Factors related to tinnitus and hyperacusis handicap in older people.

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Factors related to tinnitus and hyperacusis handicap in older people.

Int J Audiol. 2017 Jun 18;:1-8

Authors: Aazh H, Lammaing K, Moore BCJ

Abstract
OBJECTIVE: The aim was to assess factors related to tinnitus and hyperacusis handicap in older people.
DESIGN: Retrospective cross-sectional.
STUDY SAMPLE: Data were gathered for 184 patients with an average age of 69 years.
RESULTS: Tinnitus handicap as measured via the Tinnitus Handicap Inventory (THI) was significantly predicted by tinnitus annoyance as measured via the visual analogue scale (VAS) (regression coefficient, b = 2.9, p < 0.001) and the effect of tinnitus on the patient's life as measured via the VAS (b = 3.9, p < 0.001). Hyperacusis handicap as measured via the Hyperacusis Questionnaire (HQ) was significantly predicted by the score on the depression subscale of the Hospital Anxiety and Depression Scale (HADS) (b = 0.8, p < 0.001) and to a small extent by the THI score (b = 0.07, p = 0.048). Insomnia scores as measured via the Insomnia Severity Index (ISI) were significantly predicted by scores on the depression subscale of the HADS (b = 0.46, p = 0.007).
CONCLUSIONS: Since tinnitus annoyance significantly predicts tinnitus handicap, it is important to explore factors associated with annoyance that may be useful in designing appropriate rehabilitative interventions aimed at reducing tinnitus handicap in older people. Future studies should explore whether hyperacusis and insomnia in older people with tinnitus need to be managed in conjunction with treatment for depression.

PMID: 28625091 [PubMed - as supplied by publisher]

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The absence of CD56 expression can differentiate papillary thyroid carcinoma from other thyroid lesions

http://orlhealth.blogspot.com/2017/06/the-absence-of-cd56-expression-can.html

The neural cell adhesion molecule CD56 is an antigen important for the differentiation of the follicular epithelium. Recent studies have reported low or absent expression of CD56 in papillary thyroid carcinoma (PTC) and its presence in normal thyroid tissue, benign thyroid lesions, and most follicular non-PTC tumors. Aim: We wish to estimate the value of CD56 in the differentiation of PTC (including follicular variant-PTC [FV-PTC]) from other nontumoral lesions and follicular thyroid neoplasias. Settings and Design: This was a retrospective, case–control study. Subjects and Methods: We analyzed the expression of CD56 in normal thyroid follicular tissue, 15 nonneoplastic thyroid lesions (nodular hyperplasia, Graves' disease, and chronic lymphocytic thyroiditis/Hashimoto), and 38 thyroid follicular cell neoplasms (25 cases of PTC). The immunohistochemical reactions were performed on sections stained with anti-CD56 antibody. Statistical Analysis Used: We used the Chi-square test, values of P< 0.05 being considered statistically significant. Risk analysis was applied on these studied groups, by calculating the odds ratio (OR) value. Results: Our results indicated that CD56 immunoexpression had differentiated PTC from benign nonneoplastic lesions (P = 0.002), as well as from follicular neoplasias (P = 0.046). There were no significant differences regarding CD56 expression between FV-PTC and classical PTC (P = 0.436). The immunoexpression of CD56 has differentiated PTC from other thyroid non-PTC lesions (P < 0.001), with 26.4 OR value. Conclusions: CD56 has been proved to be a useful marker in the diagnosis of PTC, including FV-PTC. Its absence can help differentiate FV-PTC from other thyroid nodules with follicular patterns.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Neural representations of concurrent sounds with overlapping spectra in rat inferior colliculus: Comparisons between temporal-fine structure and envelope

Publication date: Available online 17 June 2017
Source:Hearing Research
Author(s): Lu Luo, Qian Wang, Liang Li
Perceptual segregation of multiple sounds, which overlaps in both time and spectra, into individual auditory streams is critical for hearing in natural environments. Some cues such as interaural time disparities (ITDs) play an important role in the segregation, especially when sounds are separated in space. In this study, we investigated the neural representation of two uncorrelated narrowband noises that shared the identical spectrum in the rat inferior colliculus (IC) using frequency-following-response (FFR) recordings, when the ITD for each noise stimulus was manipulated. The results of this study showed that recorded FFRs exhibited two distinctive components: the fast-varying temporal fine structure (TFS) component (FFRTFS) and the slow-varying envelope component (FFRENV). When a single narrowband noise was presented alone, the FFRTFS, but not the FFRENV, was sensitive to ITDs. When two narrowband noises were presented simultaneously, the FFRTFS took advantage of the ITD disparity that was associated with perceived spatial separation between the two concurrent sounds, and displayed a better linear synchronization to the sound with an ipsilateral-leading ITD. However, no effects of ITDs were found on the FFRENV. These results suggest that the FFRTFS and FFRENV represent two distinct signal processes in the auditory brainstem and contribute differentially to sound segregation based on spatial cues: the FFRTFS is more critical to spatial release from masking.



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Neural representations of concurrent sounds with overlapping spectra in rat inferior colliculus: Comparisons between temporal-fine structure and envelope

Publication date: Available online 17 June 2017
Source:Hearing Research
Author(s): Lu Luo, Qian Wang, Liang Li
Perceptual segregation of multiple sounds, which overlaps in both time and spectra, into individual auditory streams is critical for hearing in natural environments. Some cues such as interaural time disparities (ITDs) play an important role in the segregation, especially when sounds are separated in space. In this study, we investigated the neural representation of two uncorrelated narrowband noises that shared the identical spectrum in the rat inferior colliculus (IC) using frequency-following-response (FFR) recordings, when the ITD for each noise stimulus was manipulated. The results of this study showed that recorded FFRs exhibited two distinctive components: the fast-varying temporal fine structure (TFS) component (FFRTFS) and the slow-varying envelope component (FFRENV). When a single narrowband noise was presented alone, the FFRTFS, but not the FFRENV, was sensitive to ITDs. When two narrowband noises were presented simultaneously, the FFRTFS took advantage of the ITD disparity that was associated with perceived spatial separation between the two concurrent sounds, and displayed a better linear synchronization to the sound with an ipsilateral-leading ITD. However, no effects of ITDs were found on the FFRENV. These results suggest that the FFRTFS and FFRENV represent two distinct signal processes in the auditory brainstem and contribute differentially to sound segregation based on spatial cues: the FFRTFS is more critical to spatial release from masking.



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Neural representations of concurrent sounds with overlapping spectra in rat inferior colliculus: Comparisons between temporal-fine structure and envelope

Publication date: Available online 17 June 2017
Source:Hearing Research
Author(s): Lu Luo, Qian Wang, Liang Li
Perceptual segregation of multiple sounds, which overlaps in both time and spectra, into individual auditory streams is critical for hearing in natural environments. Some cues such as interaural time disparities (ITDs) play an important role in the segregation, especially when sounds are separated in space. In this study, we investigated the neural representation of two uncorrelated narrowband noises that shared the identical spectrum in the rat inferior colliculus (IC) using frequency-following-response (FFR) recordings, when the ITD for each noise stimulus was manipulated. The results of this study showed that recorded FFRs exhibited two distinctive components: the fast-varying temporal fine structure (TFS) component (FFRTFS) and the slow-varying envelope component (FFRENV). When a single narrowband noise was presented alone, the FFRTFS, but not the FFRENV, was sensitive to ITDs. When two narrowband noises were presented simultaneously, the FFRTFS took advantage of the ITD disparity that was associated with perceived spatial separation between the two concurrent sounds, and displayed a better linear synchronization to the sound with an ipsilateral-leading ITD. However, no effects of ITDs were found on the FFRENV. These results suggest that the FFRTFS and FFRENV represent two distinct signal processes in the auditory brainstem and contribute differentially to sound segregation based on spatial cues: the FFRTFS is more critical to spatial release from masking.



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Neural representations of concurrent sounds with overlapping spectra in rat inferior colliculus: Comparisons between temporal-fine structure and envelope

Publication date: Available online 17 June 2017
Source:Hearing Research
Author(s): Lu Luo, Qian Wang, Liang Li
Perceptual segregation of multiple sounds, which overlaps in both time and spectra, into individual auditory streams is critical for hearing in natural environments. Some cues such as interaural time disparities (ITDs) play an important role in the segregation, especially when sounds are separated in space. In this study, we investigated the neural representation of two uncorrelated narrowband noises that shared the identical spectrum in the rat inferior colliculus (IC) using frequency-following-response (FFR) recordings, when the ITD for each noise stimulus was manipulated. The results of this study showed that recorded FFRs exhibited two distinctive components: the fast-varying temporal fine structure (TFS) component (FFRTFS) and the slow-varying envelope component (FFRENV). When a single narrowband noise was presented alone, the FFRTFS, but not the FFRENV, was sensitive to ITDs. When two narrowband noises were presented simultaneously, the FFRTFS took advantage of the ITD disparity that was associated with perceived spatial separation between the two concurrent sounds, and displayed a better linear synchronization to the sound with an ipsilateral-leading ITD. However, no effects of ITDs were found on the FFRENV. These results suggest that the FFRTFS and FFRENV represent two distinct signal processes in the auditory brainstem and contribute differentially to sound segregation based on spatial cues: the FFRTFS is more critical to spatial release from masking.



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Neural representations of concurrent sounds with overlapping spectra in rat inferior colliculus: Comparisons between temporal-fine structure and envelope

Publication date: Available online 17 June 2017
Source:Hearing Research
Author(s): Lu Luo, Qian Wang, Liang Li
Perceptual segregation of multiple sounds, which overlaps in both time and spectra, into individual auditory streams is critical for hearing in natural environments. Some cues such as interaural time disparities (ITDs) play an important role in the segregation, especially when sounds are separated in space. In this study, we investigated the neural representation of two uncorrelated narrowband noises that shared the identical spectrum in the rat inferior colliculus (IC) using frequency-following-response (FFR) recordings, when the ITD for each noise stimulus was manipulated. The results of this study showed that recorded FFRs exhibited two distinctive components: the fast-varying temporal fine structure (TFS) component (FFRTFS) and the slow-varying envelope component (FFRENV). When a single narrowband noise was presented alone, the FFRTFS, but not the FFRENV, was sensitive to ITDs. When two narrowband noises were presented simultaneously, the FFRTFS took advantage of the ITD disparity that was associated with perceived spatial separation between the two concurrent sounds, and displayed a better linear synchronization to the sound with an ipsilateral-leading ITD. However, no effects of ITDs were found on the FFRENV. These results suggest that the FFRTFS and FFRENV represent two distinct signal processes in the auditory brainstem and contribute differentially to sound segregation based on spatial cues: the FFRTFS is more critical to spatial release from masking.



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