The Diagnostic Contribution of SPECT/CT Imaging in the Assessment of Gastrointestinal Bleeding: Especially for Previously Operated Patients.

xlomafota13 shared this article with you from Inoreader The Diagnostic Contribution of SPECT/CT Imaging in the Assessment of Gastrointestinal Bleeding: Especially for Previously Operated Patients. Via Mol Imaging Radionucl Ther Related Articles The Diagnostic Contribution of SPECT/CT Imaging in the Assessment of Gastrointestinal Bleeding: Especially for Previously Operated Patients. Mol Imaging Radionucl Ther. 2021 Feb 09;30(1):8-17 Authors: Soyluoğlu S, Korkmaz Ü, Özdemir B, Durmuş Altun G Abstract Objectives: Gastrointestinal bleeding (GIB) is a life-threatening problem that requires a multidisciplinary approach for successful treatment. This study aims to emphasize the clinical contribution of single photon emission computed tomography/computed tomography (SPECT/CT) for the diagnosis of acute bleeding. Methods: All 14 patients referred to the nuclear medicine department in 3 years with suspicion of acute GIB were evaluated retrospectively. Clinical records were analyzed to assess the scintigraphic findings, emphasizing the correlative contribution of the CT portion on SPECT/CT studies. Results: Five patients were negative on dynamic and static planar images. SPECT/CT was performed in 9 patients who had positive findings on planar imaging. SPECT/CT could identify the same bleeding site originating from the anastomosis in four patients with a history of abdominal surgery. SPECT/CT confirmed bleeding from the cecum in a patient with cervical cancer. SPECT/CT showed the bleeding focus in the bladder neck of a patient with bladder cancer and the bleeding from peritoneal metastases of a patient with gastric cancer. In 1 patient, the right upper quadrant activity accumulation, which may cause false positives, was found to be the gallbladder on SPECT/CT. Delayed images showed the true bleeding focus in the cecum. In 1 patient, suspicious activity accumulation in the midline of the abdomen was found to be due to a previously unknown aortic aneurysm on SPECT/CT. Conclusion: SPECT/CT imaging is a feasible technique to facilitate image interpretation in patients with GIB. SPECT/CT imaging can guide the surgeon through more accurate localization. Therefore, for proper patient management, SPECT/CT should be applied to detect the bleeding focus, if present, especially in patients who had undergone a previous operation. PMID: 33586402 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

18Fluorine-fluorodeoxyglucose PET/CT Imaging in Childhood Malignancies

xlomafota13 shared this article with you from Inoreader 18Fluorine-fluorodeoxyglucose PET/CT Imaging in Childhood Malignancies Via Mol Imaging Radionucl Ther Related Articles 18Fluorine-fluorodeoxyglucose PET/CT Imaging in Childhood Malignancies Mol Imaging Radionucl Ther. 2021 02 09;30(1):18-27 Authors: Bıçakçı N, Elli M Abstract Objectives: The aim of the study was to evaluate the utility of 18fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in the diagnosis, staging, restaging, and treatment response of childhood malignancies. Methods: This study included 52 patients (32 boys, 20 girls) who were referred to our clinic between November 2008 and December 2018 with the diagnosis of malignancy. The patients were evaluated retrospectively. Median age of the patients was 13 years (range 2-17). 18F-FDG was given to the patients intravenously, and time of flight with PET/16 slice CT was performed 1 hour thereafter. The lowest dose was 2 mCi (74 MBq) and the highest dose was 10 mCi (370 MBq). Fasting blood sugars of all patients were found below 200 mg/dL (11.1 mmol/L). Results: 18F-FDG PET/CT was performed to evaluate the response to treatment in 38 of 52 children, staging in 11 patients (staging and evaluation of the response to treatment in nine of them), restaging in 2 patients, restaging, and evaluation of the response to treatment in 1 patient. 18F-FDG PET/CT examination was reported as normal in 13 patients (5 girls, 8 boys). The pathological 18F-FDG uptake was detected in 39 patients (14 girls, 25 boys), which indicated metastasis and/or recurrence of the primary disease. Total number of deaths was 30 (13 girls, 17 boys). Conclusion: 18F-FDG PET/CT has a significant role for staging, restaging, treatment response, and detection of metastatic disease but it is limited for the early diagnosis of childhood cancers. PMID: 33586403 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension

xlomafota13 shared this article with you from Inoreader Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension Via Mol Imaging Radionucl Ther Related Articles Correlation Between Perfusion Abnormalities Extent in Ventilation/Perfusion SPECT/CT with Hemodynamic Parameters in Patients with Chronic Thromboembolic Pulmonary Hypertension Mol Imaging Radionucl Ther. 2021 02 09;30(1):28-33 Authors: Özgüven S, Kesim S, Öksüzoğlu K, Yanartaş M, Taş S, Şen F, Öneş T, İnanır S, Turoğlu HT, Mutlu B, Erdil TY, Yıldızeli B Abstract Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension with persistent pulmonary vascular obstruction and exercise intolerance, which may benefit from pulmonary endarterectomy (PEA). Ventilation/perfusion (V/Q) scan is the preferred screening test of CTEPH, which can be used to assess the anatomical extent of the disease. This study aimed to analyze the correlation between the extent of mismatched Q defects in V/Q single photon emission computed tomography/computed tomography (SPECT/CT) with preoperative clinical and hemodynamic parameters in patients with CTEPH. Methods: A total of 102 patients with CTEPH prior to PEA having V/Q SPECT/CT scans were retrospectively reviewed. Age, gender, New York Heart Association classification, intraoperative right-sided heart catheterization (mPAP and PVR), and 6-minute walk test (6MWT) findings were obtained from clinical records of patients. Results: Linear regression analysis showed a significant but weak correlation between the preoperative mPAP and PVR with the extent of mismatched Q defects in V/Q SPECT/CT (rs=0.09474 with p=0.0016 and rs=0.045 with p=0.045, respectively). No significant correlation was found between 6MWT and extent of mismatched Q defects in V/Q SPECT/CT (p>0.05). Conclusion: A quantitative assessment of Q defects on V/Q SPECT/CT might provide information about hemodynamic parameters in patients with CTEPH. PMID: 33586404 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of Radiochemical and Chemical Impurities in Liquid Wastes of Two Different 68Ge/68Ga Generators used in Nuclear Medicine PET Chemistry

xlomafota13 shared this article with you from Inoreader Comparison of Radiochemical and Chemical Impurities in Liquid Wastes of Two Different 68Ge/68Ga Generators used in Nuclear Medicine PET Chemistry Via Mol Imaging Radionucl Ther Related Articles Comparison of Radiochemical and Chemical Impurities in Liquid Wastes of Two Different 68Ge/68Ga Generators used in Nuclear Medicine PET Chemistry Mol Imaging Radionucl Ther. 2021 02 09;30(1):34-38 Authors: Uğur A, Yaylalı O, Yüksel D Abstract Objectives: Germanium-68/gallium-68 (68Ge/68Ga) generator eluate contains a number of metal cations that can compete with 68GaCl3, reducing specific radioactivity. The first step in peptide labeling with 68GaCl3 is to remove 68Ge and several other metals with a long half-life. In this purification step, the elution residue that is passed through the cartridge is collected in glass waste bottles. Waste management is included in good production practices, and in particular, the activity of long half-life 68Ge (270.95 days) and other toxic metal levels need to be examined. Our objective in this study is to determine the 68Ge activity in liquid waste produced by the generation of 68Ga and heavy metal concentrations from the generator column materials and to assess whether it can be disposed of as normal waste. Methods: Liquid wastes produced by passing the 68Ge/68Ga generator eluate of 2 different identities via PSH+ cartridge have been analyzed with the inductively coupled plasma mass spectrometry device in the advanced technology application and research center of our university. Results: The average of the 68Ge radioactive pollution was estimated to be 0.142 ppm (μg.mL-1) in the liquid waste analysis after passing through the PSH+ cartridge in the pre-elution in the GalluGEN brand generator. While there was no tin (Sn) impurity, it was determined that the average zinc (Zn) was 1.95 ppm (μg.mL-1) and the average aluminum (Al) impurity was 10.95 ppm (μg.mL-1). While no 68Ge radioactive pollution was determined in the iThemba LABS brand generator, the average Sn was 0.098 ppm (μg.mL-1), average Zn 48.6 ppm (μg.mL-1), and average Al impurity 4.135 ppm (μg.mL-1). Conclusion: All 68Ge/68Ga generators produced have their own certificates. Metallic contamination in the postmarking waste of 68Ge/68Ga generators can be different. It would be a safe method to keep these wastes in place until they are dumped into the sewage systems, given their half-lives in terms of long half-life radioactive metallic contamination. PMID: 33586405 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Physiological Biodistribution of 68Ga-DOTA-TATE in Normal Subjects

xlomafota13 shared this article with you from Inoreader Physiological Biodistribution of 68Ga-DOTA-TATE in Normal Subjects Via Mol Imaging Radionucl Ther Related Articles Physiological Biodistribution of 68Ga-DOTA-TATE in Normal Subjects Mol Imaging Radionucl Ther. 2021 02 09;30(1):39-46 Authors: Özgüven S, Filizoğlu N, Kesim S, Öksüzoğlu K, Şen F, Öneş T, İnanır S, Turoğlu HT, Erdil TY Abstract Objectives: Somatostatin is an endocrine peptide hormone that regulates neurotransmission and cell proliferation by interacting with G protein-coupled somatostatin receptors (SSTRs). SSTRs are specific molecular targets of several radiotracers for neuroendocrine tumor (NET) imaging. Gallium-68 (68Ga)-DOTA-TATE is widely used for positron emission tomography/computed tomography (PET/CT) imaging of SSTRs and has shown a higher affinity for SSTR2, the most common SSTR subtype found in NETs. We aimed to analyze the distribution pattern of 68Ga-DOTA-TATE in normal subjects. Methods: A total of 617 consecutive 68Ga-DOTA-TATE PET/CT whole-body scans performed in our department from May 2015 through April 2020 with known or suspected neuroendocrine malignancies, mostly to evaluate adrenal adenomas, were retrospectively analyzed by 2 nuclear medicine physicians. One hundred eighteen subjects without a diagnosis of NET, with no tracer avid lesion of NET on 68Ga-DOTA-TATE PET/CT, and followed up for at least 6 months (average 2-3 years) without any biochemical, clinical, or imaging findings suggestive of NET were included in this study. Results: The highest uptake of 68Ga-DOTA-TATE was noted in the spleen followed by the kidneys, adrenal glands, liver, stomach, small intestine, prostate gland, pancreas head, pancreas body, thyroid gland, and uterus, in descending order. Minimal to mild uptake was detected in the submandibular glands, parotid glands, thymus, muscles, bones, breast, lungs, and mediastinum. Conclusion: Our study shows the biodistribution pattern of 68Ga-DOTA-TATE in normal subjects and the ranges of the maximum standard uptake value (SUVmax) and SUVmean values of 68Ga-DOTA-TATE obtained in several tissues for reliably identifying malignancy in 68Ga-DOTA-TATE PET/CT studies. PMID: 33586406 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

18F-FDG PET/CT Imaging of Metastatic Testicular Choriocarcinoma Mimicking Gastric Cancer which Initial Symptom is Melena

xlomafota13 shared this article with you from Inoreader 18F-FDG PET/CT Imaging of Metastatic Testicular Choriocarcinoma Mimicking Gastric Cancer which Initial Symptom is Melena Via Mol Imaging Radionucl Ther Related Articles 18F-FDG PET/CT Imaging of Metastatic Testicular Choriocarcinoma Mimicking Gastric Cancer which Initial Symptom is Melena Mol Imaging Radionucl Ther. 2021 02 09;30(1):47-49 Authors: Göksel S, Akın S, Akdoğan RA, Rakıcı S, Abdioğlu GY, Ayvaz MA Abstract Gastric metastasis of choriocarcinoma is rarely reported in the literature. This case report presents the case of multiple metastatic testicular choriocarcinoma mimicking gastric cancer, with melena as the initial symptom. In this case, 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) showed that the testis was the primary focus. The contribution of PET/CT is significant to primary focus detection in metastatic diseases of unknown primary origin that presented gastrointestinal bleeding. In addition to its use in staging of testicular carcinoma, PET/CT provides significant benefit in evaluating patients with increased levels of tumor markers and in detecting recurrence. PMID: 33586408 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Somatostatin Receptor Scintigraphy in a Patient with Myocarditis

xlomafota13 shared this article with you from Inoreader Somatostatin Receptor Scintigraphy in a Patient with Myocarditis Via Mol Imaging Radionucl Ther Related Articles Somatostatin Receptor Scintigraphy in a Patient with Myocarditis Mol Imaging Radionucl Ther. 2021 02 09;30(1):50-53 Authors: Amini A, Dehdar F, Jafari E, Gholamrezanezhad A, Assadi M Abstract We report a case of myocarditis imaged with technetium-99m octreotide cardiac single-photon emission computed tomography which showed diffuse uptake in the myocardium, indicating inflammatory reaction to myocardial damage. Somatostatin receptor scintigraphy of the heart could be considered in patients with suspected cardiac inflammation. This could facilitate early diagnosis and guide appropriate treatment. PMID: 33586409 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Small-angle Compton Scatter Artifact in Tc-99m-IDA Hepatobiliary Scintigraphy Resulting in the Breast Overlying the Liver in Planar Dynamic Imaging.

xlomafota13 shared this article with you from Inoreader Small-angle Compton Scatter Artifact in Tc-99m-IDA Hepatobiliary Scintigraphy Resulting in the Breast Overlying the Liver in Planar Dynamic Imaging. Via Mol Imaging Radionucl Ther Related Articles Small-angle Compton Scatter Artifact in Tc-99m-IDA Hepatobiliary Scintigraphy Resulting in the Breast Overlying the Liver in Planar Dynamic Imaging. Mol Imaging Radionucl Ther. 2021 Feb 09;30(1):54-56 Authors: Qutbi M Abstract Compton scatter photons are generally considered problematic in nuclear medicine imaging. Therefore, efforts are being made to minimize the involvement of these photons by employing some special strategies in daily practice. Basically, photons scattering at a small angle and traveling in the proper direction stand a chance of getting recorded and thereby participate in the image formation. These photons may create artifactual hot spots in the vicinity of a region with high concentration of radioactivity. The present study focuses on the negative impact of such photons during routine imaging in clinical setting, through an artifact detected in technetium-99m-IDA hepatobiliary scintigraphy, with the purpose of highlighting this issue to the nuclear medicine practitioners. PMID: 33586410 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Active Giant Cell Vasculitis Diagnosis with 68Ga PSMA PET/CT Imaging.

xlomafota13 shared this article with you from Inoreader Active Giant Cell Vasculitis Diagnosis with 68Ga PSMA PET/CT Imaging. Via Mol Imaging Radionucl Ther Related Articles Active Giant Cell Vasculitis Diagnosis with 68Ga PSMA PET/CT Imaging. Mol Imaging Radionucl Ther. 2021 Feb 09;30(1):57-59 Authors: Sağer MS, Bilgiç S, Uslu L, Asa S, Sağer G, Sönmezoğlu K Abstract Vasculitis is a multisystem disease characterized by inflammation with infiltration of leukocytes into the blood vessels. Giant cell arteritis (GCA) is the most common form of vasculitis that mostly affects medium- and large-sized arteries. 18Fluorine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is increasingly used to diagnose inflammation of large arteries in GCA. Galium-68 prostate-specific membrane antigen (PSMA) PET/CT has a vital role in the assessment of patients with prostate cancer for recurrence and metastasis of the disease. Various benign and non-prostate malignant conditions may give rise to increased PSMA uptake. Herein, we demonstrate that PSMA uptake can be seen in GCA. PMID: 33586411 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Unexpected Detection of Abscessualized Lung Carcinoma on Tc-99m-HMPAO-labeled Leukocytes Scintigraphy Misdiagnosed on Chest Computed Tomography.

xlomafota13 shared this article with you from Inoreader Unexpected Detection of Abscessualized Lung Carcinoma on Tc-99m-HMPAO-labeled Leukocytes Scintigraphy Misdiagnosed on Chest Computed Tomography. Via Mol Imaging Radionucl Ther Related Articles Unexpected Detection of Abscessualized Lung Carcinoma on Tc-99m-HMPAO-labeled Leukocytes Scintigraphy Misdiagnosed on Chest Computed Tomography. Mol Imaging Radionucl Ther. 2021 Feb 09;30(1):60-62 Authors: Cosma L, Frantellizzi V, Pontico M, De Vincentis G Abstract Technetium-99m (Tc-99m)-hexamethylpropylene amine oxime (HMPAO)-labeled leukocytes scintigraphy is well established for investigating and diagnosing infections in bone and soft tissue, as well as for the detection of occult infection. A 71-year-old female who was recently diagnosed with bronchopulmonary neuroendocrine tumor of the right lung was referred for an intermittent fever of unknown origin associated with chill at night for the last month. Chest computed tomography (CT) scan showed a thrombotic widespread of the superior vena cava and a solid pathological tissue in the superior segment of the inferior lobe of the right lung with consensual atelectasis. Being a carrier of port-a-cath, an infection of this device was suspected. Therefore, Tc-99m-HMPAO-labeled leukocytes single-photon emission computed tomography (SPECT) was performed, and matching pairs of CT scan and Tc-99m-HMPAO-labeled white blood cell SPECT images were fused. Through this means, it was found that th e area of the radiotracer increased uptake corresponded with the soft tissue density mass detected by CT scan localized at the inferior lobe of the right lung. The hybrid SPECT/CT fused imaging was crucial for diagnosis of the presence of a lung abscess localized in correspondence with the known lung cancer region. PMID: 33586412 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

68Ga PSMA Uptake at Roux-en-Y Eso-jejunostomy Junction Mimicking the Recurrence of Gastric Carcinoma in PET/CT.

xlomafota13 shared this article with you from Inoreader 68Ga PSMA Uptake at Roux-en-Y Eso-jejunostomy Junction Mimicking the Recurrence of Gastric Carcinoma in PET/CT. Via Mol Imaging Radionucl Ther Related Articles 68Ga PSMA Uptake at Roux-en-Y Eso-jejunostomy Junction Mimicking the Recurrence of Gastric Carcinoma in PET/CT. Mol Imaging Radionucl Ther. 2021 Feb 09;30(1):63-66 Authors: Arslan E, Aksoy T, Cin M, Çakır C, Can Trabulus FD, Çermik TF Abstract A 67-year-old male patient had undergone total gastrectomy and Roux-en-Y eso-jejunostomy 3 years ago for the treatment of tubular adenocarcinoma located at the corpus of the stomach. The patient was diagnosed with Gleason score 8 (4+4) metastatic prostate cancer during the follow-up period and received hormone therapy. Owing to his elevated prostate-specific antigen levels (77 ng/mL), his clinician referred him gallium-68 (68Ga) prostate-specific membrane antigen 11 (PSMA) positron emission tomography/computed tomography (PET/CT) for restaging. PET/CT showed multiple 68Ga PSMA receptor-positive skeletal lesions and linear PSMA activity at the eso-jejunostomy junction. He was then referred to undergo 18fluorine-fluorodeoxyglucose (18F-FDG) PET/CT to screen for gastric carcinoma recurrence. PET/CT images demonstrated no 18F-FDG avid lesion. However, endoscopy and biopsy performed with samples from the eso-jejunostomy junction revealed superficial benign squamous epithelial frag ments. PMID: 33586413 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.