Diabetes mellitus and the incidence of hearing loss: a cohort study.

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Diabetes mellitus and the incidence of hearing loss: a cohort study.

Int J Epidemiol. 2016 Nov 6;:

Authors: Kim MB, Zhang Y, Chang Y, Ryu S, Choi Y, Kwon MJ, Moon IJ, Deal JA, Lin FR, Guallar E, Chung EC, Hong SH, Ban JH, Shin H, Cho J

Abstract
BACKGROUND: To evaluate the association between diabetes mellitus (DM) and the development of incident hearing loss.
METHODS: Prospective cohort study was performed in 253 301 adults with normal hearing tests who participated in a regular health-screening exam between 2002 and 2014. The main exposure was the presence of DM at baseline, defined as a fasting serum glucose ≥ 126 mg/dL, a self-reported history of DM or current use of anti-diabetic medications. Pre-diabetes was defined as a fasting glucose 100-125 mg/dL and no history of DM or anti-diabetic medication use. Incident hearing loss was defined as a pure-tone average of thresholds at 0.5, 1.0 and 2.0 kHz > 25 dB in both right and left ears.
RESULTS: During 1 285 704 person-years of follow-up (median follow-up of four years), 2817 participants developed incident hearing loss. The rate of hearing loss in participants with normal glucose levels, pre-diabetes and DM were 1.8, 3.1 and 9.2 per 1000 person-years, respectively (P < 0.001). The multivariable-adjusted hazard ratios for incident hearing loss for participants with pre-diabetes and DM compared with those with normal glucose levels were 1.04 (95% confidence interval 0.95-1.14) and 1.36 (1.19-1.56), respectively. In spline regression analyses, the risk of incident hearing loss increased progressively with HbA1c levels above 5%.
CONCLUSIONS: In this large cohort study of young and middle-aged men and women, DM was associated with the development of bilateral hearing loss. DM patients have a moderately increased risk of future hearing loss.

PMID: 27818377 [PubMed - as supplied by publisher]

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