the lower absorbed dose to the active marrow. These radionuclides gave the highest values of the Relative Advantage Factor (RAF).

Conclusions

According to the results, ³³P, ^117mSn, ¹⁶⁹Er, ¹⁷⁷Lu and ²²³Ra have fewer side effects on the active marrow than other investigated radionuclides. Therefore, these radionuclides may be a better choice for use in palliative radiotherapy.

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