Reconstruction of Large Tissue Defects After the Resection of Brain Tumors Using a Skin Flap With Vascular Pedicle

xlomafota13 shared this article with you from Inoreader Reconstruction of Large Tissue Defects After the Resection of Brain Tumors Using a Skin Flap With Vascular Pedicle Via leak of cerebrospinal fluid J Craniofac Surg. 2021 Nov-Dec 01;32(8):2692-2694. doi: 10.1097/SCS.0000000000007610. ABSTRACT The reconstruction of large tissue defects after the resection of brain tumors is challenging for every neurosurgeon. The authors describe the benefits of a skin flap with vascular pedicle in the reconstruction of large tissue defects after the resection of brain tumors. In this retrospective analysis, a skin flap with vascular pedicle reconstruction was used in 5 patients who underwent intracranial tumor resection, accompanied by tissue defects, cerebrospinal fluid leakage and scalp infection. The surgical techniques are described, and the outcomes were discussed. The harvested flaps showed well-vascularized healing of the transplanted skin without partial necrosis in all 5 patients. One patient had cerebrospinal rhinorrhea, which was successfully treated by endoscopic repair. Another patient had cerebrospinal fluid leakage, which was successfully treated by continuous lumbar drainage. A skin flap with vascular pedicle is an effective choice for the reconstruction of large tissue defects after the resection of brain tumors. PMID:34727473 | PMC:PMC8549454 | DOI:10.1097/SCS.0000000000007610 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Radioactive iodine dose and survival in cats with hyperthyroidism (2015-2020)

xlomafota13 shared this article with you from Inoreader Radioactive iodine dose and survival in cats with hyperthyroidism (2015-2020) Via radioactive iodine J Feline Med Surg. 2021 Nov 3:1098612X211056837. doi: 10.1177/1098612X211056837. Online ahead of print. ABSTRACT OBJECTIVES: Radioactive iodine (131I) is the preferred treatment for feline hyperthyroidism but neither the optimal 131I dose nor consistent predictors of post-treatment azotaemia have been determined. The aims of the study were to evaluate the relationships between: (1) 131I dose and survival; and (2) pretreatment and post-treatment seru m creatinine concentration. METHODS: Medical records of hyperthyroid cats treated with 131I at a single referral hospital were reviewed. Information regarding signalment, body weight, pretreatment and post-treatment serum total thyroxine concentration (TT4), serum creatinine concentration, 131I dose and survival were determined. Multivariable Cox proportional hazards analysis was used to identify variables associated with survival. Multivariable linear regression analysis was used to identify variables associated with post-treatment serum creatinine concentration. RESULTS: One hundred and ninety-eight (79 male, 119 female) cats were treated for hyperthyroidism with 131I (median dose 138 MBq; interquartile range 92-168). Median survival time was 1153 days (range 16-1871). Post-treatment serum creatinine (P <0.001) and age (P = 0.049) were significantly associated with survival. Every 10 µmol/l increase in post-treatment s erum creatinine concentration and every year increase in age was associated with a 1.07 fold (confidence interval [CI] 1.04-1.11) and 1.17-fold (CI 1.00-1.37) increase in the daily hazard of death, respectively. Pretreatment serum creatinine concentration was directly, and post-treatment serum TT4 concentration was inversely, associated with post-treatment serum creatinine concentration. Every 1 μmol/l increase in pretreatment serum creatinine concentration was associated with an increase in post-treatment serum creatinine concentration of 0.7 μmol/l (SE 0.17; P <0.001). Conversely, every 1 nmol/l decrease in post-treatment serum TT4 concentration was associated with a 1.2 μmol/l (SE 0.61; P <0.001) increase in post-treatment serum creatinine concentration. CONCLUSIONS AND RELEVANCE: Post-treatment serum TT4 concentration was associated with post-treatment azotaemia, which was associated with survival. Although 131I dose was not directly assoc iated with survival, dosing strategies that minimise post-treatment hypothyroidism and azotaemia could improve patient survival. PMID:34730466 | DOI:10.1177/1098612X211056837 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

New Drug Approvals

• Scemblix (asciminib) Tablets

  Date of Approval: October 29, 2021
  Treatment for: Chronic Myelogenous Leukemia
  Press Release | Approval History

• Vuity (pilocarpine hydrochloride) Ophthalmic Solution

  Date of Approval: October 28, 2021
  Treatment for: Presbyopia
  Press Release | Approval History

• Susvimo (ranibizumab) Injection for Intravitreal Use via Ocular Implant

  Date of Approval: October 25, 2021
  Treatment for:
  Press Release | Approval History

• Xipere (triamcinolone acetonide) Injection

  Date of Approval: October 22, 2021
  Treatment for: Macular Edema, Uveitis
  Press Release | Approval History

• Zimhi (naloxone hydrochloride) Injection

  Date of Approval: October 15, 2021
  Treatment for: Opioid Overdose
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• Seglentis (celecoxib and tramadol hydrochloride) Tablets

  Date of Approval: October 15, 2021
  Treatment for: Pain
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• Tyrvaya (varenicline) Nasal Spray

  Date of Approval: October 15, 2021
  Treatment for: Dry Eye Disease
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• Rethymic (allogeneic processed thymus tissue-agdc) for Surgical Implantation

  Date of Approval: October 8, 2021
  Treatment for: Congenital Athymia
  Press Release | Approval History

• Tavneos (avacopan) Capsules

  Date of Approval: October 7, 2021
  Treatment for: ANCA-Associated Vasculitis
  Press Release | Approval History

Anterior cruciate ligament innervation in primary knee osteoarthritis

xlomafota13 shared this article with you from Inoreader Anterior cruciate ligament innervation in primary knee osteoarthritis Via Cellular and Molecular Biology Histol Histopathol. 2021 Nov 2:18389. doi: 10.14670/HH-18-389. Online ahead of print. ABSTRACT OBJECTIVE: To relate the Anterior Cruciate Ligament (ACL) innervation and histologic degeneration status to the knee osteoarthritis radiologic and functional status. DESIGN: Prospective observational study including 30 consecutive patients affected by primary knee osteoarthritis undergoing Total Knee Arthroplasty (TKA). All patients suffering secondary knee osteoarthritis, an antecedent of an infectious process, malignant process, autoimmune disorder, or previous knee surgery were excluded. We recorded biodemographic, clinical, and radiologic variables of all participants previous to the TKA procedure. ACL tissue was harvested during TKA standard procedure and the obtained sample was fixed in 4% formalin and paraffin-embedded. ACL cross-sections were stained by haematoxylin-eosin and Gallego staining for elastic and collagen fibers, and Sevier-Munger silver staining for nervous tissue. RESULTS: ACL samples histologic degeneration classification reported 15.4% normal, 23.1% slight, 26.9% mild, 11.5% moderate and 23.1% marked. We noted 46.2% large nervous fascicles, 15.4% medium fascicles, 3.8% small fascicles, and no nerve fibers were found in 34.6% ACL samples. No significant correlation was found between the histologic degeneration and the nervous fiber quantification (p>0.05, in all cases). We noted a significant histologic degeneration inverse correlation with the VAS scale (p=0.016), and nervous fiber quantification correlation with Lequesne maximum distance walked punctuation (p=0.043). We also noted greater nervous fiber quantification with minor radiological knee osteoarthritis (Kellgren-Lawrence grade II). CONCLUSIONS: ACL degeneration and innervation deficit may play a role in primary knee osteoarthritis onset, but the lack of a defining relationship among the different parameters assessed justifies further research in greater populations. PMID:34725806 | DOI:10.14670/HH-18-389 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cutoff Age Between Pediatric and Adult Thyroid Differentiated Cancer: Is 18 Years Old Appropriate?

xlomafota13 shared this article with you from Inoreader Cutoff Age Between Pediatric and Adult Thyroid Differentiated Cancer: Is 18 Years Old Appropriate? Via liebertpub1 Thyroid, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extensive Parapharyngeal Abscess in a 4-Month-Old Infant

xlomafota13 shared this article with you from Inoreader Extensive Parapharyngeal Abscess in a 4-Month-Old Infant Via ear nose throat Ear Nose Throat J. 2021 Oct 29:1455613211049854. doi: 10.1177/01455613211049854. Online ahead of print. ABSTRACT Parapharyngeal abscess in an infant is a very rare condition. We present the case of a 4-month-old girl with large masses on the neck's left side. Computed tomography showed an extensive parapharyngeal abscess. Left tonsillectomy was performed under general anesthesia from a transoral approach, followed by an incision and evacuation of the abscess from the parapha ryngeal space. Microbiological analysis identified a massive occurrence of Streptococcus intermedius. PMID:34714174 | DOI:10.1177/01455613211049854 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of the effects of platelet-rich plasma and dexamethasone ınjection on scar formation after vocal fold ınjury in rabbits

xlomafota13 shared this article with you from Inoreader Comparison of the effects of platelet-rich plasma and dexamethasone ınjection on scar formation after vocal fold ınjury in rabbits Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Oct 30. doi: 10.1007/s00405-021-07154-0. Online ahead of print. ABSTRACT OBJECTIVES: In this study, a histopathological comparison was aimed between platelet-rich plasma (PRP) injection and dexamethasone injection in the prevention of scar formation after vocal fold injury. MATERIALS AND METHODS: Electrocautery was applied to damage the right and left vocal folds of a total of 12 New Zealand rabbits. PRP obtained from the rabbit's own blood was injected into the right vocal fold, and dexamethasone was injected into the left vocal fold. After 8 weeks, the experimental animals were euthanized, and the levels of inflammatory cell infiltration, vascularization, collagen, elastin, and hyaluronic acid (HA) were compared in histopathological evaluation. RESULTS: In statistical comparison of histopathological data obtained; in terms of plasma cell infiltration, vascularization, and edema parameters, statistically significant results were obtained in favor of the PRP group. Although the difference between collagen, elastin and HA, which are critical in vocal fold scar healing, was more positive in favor of PRP, no significant result was revealed in the statistical evaluation. CONCLUSIONS: PRP injection in rabbits with vocal fold damage reveals similar characteristics with dexamethasone injection in preventing scar formation. PRP injection has favorable effects on vascularization, prevention of edema, and number of plasma cells. PMID:34718850 | DOI:10.1007/s00405-021-07154-0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.