Evaluation of cochlear functions in children with Familial Mediterranean Fever.

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Evaluation of cochlear functions in children with Familial Mediterranean Fever.

Int J Pediatr Otorhinolaryngol. 2016 Aug;87:139-42

Authors: Lordoglu B, Acar B, Yazilitas F, Ozlu SG, Senel S

Abstract
OBJECTIVES: To evaluate cochlear functions in patients with Familial Mediterranean Fever in relation to the disease severity score and treatment duration.
METHODS: 50 patients (4-18 years) who had been followed-up with the diagnosis of FMF and regularly receiving appropriate colchicine treatment and 39 healthy controls were included in the study. All the patients and controls were evaluated by audiologic evaluation, including high-frequency pure-tone audiometry and distortion product otoacoustic emission tests (DPOAE). The disease severity was determined by scoring system developed by Pras et al.
RESULTS: Fifty patients (52% female, 48% male; mean age12.2 ± 4.1 years) and 39 controls (58.9% female, 41.1% male, mean age 11.1 ± 3.4 years) were enrolled the study. The pure tone average of FMF patients was significantly higher than that of the control group at 500, 4000, and 8000 Hz frequencies. The patients' DPOAE signal values at 6 kHz, 8 kHz frequencies and SNR values at 8 kHz were significantly higher than control group. The patients' audiometry and DPOAE results were compared with the disease severity scores. Pure tone average was significantly higher in severe and moderate patient groups compared to the mild patient group at 2000 Hz frequency. DPOAE signal values showed statistically significant differences between the patient severity scores at 1.4 and 2.8 kHz frequencies. The mean colchicine treatment duration was found to be 5.1 ± 3.7 years. There were significant differences at 250 and 500 Hz frequencies when patients' audiometry results were compared with the treatment periods.
CONCLUSIONS: FMF affects cochlear functions particularly at high frequencies.

PMID: 27368461 [PubMed - indexed for MEDLINE]

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