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Electric field-navigated transcranial magnetic stimulation for chronic tinnitus: a randomized, placebo-controlled study.
Int J Audiol. 2017 Apr 18;:1-9
Authors: Sahlsten H, Virtanen J, Joutsa J, Niinivirta-Joutsa K, Löyttyniemi E, Johansson R, Paavola J, Taiminen T, Sjösten N, Salonen J, Holm A, Rauhala E, Jääskeläinen SK
Abstract
OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) may alleviate tinnitus. We evaluated effects of electric field (E-field) navigated rTMS targeted according to tinnitus pitch. No controlled studies have investigated anatomically accurate E-field-rTMS for tinnitus.
DESIGN: Effects of E-field-rTMS were evaluated in a prospective randomised placebo-controlled 6-month follow-up study on parallel groups. Patients received 10 sessions of 1 Hz rTMS or placebo targeted to the left auditory cortex corresponding to tonotopic representation of tinnitus pitch. Effects were evaluated immediately after treatment and at 1, 3 and 6 months. Primary outcome measures were visual analogue scores (VAS 0-100) for tinnitus intensity, annoyance and distress, and the Tinnitus Handicap Inventory (THI).
STUDY SAMPLE: Thirty-nine patients (mean age 50.3 years).
RESULTS: The mean tinnitus intensity (F3 = 15.7, p < 0.0001), annoyance (F3 = 8.8, p = 0.0002), distress (F3 = 9.1, p = 0.0002) and THI scores (F4 = 13.8, p < 0.0001) decreased in both groups over time with non-significant differences between the groups. After active rTMS, 42% and 37% of the patients showed excellent response at 1 and 3 months against 15% and 10% in the placebo group (p = 0.082 and p = 0.065).
CONCLUSIONS: Despite the significant effects of rTMS on tinnitus, differences between active and placebo groups remained non-significant, due to large placebo-effect and wide inter-individual variation.
PMID: 28415897 [PubMed - as supplied by publisher]
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