ZO-2, a tight junction protein involved in gene expression, proliferation, apoptosis, and cell size regulation.

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ZO-2, a tight junction protein involved in gene expression, proliferation, apoptosis, and cell size regulation.

Ann N Y Acad Sci. 2017 Apr 17;:

Authors: González-Mariscal L, Miranda J, Raya-Sandino A, Domínguez-Calderón A, Cuellar-Perez F

Abstract
ZO-2 is a peripheral tight junction protein that belongs to the membrane-associated guanylate kinase protein family. Here, we explain the modular and supramodular organization of ZO-2 that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors. We also describe how ZO proteins evolved through metazoan evolution and analyze the intracellular traffic of ZO-2, as well as the roles played by ZO-2 at the plasma membrane and nucleus that translate into the regulation of proliferation, cell size, and apoptosis. In addition, we focus on the impact of ZO-2 expression on male fertility and on maladies like cancer, cholestasis, and hearing loss.

PMID: 28415133 [PubMed - as supplied by publisher]

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