Internal Jugular Vein Compression: A Novel Approach to Mitigate Blast Induced Hearing Injury.

Hypothesis: Internal jugular vein (IJV) compression before blast injury will lead to reduced risk of traumatic hearing injury following exposure to a blast injury. Background: IJV compression and its effects on not only intracranial, but also intracochlear pressure may potentiate blast induced hearing injury, therefore, precluding its use as a prophylactic therapy for blast induced traumatic brain injury. Methods: Twenty Sprague Dawley rats were exposed to a 17.9 +/- 0.4 PSI (195.8 dB SPL) right sided shock wave in which 10 had application of a custom IJV compression collar before injury. All rodents received baseline and post blast injury otoacoustic emission (OAE) and auditory brainstem response (ABR) testing followed by cochlear histology. Results: IJV compression was shown to significantly reduce ABR and OAE threshold shifts in comparison to the non-intervention group by: 14.9 +/- 4.8 dB (right ear ABR 0.5 kHz Day 1 post blast, p = 0.01), 13.1 +/- 4.9 dB (right ear ABR 4 kHz Day 1 post blast, p = 0.04), 16.5 +/- 4.5 dB (right ear ABR click Day 1 post blast, p = 0.003), 12.1 +/- 4.6 dB (right ear ABR click Day 6 post blast, p = 0.04), and 14.0 +/- 3.2 dB (both ears OAE 3.2-10 kHz, p

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