Objectives. To develop a differential approach to the treatment of acute psychosis induced by synthetic cannabinoids. Materials and methods. A total of 43 patients aged 18–45 years with acute psychosis due to consumption of synthetic cannabinoids were studied. Clinical psychology, psychometric, and laboratory methods were used, along with statistical analysis. Results and conclusions. Inclusion of neuroleptic agents into complex therapy increased treatment efficacy. Selection of neuroleptics requires not only the psychopathological structure of the psychosis, but also the severity of psychosis-associated somatoneurological disorders to be considered.
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