The University of Miami Miller School of Medicine's department of otolaryngology has received a $3 million grant from the National Institutes of Health (NIH) for research on biological treatments and clinical diagnosis of hearing loss. With this new grant, Xue Zhong Liu, MD, PhD, a professor of otolaryngology, human genetics, biochemistry, and pediatrics and the vice chair and Marian & Walter Hotchkiss Chair in Otolaryngology who will spearhead the research as the principal investigator, and his team will expand their genomic and phenotypic deafness database for the clinical care of deaf individuals. They also plan to identify and characterize novel genes for hearing loss using state-of-the-art genomic tools, assess the impact of genomic testing on patients, and conduct preclinical studies of gene- and cell-based therapy approach of CRISPR/Cas9-mediated genome editing to treat hearing loss. Liu said in a press release that recent breakthroughs in genetic screening, gene or cell-based therapeutics, and gene editing for the inner ear can lead to novel therapies for multiple classes of hereditary hearing loss. "Together with our program for genetic hearing loss, these tools and strategies will create a clear path to clinical treatment and accelerate the advent of a new era of personalized medicine for hereditary hearing loss," he said.
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