Association between serotonin-norepinephrine reuptake inhibitors and acute angle closure: what is known?

Association between serotonin-norepinephrine reuptake inhibitors and acute angle closure: what is known?

Surv Ophthalmol. 2018 Sep 29;:

Authors: Wiciński M, Kałużny B, Liberski S, Marczak D, Seredyka-Burduk M, Pawlak-Osińska K

Abstract
Serotonin-norepinephrine reuptake inhibitors (SNRIs) are widely used antidepressants with a relatively safe profile. One of the complications associated with this group of drugs is acute angle closure (AAC). The mechanisms linking SNRIs and AAC are complex and may be interlinked with the effects of the drug on the inhibition of serotonin and noradrenaline reuptake, as well as pseudo-anticholinergic effects, dopaminergic effects, and idiosyncratic reactions with the drug molecule in the eye. Individual characteristics, such as polymorphisms of the gene encoding the 2D6 subunit of cytochrome P450, may affect the metabolism of the SNRI; while, the combination with other drugs may lead to an increased risk of iridocorneal angle closure, and may further exacerbate other mechanisms. Improved knowledge of the mechanisms linking SNRIs and AAC and of the risk factors predisposing to patients to AAC will reduce the number of patients affected by this dangerous complication.

PMID: 30278181 [PubMed - as supplied by publisher]

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