Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Jie Li, Pengcheng Qiu, Siwang Wang, Junsheng Wu, Qiaoyan He, Kaifeng Li, Lu XuAbstractBackgroundDiabetic nephropathy (DN) is one of the most serious and dangerous chronic complications of diabetes mellitus.Panax notoginseng has been widely used with great efficacy in the long-term treatment of kidney disease. However, the mechanism by which it exerts its effects has not been fully elucidated.AimWe sought to...
Fri Mar 29, 2019 16:56
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Lirong Yi, Mei Tian, Chunnan Piao, Gang Gao, Lina Wu, Yan Pan, Jianxiang LiuAbstractAgents that provide protection against irradiation-induced hematopoietic injury are urgently needed for radiotherapy. We examined the effects of the small molecule, 1,2-propanediol (PPD), on total body irradiation (TBI)-induced hematopoietic injury in C57BL/6 mice. PPD administration 1 h before TBI significantly increased hematopoietic...
Fri Mar 29, 2019 16:56
Publication date: May 2019Source: Biomedicine & Pharmacotherapy, Volume 113Author(s):
Fri Mar 29, 2019 16:56
Fri Mar 29, 2019 18:21
Opinion statement Oropharyngeal squamous cell carcinoma (OPSCC) incidence rates have been steadily increasing over the past several decades, and this has been largely attributed to human papillomavirus (HPV)-related OPSCC. The rise of HPV-related OPSCC and the observed distinct survival advantage it offers compared to HPV-unrelated OPSCC have resulted in the development of a new staging system specifically for OPSCC in the eighth edition of the AJCC Staging Manual for head and...
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Opinion Statement Antibody-drug conjugates are an elegant approach to cancer treatment that couples the specificity of monoclonal antibodies to the cytotoxicity of classic chemotherapy agents, permitting, at least in theory, increased activity and reduced toxicity. In breast cancer, the early success of trastuzumab-emtansine (T-DM1) in the HER2-positive metastatic setting led to great hopes, later dashed by results in the early setting (KRISTINE trial) and in combination with...
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Publication date: Available online 30 March 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Yen-Jen Wang, Yen-Kai Huang, Jen-Yu Wang, Yu-Hung Wu
Sun Mar 31, 2019 12:50
Publication date: Available online 30 March 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Salem AlmoammarAbstractAimThe aim of the current study was to assess efficacy of phototherapy on mode of failure and shear bond strength among different brackets in combination with dissimilar conditioning regimens on enamel surfaceMaterial and methodsNinety maxillary premolars were arbitrarily assigned into six groups (n = 15 each) based on surface conditioning of enamel. Group 1 and group 2...
Sat Mar 30, 2019 15:52
Sat Mar 30, 2019 04:04
Publication date: Available online 30 March 2019Source: Clinical TherapeuticsAuthor(s): Theoharis C. Theoharides
Sun Mar 31, 2019 17:25
Publication date: Available online 29 March 2019Source: Clinical TherapeuticsAuthor(s): Yanguo Xin, Yinan Zhao, Xin Chen, Junli Li, Zhiyue Liu, Xiaofan Cao, Yingxian Sun, Wenyu HuAbstractPurposeCoronary artery disease is the top cause of death among the Chinese population. With the establishment of a Chinese prediction model, it is urgent to assess factors related to the prognosis of patients with acute coronary syndrome at extremely high risk.MethodsIn this retrospective study, we enrolled 601 patients...
Sat Mar 30, 2019 16:04
Publication date: Available online 28 March 2019Source: Clinical TherapeuticsAuthor(s): Matthew C. Morris, Katherine E. Cooney, Hooman Sedghamiz, Maria Abreu, Fanny Collado, Elizabeth G. Balbin, Travis J.A. Craddock, Nancy G. Klimas, Gordon Broderick, Mary Ann FletcherAbstractPurposeThe complex and varied presentation of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has made it difficult to diagnose, study, and treat. Its symptoms and likely etiology involve multiple components of endocrine...
Fri Mar 29, 2019 14:12
Publication date: Available online 28 March 2019Source: Clinical TherapeuticsAuthor(s): Edwin Lam, Ankit Rochani, Gagan Kaushal, Brandi N. Thoma, Julian Tanjuakio, Frances Mae West, Hitoshi HiroseAbstractPurposeFirst-line management of severe asthma exacerbations include the use of inhaled short-acting β-agonists, anticholinergics, and systemic corticosteroids. Continuous intravenous ketamine given at dissociative doses may be a pharmacologic option in patients who are intubated with life-threatening...
Fri Mar 29, 2019 14:12
Publication date: March 2019Source: Clinical Therapeutics, Volume 41, Issue 3Author(s):
Fri Mar 29, 2019 14:12
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Zheng Qijun, Zou Huan, Gao Ling, Chen Kaijian, Liu Wei, Ji Shuxing, Chu Xiang, Yuan Rongdi, Ye JianAbstractInflammasomes play an important role in neuroinflammation. However, their function during the secondary death of retinal cells after traumatic optic neuropathy and their dependence on pathogen stimuli remains unclear. Therefore, we evaluated the expression profiles of 10 different inflammasome-related mRNAs...
Sun Mar 31, 2019 14:47
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Shruthi Sunkari, Sowjanya Thatikonda, Venkatesh Pooladanda, Veerabhadra Swamy Challa, Chandraiah GoduguAbstractThe purpose of this study was to investigate the protective effects of ambroxol in psoriasis-like skin inflammation both in vitro and in vivo and delineate the molecular mechanism of ambroxol. Our data demonstrated that ambroxol has an imperative role in inhibiting the lipopolysaccharide (LPS) stimulated...
Sat Mar 30, 2019 12:31
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Yuan Feng, Yan Su, Chunyang Ma, Ziyang Jing, Xiaohong Yang, Daofa Zhang, Maowei Xie, Wenning Li, Jiali WeiAbstractBackgroundImmunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis and is characterized by mesangial cell proliferation and agglomeration of the mesangial matrix.MethodsIn this study, we aimed to explore the role of TNS3, PHLDB1, NTN4, and GNG2 3′untranslated region (3′UTR)...
Fri Mar 29, 2019 15:17
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Gao Chao, Xiaoli Li, Yahong Ji, Ying Zhu, Na Li, Nana Zhang, Zunyong Feng, Min NiuAbstractHigh expression levels of miR-155 are involved in the pathogenesis of inflammatory bowel disease (IBD). We observed an increase in miR-155 in peripheral regulatory T (Treg) cells from IBD patients. Mice that specifically overexpress miR-155 in Foxp3+ Treg cells exhibit spontaneous autoimmunity and more severe dextran sulfate...
Fri Mar 29, 2019 15:17
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Wei Chen, Wei Da, Chen Li, Huining Fan, Rui Liang, Junqing Yuan, Xiaoqing Huang, Renzhi Yang, Jing Zhang, Jinshui ZhuAbstractBackground and aimTaraxasterol, a pentacyclic-triterpene, has been reported to exert potent anti-inflammatory activity. However, the molecular mechanisms by which taraxasterol attenuates acute experimental colitis (AEC) remain undocumented.MethodsA network pharmacology approach was used...
Fri Mar 29, 2019 15:17
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Zhe Geng, Bingxia Ming, Shaoxian Hu, Lingli Dong, Cong YeAbstractObjectivesThe chemopreventive drug α-difluoromethylornithine (DFMO) has been shown to have an antinociceptive effect on mechanical allodynia in inflammatory arthritis by directly inhibiting ornithine decarboxylase (ODC) and decreasing polyamine production in inflammatory sites. However, little is known about the effect of DFMO on the immune system...
Fri Mar 29, 2019 15:17
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Guannan Huang, Joella Xu, Tai L. GuoAbstractDaidzein (DAZ), a dominant isoflavone in various natural products such as soybeans, has been gaining attention due to the beneficial health effects (e.g., protection against cancer and diabetes) of its metabolites. Our major hypothesis was that dietary exposure to the soy phytoestrogen DAZ could modulate the immune responses toward a protective effect and lead to improved...
Fri Mar 29, 2019 15:17
Publication date: June 2019Source: International Immunopharmacology, Volume 71Author(s): Qiyan Zeng, Faquan Lin, Linjie Zeng, Yong Deng, Lu LiAbstractLectins are proteins/glycoproteins of non-immune origin, which interact specifically and non-covalently with the carbohydrate moieties of respective receptors on the cell surface. In this study, a novel 65.2-kDa tetrameric lectin (AHL) was purified from Artocarpus hypargyreus Hance (A. hypargyreus) by affinity chromatography on a galactose-sepharose...
Fri Mar 29, 2019 15:17
Publication date: Available online 29 March 2019Source: Journal of Bodywork and Movement TherapiesAuthor(s): M.S. Ajimsha, Pramod D. ShenoyAbstractIntroductionMyofascial release (MFR) is a form of manual therapy that involves the application of a low load, long duration stretch to the myofascial complex intended to restore optimal length, decrease pain and improve function. MFR is being used to treat patients with a wide variety of conditions with favourable evidence supporting its efficacy. Critical...
Fri Mar 29, 2019 13:54
