When you look at a picture of a mug, the neurons that store your memory of what a mug is begin firing. But it’s not a pinpoint process; a host of neurons that code for related ideas and items—bowl, coffee, spoon, plate, breakfast—are activated as well. The word mug must then be selected among its neighbors. Dr Ries’ study shows these two processes, word activation and selection, co-occur in time and space.”
Our JDP students in Language and Communicative Disorders, Irina Potapova, Philip Combiths, and Jonathan Robinson Anthony, had a great time at the International Symposium on Biligualism in Limerick, Ireland, last week. Great job everyone!
[See image gallery at slhs.sdsu.edu]
When you look at a picture of a mug, the neurons that store your memory of what a mug is begin firing. But it’s not a pinpoint process; a host of neurons that code for related ideas and items—bowl, coffee, spoon, plate, breakfast—are activated as well. The word mug must then be selected among its neighbors. Dr Ries’ study shows these two processes, word activation and selection, co-occur in time and space.”
Our JDP students in Language and Communicative Disorders, Irina Potapova, Philip Combiths, and Jonathan Robinson Anthony, had a great time at the International Symposium on Biligualism in Limerick, Ireland, last week. Great job everyone!
[See image gallery at slhs.sdsu.edu]
When you look at a picture of a mug, the neurons that store your memory of what a mug is begin firing. But it’s not a pinpoint process; a host of neurons that code for related ideas and items—bowl, coffee, spoon, plate, breakfast—are activated as well. The word mug must then be selected among its neighbors. Dr Ries’ study shows these two processes, word activation and selection, co-occur in time and space.”
Our JDP students in Language and Communicative Disorders, Irina Potapova, Philip Combiths, and Jonathan Robinson Anthony, had a great time at the International Symposium on Biligualism in Limerick, Ireland, last week. Great job everyone!
[See image gallery at slhs.sdsu.edu]
by Yang Li, Kotaro Watanabe, Masato Fujioka, Kaoru Ogawa
Cochlear spiral ligament fibrocytes (SLFs) play essential roles in the physiology of hearing including ion recycling and the generation of endocochlear potential. In adult animals, SLFs can repopulate after damages, yet little is known about the characteristics of proliferating cells that support SLFs’ self-renewal. Here we report in detail about the characteristics of cycling cells in the spiral ligament (SL). Fifteen P6 mice and six noise-exposed P28 mice were injected with 5-bromo-2′-deoxyuridine (BrdU) for 7 days and we chased BrdU retaining cells for as long as 60 days. Immunohistochemistry revealed that the BrdU positive IB4 (an endotherial marker) negative cells expressed an early SLF marker Pou3f4 but negative for cleaved-Caspase 3. Marker studies revealed that type 3 SLFs displayed significantly higher percentage of BrdU+ cells compared to other subtypes. Notably, the cells retained BrdU until P72, demonstrating they were dividing slowly. In the noise-damaged mice, in contrast to the loss of the other types, the number of type 3 SLFs did not altered and the BrdU incorporating- phosphorylated Histone H3 positive type 3 cells were increased from day 1 to 14 after noise exposure. Furthermore, the cells repopulating type 1 area, where the cells diminished profoundly after damage, were positive for the type 3 SLF markers. Collectively, in the latral wall of the cochlea, type 3 SLFs have the stem cell capacity and may contribute to the endogenous regeneration of lateral wall spiral ligament. Manipulating type 3 cells may be employed for potential regenerative therapies.